Gene Expression Literature Summary

• Symbol: Gjb2
• Name: gap junction protein, beta 2
• ID: MGI:95720

78 matching records from 78 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E4.5	E5	E5.5	E6.5	E7.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)								3	1	1			1	1	3	1	1		3	1	6	3	5	1	7	2	2	6	4	6	1	1	1	1	30
In situ RNA (section)													1	1	1		1	1					5							5					4
Immunohistochemistry (whole mount)															1
In situ RNA (whole mount)														1	3		1	1			2
In situ reporter (knock in)															1				1	1	1	1	1		1	1			1					1	2
Northern blot	1	1	1	1	1		1															1			1	1	1	1	1	1					8
Western blot																			1			1	2			2			3	2	1				11
RT-PCR	1					1								3	5		4		4	1	3	1	3		2	2	2	3	2	4				1	12
cDNA clones							1																												1
Nuclease S1										1	1	1		1			1				2				2			2							2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gjb2  gap junction protein, beta 2   (Synonyms: connexin 26, Cx26, Gjb-2)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:214677 Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A, Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. Dev Biol. 2014 Jul 1;391(1):54-65
2	J:146087 Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL, Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology. 2009 Jan;136(1):309-319.e9
9	J:309431 Bowe A, Zweerink S, Muck V, Kondylis V, Schulte S, Goeser T, Nierhoff D, Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice. J Histochem Cytochem. 2018 Aug;66(8):563-576
1	J:175160 Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC, Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol. 2008 Mar;9(1):33-43
4	J:89303 Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V, An expression atlas of connexin genes in the mouse. Genomics. 2004 May;83(5):812-20
5*	J:21762 Butterweck A, Elfgang C, Willecke K, Traub O, Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin. Eur J Cell Biol. 1994 Oct;65(1):152-63
2	J:331974 Cao C, Fleming MD, Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. Development. 2022 Dec 1;149(23):dev201160
1	J:313271 Chen B, Wang Y, Geng M, Lin X, Tang W, Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear. Biomed Res Int. 2018;2018:7817453
1	J:306028 Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kucuk E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ, Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. Dev Cell. 2021 May 17;56(10):1526-1540.e7
2	J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
3*	J:165759 Chiu HS, Szucsik JC, Georgas KM, Jones JL, Rumballe BA, Tang D, Grimmond SM, Lewis AG, Aronow BJ, Lessard JL, Little MH, Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol. 2010 Aug 15;344(2):1071-87
6*	J:44410 Choudhry R, Pitts JD, Hodgins MB, Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic development. Dev Dyn. 1997 Dec;210(4):417-30
10	J:135624 Cina C, Bechberger JF, Ozog MA, Naus CC, Expression of connexins in embryonic mouse neocortical development. J Comp Neurol. 2007 Sep 20;504(3):298-313
1	J:100352 Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP, Control of liver cell fate decision by a gradient of TGFbeta signaling modulated by Onecut transcription factors. Genes Dev. 2005 Aug 15;19(16):1849-54
1	J:31171 Dahl E, Winterhager E, Reuss B, Traub O, Butterweck A, Willecke K, Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extraembryonic tissues and in the gastrulating mouse embryo, respectively. J Cell Sci. 1996 Jan;109(Pt 1):191-7
2*	J:32852 Davies TC, Barr KJ, Jones DH, Zhu D, Kidder GM, Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18(3):234-43
14	J:188626 Dicke N, Pielensticker N, Degen J, Hecker J, Tress O, Bald T, Gellhaus A, Winterhager E, Willecke K, Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci. 2011 Aug 15;124(Pt 16):2806-15
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5	J:108850 Djalilian AR, McGaughey D, Patel S, Seo EY, Yang C, Cheng J, Tomic M, Sinha S, Ishida-Yamamoto A, Segre JA, Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest. 2006 May;116(5):1243-53
3	J:150813 Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T, Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32
8	J:180242 Dupressoir A, Vernochet C, Harper F, Guegan J, Dessen P, Pierron G, Heidmann T, A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
10	J:89907 Filippov MA, Hormuzdi SG, Fuchs EC, Monyer H, A reporter allele for investigating connexin 26 gene expression in the mouse brain. Eur J Neurosci. 2003 Dec;18(12):3183-92
5	J:62241 Frenz CM, Van De Water TR, Immunolocalization of connexin 26 in the developing mouse cochlea. Brain Res Brain Res Rev. 2000 Apr;32(1):172-80
4	J:46665 Gabriel HD, Jung D, Butzler C, Temme A, Traub O, Winterhager E , Willecke K, Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. J Cell Biol. 1998 Mar 23;140(6):1453-61
1	J:325724 Gong Y, Laheji F, Berenson A, Qian A, Park SO, Kok R, Selig M, Hahn R, Sadjadi R, Kemp S, Eichler F, Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia. Cells. 2022 Jun 4;11(11)
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:284778 Huebner AK, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J, Hubner CA, Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice. J Assoc Res Otolaryngol. 2019 Jun;20(3):233-245
1	J:184432 Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E, Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol. 2012 Jan;31(1):17-28
1*	J:317598 Ito A, Ichiyanagi N, Ikeda Y, Hagiyama M, Inoue T, Kimura KB, Sakurai MA, Hamaguchi K, Murakami Y, Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet alpha-cells and prevents their excessive secretion of glucagon. Islets. 2012 Jan-Feb;4(1):49-55
1	J:332874 Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S, FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Cell Mol Life Sci. 2022 Nov 29;79(12):609
3	J:84726 Joswig A, Gabriel HD, Kibschull M, Winterhager E, Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol. 2003 May 26;1(1):44
1*	J:92356 Juneja SC, mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian J Physiol Pharmacol. 2003 Apr;47(2):147-56
4	J:209627 Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K, Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Apr 1;124(4):1598-607
7	J:215340 Kibschull M, Colaco K, Matysiak-Zablocki E, Winterhager E, Lye SJ, Connexin31.1 (gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem Cells Dev. 2014 Nov 1;23(21):2649-60
3	J:98807 Kibschull M, Magin TM, Traub O, Winterhager E, Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn. 2005 May 13;233(3):853-863
4	J:171693 Kim HM, Wangemann P, Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. PLoS One. 2011;6(3):e17949
1	J:226939 Li R, Diao H, Zhao F, Xiao S, El Zowalaty AE, Dudley EA, Mattson MP, Ye X, Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility. Endocrinology. 2015 Sep;156(9):3344-57
2	J:338821 Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ, TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605
4*	J:119031 Lillevali K, Haugas M, Matilainen T, Pussinen C, Karis A, Salminen M, Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mech Dev. 2006 Jun;123(6):415-29
8	J:3056 Miragall F, Hwang TK, Traub O, Hertzberg EL, Dermietzel R, Expression of connexins in the developing olfactory system of the mouse. J Comp Neurol. 1992 Nov 15;325(3):359-78
1	J:288268 Miwa T, Ohta K, Ito N, Hattori S, Miyakawa T, Takeo T, Nakagata N, Song WJ, Minoda R, Tsukushi is essential for the development of the inner ear. Mol Brain. 2020 Mar 3;13(1):29
1	J:162601 Mutai H, Nagashima R, Sugitani Y, Noda T, Fujii M, Matsunaga T, Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium. Dev Neurobiol. 2009 Dec;69(14):913-30
1	J:182928 Nagarajan P, Chin SS, Wang D, Liu S, Sinha S, Garrett-Sinha LA, Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci. 2010 Oct 15;123(Pt 20):3566-75
13*	J:33509 Nishi M, Kumar NM, Gilula NB, Developmental regulation of gap junction gene expression during mouse embryonic development. Dev Biol. 1991 Jul;146(1):117-30
3	J:243986 Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y, Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol Cell Biol. 2017 Jun 01;37(11)
2	J:312376 Pastar V, Lozic M, Kelam N, Filipovic N, Bernard B, Katsuyama Y, Vukojevic K, Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. Int J Mol Sci. 2021 Oct 2;22(19)
2*	J:118301 Patel S, Xi ZF, Seo EY, McGaughey D, Segre JA, Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18668-73
11	J:183924 Perez-Armendariz EM, Cruz-Miguel L, Coronel-Cruz C, Esparza-Aguilar M, Pinzon-Estrada E, Rancano-Camacho E, Zacarias-Climaco G, Olivares PF, Espinosa AM, Becker I, Saez JC, Berumen J, Perez-Palacios G, Connexin 36 is Expressed in Beta and Connexins 26 and 32 in Acinar Cells at the End of the Secondary Transition of Mouse Pancreatic Development and Increase During Fetal and Perinatal Life. Anat Rec (Hoboken). 2012 Jun;295(6):980-90
1	J:326535 Petitpre C, Faure L, Uhl P, Fontanet P, Filova I, Pavlinkova G, Adameyko I, Hadjab S, Lallemend F, Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Nat Commun. 2022 Jul 5;13(1):3878
2	J:213754 Plaks V, Gershon E, Zeisel A, Jacob-Hirsch J, Neeman M, Winterhager E, Rechavi G, Domany E, Dekel N, Blastocyst implantation failure relates to impaired translational machinery gene expression. Reproduction. 2014 Jul;148(1):87-98
1	J:347618 Qin T, So KKH, Hui CC, Sham MH, Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation. Cell Rep. 2024 Apr 23;43(4):114083
1	J:323119 Renauld JM, Khan V, Basch ML, Intermediate Cells of Dual Embryonic Origin Follow a Basal to Apical Gradient of Ingression Into the Lateral Wall of the Cochlea. Front Cell Dev Biol. 2022;10:867153
2*	J:239310 Rhee C, Edwards M, Dang C, Harris J, Brown M, Kim J, Tucker HO, ARID3A is required for mammalian placenta development. Dev Biol. 2017 Feb 15;422(2):83-91
1	J:245876 Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller JA, Krantz ID, Carstens RP, Epstein DJ, ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
8*	J:1730 Sainio K, Gilbert SF, Lehtonen E, Nishi M, Kumar NM, Gilula NB, Saxen L, Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes. Development. 1992 Jul;115(3):827-37
2	J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
1	J:234621 Shibata S, Miwa T, Wu HH, Levitt P, Ohyama T, Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing. J Neurosci. 2016 Aug 3;36(31):8200-9
2	J:59364 Shiojiri N, Sano M, Inujima S, Nitou M, Kanazawa M, Mori M, Quantitative analysis of cell allocation during liver development, using the spf(ash)-heterozygous female mouse. Am J Pathol. 2000 Jan;156(1):65-75
4*	J:70957 Sohl G, Eiberger J, Jung YT, Kozak CA, Willecke K, The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem. 2001 Jun;382(6):973-8
2	J:330219 Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ, Compartmentalized metabolism supports midgestation mammalian development. Nature. 2022 Apr;604(7905):349-353
1	J:174237 Sripathy S, Lee M, Vasioukhin V, Mammalian Llgl2 Is Necessary for Proper Branching Morphogenesis during Placental Development. Mol Cell Biol. 2011 Jul;31(14):2920-33
5	J:101228 Sun J, Ahmad S, Chen S, Tang W, Zhang Y, Chen P, Lin X, Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts. Am J Physiol Cell Physiol. 2005 Mar;288(3):C613-23
1	J:332093 Szeto IYY, Chu DKH, Chen P, Chu KC, Au TYK, Leung KKH, Huang YH, Wynn SL, Mak ACY, Chan YS, Chan WY, Jauch R, Fritzsch B, Sham MH, Lovell-Badge R, Cheah KSE, SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119
4	J:196661 Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores ER, van Bokhoven H, Lu X, Knight RA, Melino G, Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7300-5
2	J:178162 Trowe MO, Maier H, Petry M, Schweizer M, Schuster-Gossler K, Kispert A, Impaired stria vascularis integrity upon loss of E-cadherin in basal cells. Dev Biol. 2011 Nov 1;359(1):95-107
2*	J:134489 Trowe MO, Maier H, Schweizer M, Kispert A, Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes. Development. 2008 May;135(9):1725-34
1	J:160473 Trowe MO, Shah S, Petry M, Airik R, Schuster-Gossler K, Kist R, Kispert A, Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse. Dev Biol. 2010 Jun 1;342(1):51-62
7	J:36635 Valdimarsson G, De Sousa PA, Beyer EC, Paul DL, Kidder GM, Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development. Mol Reprod Dev. 1991 Sep;30(1):18-26
1	J:175239 Valiente M, Ciceri G, Rico B, Marin O, Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26. J Neurosci. 2011 Aug 10;31(32):11678-91
1	J:73084 Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85
3	J:268062 Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ, FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet. 2018 Nov;14(11):e1007787
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2*	J:93582 von Maltzahn J, Euwens C, Willecke K, Sohl G, The novel mouse connexin39 gene is expressed in developing striated muscle fibers. J Cell Sci. 2004 Oct 15;117(Pt 22):5381-92
1	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
2*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
2*	J:128922 Zheng-Fischhofer Q, Kibschull M, Schnichels M, Kretz M, Petrasch-Parwez E, Strotmann J, Reucher H, Lynn BD, Nagy JI, Lye SJ, Winterhager E, Willecke K, Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol. 2007 Dec 1;312(1):258-71
1	J:263025 Zoupa M, Xavier GM, Bryan S, Theologidis I, Arno M, Cobourne MT, Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429