Gene Expression Literature Summary
|
Symbol Name ID |
Ins2
insulin II MGI:96573 |
| Age | E0.5 | E1 | E2 | E2.5 | E3.5 | E4 | E7.5 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 2 | 1 | 4 | 2 | 9 | 2 | 16 | 1 | 38 | 1 | 42 | 6 | 68 | 12 | 133 | 3 | 53 | 7 | 72 | 17 | 149 | 2 | 9 | 1 | 4 | 323 | |||||||
| In situ RNA (section) | 1 | 1 | 1 | 1 | 2 | 4 | 3 | 1 | 1 | 1 | 1 | 7 | |||||||||||||||||||||
| Immunohistochemistry (whole mount) | 1 | 2 | 2 | 4 | 4 | 2 | 2 | 3 | 7 | ||||||||||||||||||||||||
| In situ reporter (knock in) | 1 | 1 | 3 | ||||||||||||||||||||||||||||||
| Northern blot | 1 | ||||||||||||||||||||||||||||||||
| RT-PCR | 1 | 2 | 1 | 2 | 1 | 1 | 3 | 9 | 3 | 7 | 3 | 6 | 4 | 8 | 5 | 10 | 5 | 13 | 1 | 14 | 6 | 28 | 4 | 11 | 2 | 9 | 2 | 22 | 1 | 2 | 67 | ||
| cDNA clones | 1 |
| Ins2 insulin II (Synonyms: Ins-2, InsII, Mody, Mody4) | |
| Results | Reference |
| 5 | J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504 |
| 2 | J:316658 Abdellatif AM, Ogata K, Kudo T, Xiafukaiti G, Chang YH, Katoh MC, El-Morsy SE, Oishi H, Takahashi S, Role of large MAF transcription factors in the mouse endocrine pancreas. Exp Anim. 2015;64(3):305-12 |
| 5 | J:248945 Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S, beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One. 2016;11(2):e0150010 |
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| 5 | J:308553 Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, Garcia-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J, Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Cell Rep. 2021 Apr 13;35(2):108981 |
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| 3 | J:156329 Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L, Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48 |
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| 5 | J:260459 Azizoglu DB, Braitsch C, Marciano DK, Cleaver O, Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390 |
| 3 | J:241637 Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Gottgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A, Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Dev Cell. 2017 May 08;41(3):274-286.e5 |
| 1 | J:151620 Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ, Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009 Jul;10(1):13-26 |
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| 1 | J:105207 Chu K, Tsai MJ, Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes. 2005 Apr;54(4):1064-73 |
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| 1* | J:165268 Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA, Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice. J Clin Invest. 2010 Oct 1;120(10):3713-21 |
| 1* | J:100403 Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK, Alms1-disrupted mice recapitulate human Alstrom syndrome. Hum Mol Genet. 2005 Aug 15;14(16):2323-33 |
| 4 | J:98803 Collombat P, Hecksher-Sorensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A, The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas. Development. 2005 Jul;132(13):2969-80 |
| 4 | J:86206 Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P, Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003 Oct 15;17(20):2591-603 |
| 3 | J:235909 Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R, The MAFB transcription factor impacts islet alpha-cell function in rodents and represents a unique signature of primate islet beta-cells. Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102 |
| 1 | J:92244 Cortes U, Tong WM, Coyle DL, Meyer-Ficca ML, Meyer RG, Petrilli V, Herceg Z, Jacobson EL, Jacobson MK, Wang ZQ, Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol. 2004 Aug;24(16):7163-78 |
| 3 | J:269131 Cortijo C, Gouzi M, Tissir F, Grapin-Botton A, Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep. 2012 Dec 27;2(6):1593-606 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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