Symbol Name ID |
Gjc1
gap junction protein, gamma 1 MGI:95718 |
Age | E1 | E2 | E2.5 | E3 | E3.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
Immunohistochemistry (section) | 3 | 1 | 2 | 2 | 4 | 1 | 1 | 1 | 3 | 1 | 1 | 4 | 1 | 2 | 1 | 1 | 3 | 11 | ||||||||||||
In situ RNA (section) | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||
In situ reporter (knock in) | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 5 | |||||||||||||||||||
Northern blot | 1 | 2 | 1 | 1 | 1 | 2 | 4 | |||||||||||||||||||||||
Western blot | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 9 | ||||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 3 | 7 | ||||||||
RNase protection | 1 |
Gjc1 gap junction protein, gamma 1 (Synonyms: C130009G16Rik, connexin 45, Cx45, Gja-7, Gja7) | |
Results | Reference |
26* | J:56243 Alcolea S, Theveniau-Ruissy M, Jarry-Guichard T, Marics I, Tzouanacou E, Chauvin JP, Briand JP, Moorman AF, Lamers WH, Gros DB, Downregulation of connexin 45 gene products during mouse heart development. Circ Res. 1999 Jun 25;84(12):1365-79 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
3 | J:89303 Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V, An expression atlas of connexin genes in the mouse. Genomics. 2004 May;83(5):812-20 |
2* | J:21762 Butterweck A, Elfgang C, Willecke K, Traub O, Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin. Eur J Cell Biol. 1994 Oct;65(1):152-63 |
4 | J:20907 Butterweck A, Gergs U, Elfgang C, Willecke K, Traub O, Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells. J Membr Biol. 1994 Sep;141(3):247-56 |
8 | J:181527 Chaible LM, Sanches DS, Cogliati B, Mennecier G, Dagli ML, Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol. 2011 Dec;39(7):1046-55 |
1 | J:53372 Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P, Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin. Dev Genet. 1999;24(1-2):13-26 |
4 | J:131962 Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6 |
10 | J:135624 Cina C, Bechberger JF, Ozog MA, Naus CC, Expression of connexins in embryonic mouse neocortical development. J Comp Neurol. 2007 Sep 20;504(3):298-313 |
8 | J:88394 Cohen-Salmon M, Maxeiner S, Kruger O, Theis M, Willecke K, Petit C, Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner ear. Cell Tissue Res. 2004 Apr;316(1):15-22 |
3 | J:82899 Coppen SR, Kaba RA, Halliday D, Dupont E, Skepper JN, Elneil S, Severs NJ, Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem. 2003 Jan;242(1-2):121-7 |
2 | J:53375 Coppen SR, Severs NJ, Gourdie RG, Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart. Dev Genet. 1999;24(1-2):82-90 |
1 | J:31171 Dahl E, Winterhager E, Reuss B, Traub O, Butterweck A, Willecke K, Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively. J Cell Sci. 1996 Jan;109(Pt 1):191-7 |
5* | J:32852 Davies TC, Barr KJ, Jones DH, Zhu D, Kidder GM, Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18(3):234-43 |
4* | J:29941 Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, Gros D, Theveniau-Ruissy M, Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn. 1995 Dec;204(4):358-71 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
3 | J:100441 Dupays L, Jarry-Guichard T, Mazurais D, Calmels T, Izumo S, Gros D, Theveniau-Ruissy M, Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants. J Mol Cell Cardiol. 2005 May;38(5):787-98 |
1 | J:92247 Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N, Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004 Aug 13;279(33):34741-9 |
1 | J:46665 Gabriel HD, Jung D, Butzler C, Temme A, Traub O, Winterhager E , Willecke K, Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. J Cell Biol. 1998 Mar 23;140(6):1453-61 |
1 | J:299975 Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M, GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2007322118 |
1 | J:172556 Gros D, Theveniau-Ruissy M, Bernard M, Calmels T, Kober F, Sohl G, Willecke K, Nargeot J, Jongsma HJ, Mangoni ME, Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate. Cardiovasc Res. 2010 Jan 1;85(1):45-55 |
1 | J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65 |
1* | J:317598 Ito A, Ichiyanagi N, Ikeda Y, Hagiyama M, Inoue T, Kimura KB, Sakurai MA, Hamaguchi K, Murakami Y, Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet alpha-cells and prevents their excessive secretion of glucagon. Islets. 2012 Jan-Feb;4(1):49-55 |
4 | J:102628 Johnson CM, Kanter EM, Green KG, Laing JG, Betsuyaku T, Beyer EC, Steinberg TH, Saffitz JE, Yamada KA, Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res. 2002 Mar;53(4):921-35 |
1* | J:92356 Juneja SC, mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian J Physiol Pharmacol. 2003 Apr;47(2):147-56 |
4 | J:80257 Kaba RA, Coppen SR, Dupont E, Skepper JN, Elneil S, Haw MP, Pepper JR, Yacoub MH, Rothery S, Severs NJ, Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. Cell Commun Adhes. 2001;8(4-6):339-43 |
3 | J:98807 Kibschull M, Magin TM, Traub O, Winterhager E, Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn. 2005 May 13;233(3):853-863 |
2 | J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208 |
1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
2 | J:64428 Kruger O, Plum A, Kim JS, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers WH, Willecke K, Defective vascular development in connexin 45-deficient mice. Development. 2000 Oct;127(19):4179-93 |
7* | J:63214 Kumai M, Nishii K, Nakamura K, Takeda N, Suzuki M, Shibata Y, Loss of connexin45 causes a cushion defect in early cardiogenesis. Development. 2000 Aug;127(16):3501-12 |
2 | J:152122 Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C, Connexin expression in renin-producing cells. J Am Soc Nephrol. 2009 Mar;20(3):506-12 |
3 | J:258315 Langhorst H, Juttner R, Groneberg D, Mohtashamdolatshahi A, Pelz L, Purfurst B, Schmidt-Ott KM, Friebe A, Rathjen FG, The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice. Dis Model Mech. 2018 Feb 22;11(2):dmm032128 |
1 | J:299737 Lee J, Sutani A, Kaneko R, Takeuchi J, Sasano T, Kohda T, Ihara K, Takahashi K, Yamazoe M, Morio T, Furukawa T, Ishino F, In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Nat Commun. 2020 Sep 3;11(1):4283 |
1 | J:154593 Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV, Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest. 2009 Nov;119(11):3420-36 |
1 | J:316536 Lubkemeier I, Andrie R, Lickfett L, Bosen F, Stockigt F, Dobrowolski R, Draffehn AM, Fregeac J, Schultze JL, Bukauskas FF, Schrickel JW, Willecke K, The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice. J Mol Cell Cardiol. 2013 Dec;65:19-32 |
1 | J:118250 Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W, Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7 |
5 | J:84741 Maxeiner S, Kruger O, Schilling K, Traub O, Urschel S, Willecke K, Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice. Neuroscience. 2003;119(3):689-700 |
1 | J:285878 Nishii K, Kobayashi Y, Shibata Y, Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development. Zygote. 2016 Jun;24(3):457-64 |
3* | J:231835 Nishii K, Seki A, Kumai M, Morimoto S, Miwa T, Hagiwara N, Shibata Y, Kobayashi Y, Connexin45 contributes to global cardiovascular development by establishing myocardial impulse propagation. Mech Dev. 2016 May;140:41-52 |
2 | J:312376 Pastar V, Lozic M, Kelam N, Filipovic N, Bernard B, Katsuyama Y, Vukojevic K, Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. Int J Mol Sci. 2021 Oct 2;22(19) |
2* | J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96 |
3* | J:87369 Simon AM, McWhorter AR, Dones JA, Jackson CL, Chen H, Heart and head defects in mice lacking pairs of connexins. Dev Biol. 2004 Jan 15;265(2):369-83 |
4* | J:70957 Sohl G, Eiberger J, Jung YT, Kozak CA, Willecke K, The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem. 2001 Jun;382(6):973-8 |
1* | J:74146 Vaidya D, Tamaddon HS, Lo CW, Taffet SM, Delmar M, Morley GE, Jalife J, Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res. 2001 Jun 8;88(11):1196-202 |
2* | J:93582 von Maltzahn J, Euwens C, Willecke K, Sohl G, The novel mouse connexin39 gene is expressed in developing striated muscle fibers. J Cell Sci. 2004 Oct 15;117(Pt 22):5381-92 |
2 | J:270088 Wang Y, Lu P, Wu B, Morrow BE, Zhou B, NOTCH maintains developmental cardiac gene network through WNT5A. J Mol Cell Cardiol. 2018 Dec;125:98-105 |
3 | J:46473 Ya J, Erdtsieck-Ernste EB, de Boer PA, van Kempen MJ, Jongsma H , Gros D , Moorman AF , Lamers WH, Heart defects in connexin43-deficient mice. Circ Res. 1998 Feb 23;82(3):360-6 |
1* | J:281175 Yorgan TA, Peters S, Amling M, Schinke T, Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|