Gene Expression Literature Summary

• Symbol: Fbl
• Name: fibrillarin
• ID: MGI:95486

25 matching records from 25 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E8.5	E10.5	E11.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)							1	1				1				1	1		2
In situ RNA (section)											1	2		1					1
Immunohistochemistry (whole mount)	2	3	3	5	1	3												2	2
In situ reporter (knock in)									1
Western blot		1								1			1				1		3
RT-PCR	1	2	1												1				1
cDNA clones								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fbl  fibrillarin   (Synonyms: RNU3IP1)
Results	Reference
1*	J:69869 Baran V, Brochard V, Renard JP, Flechon JE, Nopp 140 involvement in nucleologenesis of mouse preimplantation embryos. Mol Reprod Dev. 2001 Jul;59(3):277-84
3*	J:23791 Baran V, Vesela J, Rehak P, Koppel J, Flechon JE, Localization of fibrillarin and nucleolin in nucleoli of mouse preimplantation embryos. Mol Reprod Dev. 1995 Mar;40(3):305-10
1	J:28401 Bettenhausen B, Gossler A, Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1*	J:83658 Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM, Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
1	J:33174 Cuadros-Fernandez JM, Esponda P, Immunocytochemical localisation of the nucleolar protein fibrillarin and RNA polymerase I during mouse early embryogenesis. Zygote. 1996 Feb;4(1):49-58
1	J:340778 Dash S, Lamb MC, Lange JJ, McKinney MC, Tsuchiya D, Guo F, Zhao X, Corbin TJ, Kirkman M, Delventhal K, Moore EL, McKinney S, Shiang R, Trainor PA, rRNA transcription is integral to phase separation and maintenance of nucleolar structure. PLoS Genet. 2023 Aug;19(8):e1010854
1*	J:319633 Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ, Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis. PLoS Genet. 2022 Jan;18(1):e1010012
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:23142 Ferreira J, Carmo-Fonseca M, The biogenesis of the coiled body during early mouse development. Development. 1995 Feb;121(2):601-12
3	J:355060 Gregorio I, Mereu M, Contarini G, Bello L, Semplicini C, Burgio F, Russo L, Sut S, Dall'Acqua S, Braghetta P, Semenza C, Pegoraro E, Papaleo F, Bonaldo P, Cescon M, Collagen VI deficiency causes behavioral abnormalities and cortical dopaminergic dysfunction. Dis Model Mech. 2022 Sep 1;15(9):dmm049481
2	J:242098 Hamdane N, Tremblay MG, Dillinger S, Stefanovsky VY, Nemeth A, Moss T, Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies. Gene. 2017 May 15;612:5-11
1	J:349860 Hashimoto K, Ohira M, Kodama A, Kimoto M, Inoue M, Tone S, Usui Y, Hanashima A, Goto T, Ogura Y, Ujihara Y, Mohri S, Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
4*	J:281210 Krejci J, Legartova S, Bartova E, Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli. Stem Cells Int. 2017;2017:1021240
2*	J:302708 Liu HB, Muhammad T, Guo Y, Li MJ, Sha QQ, Zhang CX, Liu H, Zhao SG, Zhao H, Zhang H, Du YZ, Sun K, Liu K, Lu G, Guo XJ, Sha J, Fan HY, Gao F, Chen ZJ, RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Adv Sci (Weinh). 2019 Aug 7;6(15):1900295
3*	J:298149 Liu Y, Zhao LW, Shen JL, Fan HY, Jin Y, Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Sci Rep. 2019 Apr 18;9(1):6278
1	J:89938 Newton K, Petfalski E, Tollervey D, Caceres JF, Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol Cell Biol. 2003 Dec;23(23):8519-27
5*	J:114487 Romanova LG, Anger M, Zatsepina OV, Schultz RM, Implication of Nucleolar Protein SURF6 in Ribosome Biogenesis and Preimplantation Mouse Development. Biol Reprod. 2006 Nov;75(5):690-6
1	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
1	J:264747 Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Geleoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK, Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 Jun;188(6):1334-1344
2	J:160518 Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L, Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010 May 15;24(10):1059-72
2	J:286260 Wang X, Li ZT, Yan Y, Lin P, Tang W, Hasler D, Meduri R, Li Y, Hua MM, Qi HT, Lin DH, Shi HJ, Hui J, Li J, Li D, Yang JH, Lin J, Meister G, Fischer U, Liu MF, LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Mol Cell. 2020 Mar 5;77(5):999-1013.e6
2*	J:165972 Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H, EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol. 2010;10:99
2	J:145174 Zhang J, Tomasini AJ, Mayer AN, RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol. 2008;8:115
1	J:354447 Zhang Y, Kang HR, Jun Y, Kang H, Bang G, Ma R, Ju S, Yoon DE, Kim Y, Kim K, Kim JY, Han K, Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687