Gene Expression Literature Summary

• Symbol: Itga4
• Name: integrin alpha 4
• ID: MGI:96603

72 matching records from 72 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)								2	1	14	5	9	1	5	2	6		3	1	2	1	1	3	3				1	3	5
In situ RNA (section)										1	2	6		3	1	3	1		2		4	1	1	1	1	1		1		4
Immunohistochemistry (whole mount)	1	1		1	1		1		1					1																1
In situ RNA (whole mount)									1	3	2	5		2					3										2	1
In situ reporter (knock in)												1		1		1		1
Northern blot																	1					1					1			1
RT-PCR		1	1			1	2	1		2		3		2		3		1			1	1	3	1						9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Itga4  integrin alpha 4   (Synonyms: VLA-4 receptor, alpha 4 subunit)
Results	Reference
9*	J:93087 Bajanca F, Luz M, Duxson MJ, Thorsteinsdottir S, Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage. Dev Dyn. 2004 Oct;231(2):402-15
2*	J:81313 Bajanca F, Thorsteinsdottir S, Integrin expression patterns during early limb muscle development in the mouse. Mech Dev. 2002 Dec;119 Suppl 1:S131-4
1	J:152968 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T, Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug;17(2):175-86
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:198636 Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J, Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 2013 Jul;140(14):2961-71
2	J:229483 Borok MJ, Papaioannou VE, Sussel L, Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15;410(2):213-22
5*	J:52558 Bowen JA, Hunt JS, Expression of cell adhesion molecules in murine placentas and a placental cell line. Biol Reprod. 1999 Feb;60(2):428-34
2*	J:36690 Buck CA, Edelman JM, Buck CE, Kennedy G, Baldwin HS, Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes Commun. 1996 Aug;4(2):69-87
3*	J:97068 Cachaco AS, Pereira CS, Pardal RG, Bajanca F, Thorsteinsdottir S, Integrin repertoire on myogenic cells changes during the course of primary myogenesis in the mouse. Dev Dyn. 2005 Apr;232(4):1069-78
2	J:195350 Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, Hirota Y, Sakurai T, Imakawa K, Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7(11):e48933
1	J:84858 Chan CS, Weeber EJ, Kurup S, Sweatt JD, Davis RL, Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci. 2003 Aug 6;23(18):7107-16
1	J:194489 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
2	J:171148 Daane JM, Enders AC, Downs KM, Mesothelium of the murine allantois exhibits distinct regional properties. J Morphol. 2011 May;272(5):536-56
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:353479 Erickson AG, Motta A, Kastriti ME, Edwards S, Coulpier F, Theoulle E, Murtazina A, Poverennaya I, Wies D, Ganofsky J, Canu G, Lallemend F, Topilko P, Hadjab S, Fried K, Ruhrberg C, Schwarz Q, Castellani V, Bonanomi D, Adameyko I, Motor innervation directs the correct development of the mouse sympathetic nervous system. Nat Commun. 2024 Aug 16;15(1):7065
1	J:306456 Farini D, Cesari E, Weatheritt RJ, La Sala G, Naro C, Pagliarini V, Bonvissuto D, Medici V, Guerra M, Di Pietro C, Rizzo FR, Musella A, Carola V, Centonze D, Blencowe BJ, Marazziti D, Sette C, A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Cell Rep. 2020 Jun 2;31(9):107703
3	J:177142 Ferdous A, Morris J, Abedin MJ, Collins S, Richardson JA, Hill JA, Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2	J:171615 Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH, Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
2	J:176262 Giros A, Grgur K, Gossler A, Costell M, alpha5beta1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One. 2011;6(7):e22002
5	J:108464 Grazioli A, Alves CS, Konstantopoulos K, Yang JT, Defective blood vessel development and pericyte/pvSMC distribution in alpha4 integrin-deficient mouse embryos. Dev Biol. 2006 May 1;293(1):165-77
2	J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
5*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4	J:154032 Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F, Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles. PLoS One. 2009;4(10):e7641
1	J:22425 Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI, Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 1995 Jan 1;9(1):1-14
2*	J:84406 Hikita ST, Cann GM, Wingerd KL, Mullick LH, Wayne WC, Webb SW, Clegg DO, Integrin alpha4beta1 (VLA-4) expression and activity in retinal and peripheral neurons. Mol Cell Neurosci. 2003 Jul;23(3):427-39
2	J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
1*	J:52602 Hunter PJ, Swanson BJ, Haendel MA, Lyons GE, Cross JC, Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. Development. 1999 Mar;126(6):1247-58
10*	J:29262 Jaspers M, Wu RR, Van der Schueren B, Cassiman JJ, Localization of alpha 4m integrin at sites of mesenchyme condensation during embryonic mouse development. Differentiation. 1995 Sep;59(2):79-86
1*	J:160012 Jerome-Majewska LA, Achkar T, Luo L, Lupu F, Lacy E, The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Dev Biol. 2010 May 1;341(1):154-66
1	J:247822 Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A, Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017 Jul 25;8(1):128
3	J:328996 Kastriti ME, Faure L, Von Ahsen D, Bouderlique TG, Bostrom J, Solovieva T, Jackson C, Bronner M, Meijer D, Hadjab S, Lallemend F, Erickson A, Kaucka M, Dyachuk V, Perlmann T, Lahti L, Krivanek J, Brunet JF, Fried K, Adameyko I, Schwann cell precursors represent a neural crest-like state with biased multipotency. EMBO J. 2022 Sep 1;41(17):e108780
2*	J:182578 Kay JN, Chu MW, Sanes JR, MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature. 2012 Mar 22;483(7390):465-9
3*	J:50259 Kil SH, Krull CE, Cann G, Clegg D, Bronner-Fraser M, The alpha4 subunit of integrin is important for neural crest cell migration. Dev Biol. 1998 Oct 1;202(1):29-42
1*	J:106261 Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y, Sehara-Fujisawa A, Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28
3*	J:23137 Kwee L, Baldwin HS, Shen HM, Stewart CL, Buck C, Buck CA, Labow MA, Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development. 1995 Feb;121(2):489-503
4	J:242904 Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H, Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 2017 Jul 01;144(13):2469-2479
1	J:241636 Li J, Miao L, Zhao C, Shaikh Qureshi WM, Shieh D, Guo H, Lu Y, Hu S, Huang A, Zhang L, Cai CL, Wan LQ, Xin H, Vincent P, Singer HA, Zheng Y, Cleaver O, Fan ZC, Wu M, CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development. 2017 May 01;144(9):1635-1647
6	J:81855 Lu DP, Tian L, O'Neill C, King NJ, Regulation of cellular adhesion molecule expression in murine oocytes, peri-implantation and post-implantation embryos. Cell Res. 2002 Dec;12(5-6):373-83
2	J:197681 Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang H, A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013;11(4):e1001536
3	J:345312 Mak S, Hammes A, Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)
3*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
1	J:171515 Muller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E, The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
1	J:171374 Osorio KM, Lilja KC, Tumbar T, Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol. 2011 Apr 4;193(1):235-50
3	J:333380 Palmquist-Gomes P, Ruiz-Villalba A, Guadix JA, Romero JP, Bessieres B, MacGrogan D, Conejo L, Ortiz A, Picazo B, Houyel L, Gomez-Cabrero D, Meilhac SM, de la Pompa JL, Perez-Pomares JM, Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development. Exp Mol Med. 2023 Jan;55(1):228-239
3	J:123628 Papadaki C, Alexiou M, Cecena G, Verykokakis M, Bilitou A, Cross JC, Oshima RG, Mavrothalassitis G, Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul;27(14):5201-13
1	J:71583 Parr BA, Cornish VA, Cybulsky MI, McMahon AP, Wnt7b regulates placental development in mice. Dev Biol. 2001 Sep 15;237(2):324-32
8*	J:66536 Pinco KA, Liu S, Yang JT, alpha4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development. Mech Dev. 2001 Jan;100(1):99-103
1	J:203162 Ray A, Treloar HB, IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci. 2012 Jul;50(3-4):238-49
1	J:158886 Red-Horse K, Ueno H, Weissman IL, Krasnow MA, Coronary arteries form by developmental reprogramming of venous cells. Nature. 2010 Mar 25;464(7288):549-53
2*	J:239310 Rhee C, Edwards M, Dang C, Harris J, Brown M, Kim J, Tucker HO, ARID3A is required for mammalian placenta development. Dev Biol. 2017 Feb 15;422(2):83-91
1*	J:169009 Ring C, Ginsberg MH, Haling J, Pendergast AM, Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):149-54
1	J:181275 Romano RA, Smalley K, Magraw C, Serna VA, Kurita T, Raghavan S, Sinha S, DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development. 2012 Feb;139(4):772-82
1	J:186931 Saito Y, Kojima T, Takahashi N, Mab21l2 is essential for embryonic heart and liver development. PLoS One. 2012;7(3):e32991
1	J:218852 Sanders SS, Hou J, Sutton LM, Garside VC, Mui KK, Singaraja RR, Hayden MR, Hoodless PA, Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development. Dev Biol. 2015 Jan 15;397(2):257-66
4	J:132413 Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S, Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem. 2008 Feb 29;283(9):5460-5
3*	J:42727 Schultz JF, Mayernik L, Rout UK, Armant DR, Integrin trafficking regulates adhesion to fibronectin during differentiation of mouse peri-implantation blastocysts. Dev Genet. 1997;21(1):31-43
1	J:245878 Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K, Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. Dev Cell. 2017 Sep 25;42(6):655-666.e3
5*	J:18811 Sheppard AM, Onken MD, Rosen GD, Noakes PG, Dean DC, Expanding roles for alpha 4 integrin and its ligands in development. Cell Adhes Commun. 1994 Apr;2(1):27-43
1	J:168015 Shibata M, Garcia-Garcia MJ, The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41
2	J:330219 Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ, Compartmentalized metabolism supports midgestation mammalian development. Nature. 2022 Apr;604(7905):349-353
1	J:177821 Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, Heckmann D, Pfeifer A, Kessler H, Takagi J, Erickson HP, Fassler R, The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007 Jul 2;178(1):167-78
1	J:130422 Tanjore H, Zeisberg EM, Gerami-Naini B, Kalluri R, Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn. 2008 Jan;237(1):75-82
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:104372 van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J, The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006 Feb;133(3):419-28
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:46380 Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C, Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998 Feb;125(4):753-65
2*	J:23140 Yang JT, Rayburn H, Hynes RO, Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development. 1995 Feb;121(2):549-60
1	J:241335 Yang Y, Enis D, Zheng H, Chia S, Yang J, Chen M, Dhillon V, Papayannapoulou T, Kahn ML, Cell Adhesion Mediated by VCAM-ITGalpha9 Interactions Enables Lymphatic Development. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1179-89
1	J:137915 Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG, Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol. 2008 Aug;28(15):4794-804
1	J:327337 Zhao Y, Bai D, Wu Y, Zhang D, Liu M, Tian Y, Lu J, Wang H, Gao S, Lu Z, Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse. Development. 2022 Aug 1;149(15):dev200316