Gene Expression Literature Summary

• Symbol: Krt12
• Name: keratin 12
• ID: MGI:96687

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)	1	2	1	2	1	3	1	7	1	10	1	7	1	9	1	1	2	23
In situ RNA (section)		2		1		3		3		3				3				2
Northern blot														1				1
Western blot																		3
RT-PCR														1				3
cDNA clones																		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Krt12  keratin 12   (Synonyms: K12, Krt1-12)
Results	Reference
1	J:228518 Arya P, Rainey MA, Bhattacharyya S, Mohapatra BC, George M, Kuracha MR, Storck MD, Band V, Govindarajan V, Band H, The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol. 2015 Dec 1;408(1):41-55
1	J:218165 Bankhead EJ, Colasanto MP, Dyorich KM, Jamrich M, Murtaugh LC, Fuhrmann S, Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015 Jan;185(1):197-213
1	J:226997 Bebee TW, Park JW, Sheridan KI, Warzecha CC, Cieply BW, Rohacek AM, Xing Y, Carstens RP, The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4
1	J:105284 Birger Y, Davis J, Furusawa T, Rand E, Piatigorsky J, Bustin M, A role for chromosomal protein HMGN1 in corneal maturation. Differentiation. 2006 Feb;74(1):19-29
1	J:158529 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V, Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
1	J:318638 Chen B, Wang HL, Chen R, Chen L, Yang S, Wang Y, Xue ZF, An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line. Exp Anim. 2021;70(4):459-468
1	J:254639 Chen L, Martino V, Dombkowski A, Williams T, West-Mays J, Gage PJ, AP-2beta Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1072-81
2	J:153549 Chen Y, Carlson EC, Chen ZY, Hamik A, Jain MK, Dunwoodie SL, Yang YC, Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance. Dev Biol. 2009 Oct 1;334(1):243-52
7	J:99414 Chikama T, Hayashi Y, Liu CY, Terai N, Terai K, Kao CW, Wang L, Hayashi M, Nishida T, Sanford P, Doestchman T, Kao WW, Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):1966-72
2	J:223109 Choi JJ, Ting CT, Trogrlic L, Milevski SV, Familari M, Martinez G, de Iongh RU, A role for smoothened during murine lens and cornea development. PLoS One. 2014;9(9):e108037
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:215601 Gage PJ, Kuang C, Zacharias AL, The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea. Dev Dyn. 2014 Nov;243(11):1391-400
1*	J:136041 Gage PJ, Qian M, Wu D, Rosenberg KI, The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol. 2008 May 1;317(1):310-24
1	J:235678 Grisanti L, Revenkova E, Gordon RE, Iomini C, Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway. Development. 2016 Jun 15;143(12):2160-71
2	J:258233 Guo D, Yuan Z, Ru J, Gu X, Zhang W, Mao F, Ouyang H, Wu K, Liu Y, Liu C, A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):952-966
1	J:196827 Hahn N, Dietz CT, Kuhl S, Vossmerbaeumer U, Kroll J, KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Invest Ophthalmol Vis Sci. 2012 May;53(6):3260-8
3	J:160411 Joo JH, Kim YH, Dunn NW, Sugrue SP, Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1927-34
1	J:181400 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V, Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6887-97
9*	J:91361 Kurpakus MA, Maniaci MT, Esco M, Expression of keratins K12, K4 and K14 during development of ocular surface epithelium. Curr Eye Res. 1994 Nov;13(11):805-14
6	J:16837 Liu CY, Zhu G, Westerhausen-Larson A, Converse R, Kao CW, Sun TT, Kao WW, Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res. 1993 Nov;12(11):963-74
1*	J:58278 Lovicu FJ, Kao WW, Overbeek PA, Ectopic gland induction by lens-specific expression of keratinocyte growth factor (FGF-7) in transgenic mice. Mech Dev. 1999 Oct;88(1):43-53
3	J:171535 Lu Q, Xin Y, Ye F, Foulks G, Li Q, 14-3-3{sigma} Controls Corneal Epithelium Homeostasis and Wound Healing. Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2389-96
2*	J:133715 Maerker D, Stenzinger A, Schreiner D, Tag C, Wimmer M, Expression of PTPIP51 during mouse eye development. Histochem Cell Biol. 2008 Mar;129(3):345-56
1	J:230303 Meng Q, Mongan M, Carreira V, Kurita H, Liu CY, Kao WW, Xia Y, Eyelid closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis Sci. 2014 Nov;55(11):7652-61
3	J:226707 Mizoguchi S, Suzuki K, Zhang J, Yamanaka O, Liu CY, Okada Y, Miyajima M, Kokado M, Kao WW, Yamada G, Saika S, Disruption of eyelid and cornea morphogenesis by epithelial beta-catenin gain-of-function. Mol Vis. 2015;21:793-803
1	J:317558 Mongan M, Meng Q, Wang J, Kao WW, Puga A, Xia Y, Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. J Biol Chem. 2015 Aug 7;290(32):19770-9
1	J:315114 Nagosa S, Leesch F, Putin D, Bhattacharya S, Altshuler A, Serror L, Amitai-Lange A, Nasser W, Aberdam E, Rouleau M, Tattikota SG, Poy MN, Aberdam D, Shalom-Feuerstein R, microRNA-184 Induces a Commitment Switch to Epidermal Differentiation. Stem Cell Reports. 2017 Dec 12;9(6):1991-2004
2	J:220954 Nakamura T, Ohtsuka T, Sekiyama E, Cooper LJ, Kokubu H, Fullwood NJ, Barrandon Y, Kageyama R, Kinoshita S, Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells. 2008 May;26(5):1265-74
1	J:42107 Qin P, Piechocki M, Lu S, Kurpakus MA, Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye. Dev Dyn. 1997 Aug;209(4):367-76
10*	J:73681 Saika S, Saika S, Liu CY, Azhar M, Sanford LP, Doetschman T, Gendron RL, Kao CW, Kao WW, TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol. 2001 Dec 15;240(2):419-32
1	J:254700 Seo S, Chen L, Liu W, Zhao D, Schultz KM, Sasman A, Liu T, Zhang HF, Gage PJ, Kume T, Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1368-1377
1	J:182938 Sevilla LM, Bayo P, Latorre V, Sanchis A, Perez P, Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Mol Endocrinol. 2010 Nov;24(11):2166-78
1	J:186971 Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, Melino G, Aberdam D, DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ. 2011 May;18(5):887-96
1*	J:328556 Sunny SS, Lachova J, Dupacova N, Kozmik Z, Multiple roles of Pax6 in postnatal cornea development. Dev Biol. 2022 Aug 29;491:1-12
1	J:346907 Sunny SS, Lachova J, Kasparek P, Palkova M, Spoutil F, Prochazka J, Sedlacek R, Liskova P, Kozmik Z, Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence. Hum Mol Genet. 2024 Feb 28;33(6):491-500
4*	J:108338 Tanifuji-Terai N, Terai K, Hayashi Y, Chikama T, Kao WW, Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci. 2006 Feb;47(2):545-51
1	J:91136 Tasheva ES, Ke A, Deng Y, Jun C, Takemoto LJ, Koester A, Conrad GW, Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004 Jun 17;10:403-16
1	J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
1	J:129101 Xu X, Mannik J, Kudryavtseva E, Lin KK, Flanagan LA, Spencer J, Soto A, Wang N, Lu Z, Yu Z, Monuki ES, Andersen B, Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev Biol. 2007 Dec 15;312(2):484-500
1	J:204591 Yamben IF, Rachel RA, Shatadal S, Copeland NG, Jenkins NA, Warming S, Griep AE, Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
3*	J:65402 Yoshida N, Yoshida S, Araie M, Handa H, Nabeshima Y, Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation. Mech Dev. 2000 Oct;97(1-2):27-34
6	J:103004 Zhang H, Hara M, Seki K, Fukuda K, Nishida T, Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development. Jpn J Ophthalmol. 2005 May-Jun;49(3):195-204
1	J:242341 Zhang J, Upadhya D, Lu L, Reneker LW, Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development. PLoS One. 2015;10(1):e0117089
5	J:125580 Zhang L, Deng M, Kao CW, Kao WW, Xia Y, MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Mol Vis. 2003 Nov 3;9:584-93
2	J:141138 Zhang Y, Burgess D, Overbeek PA, Govindarajan V, Dominant inhibition of lens placode formation in mice. Dev Biol. 2008 Nov 1;323(1):53-63
2	J:159631 Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV, Kao WW, Liu CY, Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci. 2010 Apr 15;123(Pt 8):1285-94