Gene Expression Literature Summary

• Symbol: Kras
• Name: Kirsten rat sarcoma viral oncogene homolog
• ID: MGI:96680

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)						1	1		1												3
In situ RNA (section)				1		1		1		1	2	1		1					2
In situ reporter (knock in)											1			1			1				1
Northern blot								1						1			1			1	1
Western blot								2		1	1	2		2			1				4
RT-PCR	1	1	1	1	1			1	1	2	5	1	2	1	1	1	1	1	3		4
cDNA clones																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kras  Kirsten rat sarcoma viral oncogene homolog   (Synonyms: Ki-ras, K-ras, Kras-2, Kras2)
Results	Reference
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
1*	J:330081 Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O, Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 Oct 5;12(10):2434-2453
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
4	J:241998 Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP, MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Development. 2017 Jun 15;144(12):2141-2152
1	J:208600 Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL, Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 Mar;62(3):875-86
4	J:43433 Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E , Bronson RT , Umanoff H , Edelmann W , Kucherlapati R , Jacks T, K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997 Oct 1;11(19):2468-81
2	J:267258 Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ, Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. J Cell Biol. 2018 Sep 3;217(9):3219-3235
1*	J:53886 Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ , Young SG, Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem. 1999 Mar 26;274(13):8383-90
1*	J:42943 Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T , Otani H , Aiba A , Katsuki M, K-ras is essential for the development of the mouse embryo. Oncogene. 1997 Sep 4;15(10):1151-9
1	J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
6	J:329932 Minati MA, Assi M, Libert M, Cordi S, Lemaigre F, Jacquemin P, KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood. Front Cell Dev Biol. 2022;10:995013
5	J:7235 Muller R, Verma IM, Adamson ED, Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2(5):679-84
4	J:135610 Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H, Kondo H, Katsuki M, Partial functional overlap of the three ras genes in mouse embryonic development. Oncogene. 2008 May 8;27(21):2961-8
5*	J:320537 Newlaczyl AU, Coulson JM, Prior IA, Quantification of spatiotemporal patterns of Ras isoform expression during development. Sci Rep. 2017 Jan 24;7:41297
6*	J:43601 Pells S, Divjak M, Romanowski P, Impey H, Hawkins NJ, Clarke AR, Hooper ML, Williamson DJ, Developmentally-regulated expression of murine K-ras isoforms. Oncogene. 1997 Oct 9;15(15):1781-6
2*	J:95070 Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA, Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation. Int J Dev Biol. 2004;48(8-9):879-88
2	J:290284 Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM, Bellusci S, A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. Cell Mol Life Sci. 2019 Jul;76(14):2817-2832
3*	J:117790 Singh S, Yin X, Pisano MM, Greene RM, Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):35-44
4*	J:49116 Sithanandam G, Ramakrishna G, Diwan BA, Anderson LM, Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation. Oncogene. 1998 Jul 30;17(4):493-502
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2	J:24889 Wang KY, Chen KC, Chiang CP, Kuo MY, Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice. J Oral Pathol Med. 1995 Mar;24(3):103-8
3	J:328042 Wang T, Guo H, Li Q, Wu W, Yu M, Zhang L, Li C, Song J, Wang Z, Zhang J, Tang Y, Kang L, Zhang H, Zhan J, The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Rep. 2022 Aug 23;40(8):111210
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678
1*	J:314140 Yue H, Li S, Qin J, Gao T, Lyu J, Liu Y, Wang X, Guan Z, Zhu Z, Niu B, Zhong R, Guo J, Wang J, Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency. Front Neurol. 2021;12:579998