Gene Expression Literature Summary

• Symbol: En1
• Name: engrailed 1
• ID: MGI:95389

331 matching records from 331 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)				1		1	5	4	34	5	22	3	28		9		2	1	9		2	1	4	5	9	13
In situ RNA (section)			1	2	4	2	13	4	29	1	27	2	21	1	7	2	14	1	6		3		5	6	1	18
Immunohistochemistry (whole mount)				4	3	4	6	2	5		1	1													1
In situ RNA (whole mount)	1	2	4	8	25	8	43	6	44	4	12		6		2				2						9	1
In situ reporter (knock in)				1	3	2	6	1	11	4	6	4	7		4		3		4		1		3	2	2	6
Northern blot							3		2		2		3		2		2		2		3		2
Western blot						1	1					1	2						1			1				2
RT-PCR				1	1	1	2		5	1	2		7		3	1	4	1		2					1	7
cDNA clones					1								1													1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

En1  engrailed 1   (Synonyms: En-1, engrailed-1, Mo-en.1)
Results	Reference
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1*	J:92327 Adamska M, MacDonald BT, Sarmast ZH, Oliver ER, Meisler MH, En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol. 2004 Aug 1;272(1):134-44
2*	J:248848 Ahmed MU, Maurya AK, Cheng L, Jorge EC, Schubert FR, Maire P, Basson MA, Ingham PW, Dietrich S, Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility. Dev Biol. 2017 Oct 1;430(1):90-104
4	J:73526 Ahn K, Mishina Y, Hanks MC, Behringer RR, Crenshaw EB 3rd, BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 2001 Nov;128(22):4449-61
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1	J:98363 Alberi L, Sgado P, Simon HH, Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons. Development. 2004 Jul;131(13):3229-36
4	J:333368 Aldea D, Kokalari B, Atsuta Y, Dingwall HL, Zheng Y, Nace A, Cotsarelis G, Kamberov YG, Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. PLoS Genet. 2023 Feb;19(2):e1010614
4*	J:306235 Allou L, Balzano S, Magg A, Quinodoz M, Royer-Bertrand B, Schopflin R, Chan WL, Speck-Martins CE, Carvalho DR, Farage L, Lourenco CM, Albuquerque R, Rajagopal S, Nampoothiri S, Campos-Xavier B, Chiesa C, Niel-Butschi F, Wittler L, Timmermann B, Spielmann M, Robson MI, Ringel A, Heinrich V, Cova G, Andrey G, Prada-Medina CA, Pescini-Gobert R, Unger S, Bonafe L, Grote P, Rivolta C, Mundlos S, Superti-Furga A, Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator. Nature. 2021 Apr;592(7852):93-98
1	J:316641 Altieri SC, Zhao T, Jalabi W, Romito-DiGiacomo RR, Maricich SM, En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus. Dev Neurobiol. 2016 Nov;76(11):1266-1274
7	J:225216 Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ, Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun. 2014;5:4181
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1	J:135132 Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP, Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
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1	J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76
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3	J:84363 Bilovocky NA, Romito-DiGiacomo RR, Murcia CL, Maricich SM, Herrup K, Factors in the genetic background suppress the engrailed-1 cerebellar phenotype. J Neurosci. 2003 Jun 15;23(12):5105-12
2	J:137136 Blaess S, Stephen D, Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
4*	J:118802 Blak AA, Naserke T, Saarimaki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W, Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev Biol. 2007 Mar 1;303(1):231-43
3	J:98791 Blak AA, Naserke T, Weisenhorn DM, Prakash N, Partanen J, Wurst W, Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Dev Dyn. 2005 Apr 13;233(3):1023-1030
1*	J:74136 Borges AC, Marques S, Belo JA, The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development. Int J Dev Biol. 2001 Apr;45(2):441-4
1	J:316302 Bosch PJ, Fuller LC, Weiner JA, An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression. Sci Rep. 2018 Aug 16;8(1):12240
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4*	J:76815 Broccoli V, Colombo E, Cossu G, Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures. Mech Dev. 2002 Jun;114(1-2):219
1*	J:86963 Brunelli S, Innocenzi A, Cossu G, Bhlhb5 is expressed in the CNS and sensory organs during mouse embryonic development. Gene Expr Patterns. 2003 Dec;3(6):755-9
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1	J:76658 Gross MK, Dottori M, Goulding M, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16;34(4):535-49
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