Gene Expression Literature Summary
|
Symbol Name ID |
Ins1
insulin I MGI:96572 |
| Age | E0.5 | E1 | E2 | E2.5 | E4 | E7.5 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 2 | 1 | 5 | 2 | 10 | 2 | 16 | 1 | 40 | 1 | 41 | 6 | 68 | 12 | 133 | 3 | 54 | 7 | 75 | 16 | 149 | 2 | 9 | 1 | 3 | 327 | ||||||
| In situ RNA (section) | 1 | 1 | 1 | 4 | 2 | 1 | 6 | |||||||||||||||||||||||||
| Immunohistochemistry (whole mount) | 1 | 2 | 2 | 4 | 4 | 2 | 2 | 3 | 7 | |||||||||||||||||||||||
| In situ reporter (knock in) | 1 | |||||||||||||||||||||||||||||||
| Northern blot | 1 | |||||||||||||||||||||||||||||||
| RT-PCR | 1 | 1 | 1 | 1 | 1 | 3 | 6 | 3 | 6 | 2 | 5 | 4 | 8 | 4 | 6 | 5 | 11 | 1 | 14 | 4 | 26 | 3 | 10 | 2 | 10 | 22 | 2 | 3 | 59 |
| Ins1 insulin I | |
| Results | Reference |
| 5 | J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504 |
| 2 | J:316658 Abdellatif AM, Ogata K, Kudo T, Xiafukaiti G, Chang YH, Katoh MC, El-Morsy SE, Oishi H, Takahashi S, Role of large MAF transcription factors in the mouse endocrine pancreas. Exp Anim. 2015;64(3):305-12 |
| 5 | J:248945 Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S, beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One. 2016;11(2):e0150010 |
| 2 | J:219809 Afelik S, Pool B, Schmerr M, Penton C, Jensen J, Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development. Dev Biol. 2015 Mar 15;399(2):204-17 |
| 4 | J:184016 Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J, Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development. 2012 May;139(10):1744-53 |
| 4* | J:33133 Ahlgren U, Jonsson J, Edlund H, The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/ PDX1-deficient mice. Development. 1996 MAY;122(5):1409-1416 |
| 8 | J:169647 Ait-Lounis A, Bonal C, Seguin-Estevez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W, The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression. Diabetes. 2010 Jul;59(7):1674-85 |
| 2 | J:122342 Akerblom B, Anneren C, Welsh M, A role of FRK in regulation of embryonal pancreatic beta cell formation. Mol Cell Endocrinol. 2007 May 30;270(1-2):73-8 |
| 5 | J:308553 Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, Garcia-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J, Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Cell Rep. 2021 Apr 13;35(2):108981 |
| 1 | J:97344 Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, Inoue J, Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science. 2005 Apr 8;308(5719):248-51 |
| 4 | J:129667 Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M, Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab. 2005 Dec;2(6):385-97 |
| 5 | J:70719 Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T, The roles of atf3 in glucose homeostasis. a transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J Biol Chem. 2001 Aug 3;276(31):29507-14 |
| 1 | J:232360 Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Muller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A, Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia. 2016 Jan;59(1):139-50 |
| 1* | J:175542 Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L, The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug;138(15):3213-24 |
| 3 | J:156329 Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L, Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48 |
| 3 | J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331 |
| 1 | J:44143 Apelqvist A, Ahlgren U, Edlund H, Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol. 1997 Oct 1;7(10):801-4 |
| 6* | J:64688 Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC, Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42 |
| 1* | J:70585 Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, Oshimura M, Wake N, Surani MA, A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum Mol Genet. 2001 Jul 1;10(14):1475-83 |
| 2 | J:121934 Arnaud-Dabernat S, Kritzik M, Kayali AG, Zhang YQ, Liu G, Ungles C, Sarvetnick N, FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Diabetes. 2007 Jan;56(1):96-106 |
| 3* | J:231585 Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L, betalinc1 encodes a long noncoding RNA that regulates islet beta-cell formation and function. Genes Dev. 2016 Mar 1;30(5):502-7 |
| 4 | J:187468 Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L, Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug;50(8):612-24 |
| 4 | J:240765 Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM, Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology. 2016 Dec;157(12):4615-4631 |
| 6 | J:120055 Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R, MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3853-8 |
| 5 | J:169626 Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R, MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 2010 Oct;59(10):2530-9 |
| 4 | J:106430 Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R, MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 2006 Feb;55(2):297-304 |
| 4* | J:97065 Asayesh A, Alanentalo T, Khoo NK, Ahlgren U, Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments. Dev Dyn. 2005 Apr;232(4):1105-14 |
| 2 | J:111685 Asayesh A, Sharpe J, Watson RP, Hecksher-Sorensen J, Hastie ND, Hill RE, Ahlgren U, Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev. 2006 Aug 15;20(16):2208-13 |
| 3 | J:205003 Auffret J, Freemark M, Carre N, Mathieu Y, Tourrel-Cuzin C, Lombes M, Movassat J, Binart N, Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1309-18 |
| 5 | J:260459 Azizoglu DB, Braitsch C, Marciano DK, Cleaver O, Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390 |
| 3 | J:241637 Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Gottgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A, Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Dev Cell. 2017 May 08;41(3):274-286.e5 |
| 1 | J:151620 Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ, Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009 Jul;10(1):13-26 |
| 2 | J:327292 Bakhti M, Bastidas-Ponce A, Tritschler S, Czarnecki O, Tarquis-Medina M, Nedvedova E, Jaki J, Willmann SJ, Scheibner K, Cota P, Salinno C, Boldt K, Horn N, Ueffing M, Burtscher I, Theis FJ, Coskun U, Lickert H, Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun. 2022 Aug 4;13(1):4540 |
| 3 | J:204532 Balderes DA, Magnuson MA, Sussel L, Nkx2.2:Cre knock-in mouse line: A novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec;51(12):844-51 |
| 2 | J:91463 Banaei-Bouchareb L, Gouon-Evans V, Samara-Boustani D, Castellotti MC, Czernichow P, Pollard JW, Polak M, Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J Leukoc Biol. 2004 Aug;76(2):359-67 |
| 1 | J:226612 Bankaitis ED, Bechard ME, Wright CV, Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche. Genes Dev. 2015 Oct 15;29(20):2203-16 |
| 4 | J:336187 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O, Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74 |
| 2 | J:301635 Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H, Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic beta-cells. Mol Metab. 2017 Jun;6(6):524-534 |
| 1 | J:278226 Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Bottcher A, Theis FJ, Lickert H, Bakhti M, Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 2019 Jun 17;146(12):dev173849 |
| 1 | J:291485 Baumann D, Wong A, Akhaphong B, Jo S, Pritchard S, Mohan R, Chung G, Zhang Y, Alejandro EU, Role of nutrient-driven O-GlcNAc-post-translational modification in pancreatic exocrine and endocrine islet development. Development. 2020 Apr 12;147(7):dev186643 |
| 1 | J:213751 Baumgartner BK, Cash G, Hansen H, Ostler S, Murtaugh LC, Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning. Dev Biol. 2014 Jul 1;391(1):89-98 |
| 2* | J:177580 Begum S, Papaioannou VE, Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas. Gene Expr Patterns. 2011 Dec;11(8):476-83 |
| 1 | J:220253 Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS, Galphai/o-coupled receptor signaling restricts pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93 |
| 1 | J:274021 Bethea M, Liu Y, Wade AK, Mullen R, Gupta R, Gelfanov V, DiMarchi R, Bhatnagar S, Behringer R, Habegger KM, Hunter CS, The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis. Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E397-E409 |
| 1 | J:332319 Beucher A, Miguel-Escalada I, Balboa D, De Vas MG, Maestro MA, Garcia-Hurtado J, Bernal A, Gonzalez-Franco R, Vargiu P, Heyn H, Ravassard P, Ortega S, Ferrer J, The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022 Oct;24(10):1528-1540 |
| 1* | J:73072 Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R, Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development. 2001 Dec;128(24):5109-17 |
| 2 | J:218981 Bluteau G, Zhuang L, Amann R, Trueb B, Targeted disruption of the intracellular domain of receptor FgfrL1 in mice. PLoS One. 2014;9(8):e105210 |
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| 3 | J:340404 Bohuslavova R, Fabriciova V, Smolik O, Lebron-Mora L, Abaffy P, Benesova S, Zucha D, Valihrach L, Berkova Z, Saudek F, Pavlinkova G, NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development. Nat Commun. 2023 Sep 9;14(1):5554 |
| 6 | J:309174 Bohuslavova R, Smolik O, Malfatti J, Berkova Z, Novakova Z, Saudek F, Pavlinkova G, NEUROD1 Is Required for the Early alpha and beta Endocrine Differentiation in the Pancreas. Int J Mol Sci. 2021 Jun 23;22(13) |
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| 2 | J:146087 Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL, Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology. 2009 Jan;136(1):309-319.e9 |
| 1 | J:228228 Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX, Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83 |
| 3 | J:119565 Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV, Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol. 2006 Oct 15;298(2):616-31 |
| 3 | J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382 |
| 1 | J:106993 Briancon N, Weiss MC, In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J. 2006 Mar 22;25(6):1253-62 |
| 3 | J:116552 Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC, Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov;55(11):2974-85 |
| 4 | J:255164 Broche B, Ben Fradj S, Aguilar E, Sancerni T, Benard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC, Duvillie B, Mitochondrial Protein UCP2 Controls Pancreas Development. Diabetes. 2018 Jan;67(1):78-84 |
| 2 | J:334607 Bsharat S, Monni E, Singh T, Johansson JK, Achanta K, Bertonnier-Brouty L, Schmidt-Christensen A, Holmberg D, Kokaia Z, Prasad RB, Artner I, MafB-dependent neurotransmitter signaling promotes beta cell migration in the developing pancreas. Development. 2023 Mar 15;150(6):dev201009 |
| 2* | J:135698 Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA, Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol. 2008 Apr 1;316(1):74-86 |
| 1 | J:130733 Burris RE, Hebrok M, Pancreatic innervation in mouse development and beta-cell regeneration. Neuroscience. 2007 Dec 12;150(3):592-602 |
| 2 | J:307544 Burtscher I, Tarquis-Medina M, Salinno C, Schirge S, Beckenbauer J, Bakhti M, Lickert H, Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line. Int J Mol Sci. 2021 Mar 26;22(7) |
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| 2 | J:200985 Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M, Retinoblastoma tumor suppressor protein in pancreatic progenitors controls alpha- and beta-cell fate. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8 |
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| 1 | J:90990 Cano DA, Murcia NS, Pazour GJ, Hebrok M, Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development. 2004 Jul;131(14):3457-67 |
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| 1 | J:164701 Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA, Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8 |
| 1 | J:192746 Carrasco M, Delgado I, Soria B, Martin F, Rojas A, GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012 Oct 1;122(10):3504-15 |
| 1 | J:141896 Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF, Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age. Diabetes. 2008 Oct;57(10):2698-707 |
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| 2 | J:158060 Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R, Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology. 2009 Jun;150(6):2603-10 |
| 2 | J:312492 Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemeck GKH, Hrabe de Angelis M, A point mutation in the Pdia6 gene results in loss of pancreatic beta-cell identity causing overt diabetes. Mol Metab. 2021 Sep 4;54:101334 |
| 3* | J:34182 Chiang MK, Flanagan JG, PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50 |
| 1 | J:193165 Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ Jr, Grapin-Botton A, Magnuson MA, Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308 |
| 1 | J:24904 Christofori G, Naik P, Hanahan D, Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nat Genet. 1995 Jun;10(2):196-201 |
| 1 | J:105207 Chu K, Tsai MJ, Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes. 2005 Apr;54(4):1064-73 |
| 4 | J:240413 Churchill AJ, Gutierrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L, Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 Jan 10;6:e20010 |
| 1* | J:165268 Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA, Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice. J Clin Invest. 2010 Oct 1;120(10):3713-21 |
| 3 | J:337474 Cobo I, Paliwal S, Bodas C, Felipe I, Melia-Aloma J, Torres A, Martinez-Villarreal J, Malumbres M, Garcia F, Millan I, Del Pozo N, Park JC, MacDonald RJ, Munoz J, Mendez R, Real FX, NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761 |
| 1* | J:100403 Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK, Alms1-disrupted mice recapitulate human Alstrom syndrome. Hum Mol Genet. 2005 Aug 15;14(16):2323-33 |
| 4 | J:98803 Collombat P, Hecksher-Sorensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A, The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas. Development. 2005 Jul;132(13):2969-80 |
| 4 | J:86206 Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P, Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003 Oct 15;17(20):2591-603 |
| 2 | J:235909 Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R, The MAFB transcription factor impacts islet alpha-cell function in rodents and represents a unique signature of primate islet beta-cells. Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102 |
| 1 | J:92244 Cortes U, Tong WM, Coyle DL, Meyer-Ficca ML, Meyer RG, Petrilli V, Herceg Z, Jacobson EL, Jacobson MK, Wang ZQ, Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol. 2004 Aug;24(16):7163-78 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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