Gene Expression Literature Summary

• Symbol: Hmgb1
• Name: high mobility group box 1
• ID: MGI:96113

31 matching records from 31 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	1		1		1	1				1	1		1	1		3	1	2	2	2	2		1	3
In situ RNA (section)									1	1	1	2	1		1	4	3		2	1		1	2		7
Immunohistochemistry (whole mount)	1	1		1	1		1																		1
In situ RNA (whole mount)									1	1		2					1		2
Northern blot									1	1															2
Western blot																					1				1
RT-PCR	2	2	1	3	2	3	3	1			1														4
cDNA clones									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hmgb1  high mobility group box 1   (Synonyms: amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1)
Results	Reference
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:152897 Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA, Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury. Am J Pathol. 2009 Sep;175(3):958-75
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
10*	J:138375 Cui XS, Shen XH, Kim NH, High mobility group box 1 (HMGB1) is implicated in preimplantation embryo development in the mouse. Mol Reprod Dev. 2008 Aug;75(8):1290-9
2	J:316105 Dardenne AD, Wulff BC, Wilgus TA, The alarmin HMGB-1 influences healing outcomes in fetal skin wounds. Wound Repair Regen. 2013 Mar-Apr;21(2):282-91
3*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
5*	J:82501 Guazzi S, Strangio A, Franzi AT, Bianchi ME, HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain. Gene Expr Patterns. 2003 Mar;3(1):29-33
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:171052 Itou J, Taniguchi N, Oishi I, Kawakami H, Lotz M, Kawakami Y, HMGB factors are required for posterior digit development through integrating signaling pathway activities. Dev Dyn. 2011 May;240(5):1151-62
1	J:297226 Lu H, Ye C, Feng X, Liu J, Bhaumik M, Xia B, Liu C, Shen Z, Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice. Am J Pathol. 2020 Jun;190(6):1175-1187
1*	J:268359 Mughal W, Martens M, Field J, Chapman D, Huang J, Rattan S, Hai Y, Cheung KG, Kereliuk S, West AR, Cole LK, Hatch GM, Diehl-Jones W, Keijzer R, Dolinsky VW, Dixon IM, Parmacek MS, Gordon JW, Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition. Cell Death Differ. 2018 Nov;25(10):1732-1748
9*	J:16826 Pauken CM, Nagle DL, Bucan M, Lo CW, Molecular cloning, expression analysis, and chromosomal localization of mouse Hmg1-containing sequences. Mamm Genome. 1994 Feb;5(2):91-9
1	J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169
1	J:67968 Ronfani L, Ferraguti M, Croci L, Ovitt CE, Scholer HR, Consalez GG, Bianchi ME, Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001 Apr;128(8):1265-73
1	J:265031 Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM, Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437
1	J:197686 Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ, Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527
14*	J:51416 Spada F, Brunet A, Mercier Y, Renard JP, Bianchi ME, Thompson EM, High mobility group 1 (HMG1) protein in mouse preimplantation embryos. Mech Dev. 1998 Aug;76(1-2):57-66
2*	J:210059 Szenasi T, Kenesi E, Nagy A, Molnar A, Balint BL, Zvara A, Csabai Z, Deak F, Boros Olah B, Mates L, Nagy L, Puskas LG, Kiss I, Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis. Biochim Biophys Acta. 2013 Oct;1829(10):1075-91
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
2	J:144502 Taniguchi N, Carames B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, Lotz M, Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1181-6
4	J:125052 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H, Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:47656 Vaccari T, Beltrame M, Ferrari S, Bianchi ME, Hmg4, a new member of the Hmg1/2 gene family. Genomics. 1998 Apr 15;49(2):247-52
2*	J:171421 Vandunk C, Hunter LA, Gray PA, Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:304122 Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H, Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 Jul 17;9(7):1714
2	J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14