Gene Expression Literature Summary

• Symbol: Egf
• Name: epidermal growth factor
• ID: MGI:95290

52 matching records from 52 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E4	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)		1	1		1	1	2	2	1		2	1	1	1	2	2			2	2		1				3	5
In situ RNA (section)								1		1		2				3		2		1		2					4
Immunohistochemistry (whole mount)	1																										1
In situ RNA (whole mount)										2						1
Western blot	1								1		1	1	1	1	2	1	2	2	1	1	2		1		1		3
RT-PCR	1		1	1	1	2	2	1	2	3	2	2	3	5	4	4	2	6	2	3	2	4		2		1	20
RNase protection													1		1		1		1								1
Nuclease S1												1		1		1		1		1		1					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Egf  epidermal growth factor
Results	Reference
1	J:320383 Anthoni H, Sucheston LE, Lewis BA, Tapia-Paez I, Fan X, Zucchelli M, Taipale M, Stein CM, Hokkanen ME, Castren E, Pennington BF, Smith SD, Olson RK, Tomblin JB, Schulte-Korne G, Nothen M, Schumacher J, Muller-Myhsok B, Hoffmann P, Gilger JW, Hynd GW, Nopola-Hemmi J, Leppanen PH, Lyytinen H, Schoumans J, Nordenskjold M, Spencer J, Stanic D, Boon WC, Simpson E, Makela S, Gustafsson JA, Peyrard-Janvid M, Iyengar S, Kere J, The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language. Behav Genet. 2012 Jul;42(4):509-27
2*	J:84706 Assimacopoulos S, Grove EA, Ragsdale CW, Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003 Jul 23;23(16):6399-403
6	J:85878 Cai L, Zhang J, Duan E, Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation. Cytokine. 2003 Sep 21;23(6):170-8
1	J:129651 Chi L, Itaranta P, Zhang S, Vainio S, Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology. 2006 Aug;147(8):3777-88
1	J:32190 Dardik A, Smith RM, Schultz RM, Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst. Dev Biol. 1992 Dec;154(2):396-409
2	J:143845 Davy A, Soriano P, Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol. 2007 Apr 1;304(1):182-93
1	J:221164 Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM, Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
1	J:263064 Elliott KH, Millington G, Brugmann SA, A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development. Dev Dyn. 2018 Jun;247(6):818-831
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5*	J:31256 Gupta C, Singh M, Stimulation of epidermal growth factor gene expression during the fetal mouse reproductive tract differentiation: role of androgen and its receptor. Endocrinology. 1996 Feb;137(2):705-11
1	J:95759 Hayashi Y, Liu CY, Jester JJ, Hayashi M, Wang IJ, Funderburgh JL, Saika S, Roughley PJ, Kao CW, Kao WW, Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling. Dev Biol. 2005 Jan 1;277(1):222-34
1*	J:211269 Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD, Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2200-9
3	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
2*	J:80421 Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y, Otonkoski T, ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology. 2002 Nov;143(11):4437-46
3	J:36699 Iamaroon A, Tait B, Diewert VM, Cell proliferation and expression of EGF, TGF-alpha, and EGF receptor in the developing primary palate. J Dent Res. 1996 Aug;75(8):1534-9
2*	J:219373 Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T, Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015 Mar;244(3):488-96
1	J:69420 Jaskoll T, Melnick M, Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 Nov 1;256(3):252-68
1	J:104361 Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H, Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of pkd1. Am J Pathol. 2006 Jan;168(1):205-20
1*	J:153715 Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ, Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56
8	J:38205 Kashimata M, Gresik EW, Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev Dyn. 1997 Feb;208(2):149-61
10*	J:70072 Kronmiller JE, Upholt WB, Kollar EJ, Expression of epidermal growth factor mRNA in the developing mouse mandibular process. Arch Oral Biol. 1991;36(6):405-10
4	J:88398 Kumabe S, Immunohistochemical study of genesis of the mouse oral vestibule. Okajimas Folia Anat Jpn. 2003 Oct;80(4):93-102
1	J:44352 Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM, The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997 Nov 15;11(22):2996-3006
1*	J:278247 Kuony A, Ikkala K, Kalha S, Magalhaes AC, Pirttiniemi A, Michon F, Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop. Development. 2019 Jul 16;146(14):dev176693
5	J:968 Lazar LM, Blum M, Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay. J Neurosci. 1992 May;12(5):1688-97
2	J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
2	J:270002 Liu Z, Skafar DF, Kilburn B, Das SK, Armant DR, Extraembryonic heparin-binding epidermal growth factor-like growth factor deficiency compromises placentation in mice. Biol Reprod. 2019 Jan 1;100(1):217-226
2	J:246200 Lof-Ohlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H, EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity. Nat Cell Biol. 2017 Nov;19(11):1313-1325
3	J:317375 Ma CX, Song YL, Xiao L, Xue LX, Li WJ, Laforest B, Komati H, Wang WP, Jia ZQ, Zhou CY, Zou Y, Nemer M, Zhang SF, Bai X, Wu H, Zang MX, EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner. Cell Mol Life Sci. 2015 May;72(10):2005-22
2	J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733
7	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
5*	J:130339 Minami S, Iwamoto R, Mekada E, HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development. Dev Dyn. 2008 Jan;237(1):247-58
6	J:70074 Nexo E, Hollenberg MD, Figueroa A, Pratt RM, Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
2	J:353621 Patel VN, Aure MH, Choi SH, Ball JR, Lane ED, Wang Z, Xu Y, Zheng C, Liu X, Martin D, Pailin JY, Prochazkova M, Kulkarni AB, van Kuppevelt TH, Ambudkar IS, Liu J, Hoffman MP, Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
5	J:18097 Shigeta H, Taga M, Katoh A, Minaguchi H, Ontogenesis and Distribution of Epidermal Growth Factor Immunoreactivity and Binding Activity in the Mouse Fetal and Neonatal Tissues. Endocr J. 1993;40(6):641-647
7*	J:14214 Shum L, Sakakura Y, Bringas P Jr, Luo W, Snead ML, Mayo M, Crohin C, Millar S, Werb Z, Buckley S, Hall FL, Warburton D, Slavkin HC, EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Development. 1993 Jul;118(3):903-17
6	J:69793 Snead ML, Luo W, Oliver P, Nakamura M, Don-Wheeler G, Bessem C, Bell GI, Rall LB, Slavkin HC, Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development. Dev Biol. 1989 Aug;134(2):420-9
2	J:164392 Suzuki A, Sekiya S, Gunshima E, Fujii S, Taniguchi H, EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture. Lab Invest. 2010 Oct;90(10):1425-36
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
7*	J:157544 Tsai NP, Tsui YC, Pintar JE, Loh HH, Wei LN, Kappa opioid receptor contributes to EGF-stimulated neurite extension in development. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3216-21
4*	J:71390 Umeda Y, Miyazaki Y, Shiinoki H, Higashiyama S, Nakanishi Y, Hieda Y, Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland. Dev Biol. 2001 Sep 1;237(1):202-11
1	J:171966 van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD, The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res. 2010 Oct 15;107(8):1032-40
1	J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1	J:305498 Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W, LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death Dis. 2020 Jul 27;11(7):588
6*	J:32186 Warburton D, Seth R, Shum L, Horcher PG, Hall FL, Werb Z, Slavkin HC, Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. Dev Biol. 1992 Jan;149(1):123-33
3	J:93433 Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ, The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14114-9
6	J:42108 Yamane A, Mayo ML, Bringas P Jr, Chen L, Huynh M, Thai K, Shum L, Slavkin HC, TGF-alpha, EGF, and their cognate EGF receptor are co-expressed with desmin during embryonic, fetal, and neonatal myogenesis in mouse tongue development. Dev Dyn. 1997 Aug;209(4):353-66
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
4*	J:821 Yeh J, Rosen KM, Villa-Komaroff L, Messenger ribonucleic acid for transforming growth factor-alpha, but not for epidermal growth factor, is expressed in fetal and neonatal mouse brain. Am J Obstet Gynecol. 1992 Jul;167(1):242-5
3	J:334091 Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A, Ghashghaei HT, Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242
1	J:304122 Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H, Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 Jul 17;9(7):1714