Gene Expression Literature Summary

• Symbol: Tle5
• Name: TLE family member 5, transcriptional modulator
• ID: MGI:95806

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E4.5	E6.5	E7.5	E8.5	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E18.5	P
Immunohistochemistry (section)													1			2
In situ RNA (section)			1	1	1	4	2	2	2	1	3	4	1	3	1	3
In situ RNA (whole mount)					1	2		2	2
Northern blot										1						2
Western blot						1										1
RT-PCR	1	1						1	1		1	1	2		1	2
cDNA clones					1											2
RNase protection										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tle5  TLE family member 5, transcriptional modulator   (Synonyms: Aes, AES, Grg, Grg5)
Results	Reference
3	J:60107 Allen T, Lobe CG, A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):687-708
3	J:86317 Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA, TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol. 2003 Nov;17(11):2152-61
1	J:285703 Cheung LYM, Camper SA, PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression. Endocrinology. 2020 Feb 1;161(2)
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
6	J:142415 Hoffman BG, Zavaglia B, Beach M, Helgason CD, Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. 2008;8:81
2*	J:118937 Kaji K, Nichols J, Hendrich B, Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development. 2007 Mar;134(6):1123-32
1	J:317902 Kaltenbrun E, Greco TM, Slagle CE, Kennedy LM, Li T, Cristea IM, Conlon FL, A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression. J Proteome Res. 2013 Dec 6;12(12):5395-409
1*	J:35621 Koop KE, MacDonald LM, Lobe CG, Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech Dev. 1996 Sep;59(1):73-87
1*	J:37523 Leon C, Lobe CG, Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures. Dev Dyn. 1997 Jan;208(1):11-24
12*	J:13403 Mallo M, Franco del Amo F, Gridley T, Cloning and developmental expression of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Mech Dev. 1993 Jul;42(1-2):67-76
2	J:29516 Mallo M, Gendron-Maguire M, Harbison ML, Gridley T, Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
2*	J:18306 Mallo M, Steingrimsson E, Copeland NG, Jenkins NA, Gridley T, Genomic organization, alternative polyadenylation, and chromosomal localization of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Genomics. 1994 May 1;21(1):194-201
1*	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
1	J:183486 Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS, The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and beta-cell differentiation. Development. 2012 Apr;139(8):1447-56
2	J:68408 Muhr J, Andersson E, Persson M, Jessell TM, Ericson J, Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell. 2001 Mar 23;104(6):861-73
2*	J:101190 Rave-Harel N, Miller NL, Givens ML, Mellon PL, The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem. 2005 Sep 2;280(35):30975-83
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
2	J:183890 Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D, Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012 Apr;44(4):406-12, S1
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3	J:77680 Zhu CC, Dyer MA, Uchikawa M, Kondoh H, Lagutin OV, Oliver G, Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002 Jun;129(12):2835-49