Gene Expression Literature Summary

• Symbol: Fyn
• Name: Fyn proto-oncogene
• ID: MGI:95602

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E3.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E20	E	P
Immunohistochemistry (section)	1	1			1	1	1	2		2				1	1	1	1	1	1		1	1		3
In situ RNA (section)								3		1	2	3		3	1	1		2	2	1	2			6
In situ reporter (knock in)			1		1	1	1	1		1		1											1
Northern blot															1				1					2
Western blot										1				2		2		2	1	1	1		1	12
RT-PCR								1	1		1	1								1				3
cDNA clones				1	1	1	2	1				1	1		1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fyn  Fyn proto-oncogene   (Synonyms: Src Kinase p59)
Results	Reference
1	J:40680 Aizawa S, Yagi T, Furuta Y, Ikawa Y, Nada S, Nakagawa H, Okada M, Non-receptor tyrosine kinases in mammalian neurogenesis. Princess Takamatsu Symp. 1994;24:323-37
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:109819 Bock HH, Herz J, Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003 Jan 8;13(1):18-26
1*	J:157804 Corsi JM, Houbron C, Billuart P, Brunet I, Bouvree K, Eichmann A, Girault JA, Enslen H, Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76
1	J:61551 Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK, Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res. 2000 Apr 10;256(1):168-78
3*	J:86843 Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI, Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol. 2003 Dec 15;264(2):309-22
1*	J:257927 Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simo S, RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
1	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:298804 Han JS, Hino K, Li W, Reyes RV, Canales CP, Miltner AM, Haddadi Y, Sun J, Chen CY, La Torre A, Simo S, CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):23073-23084
2*	J:112731 Huang J, Sakai R, Furuichi T, The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell. 2006 Jul;17(7):3187-96
2*	J:30264 Ishino M, Ohba T, Sasaki H, Sasaki T, Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene. 1995 Dec 7;11(11):2331-8
2	J:106956 Isosaka T, Hattori K, Yagi T, NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice. Brain Res. 2006 Feb 16;1073-1074:11-9
2*	J:41036 Kai N, Mishina M, Yagi T, Molecular cloning of Fyn-associated molecules in the mouse central nervous system. J Neurosci Res. 1997 Jun 1;48(5):407-24
2	J:148253 Kao TJ, Palmesino E, Kania A, SRC family kinases are required for limb trajectory selection by spinal motor axons. J Neurosci. 2009 Apr 29;29(17):5690-700
1	J:217426 Kitase Y, Shuler CF, Palatal adhesion is dependent on Src family kinases and p38MAPK. Int J Dev Biol. 2014;58(5):335-41
1*	J:48282 Kohmura N, Senzaki K, Hamada S, Kai N, Yasuda R, Watanabe M , Ishii H , Yasuda M , Mishina M , Yagi T, Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron. 1998 Jun;20(6):1137-51
1	J:101055 Kuo G, Arnaud L, Kronstad-O'Brien P, Cooper JA, Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci. 2005 Sep 14;25(37):8578-86
2	J:19199 Larsson-Blomberg L, Dzierzak E, Isolation of tyrosine kinase related genes expressed in the early hematopoietic system. FEBS Lett. 1994 Jul 11;348(2):119-25
2	J:51720 Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ, The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Clin Invest. 1997 Mar 1;99(5):830-7
3*	J:177766 Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA, Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One. 2011;6(9):e23978
1*	J:116509 Liu H, Nakazawa T, Tezuka T, Yamamoto T, Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. J Biol Chem. 2006 Aug 18;281(33):23611-9
1	J:39581 Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J, High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
1	J:161749 Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ, Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet. 2009 Nov;5(11):e1000748
1*	J:98227 Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N, Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 2005 Feb 16;25(7):1826-35
2	J:232899 Moon UY, Park JY, Park R, Cho JY, Hughes LJ, McKenna J 3rd, Goetzl L, Cho SH, Crino PB, Gambello MJ, Kim S, Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell Rep. 2015 Aug 11;12(6):965-78
1	J:50997 Morse WR, Whitesides JG 3rd, LaMantia AS, Maness PF, p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway. J Neurobiol. 1998 Jul;36(1):53-63
1	J:244898 Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM, Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. J Neurosci. 2017 Jul 26;37(30):7125-7139
5*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
1	J:28731 Reith AD, Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase. Mamm Genome. 1995 Sep;6(9):689
1	J:59044 Senzaki K, Ogawa M, Yagi T, Proteins of the CNR family are multiple receptors for Reelin. Cell. 1999 Dec 10;99(6):635-47
2	J:205551 Simo S, Cooper JA, Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
1	J:33665 Sun XJ, Pons S, Asano T, Myers MG Jr, Glasheen E, White MF, The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem. 1996 May 3;271(18):10583-7
3*	J:194960 Tai G, Hohenstein P, Davies JA, FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol Open. 2013;2:416-423
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
5*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
4	J:70887 Umemori H, Wanaka A, Kato H, Takeuchi M, Tohyama M, Yamamoto T, Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system. Brain Res Mol Brain Res. 1992 Dec;16(3-4):303-10
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
12*	J:55945 Wang JP, Chuang SM, Shen CL, Chen ST, Expression of Src family during development of the mouse nervous system. Biomed Res. 1998 OCT;19(5):315-325
9*	J:19921 Yagi T, Shigetani Y, Furuta Y, Nada S, Okado N, Ikawa Y, Aizawa S, Fyn expression during early neurogenesis in mouse embryos. Oncogene. 1994 Sep;9(9):2433-40
1	J:130375 Ye H, Tan YL, Ponniah S, Takeda Y, Wang SQ, Schachner M, Watanabe K, Pallen CJ, Xiao ZC, Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. EMBO J. 2008 Jan 9;27(1):188-200
5	J:180006 Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T, NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Nov 30;30(23):4739-54
3	J:103576 Yuasa S, Hattori K, Yagi T, Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport. 2004 Apr 9;15(5):819-22