Gene Expression Literature Summary

• Symbol: Fgf4
• Name: fibroblast growth factor 4
• ID: MGI:95518

315 matching records from 315 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)				1	2	1	1		1										1				2		2		3		2		1		2			1		1
In situ RNA (section)		1	1			1	1		1	2	1	1	7	7	11	1	4	2	14	2	7	2	3	3	11	4	37	2	7	4	12	1	6	1	3		4	6
Immunohistochemistry (whole mount)					2	1	1														1		1	1	2		1
In situ RNA (whole mount)					2	1		1	3		3	2	9	9	9	3	13	8	95	20	42	7	15		9	2	8		3	1	2	2	1	1	2		18	1
Northern blot													1		1		1		2		3		2		3		2		1	1								3
Western blot																					1						1		1				1			1
RT-PCR	2	1	3	2	8	5	5		1	2	2		4		4		3	1	6	2	9	3	8	2	6	2	6	1	1	2	2	1	1	1	2		2	14
cDNA clones																									1												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf4  fibroblast growth factor 4   (Synonyms: Fgf-4, Fgfk, Hst1, Hstf-1, kFGF)
Results	Reference
2*	J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
6	J:350005 Adasooriya D, Jeong JK, Kyeong M, Kan S, Kim J, Cho ES, Cho SW, Notum regulates the cusp and root patterns in mouse molar. Sci Rep. 2024 Jun 13;14(1):13633
1	J:287755 Agarwal M, Sharma A, Kumar P, Kumar A, Bharadwaj A, Saini M, Kardon G, Mathew SJ, Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development. 2020 Apr 6;147(7):dev184507
1	J:73526 Ahn K, Mishina Y, Hanks MC, Behringer RR, Crenshaw EB 3rd, BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 2001 Nov;128(22):4449-61
1	J:168361 Ahn Y, Sanderson BW, Klein OD, Krumlauf R, Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct;137(19):3221-31
1*	J:243416 Ahn Y, Sims C, Murray MJ, Kuhlmann PK, Fuentes-Antras J, Weatherbee SD, Krumlauf R, Multiple modes of Lrp4 function in modulation of Wnt/beta-catenin signaling during tooth development. Development. 2017 Aug 01;144(15):2824-2836
4	J:326354 Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella LV, Pouchin P, Cohen-Tannoudji M, David L, Chazaud C, NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
6	J:313582 Anderson MJ, Magidson V, Kageyama R, Lewandoski M, Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function. Elife. 2020 Nov 19;9:e55608
1	J:232560 Anderson MJ, Schimmang T, Lewandoski M, An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016 May;12(5):e1006018
1*	J:133600 Aoki M, Kiyonari H, Nakamura H, Okamoto H, R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ. 2008 Feb;50(2):85-95
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1	J:293567 Azami T, Bassalert C, Allegre N, Valverde Estrella L, Pouchin P, Ema M, Chazaud C, Regulation of the ERK signalling pathway in the developing mouse blastocyst. Development. 2019 Jul 25;146(14):dev177139
4	J:245724 Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M, Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development. 2017 Oct 15;144(20):3706-3718
1*	J:135300 Babbs C, Furniss D, Morriss-Kay GM, Wilkie AO, Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26
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1	J:189073 Benazet JD, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R, Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development. 2012 Nov;139(22):4250-60
2	J:204472 Benazet JD, Zeller R, Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds. Genesis. 2013 Sep;51(9):660-6
1	J:171190 Bensoussan-Trigano V, Lallemand Y, Saint Cloment C, Robert B, Msx1 and Msx2 in limb mesenchyme modulate digit number and identity. Dev Dyn. 2011 May;240(5):1190-202
2*	J:217512 Bessonnard S, De Mot L, Gonze D, Barriol M, Dennis C, Goldbeter A, Dupont G, Chazaud C, Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network. Development. 2014 Oct;141(19):3637-48
2*	J:168038 Bimonte S, De Angelis A, Quagliata L, Giusti F, Tammaro R, Dallai R, Ascenzi MG, Diez-Roux G, Franco B, Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol. 2011 Jan 15;349(2):179-91
1	J:104869 Blanc I, Bach A, Robert B, Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes. Int J Dev Biol. 2002;46(7):969-74
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:316302 Bosch PJ, Fuller LC, Weiner JA, An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression. Sci Rep. 2018 Aug 16;8(1):12240
1	J:158689 Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD, Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5489-94
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1*	J:199480 Cao T, Wang C, Yang M, Wu C, Wang B, Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Dev Biol. 2013 Jul 15;379(2):221-8
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1	J:153554 Chen J, Lan Y, Baek JA, Gao Y, Jiang R, Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 Oct 1;334(1):174-85
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1	J:143544 Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A, Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol. 2009 Jan 1;325(1):225-37
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1	J:232111 Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM, T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5:e07897
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