About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Krt18
keratin 18
MGI:96692

133 matching records from 133 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5 E6 E6.5 E7 E7.5 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 1 1 1 3 1 9 1 5 1 10 1 13 1 11 2 11 2 15 4 14 2 14 1 17 6 46
In situ RNA (section) 2 1 3 1 4 1 2 1 1 2
Immunohistochemistry (whole mount) 1 1 2 2 2 1 1 1 1
In situ RNA (whole mount) 1 1 1 1 1 1
Northern blot 1 3
Western blot 1 1 1 1 1 6
RT-PCR 1 1 1 1 1 3 1 1 1 1 5 2 3 1 2 3 4 7
cDNA clones 1 1
RNase protection 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Krt18  keratin 18   (Synonyms: CK18, Endo B, K18, Krt1-18)
Results  Reference
3*J:255611 Adhikari N, Neupane S, Roh J, Jun JH, Jung JK, Sohn WJ, Kim JY, Kim JY, Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice. J Mol Histol. 2018 Feb;49(1):1-15
10*J:50678 Appert A, Fridmacher V, Locquet O, Magre S, Patterns of keratins 8, 18 and 19 during gonadal differentiation in the mouse: sex- and time-dependent expression of keratin 19. Differentiation. 1998 Sep;63(5):273-84
1J:185713 Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE, Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol. 2007 Feb;9(2):201-9
2J:235652 Bachmann C, Nguyen H, Rosenbusch J, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, Tuoc T, mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet. 2016 Sep;12(9):e1006274
3*J:119780 Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM, Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Dev Dyn. 2007 Mar 1;236(4):961-970
1J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1J:60393 Ben-Arie N, Hassan BA, Bermingham NA, Malicki DM, Armstrong D, Matzuk M, Bellen HJ, Zoghbi HY, Functional conservation of atonal and Math1 in the CNS and PNS. Development. 2000 Mar;127(5):1039-48
5*J:152099 Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009 Jun 26;108(1):295-303
1*J:180770 Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Cheng H, Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol. 2012 Feb 15;362(2):194-218
1J:248734 Bolt CC, Negi S, Guimaraes-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans SM, Stubbs L, Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One. 2016;11(4):e0154413
3J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
1*J:332853 Castilla-Ibeas A, Zdral S, Galan L, Haro E, Allou L, Campa VM, Icardo JM, Mundlos S, Oberg KC, Ros MA, Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity. Cell Rep. 2023 Jan 13;42(1):111975
1J:206433 Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Flores Gonzalez RE, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Muller N, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER, Induced multipotency in adult keratinocytes through down-regulation of DeltaNp63 or DGCR8. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E572-81
1J:153957 Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA, Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development. 2009 Nov;136(21):3657-67
2*J:280829 Chen Y, Zhang H, Han F, Yue L, Qiao C, Zhang Y, Dou P, Liu W, Li Y, The depletion of MARVELD1 leads to murine placenta accreta via integrin beta4-dependent trophoblast cell invasion. J Cell Physiol. 2018 Mar;233(3):2257-2269
1J:119657 Cheng W, Jacobs WB, Zhang JJ, Moro A, Park JH, Kushida M, Qiu W, Mills AA, Kim PC, DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development. 2006 Dec;133(23):4783-92
1*J:16855 Coleman-Krnacik S, Rosen JM, Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development. Mol Endocrinol. 1994 Feb;8(2):218-29
1*J:306179 Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klambt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, Challman TD, Zyskind J, Costin CE, Dipple KM, Duijkers FA, Ferguson M, Fitzpatrick DR, Fick R, Glass IA, Hulick PJ, Kline AD, Krey I, Kumar S, Lu W, Marco EJ, Wentzensen IM, Mefford HC, Platzer K, Povolotskaya IS, Savatt JM, Shcherbakova NV, Senguttuvan P, Squire AE, Stein DR, Thiffault I, Voinova VY, Somers MJG, Ferguson MA, Traum AZ, Daouk GH, Daga A, Rodig NM, Terhal PA, van Binsbergen E, Eid LA, Tasic V, Rasouly HM, Lim TY, Ahram DF, Gharavi AG, Reutter HM, Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F, Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Am J Hum Genet. 2020 Oct 1;107(4):727-742
1J:94136 Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M, Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov;24(21):9414-23
1*J:166893 Cote M, Provost PR, Gerard-Hudon MC, Tremblay Y, Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth. BMC Dev Biol. 2010;10:111
1J:208404 Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A, Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biol. 2014 Feb;12(2):e1001799
3*J:119954 Cui XS, Li XY, Shen XH, Bae YJ, Kang JJ, Kim NH, Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation. Mol Reprod Dev. 2007 Feb;74(2):133-43
1J:306023 Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK, A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 May 27;184(11):3056-3074.e21
1J:235040 Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E, Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development. J Invest Dermatol. 2016 Aug;136(8):1647-55
1J:291945 De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyere E, Lefebvre O, Mechine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E, Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut. 2017 Oct;66(10):1748-1760
3J:243698 Decaens T, Godard C, de Reynies A, Rickman DS, Tronche F, Couty JP, Perret C, Colnot S, Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate. Hepatology. 2008 Jan;47(1):247-58
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:242729 Ding X, Bloch W, Iden S, Ruegg MA, Hall MN, Leptin M, Partridge L, Eming SA, mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226
5J:95883 Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Kia X, Shivdasani RA, Spiegelman BM, Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 1;19(3):362-75
1J:325723 Duvall K, Crist L, Perl AJ, Pode Shakked N, Chaturvedi P, Kopan R, Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis. Development. 2022 May 15;149(10):dev200446
6J:285119 Eaton M, Davies AH, Devine J, Zhao X, Simmons DG, Mariusdottir E, Natale DRC, Matyas JR, Bering EA, Workentine ML, Hallgrimsson B, Cross JC, Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. PLoS One. 2020;15(1):e0226735
3J:55508 Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K, Functions of c-Jun in liver and heart development. J Cell Biol. 1999 May 31;145(5):1049-61
5*J:115892 Erman A, Veranic P, Psenicnik M, Jezernik K, Superficial cell differentiation during embryonic and postnatal development of mouse urothelium. Tissue Cell. 2006 Oct;38(5):293-301
1J:333262 Feng S, Wen H, Liu K, Xiong M, Li J, Gui Y, Lv C, Zhang J, Ma X, Wang X, Yuan S, hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
1J:250976 Ferrari N, Riggio AI, Mason S, McDonald L, King A, Higgins T, Rosewell I, Neil JC, Smalley MJ, Sansom OJ, Morris J, Cameron ER, Blyth K, Runx2 contributes to the regenerative potential of the mammary epithelium. Sci Rep. 2015 Oct 22;5:15658
1J:177729 Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA, p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol. 2011 Sep 19;194(6):825-39
1J:192165 Forsman CL, Ng BC, Heinze RK, Kuo C, Sergi C, Gopalakrishnan R, Yee D, Graf D, Schwertfeger KL, Petryk A, BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Dev Biol. 2013 Jan 1;373(1):95-106
1*J:145177 Foshay KM, Gallicano GI, miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation. Dev Biol. 2009 Feb 15;326(2):431-43
1J:331421 Funato N, Yanagisawa H, TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties. Sci Rep. 2022 Nov 23;12(1):20188
2J:51903 Gallicano GI, Kouklis P, Bauer C, Yin M, Vasioukhin V, Degenstein L, Fuchs E, Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol. 1998 Dec 28;143(7):2009-22
1J:204539 Gandhi D, Molotkov A, Batourina E, Schneider K, Dan H, Reiley M, Laufer E, Metzger D, Liang F, Liao Y, Sun TT, Aronow B, Rosen R, Mauney J, Adam R, Rosselot C, Van Batavia J, McMahon A, McMahon J, Guo JJ, Mendelsohn C, Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell. 2013 Sep 16;26(5):469-82
1J:174144 Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP, From the Cover: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7
1J:176045 Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL, Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct;138(19):4131-42
5*J:96841 Gong SG, Gong TW, Shum L, Identification of markers of the midface. J Dent Res. 2005 Jan;84(1):69-72
2J:352089 Grammer C, Komorowska JA, Swann JB, Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1J:112460 Hatsell SJ, Cowin P, Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development. 2006 Sep;133(18):3661-70
1J:60854 Helms AW, Abney AL, Ben-Arie N, Zoghbi HY, Johnson JE, Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development. 2000 Mar;127(6):1185-96
1*J:30820 Hermesz E, Mackem S, Mahon KA, Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development. 1996 Jan;122(1):41-52
6J:65090 Hesse M, Franz T, Tamai Y, Taketo MM, Magin TM, Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. EMBO J. 2000 Oct 2;19(19):5060-70
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2J:166089 Hosoya A, Kwak S, Kim EJ, Lunny DP, Lane EB, Cho SW, Jung HS, Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm. Anat Rec (Hoboken). 2010 Nov;293(11):1864-72
5*J:159513 Huang J, Bi Y, Zhu GH, He Y, Su Y, He BC, Wang Y, Kang Q, Chen L, Zuo GW, Luo Q, Shi Q, Zhang BQ, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009 Nov;29(10):1569-81
1*J:170495 Ikeda K, Kageyama R, Suzuki Y, Kawakami K, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54(10):1453-64
1J:235517 Kam JW, Dumontier E, Baim C, Brignall AC, Mendes da Silva D, Cowan M, Kennedy TE, Cloutier JF, RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46
1*J:169680 Karni-Schmidt O, Castillo-Martin M, Shen TH, Gladoun N, Domingo-Domenech J, Sanchez-Carbayo M, Li Y, Lowe S, Prives C, Cordon-Cardo C, Distinct Expression Profiles of p63 Variants during Urothelial Development and Bladder Cancer Progression. Am J Pathol. 2011 Mar;178(3):1350-60
1J:309103 Katoh H, Shibata S, Fukuda K, Sato M, Satoh E, Nagoshi N, Minematsu T, Matsuzaki Y, Akazawa C, Toyama Y, Nakamura M, Okano H, The dual origin of the peripheral olfactory system: placode and neural crest. Mol Brain. 2011 Sep 23;4:34
1J:170124 Khialeeva E, Lane TF, Carpenter EM, Disruption of reelin signaling alters mammary gland morphogenesis. Development. 2011 Feb;138(4):767-76
2J:300306 Kim E, Choi S, Kang B, Kong J, Kim Y, Yoon WH, Lee HR, Kim S, Kim HM, Lee H, Yang C, Lee YJ, Kang M, Roh TY, Jung S, Kim S, Ku JH, Shin K, Creation of bladder assembloids mimicking tissue regeneration and cancer. Nature. 2020 Dec;588(7839):664-669
1J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
5J:324274 Koike H, Ouchi R, Ueno Y, Nakata S, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H, Polycomb group protein Ezh2 regulates hepatic progenitor cell proliferation and differentiation in murine embryonic liver. PLoS One. 2014;9(8):e104776
4J:310129 Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H, Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice. Hepatology. 2014 Jul;60(1):323-33
4*J:240030 Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T, Taniguchi H, Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development. 2017 Mar 15;144(6):1018-1024
2J:169855 Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM, Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90
5J:195630 Krolewski RC, Packard A, Jang W, Wildner H, Schwob JE, Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One. 2012;7(12):e51737
2J:230728 Kumar V, Bouameur JE, Bar J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P, Magin TM, A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75
3J:332513 Laporte E, De Vriendt S, Hoekx J, Vankelecom H, Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury. Front Endocrinol (Lausanne). 2022;13:1092063
1J:168590 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE, Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14;19(6):807-18
4J:171094 Li B, Zheng YW, Sano Y, Taniguchi H, Evidence for mesenchymal-epithelial transition associated with mouse hepatic stem cell differentiation. PLoS One. 2011;6(2):e17092
4*J:204971 Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J, Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov;140(22):4533-43
1J:171220 Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Bruning JC, Pashmforoush M, Sucov HM, IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May;138(9):1795-805
1*J:268425 Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O, Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601
3J:296989 Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N, Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020 Sep;585(7825):404-409
2*J:296648 Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA, Smith AD, McMahon AP, Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. J Am Soc Nephrol. 2018 Mar;29(3):806-824
1*J:273779 Lindstrom NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Baskin L, Grubbs B, Kesselman C, McMahon AP, Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. J Am Soc Nephrol. 2018 Mar;29(3):785-805
1J:334438 Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP, Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013 Dec;1(6):604-19
9J:103969 Lu H, Hesse M, Peters B, Magin TM, Type II keratins precede type I keratins during early embryonic development. Eur J Cell Biol. 2005 Aug;84(8):709-18
1J:297226 Lu H, Ye C, Feng X, Liu J, Bhaumik M, Xia B, Liu C, Shen Z, Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice. Am J Pathol. 2020 Jun;190(6):1175-1187
6J:219800 Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL, Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:230833 Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA, Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4;212(1):77-89
2*J:50471 McGowan KM, Coulombe PA, Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86
3J:169431 Mikkola ML, Costanzo A, Thesleff I, Roop DR, Koster MI, Treasure or artifact: a decade of p63 research speaks for itself. Cell Death Differ. 2010 Jan;17(1):180-3; author reply 184-6
1J:69056 Mikula M, Schreiber M, Husak Z, Kucerova L, Ruth J, Wieser R, Zatloukal K, Beug H, Wagner EF, Baccarini M, Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 2001 Apr 17;20(8):1952-62
1*J:141643 Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N, Zhou Q, Ward NL, Watanabe M, Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
3J:74117 Montenegro MA, Rojas M, Dominguez S, Vergara A, Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting. J Craniofac Genet Dev Biol. 2000 Jul-Sep;20(3):137-43
1J:241460 Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H, Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016 Aug 16;7:12503
1*J:107770 Nakamura K, Stokes JB, McCray PB Jr, Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Am J Physiol Cell Physiol. 2002 Sep;283(3):C762-72
2J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
4J:67042 Nitou M, Ishikawa K, Shiojiri N, Immunohistochemical analysis of development of desmin-positive hepatic stellate cells in mouse liver. J Anat. 2000 Nov;197 Pt 4:635-46
1J:330284 Nusser A, Sagar, Swann JB, Krauth B, Diekhoff D, Calderon L, Happe C, Grun D, Boehm T, Developmental dynamics of two bipotent thymic epithelial progenitor types. Nature. 2022 Jun;606(7912):165-171
1J:184505 Oliver CH, Khaled WT, Frend H, Nichols J, Watson CJ, The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012 May 15;26(10):1086-97
2J:173538 Packard A, Schnittke N, Romano RA, Sinha S, Schwob JE, {Delta}Np63 regulates stem cell dynamics in the Mammalian olfactory epithelium. J Neurosci. 2011 Jun 15;31(24):8748-59
5J:217588 Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E, Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network. Development. 2014 Dec;141(24):4690-6
2J:234178 Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E, Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016 Jul;12(7):e1006151
3J:159267 Plante J, Simard M, Rantakari P, Cote M, Provost PR, Poutanen M, Tremblay Y, Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant. J Steroid Biochem Mol Biol. 2009 Nov;117(4-5):139-45
1J:242325 Posfai E, Petropoulos S, de Barros FR, Schell JP, Jurisica I, Sandberg R, Lanner F, Rossant J, Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. Elife. 2017 Feb 22;6:e22906
1*J:209852 Prandi S, Bromke M, Hubner S, Voigt A, Boehm U, Meyerhof W, Behrens M, A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820
1J:269217 Regano D, Visintin A, Clapero F, Bussolino F, Valdembri D, Maione F, Serini G, Giraudo E, Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1710-1721
2J:259735 Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A, The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. Cell Rep. 2015 Dec 1;13(9):1757-64
4J:163649 Sani FV, Kaartinen V, El Shahawy M, Linde A, Gritli-Linde A, Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Eur J Oral Sci. 2010 Jun;118(3):221-36
4J:290832 Schaart G, Viebahn C, Langmann W, Ramaekers F, Desmin and titin expression in early postimplantation mouse embryos. Development. 1989 Nov;107(3):585-96
2J:160375 Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS, VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol. 2010 May;176(5):2269-82
4J:326954 Seong J, Frias-Aldeguer J, Holzmann V, Kagawa H, Sestini G, Heidari Khoei H, Scholte Op Reimer Y, Kip M, Pradhan SJ, Verwegen L, Vivie J, Li L, Alemany A, Korving J, Darmis F, van Oudenaarden A, Ten Berge D, Geijsen N, Rivron NC, Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero. Cell Stem Cell. 2022 Jul 7;29(7):1102-1118.e8
4J:186971 Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, Melino G, Aberdam D, DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ. 2011 May;18(5):887-96
2*J:67189 Shiojiri N, Inujima S, Ishikawa K, Terada K, Mori M, Cell lineage analysis during liver development using the spf(ash)-heterozygous mouse. Lab Invest. 2001 Jan;81(1):17-25
1J:279029 Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L, VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. Sci Rep. 2019 May 8;9(1):7079
3J:295946 Sohn WJ, Gwon GJ, Kim HS, Neupane S, Cho SJ, Lee JH, Yamamoto H, Choi JY, An CH, Lee Y, Shin HI, Lee S, Kim JY, Mesenchymal signaling in dorsoventral differentiation of palatal epithelium. Cell Tissue Res. 2015 Dec;362(3):541-56
1J:322612 Spina E, Simundza J, Incassati A, Chandramouli A, Kugler MC, Lin Z, Khodadadi-Jamayran A, Watson CJ, Cowin P, Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency. Nat Commun. 2022 Mar 17;13(1):1421
2J:319645 Stefanski HE, Xing Y, Nicholls J, Jonart L, Goren E, Taylor PA, Mills AA, Riddle M, McGrath J, Tolar J, Hollander GA, Blazar BR, P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss. PLoS One. 2022;17(1):e0261770
1J:137356 Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS, Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol. 2008 Sep;216(3):824-34
2J:156959 Sugiyama Y, Takabe Y, Nakakura T, Tanaka S, Koike T, Shiojiri N, Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development. Dev Dyn. 2010 Feb;239(2):386-97
1J:255792 Swann JB, Krauth B, Happe C, Boehm T, Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment. Sci Rep. 2017 Aug 17;7(1):8492
3*J:204466 Tadeu AM, Horsley V, Notch signaling represses p63 expression in the developing surface ectoderm. Development. 2013 Sep;140(18):3777-86
1*J:58477 Talbot D, Loring J, Schorle H, Lorgin J [corrected to Loring J], Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice [published erratum appears in J Invest Dermatol 2000 Mar;114(3):609]. J Invest Dermatol. 1999 Nov;113(5):816-20
3J:65498 Tamai Y, Ishikawa To, Bosl MR, Mori M, Nozaki M, Baribault H, Oshima RG, Taketo MM, Cytokeratins 8 and 19 in the mouse placental development. J Cell Biol. 2000 Oct 30;151(3):563-72
1J:334814 Tang YC, Ponsin K, Graham-Paquin AL, Luthold C, Homsy K, Schindler M, Tran V, Cote JF, Bordeleau F, Khadra A, Bouchard M, Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis. Cell Rep. 2023 Mar 28;42(3):112202
1J:84273 Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R, Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol. 2003 Jul 7;162(1):139-48
4J:108342 Terszowski G, Muller SM, Bleul CC, Blum C, Schirmbeck R, Reimann J, Pasquier LD, Amagai T, Boehm T, Rodewald HR, Evidence for a functional second thymus in mice. Science. 2006 Apr 14;312(5771):284-7
2*J:137798 Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O, Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 2008 Jul;333(1):17-27
3J:311811 Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A, Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter. Development. 2012 Sep;139(17):3099-108
2J:153804 Vijayaraj P, Kroger C, Reuter U, Windoffer R, Leube RE, Magin TM, Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol. 2009 Oct 19;187(2):175-84
1J:143315 Wang X, Pasolli HA, Williams T, Fuchs E, AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol. 2008 Oct 6;183(1):37-48
1*J:121264 Watson ED, Geary-Joo C, Hughes M, Cross JC, The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta. Development. 2007 May;134(9):1809-17
1*J:81652 Wen F, Cecena G, Munoz-Ritchie V, Fuchs E, Chambon P, Oshima RG, Expression of conditional cre recombinase in epithelial tissues of transgenic mice. Genesis. 2003 Feb;35(2):100-6
2J:114400 Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T, Shiojiri N, Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development. 2006 Nov;133(21):4233-43
3J:240561 Yao B, Xie J, Liu N, Yan T, Li Z, Liu Y, Huang S, Fu X, Identification of a new sweat gland progenitor population in mice and the role of their niche in tissue development. Biochem Biophys Res Commun. 2016 Oct 28;479(4):670-675
1J:264522 Youngblood JL, Coleman TF, Davis SW, Regulation of Pituitary Progenitor Differentiation by beta-Catenin. Endocrinology. 2018 Sep 1;159(9):3287-3305
1*J:150849 Yu Z, Mannik J, Soto A, Lin KK, Andersen B, The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J. 2009 Jul 8;28(13):1890-903
3J:316098 Zhao J, Lu P, Wan C, Huang Y, Cui M, Yang X, Hu Y, Zheng Y, Dong J, Wang M, Zhang S, Liu Z, Bian S, Wang X, Wang R, Ren S, Wang D, Yao Z, Chang G, Tang F, Zhao XY, Cell-fate transition and determination analysis of mouse male germ cells throughout development. Nat Commun. 2021 Nov 25;12(1):6839
1*J:63747 Zuklys S, Balciunaite G, Agarwal A, Fasler-Kan E, Palmer E, Hollander GA, Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J Immunol. 2000 Aug 15;165(4):1976-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory