Gene Expression Literature Summary

• Symbol: Hbb
• Name: hemoglobin beta chain complex
• ID: MGI:96020

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E2	E3	E3.5	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16	E18.5	E	P
Immunohistochemistry (section)																		1
In situ RNA (section)						1			1
Northern blot						1	1	1		1			2					2
Western blot													2			1		1
RT-PCR	1	1	1	1	1		1		2	1	6	2	3	3		1	2	2
RNase protection														1	1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hbb  hemoglobin beta chain complex
Results	Reference
2	J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
3	J:106655 Bender MA, Roach JN, Halow J, Close J, Alami R, Bouhassira EE, Groudine M, Fiering SN, Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood. 2001 Oct 1;98(7):2022-7
1	J:164506 Drogat B, Kalucka J, Gutierrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmuller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ, Vegf regulates embryonic erythroid development through Gata1 modulation. Blood. 2010 Sep 23;116(12):2141-51
1	J:55508 Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K, Functions of c-Jun in liver and heart development. J Cell Biol. 1999 May 31;145(5):1049-61
4	J:141617 Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler KM, Crossley M, Dekker J, Perkins AC, A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol. 2008 May;141(3):398-406
4*	J:274867 Lim M, Brown HM, Kind KL, Breen J, Anastasi MR, Ritter LJ, Tregoweth EK, Dinh DT, Thompson JG, Dunning KR, Haemoglobin expression in in vivo murine preimplantation embryos suggests a role in oxygen-regulated gene expression. Reprod Fertil Dev. 2019 Apr;31(4):724-734
1*	J:118892 Maki K, Yamagata T, Asai T, Yamazaki I, Oda H, Hirai H, Mitani K, Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos. Blood. 2005 Sep 15;106(6):2147-55
2	J:162666 Miccio A, Blobel GA, Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010 Jul;30(14):3460-70
1	J:164806 Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H, A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol. 2010 Sep 15;345(2):226-36
1	J:306231 Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS, The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors. Matrix Biol. 2021 Mar;97:40-57
2	J:186666 Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M, Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012 Jul;32(13):2628-44
3	J:77275 Shivdasani RA, Orkin SH, Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8690-4
2	J:163685 Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL, Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15151-6
1	J:144074 Song H, Luo J, Luo W, Weng J, Wang Z, Li B, Li D, Liu M, Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway. J Biol Chem. 2008 Dec 26;283(52):36687-97
6	J:33704 Southwood CM, Downs KM, Bieker JJ, Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn. 1996 Jul;206(3):248-59
1	J:204328 Tondeleir D, Drogat B, Slowicka K, Bakkali K, Bartunkova S, Goossens S, Haigh JJ, Ampe C, Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS One. 2013;8(6):e67855
4*	J:52214 Walsh CP, Bestor TH, Cytosine methylation and mammalian development. Genes Dev. 1999 Jan 1;13(1):26-34
7	J:349564 Zhang F, Zhang B, Wang Y, Jiang R, Liu J, Wei Y, Gao X, Zhu Y, Wang X, Sun M, Kang J, Liu Y, You G, Wei D, Xin J, Bao J, Wang M, Gu Y, Wang Z, Ye J, Guo S, Huang H, Sun Q, An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature. 2023 Oct;622(7984):834-841