Symbol Name ID |
Inhbb
inhibin beta-B MGI:96571 |
Age | E1 | E2 | E3 | E3.5 | E4.5 | E5.5 | E6 | E6.5 | E7.5 | E8 | E8.5 | E9.5 | E10.5 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | ||||||||||||||||||||
In situ RNA (section) | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 6 | 1 | 1 | 4 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 8 | |||||||
Immunohistochemistry (whole mount) | 1 | ||||||||||||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | 1 | ||||||||||||||||||||||||||||
In situ reporter (knock in) | 1 | ||||||||||||||||||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||
Western blot | 1 | ||||||||||||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 3 | 4 | 1 | 4 | 1 | 8 | 1 | 8 | 1 | 5 | 1 | 3 | 1 | 1 | 3 | 4 | 20 | |||
cDNA clones | 1 | ||||||||||||||||||||||||||||||
RNase protection | 1 | 1 | 1 | 3 | 1 | 3 | 2 | 2 | 1 | 2 | 1 | 4 |
Inhbb inhibin beta-B (Synonyms: activin beta-B) | |
Results | Reference |
10* | J:17693 Albano RM, Arkell R, Beddington RS, Smith JC, Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. Development. 1994 Apr;120(4):803-13 |
4 | J:4662 Albano RM, Groome N, Smith JC, Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation. Development. 1993 Feb;117(2):711-23 |
6 | J:128363 Arai KY, Nishiyama T, Developmental Changes in Extracellular Matrix Messenger RNAs in the Mouse Placenta During the Second Half of Pregnancy: Possible Factors Involved in the Regulation of Placental Extracellular Matrix Expression. Biol Reprod. 2007 Dec;77(6):923-33 |
2 | J:285098 Billings PC, Bizzaro C, Yang E, Chung J, Mundy C, Pacifici M, Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B. PLoS One. 2020;15(2):e0229254 |
5* | J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247 |
2* | J:271281 Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P, Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018 Jul 31;24(5):1330-1341 |
2 | J:63882 Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM, Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet. 2000 Aug;25(4):453-7 |
1 | J:223288 Curtain M, Heffner CS, Maddox DM, Gudis P, Donahue LR, Murray SA, A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice. Mamm Genome. 2015 Apr;26(3-4):173-80 |
7* | J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74 |
1 | J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28 |
5* | J:21942 Feijen A, Goumans MJ, van den Eijnden-van Raaij AJ, Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development. 1994 Dec;120(12):3621-37 |
1 | J:71679 Freiman RN, Albright SR, Zheng S, Sha WC, Hammer RE, Tjian R, Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7 |
4 | J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36 |
1 | J:176045 Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL, Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct;138(19):4131-42 |
2 | J:282137 Gongrich C, Krapacher FA, Munguba H, Fernandez-Suarez D, Andersson A, Hjerling-Leffler J, Ibanez CF, ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons. J Cell Biol. 2020 Jan 6;219(1) |
1 | J:293102 Heinrich A, Potter SJ, Guo L, Ratner N, DeFalco T, Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Rep. 2020 Apr 14;31(2):107513 |
3 | J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20 |
15* | J:114963 Jones RL, Kaitu'u-Lino TJ, Nie G, Sanchez-Partida LG, Findlay JK, Salamonsen LA, Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse. Reproduction. 2006 Nov;132(5):799-810 |
1 | J:223361 Kaftanovskaya EM, Lopez C, Ferguson L, Myhr C, Agoulnik AI, Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37 |
1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
1 | J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26 |
1 | J:338821 Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ, TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605 |
1 | J:160549 Liu CF, Parker K, Yao HH, WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One. 2010;5(4):e10382 |
2 | J:16240 Lu RZ, Matsuyama S, Nishihara M, Takahashi M, Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol Reprod. 1993 Dec;49(6):1163-9 |
7 | J:63347 Maldonado TS, Kadison AS, Crisera CA, Grau JB, Alkasab SL, Longaker MT, Gittes GK, Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: implications for lineage selection. J Gastrointest Surg. 2000 May-Jun;4(3):269-75 |
3 | J:194288 Manosalva I, Gonzalez A, Kageyama R, Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Dev Biol. 2013 Mar 15;375(2):140-51 |
7* | J:1989 Manova K, Paynton BV, Bachvarova RF, Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua. Mech Dev. 1992 Feb;36(3):141-52 |
4 | J:195695 Miles DC, Wakeling SI, Stringer JM, van den Bergen JA, Wilhelm D, Sinclair AH, Western PS, Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One. 2013;8(1):e54606 |
2* | J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109 |
12* | J:48941 Moore CS, Mjaatvedt CH, Gearhart JD, Expression and function of activin beta A during mouse cardiac cushion tissue formation. Dev Dyn. 1998 Aug;212(4):548-62 |
7 | J:154471 Natale DR, Hemberger M, Hughes M, Cross JC, Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate. Dev Biol. 2009 Nov 1;335(1):120-31 |
1 | J:225731 Nicol B, Yao HH, Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice. Biol Reprod. 2015 Aug;93(2):35 |
2* | J:108109 Oxburgh L, Chu GC, Michael SK, Robertson EJ, TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605 |
1* | J:17302 Paulusma CC, Van der Kruijssen CM, Van den Eijnden-Van Raaij AJ, Localization of activin subunits in early murine development determined by subunit-specific antibodies. J Immunol Methods. 1994 Mar 10;169(2):143-52 |
1 | J:197548 Pihlajoki M, Gretzinger E, Cochran R, Kyronlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB, Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67 |
4 | J:276801 Prajapati-DiNubila M, Benito-Gonzalez A, Golden EJ, Zhang S, Doetzlhofer A, A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. Elife. 2019 Jun 12;8:e47613 |
7* | J:24357 Ritvos O, Tuuri T, Eramaa M, Sainio K, Hilden K, Saxen L, Gilbert SF, Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev. 1995 Apr;50(2-3):229-45 |
1 | J:308864 Rotgers E, Nicol B, Rodriguez K, Rattan S, Flaws JA, Yao HH, Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice. FASEB J. 2021 Aug;35(8):e21770 |
4 | J:194494 Sarraj MA, Escalona RM, Western P, Findlay JK, Stenvers KL, Effects of TGFbeta2 on Wild-Type and Tgfbr3 Knockout Mouse Fetal Testis. Biol Reprod. 2013;88(3):66 |
1 | J:87737 Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M, The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb;131(4):933-42 |
7* | J:31961 Schmitt J, Hotten G, Jenkins NA, Gilbert DJ, Copeland NG, Pohl J, Schrewe H, Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. Genomics. 1996 Mar 15;32(3):358-66 |
3 | J:339937 Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, Overman LM, Millman J, Sjoboen AH, Hadley J, Golser J, Mankad K, Sheppard H, Onar-Thomas A, Gajjar A, Robinson GW, Hovestadt V, Orr BA, Patay Z, Millen KJ, Northcott PA, Unified rhombic lip origins of group 3 and group 4 medulloblastoma. Nature. 2022 Sep;609(7929):1012-1020 |
1 | J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24) |
2 | J:100429 Tao H, Shimizu M, Kusumoto R, Ono K, Noji S, Ohuchi H, A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development. 2005 Jul;132(14):3217-30 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1 | J:133934 Tomizuka K, Horikoshi K, Kitada R, Sugawara Y, Iba Y, Kojima A, Yoshitome A, Yamawaki K, Amagai M, Inoue A, Oshima T, Kakitani M, R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling. Hum Mol Genet. 2008 May 1;17(9):1278-91 |
4* | J:3300 van den Eijnden-van Raaij AJ, Feijen A, Lawson KA, Mummery CL, Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development. Dev Biol. 1992 Dec;154(2):356-65 |
1 | J:213069 Vanorny DA, Prasasya RD, Chalpe AJ, Kilen SM, Mayo KE, Notch signaling regulates ovarian follicle formation and coordinates follicular growth. Mol Endocrinol. 2014 Apr;28(4):499-511 |
2 | J:248801 Wang Y, Bilandzic M, Ooi GT, Findlay JK, Stenvers KL, Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling. Mol Cell Endocrinol. 2016 Nov 15;436:68-77 |
1 | J:316132 Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S, hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. Theranostics. 2021;11(20):10030-10046 |
4 | J:275806 Wu D, Schieren I, Qian Y, Zhang C, Jessell TM, de Nooij JC, A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype. J Neurosci. 2019 May 29;39(22):4252-4267 |
1 | J:250205 Wu RC, Zeng Y, Chen YF, Lanz RB, Wu MY, Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network. Stem Cells. 2017 Jun;35(6):1554-1565 |
1 | J:341688 Xie X, Sun L, Duan Y, Lv Z, Yao X, Wang C, Chen X, Tian S, Yan L, Shao Y, Luo H, Liu J, SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918 |
4 | J:107812 Yao HH, Aardema J, Holthusen K, Sexually dimorphic regulation of inhibin Beta B in establishing gonadal vasculature in mice. Biol Reprod. 2006 May;74(5):978-83 |
1 | J:312465 Yin Y, Haller ME, Chadchan SB, Kommagani R, Ma L, Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization. JCI Insight. 2021 Sep 8;6(17) |
1* | J:225638 Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A, Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet. 2004 Jul 15;13(14):1487-503 |
1 | J:91887 Zhang YQ, Cleary MM, Si Y, Liu G, Eto Y, Kritzik M, Dabernat S, Kayali AG, Sarvetnick N, Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells. Diabetes. 2004 Aug;53(8):2024-33 |
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last database update 08/02/2024 MGI 6.24 |
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