Gene Expression Literature Summary

• Symbol: Hras
• Name: Harvey rat sarcoma virus oncogene
• ID: MGI:96224

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E3.5	E6.5	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)										1		1			1		1		1	1	1	1			1
In situ RNA (section)															2		3		1			2
Immunohistochemistry (whole mount)			1
In situ reporter (knock in)																	1								1
Northern blot				2	1	2	1		2		2		2		2		1		2	2	2	1	1		1
Western blot													1				4			1		1		2	4
RT-PCR	1	1						1		1	1	1	1	1	2	1	3	1		2	1	2		1	2
cDNA clones																									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hras  Harvey rat sarcoma virus oncogene   (Synonyms: c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras-1, Hras1)
Results	Reference
1	J:15751 Ahmad K, Naz RK, Presence and possible role of c-ras and nuclear (c-fos and c-jun) proto-oncogene products in preimplantation embryonic development in mice. Mol Reprod Dev. 1993 Nov;36(3):297-306
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3	J:288966 Chang S, Lu X, Wang S, Wang Z, Huo J, Huang J, Shangguan S, Li S, Zou J, Bao Y, Guo J, Wang F, Niu B, Zhang T, Qiu Z, Wu J, Wang L, The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects. FASEB J. 2019 Apr;33(4):4688-4702
1*	J:330081 Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O, Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 Oct 5;12(10):2434-2453
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:83205 Goldberg M, Wei M, Yuan L, Murty VV, Tycko B, Biallelic expression of HRAS and MUCDHL in human and mouse. Hum Genet. 2003 Apr;112(4):334-42
1	J:43433 Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E , Bronson RT , Umanoff H , Edelmann W , Kucherlapati R , Jacks T, K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997 Oct 1;11(19):2468-81
1	J:267258 Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ, Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. J Cell Biol. 2018 Sep 3;217(9):3219-3235
1*	J:53886 Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ , Young SG, Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem. 1999 Mar 26;274(13):8383-90
1*	J:112202 Krizhanovsky V, Soreq L, Kliminski V, Ben-Arie N, Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. J Mol Neurosci. 2006;28(2):211-29
5	J:198271 Lin CY, Lin TY, Lee MC, Chen SC, Chang JS, Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy. PLoS One. 2013;8(2):e56731
11	J:7235 Muller R, Verma IM, Adamson ED, Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2(5):679-84
4	J:135610 Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H, Kondo H, Katsuki M, Partial functional overlap of the three ras genes in mouse embryonic development. Oncogene. 2008 May 8;27(21):2961-8
5*	J:320537 Newlaczyl AU, Coulson JM, Prior IA, Quantification of spatiotemporal patterns of Ras isoform expression during development. Sci Rep. 2017 Jan 24;7:41297
1*	J:112961 Nunez Rodriguez N, Lee IN, Banno A, Qiao HF, Qiao RF, Yao Z, Hoang T, Kimmelman AC, Chan AM, Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling. Mol Cell Biol. 2006 Oct;26(19):7145-54
10	J:246653 Park JC, Jeong WJ, Kim MY, Min D, Choi KY, Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development. J Cell Sci. 2016 Aug 01;129(15):2997-3007
4*	J:112533 Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R, H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis. Mol Biol Cell. 2006 Apr;17(4):2046-56
2*	J:95070 Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA, Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation. Int J Dev Biol. 2004;48(8-9):879-88
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
4	J:137729 Schuhmacher AJ, Guerra C, Sauzeau V, Canamero M, Bustelo XR, Barbacid M, A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest. 2008 Jun;118(6):2169-79
13	J:178367 Slamon DJ, Cline MJ, Expression of cellular oncogenes during embryonic and fetal development of the mouse. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7141-5
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1	J:229358 Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU, Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. Exp Eye Res. 2014 Apr;121:130-42
2	J:24889 Wang KY, Chen KC, Chiang CP, Kuo MY, Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice. J Oral Pathol Med. 1995 Mar;24(3):103-8
1*	J:91734 Wang Y, Wang F, Sun T, Trostinskaia A, Wygle D, Puscheck E, Rappolee DA, Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos. Dev Dyn. 2004 Sep;231(1):72-87
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678