Gene Expression Literature Summary

• Symbol: Eln
• Name: elastin
• ID: MGI:95317

107 matching records from 107 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)		1	2	4		7	1	3		6		8		4		2	1	16		2	34
In situ RNA (section)	1							1		6		2		3		2		2			4
Immunohistochemistry (whole mount)										2											1
Northern blot					1				1				1				1	1	1		1
Western blot								1		1		1		1		2		1			6
RT-PCR		2	1	1		2	1	3	1	1	1		1	2	1	1	3	10	1	1	23
RNase protection										1		1				1		1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Eln  elastin   (Synonyms: E030024M20Rik, tropoelastin)
Results	Reference
1	J:231522 Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ, Initial Suppression of Transforming Growth Factor-beta Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. Am J Pathol. 2016 Apr;186(4):777-93
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
1	J:134891 Alkemade FE, Gittenberger-de Groot AC, Schiel AE, VanMunsteren JC, Hogers B, van Vliet LS, Poelmann RE, Havekes LM, Willems van Dijk K, DeRuiter MC, Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life. Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2228-35
1	J:205009 Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C, Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol Cell Biol. 2013 Oct;33(20):4030-40
1*	J:240991 Andrae J, Gouveia L, He L, Betsholtz C, Characterization of platelet-derived growth factor-A expression in mouse tissues using a lacZ knock-in approach. PLoS One. 2014;9(8):e105477
1*	J:229890 Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG, KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1;143(5):810-21
1	J:346138 Assali A, Chenaux G, Cho JY, Berto S, Ehrlich NA, Cowan CW, EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. Development. 2024 Mar 1;151(5)
7*	J:101483 Beck K, Dang K, Boyd CD, The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly. J Mol Histol. 2005 Mar;36(3):167-70
2	J:180979 Besnard V, Wert SE, Ikegami M, Xu Y, Heffner C, Murray SA, Donahue LR, Whitsett JA, Maternal synchronization of gestational length and lung maturation. PLoS One. 2011;6(11):e26682
1*	J:60658 Bouwman P, Gollner H, Elsasser HP, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G, Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000 Feb 15;19(4):655-61
1	J:229471 Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X, Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10
1	J:301331 Bridges JP, Sudha P, Lipps D, Wagner A, Guo M, Du Y, Brown K, Filuta A, Kitzmiller J, Stockman C, Chen X, Weirauch MT, Jobe AH, Whitsett JA, Xu Y, Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L239-L255
3	J:310741 Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML, Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22;31(6):707-21
1	J:247078 Bultmann-Mellin I, Dinger K, Debuschewitz C, Loewe KMA, Melcher Y, Plum MTW, Appel S, Rappl G, Willenborg S, Schauss AC, Jungst C, Kruger M, Dressler S, Nakamura T, Wempe F, Alejandre Alcazar MA, Sterner-Kock A, Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs. Am J Physiol Lung Cell Mol Physiol. 2017 Oct 01;313(4):L687-L698
1	J:173947 Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY, Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest. 2011 May 2;121(5):1871-81
1*	J:228706 Chandramouli A, Simundza J, Pinderhughes A, Hiremath M, Droguett G, Frendewey D, Cowin P, Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res. 2013;15(6):R111
1*	J:331053 Chandrasekaran P, Negretti NM, Sivakumar A, Liberti DC, Wen H, Peers de Nieuwburgh M, Wang JY, Michki NS, Chaudhry FN, Kaur S, Lu M, Jin A, Zepp JA, Young LR, Sucre JMS, Frank DB, CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth. Development. 2022 Nov 1;149(21):dev200909
4	J:138661 Chang CH, Kawa Y, Tsai RK, Shieh JH, Lee JW, Watabe H, Kawakami T, Soma Y, Tajima S, Mizoguchi M, Melanocyte precursors express elastin binding protein and elastin-derived peptide (VGVAPG) stimulates their melanogenesis and dendrite formation. J Dermatol Sci. 2008 Sep;51(3):158-70
1	J:137996 Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W, TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J. 2008 Aug;32(2):285-95
1	J:228894 Coles GL, Baglia LA, Ackerman KG, KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet. 2015 Oct;11(10):e1005525
1*	J:219045 Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X, Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013;11:107
3	J:321806 Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM, JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. J Clin Invest. 2022 Mar 1;132(5):e142338
1	J:114396 De Langhe SP, Carraro G, Warburton D, Hajihosseini MK, Bellusci S, Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol. 2006 Nov 1;299(1):52-62
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1	J:306256 Dupuis LE, Nelson EL, Hozik B, Porto SC, Rogers-DeCotes A, Fosang A, Kern CB, Adamts5(-/-) Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2067-2081
1	J:139945 El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M, SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development. 2008 Sep;135(17):2981-91
3	J:264144 Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ, A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7:e34110
1	J:163382 Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, Bodine P, D'Armiento J, The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol. 2010 Aug;177(2):598-607
1*	J:290862 Fulmer D, Toomer KA, Glover J, Guo L, Moore K, Moore R, Stairley R, Gensemer C, Abrol S, Rumph MK, Emetu F, Lipschutz JH, McDowell C, Bian J, Wang C, Beck T, Wessels A, Renault MA, Norris RA, Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin. Dev Biol. 2020 Jul 1;463(1):26-38
1	J:159978 Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC, Ets1 is required for proper migration and differentiation of the cardiac neural crest. Development. 2010 May;137(9):1543-51
1	J:209770 Geng Y, Li L, Dong Y, Liu X, Li XH, Ning W, Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One. 2013;8(11):e81368
6*	J:85546 Gill SE, Pape MC, Khokha R, Watson AJ, Leco KJ, A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis. Dev Biol. 2003 Sep 15;261(2):313-23
2	J:294628 Gong H, Ni J, Xu Z, Huang J, Zhang J, Huang Y, Zeng C, Zhang X, Cheng H, Ke Y, Shp2 in myocytes is essential for cardiovascular and neointima development. J Mol Cell Cardiol. 2019 Dec;137:71-81
1	J:325724 Gong Y, Laheji F, Berenson A, Qian A, Park SO, Kok R, Selig M, Hahn R, Sadjadi R, Kemp S, Eichler F, Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia. Cells. 2022 Jun 4;11(11)
1*	J:146851 Hand NJ, Master ZR, Eauclaire SF, Weinblatt DE, Matthews RP, Friedman JR, The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology. 2009 Mar;136(3):1081-90
8	J:195895 Hanson KP, Jung JP, Tran QA, Hsu SP, Iida R, Ajeti V, Campagnola PJ, Eliceiri KW, Squirrell JM, Lyons GE, Ogle BM, Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart: a blueprint for regeneration. Tissue Eng Part A. 2013 May;19(9-10):1132-43
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
4*	J:267460 Hrycaj SM, Marty-Santos L, Cebrian C, Rasky AJ, Ptaschinski C, Lukacs NW, Wellik DM, Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10605-E10614
1	J:173651 Hsu YC, Osinski J, Campbell CE, Litwack ED, Wang D, Liu S, Bachurski CJ, Gronostajski RM, Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation. Dev Biol. 2011 Jun 15;354(2):242-52
1	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1*	J:161299 Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H, The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10538-42
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1	J:63198 Iwata T, Chen L, Li Cl, Ovchinnikov DA, Behringer RR, Francomano CA, Deng CX, A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet. 2000 Jul 1;9(11):1603-13
6	J:179089 Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz DB, Davis EC, Dichek DA, Transforming Growth Factor-beta Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):e1-e11
2*	J:119271 Kagami Y, Furuichi T, Investigation of differentially expressed genes during the development of mouse cerebellum. Brain Res Gene Expr Patterns. 2001 Aug;1(1):39-59
3	J:268349 Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR, Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018 Nov 2;9(1):4600
1	J:313922 Kuiper-Makris C, Zanetti D, Vohlen C, Fahle L, Muller M, Odenthal M, Felderhoff-Muser U, Dotsch J, Alejandre Alcazar MA, Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function. Sci Rep. 2020 Dec 28;10(1):22395
1	J:331419 Labbe P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin E, Angiopoietin-like 2 is essential to aortic valve development in mice. Commun Biol. 2022 Nov 21;5(1):1277
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1*	J:171626 Li S, Xiang M, Foxn4 influences alveologenesis during lung development. Dev Dyn. 2011 Jun;240(6):1512-7
1	J:214993 Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT, Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15;392(2):324-33
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1	J:181392 Londhe VA, Maisonet TM, Lopez B, Jeng JM, Xiao J, Li C, Minoo P, Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011;12:134
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3	J:315454 Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould DB, Sun Y, Maalouf FI, Nagy N, Donahoe PK, Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016 Jul 13;14:59
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1	J:329931 Molla MR, Shimizu A, Komeno M, Rahman NIA, Soh JEC, Nguyen LKC, Khan MR, Tesega WW, Chen S, Pang X, Tanaka-Okamoto M, Takashima N, Sato A, Suzuki T, Ogita H, Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity. Commun Biol. 2022 Oct 7;5(1):1071
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1	J:228583 Nandadasa S, Nelson CM, Apte SS, ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28
1	J:350484 Neupane S, Williamson DB, Roth RA, Halabi CM, Haltiwanger RS, Holdener BC, Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues. J Biol Chem. 2024 Jun 4;300(7):107445
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1	J:137825 Passman JN, Dong XR, Wu SP, Maguire CT, Hogan KA, Bautch VL, Majesky MW, A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9349-54
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3	J:242076 Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Konigshoff M, Hind M, Minelli C, Lloyd CM, Dean CH, Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017 Apr 01;10(4):409-423
1	J:343286 Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ, Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
2	J:323229 Rosendahl AH, Monnius M, Laitala A, Railo A, Miinalainen I, Heljasvaara R, Maki JM, Myllyharju J, Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. J Biol Chem. 2022 Mar 2;298(4):101787
1	J:298990 Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N, Bohio AA, Nagi FH, Feng X, Zhang L, Zheng Y, Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
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