Gene Expression Literature Summary

• Symbol: Evx2
• Name: even-skipped homeobox 2
• ID: MGI:95462

44 matching records from 44 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E18.5	E	P
Immunohistochemistry (section)					1	3	8	1	3	1	4		2			1		2
In situ RNA (section)	1	1	1		1	2	1		5		2		3	2	2	1	1	2	3
In situ RNA (whole mount)				1	2	1	7	1	8	2	8	1			2			4
Northern blot											1
RT-PCR									1		3		4	1
cDNA clones											1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Evx2  even-skipped homeobox 2   (Synonyms: Evx-2)
Results	Reference
1	J:87948 Bai CB, Stephen D, Joyner AL, All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004 Jan;6(1):103-15
2	J:231885 Beccari L, Yakushiji-Kaminatsui N, Woltering JM, Necsulea A, Lonfat N, Rodriguez-Carballo E, Mascrez B, Yamamoto S, Kuroiwa A, Duboule D, A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Genes Dev. 2016 May 15;30(10):1172-86
2	J:203785 Delpretti S, Montavon T, Leleu M, Joye E, Tzika A, Milinkovitch M, Duboule D, Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding. Cell Rep. 2013 Oct 17;5(1):137-50
1	J:178688 Demireva EY, Shapiro LS, Jessell TM, Zampieri N, Motor neuron position and topographic order imposed by beta- and gamma-catenin activities. Cell. 2011 Oct 28;147(3):641-52
1	J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
9*	J:22839 Dolle P, Fraulob V, Duboule D, Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex. Dev Suppl. 1994;:143-53
5*	J:1122 Dush MK, Martin GR, Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak. Dev Biol. 1992 May;151(1):273-87
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:37211 Herault Y, Hraba-Renevey S, van der Hoeven F, Duboule D, Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996 Dec 2;15(23):6727-38
1	J:208415 Inamata Y, Shirasaki R, Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons. Development. 2014 Mar;141(6):1260-71
1	J:266544 Kim J, Choi TI, Park S, Kim MH, Kim CH, Lee S, Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17):dev165340
3	J:272124 Laumonnerie C, Tong YG, Alstermark H, Wilson SI, Commissural axonal corridors instruct neuronal migration in the mouse spinal cord. Nat Commun. 2015 May 11;6:7028
1	J:174785 Luu B, Ellisor D, Zervas M, The lineage contribution and role of Gbx2 in spinal cord development. PLoS One. 2011;6(6):e20940
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
5	J:356043 Maier JA, Rivas-Astroza M, Deng J, Dowling A, Oboikovitz P, Cao X, Behringer RR, Cretekos CJ, Rasweiler JJ 4th, Zhong S, Sears KE, Transcriptomic insights into the genetic basis of mammalian limb diversity. BMC Evol Biol. 2017 Mar 23;17(1):86
3	J:156172 Marklund U, Hansson EM, Sundstrom E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J, Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45
1	J:82850 Monge I, Kondo T, Duboule D, An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster. Dev Biol. 2003 Apr 15;256(2):212-20
1	J:131545 Montavon T, Le Garrec JF, Kerszberg M, Duboule D, Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. Genes Dev. 2008 Feb 1;22(3):346-59
1	J:192248 Montavon T, Thevenet L, Duboule D, Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20204-11
3*	J:96853 Mukhopadhyay P, Greene RM, Zacharias W, Weinrich MC, Singh S, Young WW Jr, Pisano MM, Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004 Dec;70(12):912-26
1	J:193399 Park S, Lee C, Sabharwal P, Zhang M, Meyers CL, Sockanathan S, GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science. 2013 Jan 18;339(6117):324-8
1	J:84976 Pattyn A, Vallstedt A, Dias JM, Sander M, Ericson J, Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development. 2003 Sep;130(17):4149-59
10	J:70191 Pierani A, Moran-Rivard L, Sunshine MJ, Littman DR, Goulding M, Jessell TM, Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron. 2001 Feb;29(2):367-84
1*	J:336421 Rodriguez-Carballo E, Lopez-Delisle L, Yakushiji-Kaminatsui N, Ullate-Agote A, Duboule D, Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes. BMC Biol. 2019 Jul 12;17(1):55
2	J:260451 Rodriguez-Carballo E, Lopez-Delisle L, Zhan Y, Fabre PJ, Beccari L, El-Idrissi I, Huynh THN, Ozadam H, Dekker J, Duboule D, The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes. Genes Dev. 2017 Nov 15;31(22):2264-2281
1	J:180121 Ruf S, Symmons O, Uslu VV, Dolle D, Hot C, Ettwiller L, Spitz F, Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat Genet. 2011 Apr;43(4):379-86
2*	J:172713 Schorderet P, Duboule D, Structural and functional differences in the long non-coding RNA hotair in mouse and human. PLoS Genet. 2011 May;7(5):e1002071
1	J:241710 Sheth R, Barozzi I, Langlais D, Osterwalder M, Nemec S, Carlson HL, Stadler HS, Visel A, Drouin J, Kmita M, Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13. Cell Rep. 2016 Dec 13;17(11):2913-2926
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:169050 Soshnikova N, Montavon T, Leleu M, Galjart N, Duboule D, Functional analysis of CTCF during mammalian limb development. Dev Cell. 2010 Dec 14;19(6):819-30
4	J:83372 Spitz F, Gonzalez F, Duboule D, A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell. 2003 May 2;113(3):405-17
1	J:207496 Symmons O, Uslu VV, Tsujimura T, Ruf S, Nassari S, Schwarzer W, Ettwiller L, Spitz F, Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar;24(3):390-400
3	J:105255 Tarchini B, Duboule D, Control of Hoxd genes' collinearity during early limb development. Dev Cell. 2006 Jan;10(1):93-103
2	J:103924 Tarchini B, Huynh TH, Cox GA, Duboule D, HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
3	J:71607 Vallstedt A, Muhr J, Pattyn A, Pierani A, Mendelsohn M, Sander M, Jessell TM, Ericson J, Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron. 2001 Sep 13;31(5):743-55
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:80206 Wijgerde M, McMahon JA, Rule M, McMahon AP, A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002 Nov 15;16(22):2849-64
1	J:91158 Yip YP, Zhou G, Capriotti C, Yip JW, Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord. J Comp Neurol. 2004 Aug 2;475(4):564-74
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:36443 Zakany J, Duboule D, Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature. 1996 Nov 7;384(6604):69-71