Gene Expression Literature Summary

• Symbol: Hoxa4
• Name: homeobox A4
• ID: MGI:96176

74 matching records from 74 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
In situ RNA (section)		1		2	1	3		1		5		18	1	4		3		4	2		1		2			2	5
In situ RNA (whole mount)		1	1	4	3	3	1	4	1	5	1	4		3		1		1	1							3
Northern blot								1		3		5		3		3		2	3		2				1	1	6
RT-PCR	1	1		4	2	8		4	1	2		1	2			1	2	1	1	1		2	1	1			5
cDNA clones							1					1															4
RNase protection											1	1			1					1		1					1
Nuclease S1											1		1														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hoxa4  homeobox A4   (Synonyms: Hox-1.4)
Results	Reference
2*	J:47284 Aubin J, Lemieux M, Tremblay M, Behringer RR, Jeannotte L, Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton. Dev Dyn. 1998 May;212(1):141-56
1*	J:34198 Boulet AM, Capecchi MR, Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol. 1996 Jul 10;177(1):232-49
4*	J:23135 Burke AC, Nelson CE, Morgan BA, Tabin C, Hox genes and the evolution of vertebrate axial morphology. Development. 1995 Feb;121(2):333-46
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
1	J:79367 Collins EC, Appert A, Ariza-McNaughton L, Pannell R, Yamada Y, Rabbitts TH, Mouse Af9 Is a Controller of Embryo Patterning, Like Mll, Whose Human Homologue Fuses with AF9 after Chromosomal Translocation in Leukemia. Mol Cell Biol. 2002 Oct;22(20):7313-24
1*	J:38487 Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M, Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development. 1997 Feb;124(3):721-9
6*	J:14757 Detmer K, Lawrence HJ, Largman C, Expression of class I homeobox genes in fetal and adult murine skin. J Invest Dermatol. 1993 Oct;101(4):517-22
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:14491 Dolle P, Lufkin T, Krumlauf R, Mark M, Duboule D, Chambon P, Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7666-70
1*	J:9951 Duboule D, Dolle P, The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
1*	J:157035 Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason CD, Hess JL, Humphries RK, Brock HW, Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev Biol. 2010 Jan 1;337(1):9-15
11*	J:32465 Galliot B, Dolle P, Vigneron M, Featherstone MS, Baron A, Duboule D, The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development. Development. 1989 Oct;107(2):343-59
1*	J:10731 Gaunt SJ, Coletta PL, Pravtcheva D, Sharpe PT, Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network. Development. 1990 Jun;109(2):329-39
3*	J:66343 Gaunt SJ, Krumlauf R, Duboule D, Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation. Development. 1989 Sep;107(1):131-41
1*	J:30750 Gaunt SJ, Sharpe PT, Duboule D, Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan. Development. 1988;104(Suppl):169-79
2*	J:18225 Gaunt SJ, Strachan L, Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers. Dev Dyn. 1994 Mar;199(3):229-40
1*	J:3103 Geada AM, Gaunt SJ, Azzawi M, Shimeld SM, Pearce J, Sharpe PT, Sequence and embryonic expression of the murine Hox-3.5 gene. Development. 1992 Oct;116(2):497-506
5*	J:149067 Grier DG, Thompson A, Lappin TR, Halliday HL, Quantification of Hox and Surfactant Protein-B Transcription during Murine Lung Development. Neonatology. 2009 Feb 10;96(1):50-60
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:148364 Hibiya K, Katsumoto T, Kondo T, Kitabayashi I, Kudo A, Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons. Dev Biol. 2009 May 15;329(2):176-90
2	J:308865 Higashijima Y, Nagai N, Yamamoto M, Kitazawa T, Kawamura YK, Taguchi A, Nakada N, Nangaku M, Furukawa T, Aburatani H, Kurihara H, Wada Y, Kanki Y, Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster. Commun Biol. 2020 Nov 30;3(1):725
2	J:266434 Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisua Belmonte JC, Shilatifard A, Evans RM, Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386
1*	J:22077 Horan GS, Wu K, Wolgemuth DJ, Behringer RR, Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12644-8
1	J:86514 Houle M, Sylvestre JR, Lohnes D, Retinoic acid regulates a subset of Cdx1 function in vivo. Development. 2003 Dec;130(26):6555-67
1	J:621 Hunt P, Gulisano M, Cook M, Sham MH, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R, A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
1	J:162938 Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET, SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23;38(2):191-201
3	J:79649 Kawazoe Y, Sekimoto T, Araki M, Takagi K, Araki K, Yamamura K, Region-specific gastrointestinal Hox code during murine embryonal gut development. Dev Growth Differ. 2002 Feb;44(1):77-84
2	J:265501 Kim H, Langohr IM, Faisal M, McNulty M, Thorn C, Kim J, Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice. PLoS One. 2018;13(8):e0203391
1	J:173414 Kondrashov N, Pusic A, Stumpf CR, Shimizu K, Hsieh AC, Xue S, Ishijima J, Shiroishi T, Barna M, Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell. 2011 Apr 29;145(3):383-97
1*	J:19219 Kostic D, Capecchi MR, Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev. 1994 Jun;46(3):231-47
1	J:338694 Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski J, Jerome-Majewska LA, Sf3b4 regulates chromatin remodeler splicing and Hox expression. Differentiation. 2023 May-Jun;131:59-73
1	J:87735 Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, Nakano T, Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development. 2004 Feb;131(4):839-49
1	J:166681 Li Z, Kawasumi M, Zhao B, Moisyadi S, Yang J, Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra. Mol Reprod Dev. 2010 Nov;77(11):990-7
1	J:301249 Lopez-Delgado AC, Delgado I, Cadenas V, Sanchez-Cabo F, Torres M, Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid. Development. 2021 Jan 4;148(1):dev193813
2	J:109284 Lorente M, Perez C, Sanchez C, Donohoe M, Shi Y, Vidal M, Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev. 2006 Apr;123(4):312-20
1	J:147041 Matsuyama M, Aizawa S, Shimono A, Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 2009 Mar;5(3):e1000427
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2*	J:130227 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI, Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan;8(2):124-39
2	J:317819 Minguillon C, Nishimoto S, Wood S, Vendrell E, Gibson-Brown JJ, Logan MP, Hox genes regulate the onset of Tbx5 expression in the forelimb. Development. 2012 Sep;139(17):3180-8
3*	J:54641 Minoo P, Su G, Drum H, Bringas P, Kimura S, Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol. 1999 May 1;209(1):60-71
1	J:144017 Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM, Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development. 2009 Feb;136(4):637-45
7*	J:44152 Mollard R, Dziadek M, Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung. Int J Dev Biol. 1997 Oct;41(5):655-66
4	J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
5*	J:66282 Packer AI, Jane-wit D, McLean L, Panteleyev AA, Christiano AM, Wolgemuth DJ, Hoxa4 expression in developing mouse hair follicles and skin. Mech Dev. 2000 Dec;99(1-2):153-7
1	J:202012 Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS, Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
4*	J:89197 Patterson LT, Potter SS, Atlas of Hox gene expression in the developing kidney. Dev Dyn. 2004 Apr;229(4):771-9
9	J:60124 Pitera JE, Smith VV, Thorogood P, Milla PJ, Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code. Gastroenterology. 1999 Dec;117(6):1339-51
1	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
2	J:32999 Rubin MR, Nguyen-Huu MC, Murine embryonic spinal cord and adult testis Hox-1.4 cDNAs are identical 3' to the homeo box. DNA Seq. 1991;1(5):329-34
8	J:8339 Rubin MR, Toth LE, Patel MD, D'Eustachio P, Nguyen-Huu MC, A mouse homeo box gene is expressed in spermatocytes and embryos. Science. 1986 Aug 8;233(4764):663-7
1	J:290220 Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H, Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates. Elife. 2020 May 29;9:e53608
3	J:181230 Scotti M, Kmita M, Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development. 2012 Feb;139(4):731-9
4*	J:218555 Sheikh BN, Downer NL, Kueh AJ, Thomas T, Voss AK, Excessive versus physiologically relevant levels of retinoic acid in embryonic stem cell differentiation. Stem Cells. 2014 Jun;32(6):1451-8
1*	J:35249 Sreenath TL, Pollock RA, Bieberich CJ, Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9636-40
1	J:267472 Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP, Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10615-E10624
1	J:125040 Tabaries S, Lemieux M, Aubin J, Jeannotte L, Comparative analysis of Hoxa5 allelic series. Genesis. 2007 Apr;45(4):218-28
2*	J:43764 Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb MA , Nomura M , Tsuchiya R , Fujita Y , Shibata Y , Higashinakagawa T , Shimada K, Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development. 1997 Oct;124(19):3673-82
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
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4*	J:34112 Toth LE, Slawin KL, Pintar JE, Nguyen-Huu MC, Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6790-4
1	J:127131 Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R, Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells. 2007 May;12(5):581-92
2	J:35539 van der Lugt NM, Alkema M, Berns A, Deschamps J, The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev. 1996 Aug;58(1-2):153-64
2	J:155755 Voss AK, Collin C, Dixon MP, Thomas T, Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity. Dev Cell. 2009 Nov;17(5):674-86
1	J:78736 Wang J, Mager J, Schnedier E, Magnuson T, The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome. 2002 Sep;13(9):493-503
3	J:4189 Watrin F, Wolgemuth DJ, Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene. Dev Biol. 1993 Mar;156(1):136-45
3*	J:24201 Wolgemuth DJ, Behringer RR, Mostoller MP, Brinster RL, Palmiter RD, Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development. Nature. 1989 Feb 2;337(6206):464-7
5	J:8355 Wolgemuth DJ, Engelmyer E, Duggal RN, Gizang-Ginsberg E, Mutter GL, Ponzetto C, Viviano C, Zakeri ZF, Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology. EMBO J. 1986 Jun;5(6):1229-35
8*	J:8812 Wolgemuth DJ, Viviano CM, Gizang-Ginsberg E, Frohman MA, Joyner AL, Martin GR, Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5813-7
1*	J:241982 Woltering JM, Noordermeer D, Leleu M, Duboule D, Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits. PLoS Biol. 2014 Jan;12(1):e1001773
1	J:226712 Wong SF, Agarwal V, Mansfield JH, Denans N, Schwartz MG, Prosser HM, Pourquie O, Bartel DP, Tabin CJ, McGlinn E, Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4884-93
1*	J:48270 Yamaguchi M, Nakamoto M, Honda H, Nakagawa T, Fujita H, Nakamura T, Hirai H, Narumiya S, Kakizuka A, Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7491-6
2*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:154374 Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki J, Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes. Dev Biol. 2009 Nov 1;335(1):216-27
1	J:225113 Zhang Y, Liu Z, Medrzycki M, Cao K, Fan Y, Reduction of Hox gene expression by histone H1 depletion. PLoS One. 2012;7(6):e38829