Gene Expression Literature Summary

• Symbol: Hoxc5
• Name: homeobox C5
• ID: MGI:96196

58 matching records from 58 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)								3		3		1		1		2		1			2	1			1
In situ RNA (section)				1		2		7		11		4	1	2		5	1	2		1	1				6
In situ RNA (whole mount)	1	2	3	4	1	9	2	6	1	3	1	2		1		3		1						1
In situ reporter (knock in)				1		1	1		1	1														1
Northern blot				1		1		1		1		1													1
Western blot										1											1				1
RT-PCR		2		3		2	1	5		2	1	1	1	5	1			2	1		5	1	1		3
cDNA clones		1																							1
RNase protection								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hoxc5  homeobox C5   (Synonyms: Hox-3.4, Hox-6.2)
Results	Reference
1*	J:33159 Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H, A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development. 1996 MAY;122(5):1513-1522
1	J:202792 Boucherat O, Montaron S, Berube-Simard FA, Aubin J, Philippidou P, Wellik DM, Dasen JS, Jeannotte L, Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L817-30
1*	J:34198 Boulet AM, Capecchi MR, Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol. 1996 Jul 10;177(1):232-49
4*	J:23135 Burke AC, Nelson CE, Morgan BA, Tabin C, Hox genes and the evolution of vertebrate axial morphology. Development. 1995 Feb;121(2):333-46
2	J:322321 Catela C, Chen Y, Weng Y, Wen K, Kratsios P, Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766
1	J:284139 Chaimowicz C, Ruffault PL, Cheret C, Woehler A, Zampieri N, Fortin G, Garratt AN, Birchmeier C, Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. Development. 2019 Sep 6;146(17):dev174045
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1*	J:88580 Cordes R, Schuster-Gossler K, Serth K, Gossler A, Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development. 2004 Mar;131(6):1221-33
1*	J:38487 Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M, Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development. 1997 Feb;124(3):721-9
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:297683 Fernandez-Guerrero M, Yakushiji-Kaminatsui N, Lopez-Delisle L, Zdral S, Darbellay F, Perez-Gomez R, Bolt CC, Sanchez-Martin MA, Duboule D, Ros MA, Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30509-30519
1*	J:10731 Gaunt SJ, Coletta PL, Pravtcheva D, Sharpe PT, Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network. Development. 1990 Jun;109(2):329-39
8*	J:30848 Geada AM, Coletta PL, Sharpe PT, Characterization of the murine Hoxc-5 gene. Mamm Genome. 1996 Jan;7(1):81-4
1*	J:3103 Geada AM, Gaunt SJ, Azzawi M, Shimeld SM, Pearce J, Sharpe PT, Sequence and embryonic expression of the murine Hox-3.5 gene. Development. 1992 Oct;116(2):497-506
5	J:279182 Genabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L, Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Sci Rep. 2017 Aug 15;7(1):8295
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
5*	J:149067 Grier DG, Thompson A, Lappin TR, Halliday HL, Quantification of Hox and Surfactant Protein-B Transcription during Murine Lung Development. Neonatology. 2009 Feb 10;96(1):50-60
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:308865 Higashijima Y, Nagai N, Yamamoto M, Kitazawa T, Kawamura YK, Taguchi A, Nakada N, Nangaku M, Furukawa T, Aburatani H, Kurihara H, Wada Y, Kanki Y, Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster. Commun Biol. 2020 Nov 30;3(1):725
4*	J:233611 Hirata A, Katayama K, Tsuji T, Imura H, Natsume N, Sugahara T, Kunieda T, Nakamura H, Otsuki Y, Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9
5	J:266434 Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisua Belmonte JC, Shilatifard A, Evans RM, Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386
8	J:232894 Hrycaj SM, Dye BR, Baker NC, Larsen BM, Burke AC, Spence JR, Wellik DM, Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development. Cell Rep. 2015 Aug 11;12(6):903-12
5*	J:267460 Hrycaj SM, Marty-Santos L, Cebrian C, Rasky AJ, Ptaschinski C, Lukacs NW, Wellik DM, Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10605-E10614
1*	J:157698 Ideguchi M, Palmer TD, Recht LD, Weimann JM, Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci. 2010 Jan 20;30(3):894-904
1	J:166088 Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS, Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 2010 Sep 9;67(5):781-96
2*	J:121991 Katayama K, Furuno A, Akiyama K, Tsuji T, Kunieda T, Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate. Mamm Genome. 2007 Apr;18(4):246-54
3	J:79649 Kawazoe Y, Sekimoto T, Araki M, Takagi K, Araki K, Yamamura K, Region-specific gastrointestinal Hox code during murine embryonal gut development. Dev Growth Differ. 2002 Feb;44(1):77-84
1	J:173414 Kondrashov N, Pusic A, Stumpf CR, Shimizu K, Hsieh AC, Xue S, Ishijima J, Shiroishi T, Barna M, Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell. 2011 Apr 29;145(3):383-97
1	J:338694 Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski J, Jerome-Majewska LA, Sf3b4 regulates chromatin remodeler splicing and Hox expression. Differentiation. 2023 May-Jun;131:59-73
1	J:195163 Lacombe J, Hanley O, Jung H, Philippidou P, Surmeli G, Grinstein J, Dasen JS, Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013 Jan;9(1):e1003184
1	J:241156 Lizen B, Hutlet B, Bissen D, Sauvegarde D, Hermant M, Ahn MT, Gofflot F, HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons. J Comp Neurol. 2017 Apr 01;525(5):1155-1175
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
6	J:124112 McIntyre DC, Rakshit S, Yallowitz AR, Loken L, Jeannotte L, Capecchi MR, Wellik DM, Hox patterning of the vertebrate rib cage. Development. 2007 Aug;134(16):2981-9
1	J:249220 Melhuish TA, Taniguchi K, Wotton D, Tgif1 and Tgif2 Regulate Axial Patterning in Mouse. PLoS One. 2016;11(5):e0155837
6*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
6	J:204667 Min H, Lee JY, Kim MH, Hoxc gene collinear expression and epigenetic modifications established during embryogenesis are maintained until after birth. Int J Biol Sci. 2013;9(9):960-5
2	J:317819 Minguillon C, Nishimoto S, Wood S, Vendrell E, Gibson-Brown JJ, Logan MP, Hox genes regulate the onset of Tbx5 expression in the forelimb. Development. 2012 Sep;139(17):3180-8
1	J:152419 Mugford JW, Yu J, Kobayashi A, McMahon AP, High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15;333(2):312-23
1	J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
2*	J:211197 Nishimoto S, Minguillon C, Wood S, Logan MP, A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. PLoS Genet. 2014 Mar;10(3):e1004245
4*	J:89197 Patterson LT, Potter SS, Atlas of Hox gene expression in the developing kidney. Dev Dyn. 2004 Apr;229(4):771-9
1	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
11	J:60124 Pitera JE, Smith VV, Thorogood P, Milla PJ, Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code. Gastroenterology. 1999 Dec;117(6):1339-51
1	J:290220 Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H, Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates. Elife. 2020 May 29;9:e53608
1	J:221396 Sheikh BN, Downer NL, Phipson B, Vanyai HK, Kueh AJ, McCarthy DJ, Smyth GK, Thomas T, Voss AK, MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5437-42
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1*	J:29755 Subramanian V, Meyer BI, Gruss P, Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995 Nov 17;83(4):641-53
1	J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:231980 Tomas-Roca L, Corral-San-Miguel R, Aroca P, Puelles L, Marin F, Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016 Mar;221(2):815-38
2	J:35539 van der Lugt NM, Alkema M, Berns A, Deschamps J, The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev. 1996 Aug;58(1-2):153-64
1	J:78736 Wang J, Mager J, Schnedier E, Magnuson T, The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome. 2002 Sep;13(9):493-503
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
6	J:203059 Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM, Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43
2*	J:246912 Ye A, Kim H, Kim J, PEG3 control on the mammalian MSL complex. PLoS One. 2017;12(6):e0178363
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:225113 Zhang Y, Liu Z, Medrzycki M, Cao K, Fan Y, Reduction of Hox gene expression by histone H1 depletion. PLoS One. 2012;7(6):e38829