Gene Expression Literature Summary

• Symbol: Gdf9
• Name: growth differentiation factor 9
• ID: MGI:95692

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E3	E3.5	E9.5	E11.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)	1		1							1		1					4
In situ RNA (section)							1	1	1		1			1			2
Western blot																	1
RT-PCR	3	2	1	2	1	1		1	1	2	2		4	2	1	1	18

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gdf9  growth differentiation factor 9   (Synonyms: Gdf-9)
Results	Reference
1	J:226026 Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C, Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42
1*	J:310178 Efimenko E, Padua MB, Manuylov NL, Fox SC, Morse DA, Tevosian SG, The transcription factor GATA4 is required for follicular development and normal ovarian function. Dev Biol. 2013 Sep 1;381(1):144-58
1	J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36
3*	J:324293 Gindi N, Grossman H, Bar-Joseph H, Miller I, Nemerovsky L, Hadas R, Nevo N, Galiani D, Dekel N, Shalgi R, Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation. Cell Cycle. 2022 Apr;21(8):792-804
2	J:307968 He Y, Chen Q, Dai J, Cui Y, Zhang C, Wen X, Li J, Xiao Y, Peng X, Liu M, Shen B, Sha J, Hu Z, Li J, Shu W, Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
2	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
1	J:282136 Kato Y, Iwamori T, Ninomiya Y, Kohda T, Miyashita J, Sato M, Saga Y, ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. EMBO Rep. 2019 Dec 5;20(12):e48251
1*	J:145797 Kim KH, Kim EY, Lee KA, SEBOX is essential for early embryogenesis at the two-cell stage in the mouse. Biol Reprod. 2008 Dec;79(6):1192-201
1	J:222787 Liu C, Peng J, Matzuk MM, Yao HH, Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015;6:6934
1	J:306136 Manti M, Pui HP, Edstrom S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E, Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. FASEB J. 2020 Nov;34(11):14440-14457
4	J:23079 McGrath SA, Esquela AF, Lee SJ, Oocyte-specific expression of growth/differentiation factor-9. Mol Endocrinol. 1995 Jan;9(1):131-6
1	J:300503 Nicol B, Rodriguez K, Yao HH, Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice. Biol Reprod. 2020 Oct 29;103(5):966-977
2*	J:108109 Oxburgh L, Chu GC, Michael SK, Robertson EJ, TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
1	J:110210 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A, Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8090-5
1*	J:326026 Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM, Western PS, An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
8	J:92421 Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM, NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
1	J:213445 Rutledge CE, Lau HT, Mangan H, Hardy LL, Sunnotel O, Guo F, MacNicol AM, Walsh CP, Lees-Murdock DJ, Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. PLoS One. 2014;9(2):e88385
1	J:87737 Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M, The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb;131(4):933-42
1	J:244395 Shin YH, Ren Y, Suzuki H, Golnoski KJ, Ahn HW, Mico V, Rajkovic A, Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I. J Clin Invest. 2017 Jun 01;127(6):2106-2117
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:143535 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J, Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol. 2009 Jan 1;325(1):238-48
2*	J:276900 Uysal F, Ozturk S, Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos. J Cell Biochem. 2019 Mar;120(3):4694-4709
1	J:213069 Vanorny DA, Prasasya RD, Chalpe AJ, Kilen SM, Mayo KE, Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol. 2014 Apr;28(4):499-511
5*	J:152501 Wang Y, Nicholls PK, Stanton PG, Harrison CA, Sarraj M, Gilchrist RB, Findlay JK, Farnworth PG, Extra-ovarian expression and activity of growth differentiation factor 9. J Endocrinol. 2009 Sep;202(3):419-30
1*	J:152924 Yoon SJ, Kim EY, Kim YS, Lee HS, Kim KH, Bae J, Lee KA, Role of Bcl2-like 10 (Bcl2l10) in Regulating Mouse Oocyte Maturation. Biol Reprod. 2009 Sep;81(3):497-506
7	J:205485 Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21