Gene Expression Literature Summary

• Symbol: Gas1
• Name: growth arrest specific 1
• ID: MGI:95655

60 matching records from 60 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)					1		1		3	2	3		3	1	2		2		1	2	1	2	1	3
In situ RNA (section)					1		7		8	12	10	1	11	1	16		10		2	2		2		4
In situ RNA (whole mount)	1	1	2	1	2	2	3	2	4	2	3		1		1
In situ reporter (knock in)		1		1	3		4		3	3	1		1		2		1					1
Northern blot																								1
Western blot									1	1					1									1
RT-PCR	1						1		4	2	1				1	1		1	1				1	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gas1  growth arrest specific 1   (Synonyms: Gas-1)
Results	Reference
2	J:173604 Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP, Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87
5	J:121553 Allen BL, Tenzen T, McMahon AP, The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007 May 15;21(10):1244-57
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7	J:192870 Biau S, Jin S, Fan CM, Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013;2(2):144-155
1	J:307956 Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED, Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker. Nat Commun. 2021 Jun 17;12(1):3714
2	J:239874 Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE, LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48
1*	J:91052 Cobourne MT, Miletich I, Sharpe PT, Restriction of sonic hedgehog signalling during early tooth development. Development. 2004 Jun;131(12):2875-85
2	J:243698 Decaens T, Godard C, de Reynies A, Rickman DS, Tronche F, Couty JP, Perret C, Colnot S, Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate. Hepatology. 2008 Jan;47(1):247-58
3	J:300506 Echevarria-Andino ML, Allen BL, The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020 Dec 14;147(23):dev189076
5*	J:330830 Echevarria-Andino ML, Franks NE, Schrader HE, Hong M, Krauss RS, Allen BL, CDON contributes to Hedgehog-dependent patterning and growth of the developing limb. Dev Biol. 2022 Oct 17;493:1-11
6	J:257526 Feuerstein M, Chleilat E, Khakipoor S, Michailidis K, Ophoven C, Roussa E, Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell Tissue Res. 2017 Nov;370(2):211-225
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3	J:167212 Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ, Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23;468(7327):1095-9
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2*	J:316184 Hussein MT, Attaai A, Kamel G, Mokhtar DM, Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons. Gene Expr Patterns. 2021 Dec;42:119217
1	J:242713 Ikeda Y, Zabbarova I, Schaefer CM, Bushnell D, De Groat WC, Kanai A, Bates CM, Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017 Apr 01;312(4):F607-F618
3	J:173603 Izzi L, Levesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F, Boc and gas1 each form distinct shh receptor complexes with ptch1 and are required for shh-mediated cell proliferation. Dev Cell. 2011 Jun 14;20(6):788-801
1	J:218163 Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M, Fan CM, Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80
1	J:315774 Junker JP, Peterson KA, Nishi Y, Mao J, McMahon AP, van Oudenaarden A, A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. Dev Cell. 2014 Nov 24;31(4):448-60
2	J:220461 Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA, WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66
3	J:291852 Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH, Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020 Apr 24;11(1):1994
6*	J:71832 Lee CS, Buttitta L, Fan CM, Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11347-52
15*	J:68155 Lee CS, Fan C, Embryonic expression patterns of the mouse and chick Gas1 genes. Mech Dev. 2001 Mar;101(1-2):293-7
11*	J:70735 Lee CS, May NR, Fan CM, Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol. 2001 Aug 1;236(1):17-29
1	J:338829 Lee J, Kim Y, Ataliotis P, Kim HG, Kim DW, Bennett DC, Brown NA, Layman LC, Kim SH, Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development. Sci Rep. 2023 Jul 29;13(1):12309
10*	J:69636 Lee KK, Leung AK, Tang MK, Cai DQ, Schneider C, Brancolini C, Chow PH, Functions of the growth arrest specific 1 gene in the development of the mouse embryo. Dev Biol. 2001 Jun 1;234(1):188-203
2	J:346064 Leung AOW, Poon ACH, Wang X, Feng C, Chen P, Zheng Z, To MK, Chan WCW, Cheung M, Chan D, Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1. Nat Commun. 2024 Mar 12;15(1):2229
6	J:332136 Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP, Wallace V, Blackshaw S, Li P, Levine EM, Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis. Elife. 2022 Dec 2;11
10	J:79482 Liu Y, Liu C, Yamada Y, Fan CM, growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002 Nov;129(22):5289-300
1*	J:270210 Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ, Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134
1*	J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3*	J:314133 Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE, GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Development. 2021 Nov 1;148(21):dev200080
5	J:121554 Martinelli DC, Fan CM, Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007 May 15;21(10):1231-43
1	J:138405 Matt N, Ghyselinck NB, Pellerin I, Dupe V, Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis. Dev Biol. 2008 Aug 1;320(1):140-8
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2	J:146634 Ohazama A, Haycraft CJ, Seppala M, Blackburn J, Ghafoor S, Cobourne M, Martinelli DC, Fan CM, Peterkova R, Lesot H, Yoder BK, Sharpe PT, Primary cilia regulate Shh activity in the control of molar tooth number. Development. 2009 Mar;136(6):897-903
1	J:284130 Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT, Iseki S, Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development. 2019 Nov 12;146(21):dev180075
1	J:263215 Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R, HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell. 2014 Nov 10;31(3):345-357
4	J:335153 Qiu T, Huteckova B, Seppala M, Cobourne MT, Chen Z, Hovorakova M, Buchtova M, Tucker AS, Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464
4	J:260965 Quezada-Ramirez MA, Castaneda-Arellano R, Perez-Sanchez G, Hernandez-Soto J, Segovia J, The Growth arrest specific 1 (Gas1) gene is transcriptionally regulated by NeuroD1 via two distal E-boxes. Exp Cell Res. 2018 Feb 15;363(2):332-341
1	J:239799 Raines AM, Magella B, Adam M, Potter SS, Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015 Jul 19;15:28
1	J:327434 Ramirez M, Badayeva Y, Yeung J, Wu J, Abdalla-Wyse A, Yang E, Trost B, Scherer SW, Goldowitz D, Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions. Elife. 2022 Aug 9;11:e74207
2*	J:104154 Rice R, Connor E, Rice DP, Expression patterns of Hedgehog signalling pathway members during mouse palate development. Gene Expr Patterns. 2006 Jan;6(2):206-12
2*	J:93571 Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL, Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct;131(20):5139-52
1	J:266826 Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR, Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21;91(6):1260-1275
2	J:122159 Seppala M, Depew MJ, Martinelli DC, Fan CM, Sharpe PT, Cobourne MT, Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. J Clin Invest. 2007 Jun;117(6):1575-84
4*	J:335331 Seppala M, Thivichon-Prince B, Xavier GM, Shaffie N, Sangani I, Birjandi AA, Rooney J, Lau JNS, Dhaliwal R, Rossi O, Riaz MA, Stonehouse-Smith D, Wang Y, Papageorgiou SN, Viriot L, Cobourne MT, Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog. J Dent Res. 2022 Apr;101(4):473-482
4	J:216223 Seppala M, Xavier GM, Fan CM, Cobourne MT, Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function. Biol Open. 2014;3(8):728-40
5*	J:252976 Shin JO, Ankamreddy H, Jakka NM, Lee S, Kim UK, Bok J, Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear. Int J Dev Biol. 2017;61(8-9):557-563
1	J:99926 Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M, Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005 May 13;280(19):19185-95
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2*	J:151233 Trimarchi JM, Cho SH, Cepko CL, Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep;238(9):2327-9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:252754 Woods L, Perez-Garcia V, Kieckbusch J, Wang X, DeMayo F, Colucci F, Hemberger M, Decidualisation and placentation defects are a major cause of age-related reproductive decline. Nat Commun. 2017 Sep 05;8(1):352
3*	J:310333 Xavier GM, Seppala M, Papageorgiou SN, Fan CM, Cobourne MT, Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis. Oncotarget. 2016 Nov 29;7(48):79233-79246
1	J:187715 Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP, Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14;23(2):280-91
1	J:296001 Xu H, Xiang M, Qin Y, Cheng H, Chen D, Fu Q, Zhang KK, Xie L, Tbx5 inhibits hedgehog signaling in determination of digit identity. Hum Mol Genet. 2020 Jun 3;29(9):1405-1416