Gene Expression Literature Summary

• Symbol: Fmr1
• Name: fragile X messenger ribonucleoprotein 1
• ID: MGI:95564

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E2	E2.5	E3	E7	E7.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)													1				2	1	1	1			1	1	5
In situ RNA (section)	1	1	1	1								2	2	3	3		2		1		1		1		6
In situ RNA (whole mount)														1
Northern blot										1			1						1						2
Western blot									1			1	1		2		1	2		2	1	1	2		9
RT-PCR				1	1	1	1	1			1		1	3		2				1	1	2			9
cDNA clones																									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fmr1  fragile X messenger ribonucleoprotein 1   (Synonyms: Fmr-1, FMRP, fragile X mental retardation 1)
Results	Reference
8	J:16233 Bachner D, Manca A, Steinbach P, Wohrle D, Just W, Vogel W, Hameister H, Poustka A, Enhanced expression of the murine FMR1 gene during germ cell proliferation suggests a special function in both the male and the female gonad. Hum Mol Genet. 1993 Dec;2(12):2043-50
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4	J:308813 Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy LC, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Roest Crollius H, FitzPatrick DR, Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. PLoS One. 2021;16(8):e0256181
1	J:228732 Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Penagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA, Geschwind DH, JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015 Dec 16;88(6):1173-91
1	J:349721 Borisova E, Newman AG, Couce Iglesias M, Dannenberg R, Schaub T, Qin B, Rusanova A, Brockmann M, Koch J, Daniels M, Turko P, Jahn O, Kaplan DR, Rosario M, Iwawaki T, Spahn CMT, Rosenmund C, Meierhofer D, Kraushar ML, Tarabykin V, Ambrozkiewicz MC, Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
4	J:199841 Brackett DM, Qing F, Amieux PS, Sellers DL, Horner PJ, Morris DR, FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain. PLoS One. 2013;8(3):e58296
1*	J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167
4	J:326379 Chaya T, Ishikane H, Varner LR, Sugita Y, Maeda Y, Tsutsumi R, Motooka D, Okuzaki D, Furukawa T, Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity. Hum Mol Genet. 2022 Feb 21;31(4):535-547
2	J:148744 Chiba H, Hirasawa R, Kaneda M, Amakawa Y, Li E, Sado T, Sasaki H, De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes. Genesis. 2008 Dec;46(12):768-74
2	J:170787 Cunningham CL, Martinez Cerdeno V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC, Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 1;20(1):64-79
2	J:330390 Gura MA, Relovska S, Abt KM, Seymour KA, Wu T, Kaya H, Turner JMA, Fazzio TG, Freiman RN, TAF4b transcription networks regulating early oocyte differentiation. Development. 2022 Feb 1;149(3):dev200074
1	J:88217 Hedlund E, Karsten SL, Kudo L, Geschwind DH, Carpenter EM, Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. J Neurosci Res. 2004 Feb 1;75(3):307-19
1	J:173577 Hoki Y, Ikeda R, Mise N, Sakata Y, Ohhata T, Sasaki H, Abe K, Sado T, Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. Development. 2011 Jul;138(13):2649-59
4	J:150959 Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T, Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature. 2009 Jul 30;460(7255):647-51
4	J:317365 Kurosaki T, Sakano H, Proschel C, Wheeler J, Hewko A, Maquat LE, NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome. Genome Biol. 2021 Nov 16;22(1):317
1	J:219376 La Fata G, Gartner A, Dominguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C, FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci. 2014 Dec;17(12):1693-700
3	J:313459 Lee B, Panda S, Lee HY, Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome. Stem Cell Reports. 2020 Aug 11;15(2):454-466
2	J:251308 Lin JC, Chi YL, Peng HY, Lu YH, RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes. Biochim Biophys Acta. 2016 Nov;1859(11):1368-1379
4	J:320190 Liu T, Wan RP, Tang LJ, Liu SJ, Li HJ, Zhao QH, Liao WP, Sun XF, Yi YH, Long YS, A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Mol Neurobiol. 2015;51(3):1053-63
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
1	J:306874 McSweeney C, Dong F, Chen M, Vitale J, Xu L, Crowley N, Luscher B, Zou D, Mao Y, Full function of exon junction complex factor, Rbm8a, is critical for interneuron development. Transl Psychiatry. 2020 Nov 5;10(1):379
2	J:296955 Niu W, Spradling AC, Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20015-20026
1	J:225200 Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS, Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014;5:4692
2	J:127940 Pacey LK, Doering LC, Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome. Glia. 2007 Nov 15;55(15):1601-9
4	J:168545 Saffary R, Xie Z, FMRP Regulates the Transition from Radial Glial Cells to Intermediate Progenitor Cells during Neocortical Development. J Neurosci. 2011 Jan 26;31(4):1427-39
1	J:306228 Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF, Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction. 2012 May;143(5):611-24
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:310343 Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ, Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. iScience. 2020 May 22;23(5):101132
1	J:262238 Wise TL, Changes in insulin-like growth factor signaling alter phenotypes in Fragile X Mice. Genes Brain Behav. 2017 Feb;16(2):241-249
2	J:356593 Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B, The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell. 2007 Mar 9;128(5):977-89
8*	J:150467 Xie W, Dolzhanskaya N, LaFauci G, Dobkin C, Denman RB, Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms. Neurobiol Dis. 2009 Jul;35(1):52-62
1*	J:176126 Xu XL, Zong R, Li Z, Biswas MH, Fang Z, Nelson DL, Gao FB, FXR1P But Not FMRP Regulates the Levels of Mammalian Brain-Specific microRNA-9 and microRNA-124. J Neurosci. 2011 Sep 28;31(39):13705-9
5	J:321201 Yang K, Shi Y, Du X, Wang J, Zhang Y, Shan S, Yuan Y, Wang R, Zhou C, Liu Y, Cai Z, Wang Y, Fan L, Xu H, Yu J, Cheng J, Li F, Qiu Z, SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. Cell Rep. 2021 Nov 2;37(5):109939
2	J:244911 Zhang M, Chen D, Xia J, Han W, Cui X, Neuenkirchen N, Hermes G, Sestan N, Lin H, Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. Genes Dev. 2017 Jul 1;31(13):1354-1369