Gene Expression Literature Summary

• Symbol: Hspb1
• Name: heat shock protein 1
• ID: MGI:96240

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E3	E3.5	E8	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E19.5	P
Immunohistochemistry (section)											1	3		2	2		3		4	3	2	1	10
In situ RNA (section)															1								3
Immunohistochemistry (whole mount)	1	1	1	1	1																		1
In situ RNA (whole mount)									1
In situ reporter (knock in)						1	1	1		1		2		1									2
Northern blot										1	1	1		1	1		1		1	1	1
Western blot							2		1	2	3	2		2	1		2	1	2	1	2		9
RT-PCR	1	1	1	1	1							4	1	1	2	1	1	1					10
cDNA clones									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hspb1  heat shock protein 1   (Synonyms: Hsp25)
Results	Reference
1	J:235148 Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN, Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503
6	J:65871 Armstrong CL, Krueger-Naug AM, Currie RW, Hawkes R, Expression of heat-shock protein hsp25 in mouse purkinje cells during development reveals novel features of cerebellar compartmentation. J Comp Neurol. 2001 Jan 1;429(1):7-21
3	J:69288 Armstrong CL, Krueger-Naug AM, Currie RW, Hawkes R, Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse. J Comp Neurol. 2001 Jun 4;434(3):262-74
6*	J:292622 Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, Fowler VM, Lachke SA, The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. Hum Mol Genet. 2020 Jul 29;29(12):2076-2097
1*	J:288137 Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R, Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. ACS Chem Neurosci. 2020 Jun 3;11(11):1555-1562
1	J:334092 Broadway-Stringer S, Jiang H, Wadmore K, Hooper C, Douglas G, Steeples V, Azad AJ, Singer E, Reyat JS, Galatik F, Ehler E, Bennett P, Kalisch-Smith JI, Sparrow DB, Davies B, Djinovic-Carugo K, Gautel M, Watkins H, Gehmlich K, Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2. Cells. 2023 Feb 24;12(5)
1	J:110576 Croci L, Chung SH, Masserdotti G, Gianola S, Bizzoca A, Gennarini G, Corradi A, Rossi F, Hawkes R, Consalez GG, A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Development. 2006 Jul;133(14):2719-29
1	J:108510 Diehl AG, Zareparsi S, Qian M, Khanna R, Angeles R, Gage PJ, Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Invest Ophthalmol Vis Sci. 2006 May;47(5):1785-93
2	J:102677 Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H, Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J. 2005 Nov;19(13):1854-6
19*	J:74044 Eriksson M, Jokinen E, Sistonen L, Leppa S, Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol. 2000 Aug;44(5):471-7
2*	J:311225 Evgrafov OV, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung CL, Schagina O, Verpoorten N, Van Impe K, Fedotov V, Dadali E, Auer-Grumbach M, Windpassinger C, Wagner K, Mitrovic Z, Hilton-Jones D, Talbot K, Martin JJ, Vasserman N, Tverskaya S, Polyakov A, Liem RK, Gettemans J, Robberecht W, De Jonghe P, Timmerman V, Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Nat Genet. 2004 Jun;36(6):602-6
1*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3	J:320519 Geuens T, De Winter V, Rajan N, Achsel T, Mateiu L, Almeida-Souza L, Asselbergh B, Bouhy D, Auer-Grumbach M, Bagni C, Timmerman V, Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease. Acta Neuropathol Commun. 2017 Jan 11;5(1):5
9	J:125325 Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D, Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007 Aug;45(8):487-501
12*	J:73470 Kim M, Geum D, Khang I, Park YM, Kang BM, Lee KA, Kim K, Expression pattern of HSP25 in mouse preimplantation embryo: Heat shock responses during oocyte maturation. Mol Reprod Dev. 2002 Jan;61(1):3-13
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
3	J:169836 Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL, Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6
1*	J:52895 Loones MT, Morange M, Hsp and chaperone distribution during endochondral bone development in mouse embryo. Cell Stress Chaperones. 1998 Dec;3(4):237-44
1*	J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
4	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1	J:330284 Nusser A, Sagar, Swann JB, Krauth B, Diekhoff D, Calderon L, Happe C, Grun D, Boehm T, Developmental dynamics of two bipotent thymic epithelial progenitor types. Nature. 2022 Jun;606(7912):165-171
10	J:122775 O'Shaughnessy RF, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C, AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation. J Biol Chem. 2007 Jun 8;282(23):17297-305
1	J:279439 Rahimi-Balaei M, Buchok M, Vihko P, Parkinson FE, Marzban H, Loss of prostatic acid phosphatase and alpha-synuclein cause motor circuit degeneration without altering cerebellar patterning. PLoS One. 2019;14(9):e0222234
1*	J:39331 Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V, Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2392-7
7	J:82153 Shimada M, Yamamoto M, Wakayama T, Iseki S, Amano O, Different expression of 25-kDa heat-shock protein (Hsp25) in Meckel's cartilage compared with other cartilages in the mouse. Anat Embryol (Berl). 2003 Feb;206(3):163-73
3*	J:117790 Singh S, Yin X, Pisano MM, Greene RM, Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):35-44
4*	J:83730 Wang G, Zhang J, Moskophidis D, Mivechi NF, Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003 May;36(1):48-61
1	J:293436 Wilson SL, Kalinovsky A, Orvis GD, Joyner AL, Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types. Cerebellum. 2011 Sep;10(3):356-72
4	J:58383 Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, Benjamin IJ, HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 1999 Nov 1;18(21):5943-52
1	J:296772 Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR, Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019 Mar;53(3)