About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Itgb1
integrin beta 1 (fibronectin receptor beta)
MGI:96610

241 matching records from 241 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2 E2.5 E3 E3.5 E4 E4.5 E5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E P
Immunohistochemistry (section) 1 4 2 5 2 3 2 3 1 2 2 1 17 2 12 2 19 3 17 5 18 6 15 6 14 3 10 1 14 15 1 6 59
In situ RNA (section) 1 1 3 1 4 4 1 9 3 1 3 2 1 5
Immunohistochemistry (whole mount) 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 3
In situ RNA (whole mount) 1
In situ reporter (knock in) 1 1 1
Northern blot 1 1 1 1 1 1 1 1 1 3
Western blot 2 2 1 4 2 3 2 1 5 1 1 2 1 4 3 22
RT-PCR 2 2 2 1 1 3 1 2 5 1 8 1 8 3 6 3 2 2 3 2 4 2 20
cDNA clones 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Itgb1  integrin beta 1 (fibronectin receptor beta)   (Synonyms: 4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863)
Results  Reference
1J:277133 Alfano D, Altomonte A, Cortes C, Bilio M, Kelly RG, Baldini A, Tbx1 regulates extracellular matrix-cell interactions in the second heart field. Hum Mol Genet. 2019 Jul 15;28(14):2295-2308
1J:104989 Amici SA, Dunn WA Jr, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, Notterpek L, Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J Neurosci. 2006 Jan 25;26(4):1179-89
1J:153597 Anderson C, Thorsteinsdottir S, Borycki AG, Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Development. 2009 Oct;136(20):3495-504
3*J:55247 Anderson R, Fassler R, Georges-Labouesse E, Hynes RO, Bader BL, Kreidberg JA, Schaible K, Heasman J, Wylie C, Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 1999 Apr;126(8):1655-64
3J:196665 Arvanitis DN, Behar A, Tryoen-Toth P, Bush JO, Jungas T, Vitale N, Davy A, Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May;140(10):2082-92
1J:335233 Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A, Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21
2J:85994 Aszodi A, Hunziker EB, Brakebusch C, Fassler R, Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 2003 Oct 1;17(19):2465-79
1J:346910 Ayyangar U, Karkhanis A, Tay H, Afandi AFB, Bhattacharjee O, Ks L, Lee SH, Chan J, Raghavan S, Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
1*J:93087 Bajanca F, Luz M, Duxson MJ, Thorsteinsdottir S, Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage. Dev Dyn. 2004 Oct;231(2):402-15
1J:108443 Bajanca F, Luz M, Raymond K, Martins GG, Sonnenberg A, Tajbakhsh S, Buckingham M, Thorsteinsdottir S, Integrin {alpha}6{beta}1-laminin interactions regulate early myotome formation in the mouse embryo. Development. 2006 May;133(9):1635-44
1J:94436 Barbour W, Saika S, Miyamoto T, Ohkawa K, Utsunomiya H, Ohnishi Y, Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing. Curr Eye Res. 2004 Jul;29(1):1-10
2J:181887 Barlow AJ, Dixon J, Dixon MJ, Trainor PA, Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formation. Hum Mol Genet. 2012 Apr 15;21(8):1782-93
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1J:134927 Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB, Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol. 2007 Jun 18;177(6):1051-61
1J:229394 Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova TV, DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest. 2015 Dec;125(12):4572-86
1J:224431 Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR, Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73
6J:96910 Blaess S, Graus-Porta D, Belvindrah R, Radakovits R, Pons S, Littlewood-Evans A, Senften M, Guo H, Li Y, Miner JH, Reichardt LF, Muller U, Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci. 2004 Mar 31;24(13):3402-12
4J:114702 Blanpain C, Lowry WE, Pasolli HA, Fuchs E, Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 2006 Nov 1;20(21):3022-35
1*J:84903 Bolcato-Bellemin AL, Lefebvre O, Arnold C, Sorokin L, Miner JH, Kedinger M, Simon-Assmann P, Laminin alpha5 chain is required for intestinal smooth muscle development. Dev Biol. 2003 Aug 15;260(2):376-90
1J:89658 Bolis A, Corbetta S, Cioce A, de Curtis I, Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci. 2003 Nov;18(9):2417-24
3J:340618 Bondarenko V, Nikolaev M, Kromm D, Belousov R, Wolny A, Blotenburg M, Zeller P, Rezakhani S, Hugger J, Uhlmann V, Hufnagel L, Kreshuk A, Ellenberg J, van Oudenaarden A, Erzberger A, Lutolf MP, Hiiragi T, Embryo-uterine interaction coordinates mouse embryogenesis during implantation. EMBO J. 2023 Sep 4;42(17):e113280
1J:117635 Bose K, Nischt R, Page A, Bader BL, Paulsson M, Smyth N, Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. J Biol Chem. 2006 Dec 22;281(51):39620-9
1J:185558 Bottcher RT, Stremmel C, Meves A, Meyer H, Widmaier M, Tseng HY, Fassler R, Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol. 2012 Jun;14(6):584-92
1*J:226923 Bowen CJ, Zhou J, Sung DC, Butcher JT, Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation. Dev Biol. 2015 Nov 1;407(1):145-57
5J:52558 Bowen JA, Hunt JS, Expression of cell adhesion molecules in murine placentas and a placental cell line. Biol Reprod. 1999 Feb;60(2):428-34
6*J:44846 Brakebusch C, Hirsch E, Potocnik A, Fassler R, Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. J Cell Sci. 1997 Dec;110(Pt 23):2895-904
8J:49179 Brancaccio M, Cabodi S, Belkin AM, Collo G, Koteliansky VE, Tomatis D, Altruda F, Silengo L, Tarone G, Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun. 1998 Mar;5(3):193-205
1*J:183947 Broders-Bondon F, Paul-Gilloteaux P, Carlier C, Radice GL, Dufour S, N-cadherin and beta1-integrins cooperate during the development of the enteric nervous system. Dev Biol. 2012 Apr 15;364(2):178-91
2J:195548 Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y, Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621
2J:261924 Brunner M, Mandier N, Gautier T, Chevalier G, Ribba AS, Guardiola P, Block MR, Bouvard D, beta1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis. PLoS One. 2018;13(4):e0196021
1J:82463 Cachaco AS, Chuva de Sousa Lopes SM, Kuikman I, Bajanca F, Abe K, Baudoin C, Sonnenberg A, Mummery CL, Thorsteinsdottir S, Knock-in of integrin beta 1D affects primary but not secondary myogenesis in mice. Development. 2003 Apr;130(8):1659-71
1J:125911 Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP, DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2733-7
2J:137137 Carlson TR, Hu H, Braren R, Kim YH, Wang RA, Cell-autonomous requirement for {beta}1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development. 2008 Jun;135(12):2193-202
1*J:221094 Carracedo S, Sacher F, Brandes G, Braun U, Leitges M, Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PLoS One. 2014;9(8):e103686
2*J:51702 Carroll JM, Luetteke NC, Lee DC, Watt FM, Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion. Mech Dev. 1998 Nov;78(1-2):37-45
4J:195350 Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, Hirota Y, Sakurai T, Imakawa K, Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7(11):e48933
2J:84858 Chan CS, Weeber EJ, Kurup S, Sweatt JD, Davis RL, Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci. 2003 Aug 6;23(18):7107-16
2J:194489 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
2J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
1J:286704 Cheng HW, Onder L, Novkovic M, Soneson C, Lutge M, Pikor N, Scandella E, Robinson MD, Miyazaki JI, Tersteegen A, Sorg U, Pfeffer K, Rulicke T, Hehlgans T, Ludewig B, Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun. 2019 Apr 15;10(1):1739
3J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1J:153959 Conti FJ, Monkley SJ, Wood MR, Critchley DR, Muller U, Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development. 2009 Nov;136(21):3597-606
1*J:202224 Crish J, Conti MA, Sakai T, Adelstein RS, Egelhoff TT, Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol. 2013 Oct 1;382(1):136-48
1J:291945 De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyere E, Lefebvre O, Mechine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E, Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut. 2017 Oct;66(10):1748-1760
1*J:56564 De Arcangelis A, Mark M, Kreidberg J, Sorokin L, Georges-Labouesse E, Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development. 1999 Sep;126(17):3957-68
1J:291994 de Groot NE, van den Hoogenhof MMG, Najafi A, van der Made I, van der Velden J, Beqqali A, Pinto YM, Creemers EE, Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function. Sci Rep. 2020 May 6;10(1):7687
1J:96525 Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J, Maness PF, Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron. 2004 Oct 28;44(3):423-37
1J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
2J:199303 Diaferia GR, Jimenez-Caliani AJ, Ranjitkar P, Yang W, Hardiman G, Rhodes CJ, Crisa L, Cirulli V, beta1 integrin is a crucial regulator of pancreatic beta-cell expansion. Development. 2013 Aug;140(16):3360-72
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:120095 Donner AL, Ko F, Episkopou V, Maas RL, Pax6 is misexpressed in Sox1 null lens fiber cells. Gene Expr Patterns. 2007 Apr;7(5):606-613
1J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
1J:235531 Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ, Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development. 2016 May 15;143(10):1674-87
1J:309675 Elias S, Thion MS, Yu H, Sousa CM, Lasgi C, Morin X, Humbert S, Huntingtin regulates mammary stem cell division and differentiation. Stem Cell Reports. 2014 Apr 8;2(4):491-506
1J:135515 Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM, Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol. 2008 Apr;128(4):825-32
1J:315134 Ezan P, Andre P, Cisternino S, Saubamea B, Boulay AC, Doutremer S, Thomas MA, Quenech'du N, Giaume C, Cohen-Salmon M, Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012 Aug;32(8):1457-67
3*J:37568 Falk M, Salmivirta K, Durbeej M, Larsson E, Ekblom M, Vestweber D, Ekblom P, Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. J Cell Sci. 1996 Dec;109(Pt 12):2801-10
5J:28330 Fassler R, Meyer M, Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995 Aug 1;9(15):1896-908
3J:100236 Flintoff-Dye NL, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W, Burkin DJ, Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn. 2005 Sep;234(1):11-21
1J:140104 Franco CA, Mericskay M, Parlakian A, Gary-Bobo G, Gao-Li J, Paulin D, Gustafsson E, Li Z, Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell. 2008 Sep;15(3):448-61
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1J:140245 French WJ, Creemers EE, Tallquist MD, Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep;28(18):5646-57
1J:108325 Fukumoto S, Miner JH, Ida H, Fukumoto E, Yuasa K, Miyazaki H, Hoffman MP, Yamada Y, Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem. 2006 Feb 24;281(8):5008-16
1J:335821 Gao G, Li X, Jiang Z, Osorio L, Tang YL, Yu X, Jin G, Zhou Z, Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development. Nat Commun. 2023 Apr 25;14(1):2378
2J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
2J:253773 Gazquez E, Watanabe Y, Broders-Bondon F, Paul-Gilloteaux P, Heysch J, Baral V, Bondurand N, Dufour S, Endothelin-3 stimulates cell adhesion and cooperates with beta1-integrins during enteric nervous system ontogenesis. Sci Rep. 2016 Dec 1;6:37877
4J:79739 Georges-Labouesse E, Mark M, Messaddeq N, Gansmuller A, Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol. 1998 Aug 27;8(17):983-6
1J:316177 Govindasamy N, Long H, Jeong HW, Raman R, Ozcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I, 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Dev Cell. 2021 Dec 6;56(23):3276-3287.e8
4J:71122 Graus-Porta D, Blaess S, Senften M, Littlewood-Evans A, Damsky C, Huang Z, Orban P, Klein R, Schittny JC, Muller U, Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001 Aug 16;31(3):367-79
1J:145708 Greiner TU, Kesavan G, Stahlberg A, Semb H, Rac1 regulates pancreatic islet morphogenesis. BMC Dev Biol. 2009;9:2
1J:104408 Grote D, Souabni A, Busslinger M, Bouchard M, Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 2006 Jan;133(1):53-61
1J:253913 Guimaraes-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM, Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5
5J:301045 Guo SS, Au TYK, Wynn S, Aszodi A, Chan D, Fassler R, Cheah KSE, beta1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs. Development. 2020 Nov 18;147(22):dev192724
1J:132079 Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL, Yang B, Williamson RA, Chen J, Lin CI, Lin JJ, Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2680-92
4J:194396 Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F, A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013 Feb 12;32(5):629-44
1*J:331476 Hazra R, Brine L, Garcia L, Benz B, Chirathivat N, Shen MM, Wilkinson JE, Lyons SK, Spector DL, Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 Nov 7;57(21):2450-2468.e7
1J:293102 Heinrich A, Potter SJ, Guo L, Ratner N, DeFalco T, Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Rep. 2020 Apr 14;31(2):107513
3*J:32724 Hierck BP, Poelmann RE, van Iperen L, Brouwer A, Gittenberger-de Groot AC, Differential expression of alpha-6 and other subunits of laminin binding integrins during development of the murine heart. Dev Dyn. 1996 May;206(1):100-11
1J:18999 Hierck BP, Thorsteinsdottir S, Niessen CM, Freund E, Iperen LV, Feyen A, Hogervorst F, Poelmann RE, Mummery CL, Sonnenberg A, Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit [published erratum appears in Cell Adhes Commun 1993 Sep;1(2):following 190]. Cell Adhes Commun. 1993 May;1(1):33-53
2*J:84406 Hikita ST, Cann GM, Wingerd KL, Mullick LH, Wayne WC, Webb SW, Clegg DO, Integrin alpha4beta1 (VLA-4) expression and activity in retinal and peripheral neurons. Mol Cell Neurosci. 2003 Jul;23(3):427-39
1J:292950 Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM, GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2018 Mar;29(3):857-868
1J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
3J:149815 Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW, Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73
1J:171452 Holtz ML, Misra RP, Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev Biol. 2011;11:18
1J:342152 Honda A, Nozumi M, Ito Y, Natsume R, Kawasaki A, Nakatsu F, Abe M, Uchino H, Matsushita N, Ikeda K, Arita M, Sakimura K, Igarashi M, Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Cell Rep. 2023 Oct 31;42(10):113195
1J:213355 Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL, Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One. 2014;9(2):e89352
2*J:198192 Huang J, Arsenault M, Kann M, Lopez-Mendez C, Saleh M, Wadowska D, Taglienti M, Ho J, Miao Y, Sims D, Spears J, Lopez A, Wright G, Hartwig S, The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013 Jun;242(6):790-9
1*J:69463 Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W, beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
2J:184432 Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E, Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol. 2012 Jan;31(1):17-28
7*J:203017 Ida-Yonemochi H, Harada H, Ohshima H, Saku T, Reciprocal expressions between alpha-dystroglycan and integrin beta1, perlecan receptors, in the murine enamel organ development. Gene Expr Patterns. 2013 Dec;13(8):293-302
7J:146619 Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D, Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb;16(2):233-44
3J:303495 Iwaki A, Moriwaki K, Sobajima T, Taniguchi M, Yoshimura SI, Kunii M, Kanda S, Kamada Y, Miyoshi E, Harada A, Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. FASEB J. 2020 Jul;34(7):9450-9465
1J:149833 Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, Watt FM, Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell. 2009 May 8;4(5):427-39
3J:99699 Jiang FX, Harrison LC, Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells. Exp Cell Res. 2005 Aug 1;308(1):114-22
1*J:190121 Jung Y, McCarty JH, Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun. 2012 Oct 5;426(4):578-84
1J:130822 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R, Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15;313(2):584-93
2J:322702 Kaplan MM, Flucher BE, Counteractive and cooperative actions of muscle beta-catenin and CaV1.1 during early neuromuscular synapse formation. iScience. 2022 Apr 15;25(4):104025
7J:38205 Kashimata M, Gresik EW, Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev Dyn. 1997 Feb;208(2):149-61
1*J:295945 Kawamura N, Takaoka K, Hamada H, Hadjantonakis AK, Sun-Wada GH, Wada Y, Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism. Cell Rep. 2020 Jun 9;31(10):107733
2J:321498 Kim EJY, Sorokin L, Hiiragi T, ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development. 2022 Jan 1;149(1):dev200140
1J:100263 Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV, The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005 Jun 10;280(23):22278-86
1J:170286 Kitase Y, Yamashiro K, Fu K, Richman JM, Shuler CF, Spatiotemporal localization of periostin and its potential role in epithelial-mesenchymal transition during palatal fusion. Cells Tissues Organs. 2011;193(1-2):53-63
1*J:19566 Klinowska TC, Ireland GW, Kimber SJ, A new in vitro model of murine mesoderm migration: the role of fibronectin and laminin. Differentiation. 1994 Jun;57(1):7-19
1J:153248 Kogata N, Tribe RM, Fassler R, Way M, Adams RH, Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction. Genes Dev. 2009 Oct 1;23(19):2278-83
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
3J:239115 Kurbet AS, Hegde S, Bhattacharjee O, Marepally S, Vemula PK, Raghavan S, Sterile Inflammation Enhances ECM Degradation in Integrin beta1 KO Embryonic Skin. Cell Rep. 2016 Sep 20;16(12):3334-47
2J:250555 Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH, Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017 Mar;19(3):189-201
3J:129899 Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol. 2007 Dec 20;505(6):630-43
2J:130230 Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross RS, Giordano FJ, Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol. 2008 Jan;28(2):794-802
1J:241636 Li J, Miao L, Zhao C, Shaikh Qureshi WM, Shieh D, Guo H, Lu Y, Hu S, Huang A, Zhang L, Cai CL, Wan LQ, Xin H, Vincent P, Singer HA, Zheng Y, Cleaver O, Fan ZC, Wu M, CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development. 2017 May 01;144(9):1635-1647
1J:285766 Lian G, Wong T, Lu J, Hu J, Zhang J, Sheen V, Cytoskeletal Associated Filamin A and RhoA Affect Neural Progenitor Specification During Mitosis. Cereb Cortex. 2019 Mar 1;29(3):1280-1290
1J:167114 Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM, Chen J, Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18;120(7):568-76
1J:112061 Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA, Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet. 2006 Jul 1;15(13):2087-97
1*J:61486 Littlewood Evans A, Muller U, Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000 Apr;24(4):424-8
1J:175092 Liu J, He X, Qi Y, Tian X, Monkley SJ, Critchley DR, Corbett SA, Lowry SF, Graham AM, Li S, Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis. Mol Cell Biol. 2011 Aug;31(16):3366-77
3J:279065 Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang C, Li Y, MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death Dis. 2018 Sep 24;9(10):999
3J:266626 Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, Bodis K, Hwang JH, Mussig K, Eberhard D, Stypmann J, Kuss O, Roden M, Alitalo K, Haussinger D, Lammert E, Mechanosensing by beta1 integrin induces angiocrine signals for liver growth and survival. Nature. 2018 Oct;562(7725):128-132
4J:152707 Loulier K, Lathia JD, Marthiens V, Relucio J, Mughal MR, Tang SC, Coksaygan T, Hall PE, Chigurupati S, Patton B, Colognato H, Rao MS, Mattson MP, Haydar TF, Ffrench-Constant C, beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol. 2009 Aug;7(8):e1000176
1J:164479 Lozovatsky L, Abayasekara N, Piawah S, Walther Z, CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell. 2009 Nov;20(21):4489-99
1J:317062 Lv J, Pan Z, Chen J, Xu R, Wang D, Huang J, Dong Y, Jiang J, Yin X, Cheng H, Guo X, Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy. Front Cardiovasc Med. 2021;8:753072
2J:247626 Ma X, Sung DC, Yang Y, Wakabayashi Y, Adelstein RS, Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation. J Cell Sci. 2017 Aug 15;130(16):2696-2706
1J:178484 Maddala R, Chauhan BK, Walker C, Zheng Y, Robinson ML, Lang RA, Rao PV, Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol. 2011 Dec 1;360(1):30-43
1*J:226036 Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV, Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol. 2015 Oct 1;406(1):74-91
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:119922 Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS, BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb;12(2):221-34
1J:321068 Maimets M, Pedersen MT, Guiu J, Dreier J, Thodberg M, Antoku Y, Schweiger PJ, Rib L, Bressan RB, Miao Y, Garcia KC, Sandelin A, Serup P, Jensen KB, Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling. Nat Commun. 2022 Feb 7;13(1):715
1*J:195652 Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS, Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 8;288(6):4252-64
2J:159465 Marchetti G, Escuin S, van der Flier A, De Arcangelis A, Hynes RO, Georges-Labouesse E, Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. Eur J Neurosci. 2010 Feb;31(3):399-409
1J:314274 Marin-Llera JC, Lorda-Diez CI, Hurle JM, Chimal-Monroy J, SCA-1/Ly6A Mesodermal Skeletal Progenitor Subpopulations Reveal Differential Commitment of Early Limb Bud Cells. Front Cell Dev Biol. 2021;9:656999
1*J:185336 Marteau L, Pacary E, Valable S, Bernaudin M, Guillemot F, Petit E, Angiopoietin-2 regulates cortical neurogenesis in the developing telencephalon. Cereb Cortex. 2011 Jul;21(7):1695-702
1J:133954 Martinez-Sanz E, Del Rio A, Barrio C, Murillo J, Maldonado E, Garcillan B, Amoros M, Fuerte T, Fernandez A, Trinidad E, Rabadan MA, Lopez Y, Martinez ML, Martinez-Alvarez C, Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains. Differentiation. 2008 Apr;76(4):417-30
3J:123412 Matilainen T, Haugas M, Kreidberg JA, Salminen M, Analysis of Netrin 1 receptors during inner ear development. Int J Dev Biol. 2007;51(5):409-14
2J:147041 Matsuyama M, Aizawa S, Shimono A, Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 2009 Mar;5(3):e1000427
1J:69285 McCarthy M, Na E, Neyt C, Langston A, Fishell G, Calcium-dependent adhesion is necessary for the maintenance of prosomeres. Dev Biol. 2001 May 1;233(1):80-94
2J:199683 McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD, Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
1*J:78246 Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA, Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn. 2002 Jul;224(3):321-33
1J:177773 Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P, Dysregulation of Semaphorin7A/beta1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Hum Mol Genet. 2011 Dec 15;20(24):4759-74
1J:205235 Miki T, Shamma A, Kitajima S, Takegami Y, Noda M, Nakashima Y, Watanabe K, Takahashi C, The ss1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res. 2010 May;8(5):665-76
2J:232801 Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM, Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med. 2016 Mar 7;213(3):451-63
2J:141609 Mokkapati S, Baranowsky A, Mirancea N, Smyth N, Breitkreutz D, Nischt R, Basement membranes in skin are differently affected by lack of nidogen 1 and 2. J Invest Dermatol. 2008 Sep;128(9):2259-67
2J:167775 Mokkapati S, Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, Nischt R, Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin {gamma}1 Chain. J Biol Chem. 2011 Jan 21;286(3):1911-8
3J:291494 Mole MA, Galea GL, Rolo A, Weberling A, Nychyk O, De Castro SC, Savery D, Fassler R, Ybot-Gonzalez P, Greene NDE, Copp AJ, Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure. Dev Cell. 2020 Feb 10;52(3):321-334.e6
3J:306167 Mole MA, Weberling A, Fassler R, Campbell A, Fishel S, Zernicka-Goetz M, Integrin beta1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Rep. 2021 Mar 9;34(10):108834
1J:171515 Muller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E, The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
4J:38838 Muller U, Wang D, Denda S, Meneses JJ, Pedersen RA, Reichardt LF, Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
1*J:341326 Nag P, Inubushi T, Sasaki JI, Murotani T, Kusano S, Nakanishi Y, Shiraishi Y, Kurosaka H, Imazato S, Yamaguchi Y, Yamashiro T, Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J Dent Res. 2023 Sep;102(10):1162-1171
3J:309403 Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS, Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int. 2015 Jun;87(6):1125-40
1J:220954 Nakamura T, Ohtsuka T, Sekiyama E, Cooper LJ, Kokubu H, Fullwood NJ, Barrandon Y, Kageyama R, Kinoshita S, Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells. 2008 May;26(5):1265-74
1J:228583 Nandadasa S, Nelson CM, Apte SS, ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28
1J:272609 Nantie LB, Young RE, Paltzer WG, Zhang Y, Johnson RL, Verheyden JM, Sun X, Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing. Development. 2018 Nov 9;145(21):dev163105
2J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1*J:234115 Nik AM, Johansson JA, Ghiami M, Reyahi A, Carlsson P, Foxf2 is required for secondary palate development and Tgfbeta signaling in palatal shelf mesenchyme. Dev Biol. 2016 Jul 1;415(1):14-23
1J:288722 Nilsson D, Heglind M, Arani Z, Enerback S, Foxc2 is essential for podocyte function. Physiol Rep. 2019 May;7(9):e14083
2J:137852 Nodari A, Previtali SC, Dati G, Occhi S, Court FA, Colombelli C, Zambroni D, Dina G, Del Carro U, Campbell KP, Quattrini A, Wrabetz L, Feltri ML, Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008 Jun 25;28(26):6714-9
1J:185597 Ohmura T, Shioi G, Hirano M, Aizawa S, Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012 Aug;241(8):1350-64
5J:44398 Ohyama K, Kawano H, Kawamura K, Localization of extracellular matrix molecules, integrins and their regulators, TGF betas, is correlated with axon pathfinding in the spinal cord of normal and Danforth's short tail mice. Brain Res Dev Brain Res. 1997 Nov 12;103(2):143-54
1J:290415 Ozguldez HO, Fan R, Bedzhov I, Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination. Development. 2020 Jul 3;147(13):dev190371
5J:334840 Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D, Trappmann B, Ranga A, Bedzhov I, Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage. Cell Rep. 2023 Mar 28;42(4):112313
2J:308917 Panicker N, Coutman M, Lawlor-O'Neill C, Kahl RGS, Roselli S, Verrills NM, Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development. Front Cell Dev Biol. 2020;8:358
1J:212881 Papangeli I, Scambler PJ, Tbx1 genetically interacts with the transforming growth factor-beta/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling. Circ Res. 2013 Jan 4;112(1):90-102
1J:192809 Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, Giacobini P, Suppression of beta1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations. J Neurosci. 2012 Nov 21;32(47):16992-7002
1J:71583 Parr BA, Cornish VA, Cybulsky MI, McMahon AP, Wnt7b regulates placental development in mice. Dev Biol. 2001 Sep 15;237(2):324-32
3J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1J:191071 Petzold KM, Naumann H, Spagnoli FM, Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
2J:181761 Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E, Mechanoinduction of lymph vessel expansion. EMBO J. 2012 Feb 15;31(4):788-804
1J:217594 Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R, Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec;141(24):4751-62
3*J:84372 Previtali SC, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, Wrabetz L, Quattrini A, Feltri ML, Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003 Jul 2;23(13):5520-30
1*J:253620 Pryce BR, Al-Zahrani KN, Dufresne S, Belkina N, Labreche C, Patino-Lopez G, Frenette J, Shaw S, Sabourin LA, Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017 Feb 2;7(1):3
1J:165260 Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA, Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct 1;120(10):3617-28
1J:208132 Rago L, Beattie R, Taylor V, Winter J, miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin. EMBO J. 2014 Apr 16;33(8):906-20
1J:119481 Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Ackerson T, Qin Y, Malik AB, Costa RH, Kalinichenko VV, Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box m1 transcription factor. Dev Dyn. 2007 Mar 15;236(4):1000-1013
2J:336152 Rashid M, Olson EC, Delayed cortical development in mice with a neural specific deletion of beta1 integrin. Front Neurosci. 2023;17:1158419
1J:334526 Ray AT, Soriano P, FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion. Development. 2023 Mar 15;150(6):dev201293
2J:239656 Reyahi A, Nik AM, Ghiami M, Gritli-Linde A, Ponten F, Johansson BR, Carlsson P, Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell. 2015 Jul 06;34(1):19-32
3J:213067 Riccomagno MM, Sun LO, Brady CM, Alexandropoulos K, Seo S, Kurokawa M, Kolodkin AL, Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
1J:332639 Rinta-Jaskari MM, Naillat F, Ruotsalainen HJ, Koivunen JT, Sasaki T, Pietila I, Elamaa HP, Kaur I, Manninen A, Vainio SJ, Pihlajaniemi TA, Temporally and Spatially Regulated Collagen XVIII Isoforms Are Involved in Ureteric Tree Development Via the TSP1-like Domain. Matrix Biol. 2023 Jan 6;
2J:187297 Ritie L, Spenle C, Lacroute J, Bolcato-Bellemin AL, Lefebvre O, Bole-Feysot C, Jost B, Klein A, Arnold C, Kedinger M, Bagnard D, Orend G, Simon-Assmann P, Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice. PLoS One. 2012;7(5):e37710
3J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
2J:181275 Romano RA, Smalley K, Magraw C, Serna VA, Kurita T, Raghavan S, Sinha S, DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development. 2012 Feb;139(4):772-82
2J:266746 Rudkouskaya A, Welch I, Dagnino L, ILK modulates epithelial polarity and matrix formation in hair follicles. Mol Biol Cell. 2014 Mar;25(5):620-32
9*J:26839 Ruiz P, Wiles MV, Imhof BA, Alpha 6 integrins participate in pro-T cell homing to the thymus. Eur J Immunol. 1995 Jul;25(7):2034-41
4*J:31158 Salmivirta K, Gullberg D, Hirsch E, Altruda F, Ekblom P, Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development. Dev Dyn. 1996 Feb;205(2):104-13
1*J:262208 Sato Y, Heimeier RA, Li C, Deng C, Shi YB, Extracellular domain of CD98hc is required for early murine development. Cell Biosci. 2011 Feb 25;1(1):7
1J:242275 Schell C, Rogg M, Suhm M, Helmstadter M, Sellung D, Yasuda-Yamahara M, Kretz O, Kuttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB, The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Proc Natl Acad Sci U S A. 2017 Jun 06;114(23):E4621-E4630
1J:146417 Schwander M, Shirasaki R, Pfaff SL, Muller U, Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. J Neurosci. 2004 Sep 15;24(37):8181-91
12J:238844 Scully KM, Skowronska-Krawczyk D, Krawczyk M, Merkurjev D, Taylor H, Livolsi A, Tollkuhn J, Stan RV, Rosenfeld MG, Epithelial cell integrin beta1 is required for developmental angiogenesis in the pituitary gland. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13408-13413
1J:263267 Serjanov D, Bachay G, Hunter DD, Brunken WJ, Laminin beta2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation via Dystroglycan. J Neurosci. 2018 Jun 27;38(26):5996-6010
2*J:230729 Shafaq-Zadah M, Gomes-Santos CS, Bardin S, Maiuri P, Maurin M, Iranzo J, Gautreau A, Lamaze C, Caswell P, Goud B, Johannes L, Persistent cell migration and adhesion rely on retrograde transport of beta(1) integrin. Nat Cell Biol. 2016 Jan;18(1):54-64
1J:248896 Shah B, Lutter D, Bochenek ML, Kato K, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Adams RH, Puschel AW, C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One. 2016;11(4):e0154174
2J:241040 Shah B, Lutter D, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Puschel AW, Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex. Cereb Cortex. 2017 Feb 01;27(2):1253-1269
1J:168015 Shibata M, Garcia-Garcia MJ, The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41
2*J:32804 Shim C, Kwon HB, Kim K, Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development. Mol Reprod Dev. 1996 May;44(1):44-55
6J:94926 Shiojiri N, Sugiyama Y, Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology. 2004 Aug;40(2):346-55
2J:122566 Simirskii VN, Wang Y, Duncan MK, Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev Biol. 2007 Jun 15;306(2):658-68
1J:69804 Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM, Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001 May 28;153(5):933-46
1J:165815 Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fassler R, Pozzi A, Rosenblum ND, Zent R, Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development. 2010 Oct;137(19):3233-43
1J:83727 Stenvers KL, Tursky ML, Harder KW, Kountouri N, Amatayakul-Chantler S, Grail D, Small C, Weinberg RA, Sizeland AM, Zhu HJ, Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol. 2003 Jun;23(12):4371-85
1J:28266 Stephens LE, Sutherland AE, Klimanskaya IV, Andrieux A, Meneses J, Pedersen RA, Damsky CH, Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 1995 Aug 1;9(15):1883-95
1J:53320 Stepp MA, Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids. Dev Dyn. 1999 Mar;214(3):216-28
2*J:194131 Sugiyama D, Kulkeaw K, Mizuochi C, TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
5J:74151 Sund M, Vaisanen T, Kaukinen S, Ilves M, Tu H, Autio-Harmainen H, Rauvala H, Pihlajaniemi T, Distinct expression of type XIII collagen in neuronal structures and other tissues during mouse development. Matrix Biol. 2001 Jul;20(4):215-31
1*J:16243 Sutherland AE, Calarco PG, Damsky CH, Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development. 1993 Dec;119(4):1175-86
1J:272614 Suzuki A, Minamide R, Iwata J, WNT/beta-catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development. Development. 2018 Nov 27;145(23):dev168351
1J:242317 Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG, Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4
1J:130422 Tanjore H, Zeisberg EM, Gerami-Naini B, Kalluri R, Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn. 2008 Jan;237(1):75-82
2J:307814 Tannous C, Deloux R, Karoui A, Mougenot N, Burkin D, Blanc J, Coletti D, Lavery G, Li Z, Mericskay M, NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging. Int J Mol Sci. 2021 Mar 29;22(7)
1J:327276 Thievessen I, Suhr F, Vergarajauregui S, Bottcher RT, Brixius K, Rosenberger G, Dewald O, Fleischmann BK, Ghanem A, Kruger M, Engel FB, Fabry B, Bloch W, Fassler R, The focal adhesion protein beta-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Curr Biol. 2022 Jul 25;32(14):3033-3047.e9
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3J:348298 Tixi W, Maldonado M, Chang YT, Chiu A, Yeung W, Parveen N, Nelson MS, Hart R, Wang S, Hsu WJ, Fueger P, Kopp JL, Huising MO, Dhawan S, Shih HP, Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation. Elife. 2023 Aug 23;12
2J:264500 Tsuchiya Y, Mii Y, Okada K, Furuse M, Okubo T, Takada S, Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches. Dev Growth Differ. 2018 Feb;60(2):87-96
7J:184940 Turlo KA, Noel OD, Vora R, LaRussa M, Fassler R, Hall-Glenn F, Iruela-Arispe ML, An essential requirement for beta1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol. 2012 May 1;365(1):23-35
6J:44406 van der Flier A, Gaspar AC, Thorsteinsdottir S, Baudoin C, Groeneveld E, Mummery CL, Sonnenberg A, Spatial and temporal expression of the beta1D integrin during mouse development. Dev Dyn. 1997 Dec;210(4):472-86
1J:59036 van der Neut R, Cachaco AS, Thorsteinsdottir S, Janssen H, Prins D, Bulthuis J, van der Valk M, Calafat J, Sonnenberg A, Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene. J Cell Sci. 1999 Nov;112(Pt 22):3911-22
1J:305685 Vijayaraj P, Kroeger C, Reuter U, Hartmann D, Magin TM, Keratins regulate yolk sac hematopoiesis and vasculogenesis through reduced BMP-4 signaling. Eur J Cell Biol. 2010 Apr;89(4):299-306
2J:31981 Wada J, Kumar A, Liu Z, Ruoslahti E, Reichardt L, Marvaldi J, Kanwar YS, Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J Cell Biol. 1996 Mar;132(6):1161-76
1J:234925 Wang B, Qi T, Chen SQ, Ye L, Huang ZS, Li H, RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos. Mol Reprod Dev. 2016 Jul;83(7):606-14
1*J:308454 Wang S, Matsumoto K, Lish SR, Cartagena-Rivera AX, Yamada KM, Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion. Cell. 2021 Jul 8;184(14):3702-3716.e30
1J:258463 Wang Y, Terrell AM, Riggio BA, Anand D, Lachke SA, Duncan MK, beta1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3896-3922
1*J:199486 Watanabe Y, Broders-Bondon F, Baral V, Paul-Gilloteaux P, Pingault V, Dufour S, Bondurand N, Sox10 and Itgb1 interaction in enteric neural crest cell migration. Dev Biol. 2013 Jul 1;379(1):92-106
2J:306317 Weberling A, Zernicka-Goetz M, Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. 2021 Jan 19;34(3):108655
1J:70388 Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L, Deng CX, Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol. 2001 Aug;21(15):5122-31
2J:309386 Win PW, Oakie A, Li J, Wang R, Beta-cell beta1 integrin deficiency affects in utero development of islet growth and vascularization. Cell Tissue Res. 2020 Jul;381(1):163-175
3J:224370 Wu C, Jiao H, Lai Y, Zheng W, Chen K, Qu H, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G, Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015;6:7531
5*J:17839 Wu JE, Santoro SA, Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Dev Dyn. 1994 Apr;199(4):292-314
1J:333147 Wu T, Xu Y, Zhang L, Liang Z, Zhou X, Evans SM, Chen J, Filamin C is Essential for mammalian myocardial integrity. PLoS Genet. 2023 Jan;19(1):e1010630
1J:313628 Xi L, Carroll T, Matos I, Luo JD, Polak L, Pasolli HA, Jaffrey SR, Fuchs E, m6A RNA methylation impacts fate choices during skin morphogenesis. Elife. 2020 Aug 26;9:e56980
1J:278242 Xia M, Luo W, Jin H, Yang Z, HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13):dev177477
1J:212357 Xu JC, Xiao MF, Jakovcevski I, Sivukhina E, Hargus G, Cui YF, Irintchev A, Schachner M, Bernreuther C, The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice. J Cell Sci. 2014 Feb 1;127(Pt 3):641-52
8*J:33979 Yamada S, Brown KE, Yamada KM, Differential mRNA regulation of integrin subunits alpha V, beta 1, beta 3, and beta 5 during mouse embryonic organogenesis. Cell Adhes Commun. 1995 Nov;3(4):311-25
2J:178649 Yang DH, McKee KK, Chen ZL, Mernaugh G, Strickland S, Zent R, Yurchenco PD, Renal collecting system growth and function depend upon embryonic gamma1 laminin expression. Development. 2011 Oct;138(20):4535-44
4J:310840 Yang GN, Ahangar P, Strudwick XL, Kopecki Z, Cowin AJ, Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells. Int J Mol Sci. 2021 Jul 30;22(15)
1J:321251 Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH, Dang S, Zhang W, Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. J Dent Res. 2022 Feb;101(2):226-234
1J:271268 Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB, YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018 Jan 4;22(1):35-49.e7
1J:153635 Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fassler R, Yurchenco P, Pozzi A, Zent R, beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development. 2009 Oct;136(19):3357-66
5J:288809 Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J, Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 Mar 19;139(12):1554-1556
2J:346069 Zhang Z, Zhang Q, Liu Z, Wang C, Chen H, Luo X, Shen L, Long C, Wei G, Liu X, Rab25 is involved in hypospadias via the beta1 integrin/EGFR pathway. Exp Cell Res. 2024 Feb 23;436(2):113980
1J:248901 Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D, Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances. PLoS One. 2016;11(4):e0154480
1J:125640 Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM, Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct;39(10):1225-34
2J:222550 Zhu Y, Matsumoto T, Nagasawa T, Mackay F, Murakami F, Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells. J Neurosci. 2015 Jun 17;35(24):9211-24
2J:157920 Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML, Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19;18(1):39-51
10J:49158 Zuccotti M, Rossi PG, Fiorillo E, Garagna S, Forabosco A, Redi CA, Timing of gene expression and oolemma localization of mouse alpha6 and beta1 integrin subunits during oogenesis. Dev Biol. 1998 Aug 1;200(1):27-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/02/2024
MGI 6.13
The Jackson Laboratory