Gene Expression Literature Summary

• Symbol: Hba-x
• Name: hemoglobin X, alpha-like embryonic chain in Hba complex
• ID: MGI:96019

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E18.5	E	P
In situ RNA (section)		1	2		4		2		2		1		1								1
In situ RNA (whole mount)				1	2	1	2		1		1		1
Western blot					1
RT-PCR	1	1	2		10		8	1	8	1	2	1	5	4	6	3		2	3	1	2
cDNA clones												1
RNase protection							3		2	1			1		1	1	1			1
Nuclease S1									1				1		1			1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hba-x  hemoglobin X, alpha-like embryonic chain in Hba complex   (Synonyms: zeta globin)
Results	Reference
1*	J:51469 Baron MH, Farrington SM, Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells. Mol Cell Biol. 1994 May;14(5):3108-14
1	J:149115 Basu P, Lung TK, Lemsaddek W, Sargent TG, Williams DC Jr, Basu M, Redmond LC, Lingrel JB, Haar JL, Lloyd JA, EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood. 2007 Nov 1;110(9):3417-25
1*	J:119377 Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler KM, Lloyd JA, KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 1;106(7):2566-71
2	J:117669 Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A, Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation. FASEB J. 2003 Aug;17(11):1496-8
2	J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
2	J:239299 Brooke-Bisschop T, Savory JG, Foley T, Ringuette R, Lohnes D, Essential roles for Cdx in murine primitive hematopoiesis. Dev Biol. 2017 Feb 15;422(2):115-124
2*	J:53293 Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A, Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development. 1999 Apr;126(8):1631-42
2*	J:26913 Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ, Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development. 1995 Jun;121(6):1845-54
4*	J:188116 Dobreva MP, Lhoest L, Pereira PN, Umans L, Chuva de Sousa Lopes SM, Zwijsen A, Periostin as a biomarker of the amniotic membrane. Stem Cells Int. 2012;2012:987185
2*	J:142972 Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS, UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7;283(45):30461-70
1	J:37831 Farace MG, Hill A, Tripodi M, Padgett RW, Raschella G, Gambari R, Fantoni A, Hutchison CA 3rd, Edgell MH, Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. Gene. 1984 Nov;31(1-3):241-5
2*	J:100942 Fu XH, Liu DP, Tang XB, Liu G, Lv X, Li YJ, Liang CC, A conserved, extended chromatin opening within alpha-globin locus during development. Exp Cell Res. 2005 Sep 10;309(1):174-84
1*	J:36249 Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH, Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12355-8
1	J:204573 Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M, Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol. 2013 Aug;33(15):2976-87
2*	J:79924 Greene ND, Leung KY, Wait R, Begum S, Dunn MJ, Copp AJ, Differential protein expression at the stage of neural tube closure in the mouse embryo. J Biol Chem. 2002 Nov 1;277(44):41645-51
1	J:130852 Griffin CT, Brennan J, Magnuson T, The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb;135(3):493-500
1*	J:271614 Gudmundsdottir B, Gudmundsson KO, Klarmann KD, Singh SK, Sun L, Singh S, Du Y, Coppola V, Stockwin L, Nguyen N, Tessarollo L, Thorsteinsson L, Sigurjonsson OE, Gudmundsson S, Rafnar T, Tisdale JF, Keller JR, POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248
7*	J:29665 Hendrey J, Lin D, Dziadek M, Developmental analysis of the Hba(th-J) mouse mutation: effects on mouse peri-implantation development and identification of two candidate genes. Dev Biol. 1995 Nov;172(1):253-63
9	J:133333 Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J, 'Maturational' globin switching in primary primitive erythroid cells. Blood. 2006 Feb 15;107(4):1665-72
9	J:3683 Leder A, Kuo A, Shen MM, Leder P, In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors. Development. 1992 Dec;116(4):1041-9
2	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
1*	J:147318 Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R, Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct;149(10):5012-23
2	J:133298 Lux CT, Yoshimoto M, McGrath K, Conway SJ, Palis J, Yoder MC, All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood. 2008 Apr 1;111(7):3435-8
1*	J:66591 Mahlapuu M, Ormestad M, Enerback S, Carlsson P, The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development. 2001 Jan;128(2):155-66
1	J:40354 Marin M, Karis A, Visser P, Grosveld F, Philipsen S, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
2	J:162666 Miccio A, Blobel GA, Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010 Jul;30(14):3460-70
3*	J:96853 Mukhopadhyay P, Greene RM, Zacharias W, Weinrich MC, Singh S, Young WW Jr, Pisano MM, Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004 Dec;70(12):912-26
1*	J:40963 Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito Y, Satake M, Noda T, Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5697-702
1	J:264340 Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W, Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol. 2011 Jun 26;13(8):944-51
2	J:186666 Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M, Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012 Jul;32(13):2628-44
3	J:47299 Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN, Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95
1	J:25651 Perkins AC, Sharpe AH, Orkin SH, Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
2	J:67993 Ramamurthy L, Barbour V, Tuckfield A, Clouston DR, Topham D, Cunningham JM, Jane SM, Targeted disruption of the CP2 gene, a member of the NTF family of transcription factors. J Biol Chem. 2001 Mar 16;276(11):7836-42
1	J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
1*	J:23061 Shivdasani RA, Mayer EL, Orkin SH, Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 2;373(6513):432-4
2	J:77275 Shivdasani RA, Orkin SH, Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8690-4
1	J:144074 Song H, Luo J, Luo W, Weng J, Wang Z, Li B, Li D, Liu M, Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway. J Biol Chem. 2008 Dec 26;283(52):36687-97
1*	J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
9	J:52217 Trimborn T, Gribnau J, Grosveld F, Fraser P, Mechanisms of developmental control of transcription in the murine alpha-and beta-globin loci. Genes Dev. 1999 Jan 1;13(1):112-24
2	J:127131 Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R, Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells. 2007 May;12(5):581-92
1*	J:285404 Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y, Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver. Stem Cell Reports. 2019 Dec 10;13(6):992-1005
2	J:117887 Wallace HA, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, Hughes J, Wood WG, Higgs DR, Smith AJ, Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell. 2007 Jan 12;128(1):197-209
2*	J:115753 Yi Z, Cohen-Barak O, Hagiwara N, Kingsley PD, Fuchs DA, Erickson DT, Epner EM, Palis J, Brilliant MH, Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet. 2006 Feb;2(2):e14
1	J:312414 Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K, Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204
3	J:349564 Zhang F, Zhang B, Wang Y, Jiang R, Liu J, Wei Y, Gao X, Zhu Y, Wang X, Sun M, Kang J, Liu Y, You G, Wei D, Xin J, Bao J, Wang M, Gu Y, Wang Z, Ye J, Guo S, Huang H, Sun Q, An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature. 2023 Oct;622(7984):834-841
1	J:70581 Zwijsen A, van Grunsven LA, Bosman EA, Collart C, Nelles L, Umans L, Van de Putte T, Wuytens G, Huylebroeck D, Verschueren K, Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo. Mol Cell Endocrinol. 2001 Jun 30;180(1-2):13-24