Symbol Name ID |
Ivl
involucrin MGI:96626 |
Age | E13.5 | E14 | E14.5 | E15.5 | E16.5 | E17 | E17.5 | E18.5 | E19 | E19.5 | E | P |
Immunohistochemistry (section) | 2 | 3 | 6 | 5 | 2 | 14 | 27 | 1 | 1 | 38 | ||
In situ RNA (section) | 1 | 1 | 1 | 1 | ||||||||
In situ reporter (knock in) | 1 | |||||||||||
Northern blot | 1 | 1 | ||||||||||
Western blot | 1 | 3 | 5 | 1 | 10 | |||||||
RT-PCR | 1 | 4 | 2 | 6 | 2 | 7 | 1 | 9 |
Ivl involucrin (Synonyms: 1110019C06Rik) | |
Results | Reference |
2 | J:76477 Andl T, Reddy ST, Gaddapara T, Millar SE, WNT Signals Are Required for the Initiation of Hair Follicle Development. Dev Cell. 2002 May;2(5):643-53 |
1 | J:141601 Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuckermann J, Schutz G, Perez P, Glucocorticoid receptor is required for skin barrier competence. Endocrinology. 2008 Mar;149(3):1377-88 |
1 | J:205657 Boase NA, Rychkov GY, Townley SL, Dinudom A, Candi E, Voss AK, Tsoutsman T, Semsarian C, Melino G, Koentgen F, Cook DI, Kumar S, Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun. 2011;2:287 |
1* | J:168020 Boglev Y, Wilanowski T, Caddy J, Parekh V, Auden A, Darido C, Hislop NR, Cangkrama M, Ting SB, Jane SM, The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol. 2011 Jan 15;349(2):512-22 |
3 | J:335426 Butera A, Agostini M, Cassandri M, De Nicola F, Fanciulli M, D'Ambrosio L, Falasca L, Nardacci R, Wang L, Piacentini M, Knight RA, Jia W, Sun Q, Shi Y, Wang Y, Candi E, Melino G, ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423 |
1 | J:125911 Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP, DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2733-7 |
1* | J:304350 Carley E, Stewart RM, Zieman A, Jalilian I, King DE, Zubek A, Lin S, Horsley V, King MC, The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. Elife. 2021 Mar;:e58541 |
1 | J:300611 Carper MB, Troutman S, Wagner BL, Byrd KM, Selitsky SR, Parag-Sharma K, Henry EC, Li W, Parker JS, Montgomery SA, Cleveland JL, Williams SE, Kissil JL, Hayes DN, Amelio AL, An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma. Cell Rep. 2019 Nov 5;29(6):1660-1674.e7 |
1 | J:159633 Celetti SJ, Cowan KN, Penuela S, Shao Q, Churko J, Laird DW, Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci. 2010 Apr 15;123(Pt 8):1363-72 |
1 | J:205488 Chin SS, Romano RA, Nagarajan P, Sinha S, Garrett-Sinha LA, Aberrant epidermal differentiation and disrupted DeltaNp63/Notch regulatory axis in Ets1 transgenic mice. Biol Open. 2013;2(12):1336-45 |
1* | J:217209 Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM, Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet. 2015 Jan 15;24(2):436-49 |
4* | J:198837 Cui CY, Klar J, Georgii-Heming P, Frojmark AS, Baig SM, Schlessinger D, Dahl N, Frizzled6 deficiency disrupts the differentiation process of nail development. J Invest Dermatol. 2013 Aug;133(8):1990-7 |
1 | J:269851 Dainichi T, Hayden MS, Park SG, Oh H, Seeley JJ, Grinberg-Bleyer Y, Beck KM, Miyachi Y, Kabashima K, Hashimoto T, Ghosh S, PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division. Cell Rep. 2016 May 24;15(8):1615-23 |
1 | J:178952 Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM, Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011 Nov 15;20(5):635-48 |
1 | J:335805 Deng Z, Butt T, Arhatari BD, Darido C, Auden A, Swaroop D, Partridge DD, Haigh K, Nguyen T, Haigh JJ, Carpinelli MR, Jane SM, Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects. Dev Dyn. 2023 May;252(5):647-667 |
3 | J:207252 Drosten M, Lechuga CG, Barbacid M, Ras signaling is essential for skin development. Oncogene. 2014 May 29;33(22):2857-65 |
1 | J:157054 Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S, Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 2009 Oct;129(10):2386-95 |
1 | J:282953 Ellis SJ, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E, Distinct modes of cell competition shape mammalian tissue morphogenesis. Nature. 2019 May;569(7757):497-502 |
2 | J:183190 Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, Michels C, Gunschmann C, Sandhoff K, Niessen CM, Niemann C, TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. J Invest Dermatol. 2012 Feb;132(2):337-45 |
1 | J:177729 Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA, p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol. 2011 Sep 19;194(6):825-39 |
1 | J:225600 Georgy SR, Cangkrama M, Srivastava S, Partridge D, Auden A, Dworkin S, McLean CA, Jane SM, Darido C, Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst. 2015 Sep;107(9) |
2 | J:320249 Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M, Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E, Missero C, Gudjonsson JE, Green KJ, Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest. 2022 Feb 1;132(3):e144363 |
2 | J:147182 Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK, Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol. 2009 Jun;129(6):1459-70 |
1* | J:240055 Grond S, Radner FP, Eichmann TO, Kolb D, Grabner GF, Wolinski H, Gruber R, Hofer P, Heier C, Schauer S, Rulicke T, Hoefler G, Schmuth M, Elias PM, Lass A, Zechner R, Haemmerle G, Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation. J Invest Dermatol. 2017 Feb;137(2):403-413 |
1 | J:91366 Gugasyan R, Voss A, Varigos G, Thomas T, Grumont RJ, Kaur P, Grigoriadis G, Gerondakis S, The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms. Mol Cell Biol. 2004 Jul;24(13):5733-45 |
1 | J:199282 Gunschmann C, Stachelscheid H, Akyuz MD, Schmitz A, Missero C, Bruning JC, Niessen CM, Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Dev Cell. 2013 Jul 29;26(2):176-87 |
1* | J:208287 Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW, Endogenous beta-glucocerebrosidase activity in Abca12(-)/(-)epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res. 2014 Mar;55(3):493-503 |
1* | J:49863 Hanley K, Feingold KR, Komuves LG, Elias PM, Muglia LJ, Majzoub JA, Williams ML, Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. J Invest Dermatol. 1998 Sep;111(3):440-4 |
3 | J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20 |
1 | J:263185 Huang M, He H, Belenkaya T, Lin X, Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10):jcs210781 |
1* | J:191045 Huebner AJ, Dai D, Morasso M, Schmidt EE, Schafer M, Werner S, Roop DR, Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012 Dec 11;23(6):1238-46 |
1* | J:69463 Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W, beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45 |
1 | J:97750 Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E, A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 2005 Jan;3(1):e11 |
2 | J:83259 Jaubert J, Cheng J, Segre JA, Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development. 2003 Jun;130(12):2767-77 |
1 | J:252735 Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee DK, Zhang L, Lee YC, Yuan J, Abrams JA, Wang TC, Sepulveda AR, Wu Q, Chen H, Sun X, She J, Chen X, Que J, Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus. Nature. 2017 Oct 26;550(7677):529-533 |
2 | J:163299 Jiang YJ, Lu B, Crumrine D, Elias PM, Feingold KR, IL-6 Stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation. Exp Dermatol. 2010 Aug;19(8):e31-6 |
3 | J:180837 Kirschner N, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM, CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol. 2011 Apr;131(4):932-43 |
3 | J:208053 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ, Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. J Pathol. 2014 Apr;232(5):541-52 |
1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
2 | J:218061 Krishnaswami SR, Kumar S, Ordoukhanian P, Yu BD, Fate and Plasticity of the Epidermis in Response to Congenital Activation of BRAF. J Invest Dermatol. 2015 Feb;135(2):481-9 |
3 | J:230728 Kumar V, Bouameur JE, Bar J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P, Magin TM, A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75 |
6* | J:239298 Kur-Piotrowska A, Kopcewicz M, Kozak LP, Sachadyn P, Grabowska A, Gawronska-Kozak B, Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing. BMC Genomics. 2017 Jan 09;18(1):56 |
1 | J:114152 Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R, Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146 |
1* | J:93615 Kurita T, Medina RT, Mills AA, Cunha GR, Role of p63 and basal cells in the prostate. Development. 2004 Oct;131(20):4955-64 |
2 | J:277726 Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C, Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2) |
1 | J:213415 Lee B, Villarreal-Ponce A, Fallahi M, Ovadia J, Sun P, Yu QC, Ito S, Sinha S, Nie Q, Dai X, Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014 Apr 14;29(1):47-58 |
1 | J:54224 Lee D, Prowse DM, Brissette JL, Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev Biol. 1999 Apr 15;208(2):362-74 |
1 | J:320850 Lessard JC, Kalinin A, Bible PW, Morasso MI, Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice. Exp Dermatol. 2015 Jan;24(1):55-7 |
1 | J:191599 Li J, Jiang TX, Hughes MW, Wu P, Widelitz RB, Fan G, Chuong CM, Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec;132(12):2681-90 |
1* | J:255485 Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK, Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427 |
1 | J:316189 Lin C, Hindes A, Burns CJ, Koppel AC, Kiss A, Yin Y, Ma L, Blumenberg M, Khnykin D, Jahnsen FL, Crosby SD, Ramanan N, Efimova T, Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis. J Invest Dermatol. 2013 Mar;133(3):608-617 |
1 | J:154022 Lopez RG, Garcia-Silva S, Moore SJ, Bereshchenko O, Martinez-Cruz AB, Ermakova O, Kurz E, Paramio JM, Nerlov C, C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. Nat Cell Biol. 2009 Oct;11(10):1181-90 |
1* | J:245622 Madon-Simon M, Grad I, Bayo P, Perez P, Picard D, Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. PLoS One. 2017;12(6):e0180035 |
1 | J:119922 Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS, BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb;12(2):221-34 |
1 | J:230833 Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA, Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4;212(1):77-89 |
1 | J:116504 Matsui T, Kinoshita-Ida Y, Hayashi-Kisumi F, Hata M, Matsubara K, Chiba M, Katahira-Tayama S, Morita K, Miyachi Y, Tsukita S, Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation. J Biol Chem. 2006 Sep 15;281(37):27512-25 |
2 | J:71272 Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W, Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol. 2001 Aug 20;154(4):799-814 |
2 | J:235073 Miyai M, Hamada M, Moriguchi T, Hiruma J, Kamitani-Kawamoto A, Watanabe H, Hara-Chikuma M, Takahashi K, Takahashi S, Kataoka K, Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation. J Invest Dermatol. 2016 Sep;136(9):1848-57 |
1* | J:286705 Miyamoto M, Itoh N, Sawai M, Sassa T, Kihara A, Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production. J Invest Dermatol. 2020 Feb;140(2):319-326.e4 |
4 | J:135158 Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M, Multiple roles of Notch signaling in the regulation of epidermal development. Dev Cell. 2008 Apr;14(4):594-604 |
1* | J:48924 Murgia C, Blaikie P, Kim N, Dans M, Petrie HT, Giancotti FG, Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 1998 Jul 15;17(14):3940-51 |
2 | J:182928 Nagarajan P, Chin SS, Wang D, Liu S, Sinha S, Garrett-Sinha LA, Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci. 2010 Oct 15;123(Pt 20):3566-75 |
1* | J:296400 Nakazawa S, Shimauchi T, Funakoshi A, Aoshima M, Phadungsaksawasdi P, Sakabe JI, Asakawa S, Hirasawa N, Ito T, Tokura Y, Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Sci Rep. 2020 Sep 3;10(1):14559 |
1 | J:155012 Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E, Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet. 2009 Oct;41(10):1068-75 |
3* | J:234993 Nishiguchi Y, Ohmoto M, Koki J, Enomoto T, Kominami R, Matsumoto I, Hirota J, Bcl11b/Ctip2 is required for development of lingual papillae in mice. Dev Biol. 2016 Aug 1;416(1):98-110 |
1 | J:207286 Nowak JA, Polak L, Pasolli HA, Fuchs E, Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell. 2008 Jul 3;3(1):33-43 |
1 | J:192725 Okano J, Lichti U, Mamiya S, Aronova M, Zhang G, Yuspa SH, Hamada H, Sakai Y, Morasso MI, Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci. 2012 Apr 1;125(Pt 7):1827-36 |
3* | J:242353 Pichery M, Huchenq A, Sandhoff R, Severino-Freire M, Zaafouri S, Opalka L, Levade T, Soldan V, Bertrand-Michel J, Lhuillier E, Serre G, Maruani A, Mazereeuw-Hautier J, Jonca N, PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. Hum Mol Genet. 2017 May 15;26(10):1787-1800 |
1* | J:320312 Pitolli C, Pietroni V, Marekov L, Terrinoni A, Yamanishi K, Mazzanti C, Melino G, Candi E, Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis. Amino Acids. 2017 Mar;49(3):635-642 |
2 | J:122531 Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL, Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007 Jul;134(13):2521-31 |
2 | J:180027 Restivo G, Nguyen BC, Dziunycz P, Ristorcelli E, Ryan RJ, Ozuysal OY, Di Piazza M, Radtke F, Dixon MJ, Hofbauer GF, Lefort K, Dotto GP, IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J. 2011 Nov 16;30(22):4571-85 |
1 | J:166768 Rodriguez P, Da Silva S, Oxburgh L, Wang F, Hogan BL, Que J, BMP signaling in the development of the mouse esophagus and forestomach. Development. 2010 Dec;137(24):4171-6 |
2 | J:168262 Romano RA, Smalley K, Liu S, Sinha S, Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development. 2010 May;137(9):1431-9 |
3 | J:181275 Romano RA, Smalley K, Magraw C, Serna VA, Kurita T, Raghavan S, Sinha S, DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development. 2012 Feb;139(4):772-82 |
1 | J:200244 Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM, Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79 |
1* | J:159585 Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean C Jr, Peschon JJ, Holland PM, RIP4 regulates epidermal differentiation and cutaneous inflammation. J Invest Dermatol. 2010 Jan;130(1):102-12 |
1* | J:204477 Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A, Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol. 2013 Jul;33(14):2787-96 |
2 | J:106549 Schmidt-Ullrich R, Tobin DJ, Lenhard D, Schneider P, Paus R, Scheidereit C, NF-{kappa}B transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development. 2006 Mar;133(6):1045-57 |
2* | J:81021 Schmuth M, Schoonjans K, Yu QC, Fluhr JW, Crumrine D, Hachem JP, Lau P, Auwerx J, Elias PM, Feingold KR, Role of Peroxisome Proliferator-Activated Receptor alpha in Epidermal Development in Utero. J Invest Dermatol. 2002 Dec;119(6):1298-303 |
1 | J:265031 Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM, Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437 |
1 | J:131056 Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Maatta A, Watt FM, Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol. 2007 Dec 31;179(7):1599-612 |
2 | J:83949 Sharov AA, Weiner L, Sharova TY, Siebenhaar F, Atoyan R, Reginato AM, McNamara CA, Funa K, Gilchrest BA, Brissette JL, Botchkarev VA, Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J. 2003 Jun 16;22(12):2992-3003 |
1 | J:270947 Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE, Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. Cell Rep. 2018 Dec 11;25(11):2981-2991.e3 |
1 | J:238904 Suzuki D, Sahu R, Leu NA, Senoo M, The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. 2015 Jan 15;142(2):282-90 |
1 | J:54315 Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S, Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6 |
1 | J:73084 Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85 |
1 | J:206321 Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY, Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec;140(24):4870-80 |
1 | J:86392 Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M, Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov;35(3):238-45 |
2 | J:143315 Wang X, Pasolli HA, Williams T, Fuchs E, AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol. 2008 Oct 6;183(1):37-48 |
1 | J:313628 Xi L, Carroll T, Matos I, Luo JD, Polak L, Pasolli HA, Jaffrey SR, Fuchs E, m6A RNA methylation impacts fate choices during skin morphogenesis. Elife. 2020 Aug 26;9:e56980 |
1 | J:242196 Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE, WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 07;8:15397 |
1 | J:54637 Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22;398(6729):714-8 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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