Gene Expression Literature Summary

• Symbol: Jup
• Name: junction plakoglobin
• ID: MGI:96650

63 matching records from 63 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3.5	E4	E4.5	E5.5	E6.5	E7.5	E9	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)	1	2	1	1	1	1	1	1	4	4	2	5	2	3		1	3	2	1	1	3	10	1	1	3	19
In situ RNA (section)									1			1		3						1						1
Immunohistochemistry (whole mount)				1																					2
In situ reporter (knock in)											1															1
Northern blot										1
Western blot										1	1	1	1	1	1		1					2			3	14
RT-PCR	1										1		1	1	1	1	1			1		2			1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Jup  junction plakoglobin   (Synonyms: Ctnng, D930025P04Rik, gamma-catenin, PG, plakoglobin)
Results	Reference
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1*	J:51129 Bierkamp C, Schwarz H, Huber O, Kemler R, Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development. 1999 Jan;126(2):371-81
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6*	J:48097 Cifuentes-Diaz C, Goudou D, Mege RM, Velasco E, Nicolet M, Herrenknecht K, Rubin L, Rieger F, Distinct location and prevalence of alpha-, beta-catenins and gamma-catenin/plakoglobin in developing and denervated skeletal muscle. Cell Adhes Commun. 1998 Mar;5(2):161-76
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1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
6*	J:47740 Fausser JL, Schlepp O, Aberdam D, Meneguzzi G, Ruch JV, Lesot H, Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis. Differentiation. 1998 May;63(1):1-11
3	J:191121 Ferone G, Mollo MR, Thomason HA, Antonini D, Zhou H, Ambrosio R, De Rosa L, Salvatore D, Getsios S, van Bokhoven H, Dixon J, Missero C, p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:266784 Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L, Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015 Apr 11;13:24
2	J:320249 Godsel LM, Roth-Carter QR, Koetsier JL, Tsoi LC, Huffine AL, Broussard JA, Fitz GN, Lloyd SM, Kweon J, Burks HE, Hegazy M, Amagai S, Harms PW, Xing X, Kirma J, Johnson JL, Urciuoli G, Doglio LT, Swindell WR, Awatramani R, Sprecher E, Bao X, Cohen-Barak E, Missero C, Gudjonsson JE, Green KJ, Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest. 2022 Feb 1;132(3):e144363
1	J:93314 Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W, Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 2004 Nov 11;167(1):149-60
2	J:132079 Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL, Yang B, Williamson RA, Chen J, Lin CI, Lin JJ, Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2680-92
1*	J:166749 Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM 3rd, Levitt P, Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32
1	J:83398 Hollnagel A, Grund C, Franke WW, Arnold HH, The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol Cell Biol. 2002 Jul;22(13):4760-70
1	J:60391 Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C, Birchmeier W, Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
1*	J:69463 Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W, beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
2*	J:97304 Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD, Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005 Mar 25;120(6):843-56
2	J:267258 Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ, Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. J Cell Biol. 2018 Sep 3;217(9):3219-3235
3*	J:74183 Kieffer-Combeau S, Meyer JM, Lesot H, Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor. Int J Dev Biol. 2001 Sep;45(5-6):733-42
5*	J:337971 Kohler TN, De Jonghe J, Ellermann AL, Yanagida A, Herger M, Slatery EM, Weberling A, Munger C, Fischer K, Mulas C, Winkel A, Ross C, Bergmann S, Franze K, Chalut K, Nichols J, Boroviak TE, Hollfelder F, Plakoglobin is a mechanoresponsive regulator of naive pluripotency. Nat Commun. 2023 Jul 7;14(1):4022
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
2	J:230728 Kumar V, Bouameur JE, Bar J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P, Magin TM, A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75
1	J:277726 Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C, Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2)
2	J:177567 Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W, Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
1	J:170618 Li J, Swope D, Raess N, Cheng L, Muller EJ, Radice GL, Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011 Mar;31(6):1134-44
1	J:296989 Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N, Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020 Sep;585(7825):404-409
1	J:175262 Lin C, Fisher AV, Yin Y, Maruyama T, Veith GM, Dhandha M, Huang GJ, Hsu W, Ma L, The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus. Dev Biol. 2011 Aug 1;356(1):40-50
1	J:131012 Marose TD, Merkel CE, McMahon AP, Carroll TJ, Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol. 2008 Feb 1;314(1):112-26
2*	J:194034 Mazahery AR, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis GD, Behringer RR, Yamada G, Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
2	J:78246 Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA, Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn. 2002 Jul;224(3):321-33
1	J:102698 Murtaugh LC, Law AC, Dor Y, Melton DA, Beta-catenin is essential for pancreatic acinar but not islet development. Development. 2005 Nov;132(21):4663-74
1*	J:291583 Novakova M, Hampl M, Vrabel D, Prochazka J, Petrezselyova S, Prochazkova M, Sedlacek R, Kavkova M, Zikmund T, Kaiser J, Juan HC, Fann MJ, Buchtova M, Kohoutek J, Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13. Front Cell Dev Biol. 2019;7:155
3	J:35077 Ohsugi M, Hwang SY, Butz S, Knowles BB, Solter D, Kemler R, Expression and cell membrane localization of catenins during mouse preimplantation development. Dev Dyn. 1996 Aug;206(4):391-402
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1*	J:105983 Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK, Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar;133(5):865-75
1	J:69097 Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross J Jr, Hefti A, Aebi U, Beckerle MC, Chien KR, Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001 May;7(5):591-7
1	J:313370 Pena-Jimenez D, Fontenete S, Megias D, Fustero-Torre C, Grana-Castro O, Castellana D, Loewe R, Perez-Moreno M, Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo. EMBO J. 2019 Oct 1;38(19):e101688
1	J:201523 Ray S, Foote HP, Lechler T, beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol. 2013 Jul 8;202(1):45-52
2*	J:244304 Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J, p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828
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3	J:238122 Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP, Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008 May;47(5):1667-79
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2	J:97223 Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM, E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005 Mar 23;24(6):1146-56
2	J:73084 Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85
5	J:143362 Walker JL, Menko AS, Khalil S, Rebustini I, Hoffman MP, Kreidberg JA, Kukuruzinska MA, Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 2008 Nov;237(11):3128-41
2	J:105811 Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C, Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
1	J:310904 Yashirogi S, Nagao T, Nishida Y, Takahashi Y, Qaqorh T, Yazawa I, Katayama T, Kioka H, Matsui TS, Saito S, Masumura Y, Tsukamoto O, Kato H, Ueda H, Yamaguchi O, Yashiro K, Yamazaki S, Takashima S, Shintani Y, AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170. EMBO Rep. 2021 Jan 7;22(1):e50949