Symbol Name ID |
Evx1
even-skipped homeobox 1 MGI:95461 |
Age | E4.5 | E5 | E5.5 | E6 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13.5 | E14 | E14.5 | E15.5 | E16.5 | E17 | E18.5 | E | P |
Immunohistochemistry (section) | 1 | 3 | 19 | 2 | 15 | 3 | 23 | 5 | 2 | 1 | 2 | 2 | 1 | 1 | 4 | 4 | ||||||||||
In situ RNA (section) | 1 | 1 | 1 | 3 | 5 | 2 | 8 | 3 | 6 | 1 | 2 | 4 | 13 | 9 | 1 | 7 | 3 | 3 | 2 | 1 | 2 | 1 | 3 | |||
In situ RNA (whole mount) | 3 | 2 | 6 | 3 | 3 | 4 | 1 | 9 | 1 | 3 | 2 | 1 | 1 | 3 | ||||||||||||
Northern blot | 1 | |||||||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | ||||||||||||||||||||||
cDNA clones | 1 |
Evx1 even-skipped homeobox 1 (Synonyms: Evx-1) | |
Results | Reference |
1* | J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90 |
1* | J:68216 Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H, Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97 |
2 | J:187218 Andersson LS, Larhammar M, Memic F, Wootz H, Schwochow D, Rubin CJ, Patra K, Arnason T, Wellbring L, Hjalm G, Imsland F, Petersen JL, McCue ME, Mickelson JR, Cothran G, Ahituv N, Roepstorff L, Mikko S, Vallstedt A, Lindgren G, Andersson L, Kullander K, Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Nature. 2012 Aug 30;488(7413):642-6 |
1* | J:81180 Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R, Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003 Jan 1;17(1):126-40 |
1 | J:87948 Bai CB, Stephen D, Joyner AL, All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004 Jan;6(1):103-15 |
1 | J:257081 Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL, Presenilin-dependent receptor processing is required for axon guidance. Cell. 2011 Jan 7;144(1):106-18 |
1* | J:321845 Bernhardt N, Memic F, Velica A, Tran MA, Vieillard J, Sayyab S, Chersa T, Andersson L, Whelan PJ, Boije H, Kullander K, Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. eNeuro. 2022 Mar-Apr;9(2):ENEURO.0518-21.2022 |
2 | J:165285 Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chedotal A, Fortin G, Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci. 2010 Sep;13(9):1066-74 |
1 | J:99491 Britanova O, Akopov S, Lukyanov S, Gruss P, Tarabykin V, Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur J Neurosci. 2005 Feb;21(3):658-68 |
1* | J:302463 Buers I, Pennekamp P, Nitschke Y, Lowe C, Skryabin BV, Rutsch F, Lmbrd1 expression is essential for the initiation of gastrulation. J Cell Mol Med. 2016 Aug;20(8):1523-33 |
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3 | J:124082 Cambray N, Wilson V, Two distinct sources for a population of maturing axial progenitors. Development. 2007 Aug;134(15):2829-40 |
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1 | J:174745 Chen JA, Huang YP, Mazzoni EO, Tan GC, Zavadil J, Wichterle H, Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron. 2011 Feb 24;69(4):721-35 |
1 | J:238975 Clovis YM, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S, Lee SK, Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016 Aug 09;16(6):1642-52 |
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3 | J:243956 Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR, Id genes are essential for early heart formation. Genes Dev. 2017 Aug 9; |
1 | J:54652 Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM, Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron. 1999 Apr;22(4):677-91 |
1 | J:278241 Delile J, Rayon T, Melchionda M, Edwards A, Briscoe J, Sagner A, Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord. Development. 2019 Mar 27;146(12):dev173807 |
1 | J:178688 Demireva EY, Shapiro LS, Jessell TM, Zampieri N, Motor neuron position and topographic order imposed by beta- and gamma-catenin activities. Cell. 2011 Oct 28;147(3):641-52 |
1 | J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
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3 | J:139748 Dinger ME, Amaral PP, Mercer TR, Pang KC, Bruce SJ, Gardiner BB, Askarian-Amiri ME, Ru K, Solda G, Simons C, Sunkin SM, Crowe ML, Grimmond SM, Perkins AC, Mattick JS, Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res. 2008 Sep;18(9):1433-45 |
7* | J:22839 Dolle P, Fraulob V, Duboule D, Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex. Dev Suppl. 1994;:143-53 |
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1* | J:227640 Economou C, Tsakiridis A, Wymeersch FJ, Gordon-Keylock S, Dewhurst RE, Fisher D, Medvinsky A, Smith AJ, Wilson V, Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. BMC Dev Biol. 2015;15:35 |
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2 | J:134674 Fogel JL, Chiang C, Huang X, Agarwala S, Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Dev Dyn. 2008 May;237(5):1359-72 |
1* | J:79391 Fujiwara T, Dehart DB, Sulik KK, Hogan BL, Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. Development. 2002 Oct;129(20):4685-96 |
1 | J:252092 Gard C, Gonzalez Curto G, Frarma YE, Chollet E, Duval N, Auzie V, Aurade F, Vigier L, Relaix F, Pierani A, Causeret F, Ribes V, Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons. Dev Biol. 2017 Dec 1;432(1):24-33 |
2* | J:44409 Gofflot F, Hall M, Morriss-Kay GM, Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev Dyn. 1997 Dec;210(4):431-45 |
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1 | J:305179 Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T, Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Mol Brain. 2020 May 29;13(1):85 |
2* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
1 | J:76658 Gross MK, Dottori M, Goulding M, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16;34(4):535-49 |
1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1 | J:135128 Guo Q, Li JY, Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development. 2007 Jun;134(12):2251-60 |
1 | J:263271 Haque F, Rancic V, Zhang W, Clugston R, Ballanyi K, Gosgnach S, WT1-Expressing Interneurons Regulate Left-Right Alternation during Mammalian Locomotor Activity. J Neurosci. 2018 Jun 20;38(25):5666-5676 |
1 | J:94391 Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R, Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development. 2004 Nov;131(22):5539-50 |
2* | J:18126 Holdener BC, Faust C, Rosenthal NS, Magnuson T, msd is required for mesoderm induction in mice. Development. 1994 May;120(5):1335-46 |
1 | J:199287 Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, McMahon AP, Allen BL, Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug;140(16):3423-34 |
1 | J:208415 Inamata Y, Shirasaki R, Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons. Development. 2014 Mar;141(6):1260-71 |
1 | J:193861 Kang K, Lee D, Hong S, Park SG, Song MR, The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord. J Biol Chem. 2013 Jan 25;288(4):2580-92 |
1 | J:186538 Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y, Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord. J Neurosci. 2012 Jul 25;32(30):10396-407 |
1 | J:266544 Kim J, Choi TI, Park S, Kim MH, Kim CH, Lee S, Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17):dev165340 |
2 | J:62984 Kitajima S, Takagi A, Inoue T, Saga Y, MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26 |
1 | J:78622 Kruger M, Schafer K, Braun T, The homeobox containing gene Lbx1 is required for correct dorsal-ventral patterning of the neural tube. J Neurochem. 2002 Aug;82(4):774-82 |
1* | J:38380 Kuhlman J, Niswander L, Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge. Development. 1997 Jan;124(1):133-9 |
1 | J:89813 Lanuza GM, Gosgnach S, Pierani A, Jessell TM, Goulding M, Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004 May 13;42(3):375-86 |
3 | J:272124 Laumonnerie C, Tong YG, Alstermark H, Wilson SI, Commissural axonal corridors instruct neuronal migration in the mouse spinal cord. Nat Commun. 2015 May 11;6:7028 |
1 | J:228865 Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A, Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76 |
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1 | J:92067 Lei Q, Zelman AK, Kuang E, Li S, Matise MP, Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development. 2004 Aug;131(15):3593-604 |
1 | J:169530 Li J, Wang C, Pan Y, Bai Z, Wang B, Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Dev Dyn. 2011 Apr;240(4):766-74 |
1 | J:118347 Liu B, Liu Z, Chen T, Li H, Qiang B, Yuan J, Peng X, Qiu M, Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord. Dev Dyn. 2007 Mar;236(3):829-35 |
1 | J:174785 Luu B, Ellisor D, Zervas M, The lineage contribution and role of Gbx2 in spinal cord development. PLoS One. 2011;6(6):e20940 |
1 | J:291948 Ma P, Song NN, Cheng X, Zhu L, Zhang Q, Zhang LL, Yang X, Wang H, Kong Q, Shi D, Ding YQ, Mao B, ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. J Mol Cell Biol. 2020 Jun 11;12(5):337-344 |
2 | J:291960 Ma P, Song NN, Li Y, Zhang Q, Zhang L, Zhang L, Kong Q, Ma L, Yang X, Ren B, Li C, Zhao X, Li Y, Xu Y, Gao X, Ding YQ, Mao B, Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep. 2019 Jul 9;28(2):541-553.e4 |
1* | J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59 |
3* | J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86 |
1* | J:51645 Mansouri A, Gruss P, Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. Mech Dev. 1998 Nov;78(1-2):171-8 |
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2* | J:43464 Matise MP, Joyner AL, Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons. J Neurosci. 1997 Oct 15;17(20):7805-16 |
1 | J:202820 Moore S, Ribes V, Terriente J, Wilkinson D, Relaix F, Briscoe J, Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube. PLoS Genet. 2013 Oct;9(10):e1003811 |
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4 | J:153192 Morikawa Y, Hisaoka T, Senba E, Characterization of Foxp2-expressing cells in the developing spinal cord. Neuroscience. 2009 Sep 15;162(4):1150-62 |
1 | J:156251 Morikawa Y, Komori T, Hisaoka T, Senba E, Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis. Dev Neurosci. 2009;31(6):511-22 |
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6* | J:14721 Niswander L, Martin GR, FGF-4 regulates expression of Evx-1 in the developing mouse limb. Development. 1993 Sep;119(1):287-94 |
1* | J:71951 Ohnemus S, Bobola N, Kanzler B, Mallo M, Different levels of Hoxa2 are required for particular developmental processes. Mech Dev. 2001 Oct;108(1-2):135-47 |
2 | J:121344 Pachikara A, Dolson DK, Martinu L, Riccomagno MM, Jeong Y, Epstein DJ, Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms. Dev Biol. 2007 May 1;305(1):52-62 |
1 | J:164670 Panayi H, Panayiotou E, Orford M, Genethliou N, Mean R, Lapathitis G, Li S, Xiang M, Kessaris N, Richardson WD, Malas S, Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord. J Neurosci. 2010 Sep 15;30(37):12274-80 |
1* | J:203015 Panayiotou E, Panayi E, Lapathitis G, Francius C, Clotman F, Kessaris N, Richardson WD, Malas S, Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice. Gene Expr Patterns. 2013 Dec;13(8):328-34 |
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1 | J:81339 Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56 |
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2 | J:103506 Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S, Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ. 2002 Nov;9(11):1196-206 |
1 | J:327338 Sartoretti MM, Campetella CA, Lanuza GM, Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling. Development. 2022 Aug 1;149(15):dev200750 |
1 | J:302572 Schnerwitzki D, Hayn C, Perner B, Englert C, Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration. Front Neurosci. 2020;14:529487 |
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1 | J:181230 Scotti M, Kmita M, Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development. 2012 Feb;139(4):731-9 |
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4* | J:20014 Spyropoulos DD, Capecchi MR, Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev. 1994 Aug 15;8(16):1949-61 |
1 | J:56519 Sun X, Meyers EN, Lewandoski M, Martin GR, Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999 Jul 15;13(14):1834-46 |
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last database update 08/21/2024 MGI 6.24 |
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