Gene Expression Literature Summary

• Symbol: Hoxb8
• Name: homeobox B8
• ID: MGI:96189

83 matching records from 83 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)												1				1
In situ RNA (section)		1	1	2		1		1		8		5		4		4		5		3		2		2		3	5
In situ RNA (whole mount)		2	2	5	4	16	2	8	2	7		3		1				2		1						4
In situ reporter (knock in)					1			2		3	1			1				1				1		1			1
Northern blot												3			1	1			1				1				2
RT-PCR	1	1	1	7	2	8	1	4	1	5		4	1	2		3	1	1		2	1	1		3	2		4
cDNA clones		1		1				1	1	1							1				1					1
RNase protection											1				1						1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hoxb8  homeobox B8   (Synonyms: Hox-2.4)
Results	Reference
1	J:81154 Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG, Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003 Feb;130(3):623-33
3*	J:208763 Ahn Y, Mullan HE, Krumlauf R, Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
1*	J:33159 Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H, A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development. 1996 MAY;122(5):1513-1522
1	J:12875 Bittner D, De Robertis EM, Cho KW, Characterization of the Xenopus Hox 2.4 gene and identification of control elements in its intron. Dev Dyn. 1993 Jan;196(1):11-24
4*	J:18568 Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC, Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. Am J Physiol. 1994 Apr;266(4 Pt 1):L448-54
3	J:23135 Burke AC, Nelson CE, Morgan BA, Tabin C, Hox genes and the evolution of vertebrate axial morphology. Development. 1995 Feb;121(2):333-46
1*	J:139570 Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L, Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
2*	J:27786 Chan DC, Laufer E, Tabin C, Leder P, Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development. 1995 Jul;121(7):1971-8
4*	J:19897 Charite J, de Graaff W, Shen S, Deschamps J, Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell. 1994 Aug 26;78(4):589-601
1*	J:29038 Charite J, de Graaff W, Vogels R, Meijlink F, Deschamps J, Regulation of the Hoxb-8 gene: synergism between multimerized cis-acting elements increases responsiveness to positional information. Dev Biol. 1995 Oct;171(2):294-305
2	J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
2	J:325251 Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Munoz-Canoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlen M, Esteban MA, Li Y, Liu L, Xu X, Wang J, Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022 May 12;185(10):1777-1792.e21
1*	J:37847 Chen F, Capecchi MR, Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol. 1997 Jan 15;181(2):186-96
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
8*	J:263986 De S, Van Deren D, Peden E, Hockin M, Boulet A, Titen S, Capecchi MR, Two distinct ontogenies confer heterogeneity to mouse brain microglia. Development. 2018 Jul 4;145(13):dev152306
1*	J:114714 DeLaurier A, Schweitzer R, Logan M, Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb. Dev Biol. 2006 Nov 1;299(1):22-34
5*	J:4303 Deschamps J, Wijgerde M, Two phases in the establishment of HOX expression domains. Dev Biol. 1993 Apr;156(2):473-80
4*	J:14757 Detmer K, Lawrence HJ, Largman C, Expression of class I homeobox genes in fetal and adult murine skin. J Invest Dermatol. 1993 Oct;101(4):517-22
1	J:92064 Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF, Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug;131(15):3693-703
2*	J:84603 Forlani S, Lawson KA, Deschamps J, Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development. 2003 Aug;130(16):3807-19
5	J:109525 Fujimura Y, Isono K, Vidal M, Endoh M, Kajita H, Mizutani-Koseki Y, Takihara Y, van Lohuizen M, Otte A, Jenuwein T, Deschamps J, Koseki H, Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development. 2006 Jun;133(12):2371-81
5*	J:32030 Graham A, Maden M, Krumlauf R, The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development. Development. 1991 May;112(1):255-64
3*	J:9784 Graham A, Papalopulu N, Krumlauf R, The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell. 1989 May 5;57(3):367-78
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2	J:73745 Greer JM, Capecchi MR, Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002 Jan 3;33(1):23-34
5*	J:149067 Grier DG, Thompson A, Lappin TR, Halliday HL, Quantification of Hox and Surfactant Protein-B Transcription during Murine Lung Development. Neonatology. 2009 Feb 10;96(1):50-60
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:8129 Hart CP, Awgulewitsch A, Fainsod A, McGinnis W, Ruddle FH, Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
2	J:308865 Higashijima Y, Nagai N, Yamamoto M, Kitazawa T, Kawamura YK, Taguchi A, Nakada N, Nangaku M, Furukawa T, Aburatani H, Kurihara H, Wada Y, Kanki Y, Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster. Commun Biol. 2020 Nov 30;3(1):725
7	J:134668 Holstege JC, de Graaff W, Hossaini M, Cano SC, Jaarsma D, van den Akker E, Deschamps J, Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6338-43
2*	J:307833 Honda M, Oki S, Kimura R, Harada A, Maehara K, Tanaka K, Meno C, Ohkawa Y, High-depth spatial transcriptome analysis by photo-isolation chemistry. Nat Commun. 2021 Jul 20;12(1):4416
2	J:103424 Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ, The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature. 2005 Dec 1;438(7068):671-4
1	J:142008 Huang M, Huang T, Xiang Y, Xie Z, Chen Y, Yan R, Xu J, Cheng L, Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons. Dev Biol. 2008 Jul 2;322(2):394-405
1	J:621 Hunt P, Gulisano M, Cook M, Sham MH, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R, A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
2	J:100027 Isono K, Fujimura Y, Shinga J, Yamaki M, O-Wang J, Takihara Y, Murahashi Y, Takada Y, Mizutani-Koseki Y, Koseki H, Mammalian polyhomeotic homologues phc2 and phc1 act in synergy to mediate polycomb repression of hox genes. Mol Cell Biol. 2005 Aug;25(15):6694-706
2	J:96358 Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H, Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 2005 Mar 1;19(5):536-41
3*	J:85471 Juan AH, Ruddle FH, Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development. 2003 Oct;130(20):4823-34
1	J:338694 Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski J, Jerome-Majewska LA, Sf3b4 regulates chromatin remodeler splicing and Hox expression. Differentiation. 2023 May-Jun;131:59-73
1	J:170279 Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H, Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011 Jan;31(2):351-64
3	J:136396 Liao X, Collins MD, All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis. Dev Dyn. 2008 Jun;237(6):1553-64
3	J:79482 Liu Y, Liu C, Yamada Y, Fan CM, growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002 Nov;129(22):5289-300
2	J:109284 Lorente M, Perez C, Sanchez C, Donohoe M, Shi Y, Vidal M, Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev. 2006 Apr;123(4):312-20
2	J:93952 Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT, MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct;36(10):1079-83
2	J:42706 McGrath KE, Palis J, Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation. Mol Reprod Dev. 1997 Oct;48(2):145-53
1*	J:86684 Medina-Martinez O, Ramirez-Solis R, In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster. Dev Biol. 2003 Dec 1;264(1):77-90
2*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2	J:321503 Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P, Hildebrandt H, Trowe MO, Kispert A, FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
1*	J:44152 Mollard R, Dziadek M, Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung. Int J Dev Biol. 1997 Oct;41(5):655-66
5	J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
4*	J:89166 Oosterveen T, Meijlink F, Deschamps J, Expression of retinaldehyde dehydrogenase II and sequential activation of 5' Hoxb genes in the mouse caudal hindbrain. Gene Expr Patterns. 2004 May;4(3):243-7
3	J:81400 Oosterveen T, Niederreither K, Dolle P, Chambon P, Meijlink F, Deschamps J, Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain. EMBO J. 2003 Jan 15;22(2):262-9
4*	J:89197 Patterson LT, Potter SS, Atlas of Hox gene expression in the developing kidney. Dev Dyn. 2004 Apr;229(4):771-9
1*	J:25199 Pollock RA, Sreenath T, Ngo L, Bieberich CJ, Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4492-6
1	J:76655 Qian Y, Shirasawa S, Chen CL, Cheng L, Ma Q, Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev. 2002 May 15;16(10):1220-33
1	J:43769 Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA , Wisdom R, Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development. 1997 Oct;124(20):3999-4008
1	J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
1	J:290220 Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H, Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates. Elife. 2020 May 29;9:e53608
1	J:79851 Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H, Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development. 2002 Sep;129(18):4171-83
1	J:221589 Szabo NE, da Silva RV, Sotocinal SG, Zeilhofer HU, Mogil JS, Kania A, Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015 Apr 1;35(13):5233-46
1	J:77675 te Welscher P, Fernandez-Teran M, Ros MA, Zeller R, Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 2002 Feb 15;16(4):421-6
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
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2	J:231980 Tomas-Roca L, Corral-San-Miguel R, Aroca P, Puelles L, Marin F, Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016 Mar;221(2):815-38
1	J:127131 Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R, Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells. 2007 May;12(5):581-92
3*	J:75947 van den Akker E, Forlani S, Chawengsaksophak K, de Graaff W, Beck F, Meyer BI, Deschamps J, Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 2002 May;129(9):2181-93
1*	J:68720 van den Akker E, Fromental-Ramain C, de Graaff W, Le Mouellic H, Brulet P, Chambon P, Deschamps J, Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development. 2001 May;128(10):1911-21
1	J:185604 van Rooijen C, Simmini S, Bialecka M, Neijts R, van de Ven C, Beck F, Deschamps J, Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence. Development. 2012 Jul;139(14):2576-83
1	J:155755 Voss AK, Collin C, Dixon MP, Thomas T, Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity. Dev Cell. 2009 Nov;17(5):674-86
1	J:262219 Wang B, Zheng Y, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M, Xu X, Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017 Feb;16(2):296-307
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2	J:90106 Yekta S, Shih IH, Bartel DP, MicroRNA-directed cleavage of HOXB8 mRNA. Science. 2004 Apr 23;304(5670):594-6
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
4	J:154781 Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009 Oct;17(4):516-26
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1	J:170604 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X, The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65
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