Gene Expression Literature Summary

• Symbol: G6pc1
• Name: glucose-6-phosphatase catalytic subunit 1
• ID: MGI:95607

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	P
Immunohistochemistry (section)								1
In situ RNA (section)				1			1				1		1				1
In situ RNA (whole mount)	1
Northern blot						1			2		2	1	3	1	2	1	6
RT-PCR		1	3		3		3	3	1	3		3		10		1	21

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

G6pc1  glucose-6-phosphatase catalytic subunit 1   (Synonyms: G6Pase, G6pc, G6pt, Glc-6-Pase, Glc-6-Pase-alpha)
Results	Reference
1*	J:64688 Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC, Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
1*	J:88490 Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG, ATP-citrate lyase deficiency in the mouse. J Biol Chem. 2004 Mar 5;279(10):9557-64
2	J:193325 Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
1*	J:236179 Bowman CE, Zhao L, Hartung T, Wolfgang MJ, Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104
1	J:240028 Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A, Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4
2	J:348105 Chen H, Luo S, Deng X, Li S, Mao Y, Yan J, Cheng Y, Liu X, Pan J, Huang H, Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
1	J:27441 Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
1	J:247084 Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC, FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014 Jul 07;115(2):238-251
1	J:343810 Guo CG, Sun R, Wang X, Yuan Y, Xu Y, Li S, Sun X, Wang J, Hu X, Guo T, Chen XW, Xiao RP, Zhang X, Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Mol Metab. 2023 Nov 30;79:101847
1	J:334703 Habeos GI, Filippopoulou F, Habeos EE, Kalaitzopoulou E, Skipitari M, Papadea P, Lagoumintzis G, Niarchos A, Georgiou CD, Chartoumpekis DV, Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2. Antioxidants (Basel). 2022 Nov 17;11(11)
2	J:333870 Jazwiec PA, Patterson VS, Ribeiro TA, Yeo E, Kennedy KM, Mathias PCF, Petrik JJ, Sloboda DM, Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biol Reprod. 2022 Aug 9;107(2):574-589
1	J:53312 Kaestner KH, Katz J, Liu Y, Drucker DJ, Schutz G, Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev. 1999 Feb 15;13(4):495-504
3*	J:54660 Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T, Miyajima A, Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
1	J:199204 Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M, Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013 Jun;57(6):2502-13
2	J:95098 Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T, The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology. 2004 Dec;127(6):1775-86
1*	J:273442 Lee YS, De Vadder F, Tremaroli V, Wichmann A, Mithieux G, Backhed F, Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production. Mol Metab. 2016 Apr;5(4):263-270
9*	J:146970 Li T, Huang J, Jiang Y, Zeng Y, He F, Zhang MQ, Han Z, Zhang X, Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development. Genomics. 2009 Mar;93(3):235-42
1	J:224441 Lim GE, Albrecht T, Piske M, Sarai K, Lee JT, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD, 14-3-3zeta coordinates adipogenesis of visceral fat. Nat Commun. 2015;6:7671
5*	J:51217 Lin B, Annabi B, Hiraiwa H, Pan CJ, Chou JY, Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
1*	J:147857 Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Huang SF, Chen YM, Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007 Nov;46(5):1413-25
1*	J:122356 Lovgren AK, Kovarova M, Koller BH, cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol. 2007 Jun;27(12):4416-30
1	J:321671 Monica Shih MC, Huang CC, Chu HP, Hsu NC, Chung BC, Embryonic Steroids Control Developmental Programming of Energy Balance. Endocrinology. 2021 Dec 1;162(12)
2*	J:316295 Ochiai W, Hirose A, Kawamura T, Komachi K, Yamamoto Y, Kitaoka S, Hatogai J, Kusunoki Y, Kon R, Ikarashi N, Sugiyama K, Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development. Biol Pharm Bull. 2016;39(12):2015-2021
1	J:357360 Oelkrug R, Harder L, Pedaran M, Hoffmann A, Kolms B, Inderhees J, Gachkar S, Resch J, Johann K, Johren O, Krause K, Mittag J, Maternal thyroid hormone receptor beta activation in mice sparks brown fat thermogenesis in the offspring. Nat Commun. 2023 Oct 24;14(1):6742
1	J:146853 Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H, Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology. 2009 Mar;136(3):1000-11
9	J:50266 Pan CJ, Lei KJ, Chen H, Ward JM, Chou JY, Ontogeny of the murine glucose-6-phosphatase system. Arch Biochem Biophys. 1998 Oct 1;358(1):17-24
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
8	J:296367 Roberts GAG, Tunster SJ, Characterising the dynamics of placental glycogen stores in the mouse. Placenta. 2020 Sep 15;99:131-140
1	J:179468 Saedler K, Hochgeschwender U, Impaired neonatal survival of pro-opiomelanocortin null mutants. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):6-13
1	J:187729 Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M, A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep;139(18):3363-72
1*	J:88742 Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV Jr, Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19;279(12):11767-76
2*	J:272586 Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4):dev168146
2*	J:103404 Tan EH, Hooi SC, Laban M, Wong E, Ponniah S, Wee A, Wang ND, CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res. 2005 Nov 15;65(22):10330-7
2*	J:137798 Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O, Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 2008 Jul;333(1):17-27
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:235644 Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K, Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355
1	J:282241 Yang Y, Liu S, Lei Z, Chen G, Huang L, Yang F, Lei Y, Liu Y, Yang L, Liu W, Lai L, Guo J, Circular RNA profile in liver tissue of EpCAM knockout mice. Int J Mol Med. 2019 Sep;44(3):1063-1077
4	J:91859 Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F, The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Endocrinology. 2004 Sep;145(9):4268-77