Gene Expression Literature Summary

• Symbol: Iapp
• Name: islet amyloid polypeptide
• ID: MGI:96382

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11	E12	E12.5	E13	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)	1			1					1			1	8	6
In situ RNA (section)							2
RT-PCR		1	1		1	1		1	1	1	1		1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Iapp  islet amyloid polypeptide   (Synonyms: amylin)
Results	Reference
6*	J:64688 Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC, Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
1	J:193325 Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:248949 Ejarque M, Mir-Coll J, Gomis R, German MS, Lynn FC, Gasa R, Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8). PLoS One. 2016;11(1):e0146273
1	J:112173 Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C, The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006 Sep 1;20(17):2465-78
1*	J:84902 Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J, Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol. 2003 Aug 15;260(2):426-37
1	J:92173 Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P, The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol. 2004 Apr 1;268(1):123-34
1	J:98770 Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M, NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas. Development. 2005 Jul;132(13):3139-49
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:62595 Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP, Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
2	J:176201 Kordowich S, Collombat P, Mansouri A, Serup P, Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol. 2011;11:52
1	J:122518 Nelson SB, Schaffer AE, Sander M, The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development. 2007 Jul;134(13):2491-500
1	J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
1	J:353482 Ortiz JA, Ghazalli N, Lopez K, Rawson J, McCown EM, Oh E, Irimia JM, Jou K, Mares J, Chen MH, Wu X, Zook HN, Quijano JC, Erdem N, Lizarraga A, Kandeel F, Fueger PT, Thurmond DC, Ku HT, Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
1	J:65594 Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M, Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec;127(24):5533-40
1	J:141017 Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M, A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 1;323(1):19-30
1	J:172308 Stefan M, Simmons RA, Bertera S, Trucco M, Esni F, Drain P, Nicholls RD, Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011 May;300(5):E909-22
1	J:48576 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA , Rubenstein JL , German MS, Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
1	J:87406 Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B, The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 1;266(1):178-89
1	J:130423 Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B, Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Dev Dyn. 2008 Jan;237(1):51-61
5*	J:77320 Wilson ME, Kalamaras JA, German MS, Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev. 2002 Jul;115(1-2):171-6