Gene Expression Literature Summary

• Symbol: Ldha
• Name: lactate dehydrogenase A
• ID: MGI:96759

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19.5	P
Immunohistochemistry (section)		1		1		1	2		1				1
In situ RNA (section)		1				5	1	4				1			1
In situ RNA (whole mount)		1	1	2
Northern blot										1
Western blot		1		2	1	1	2		1	1			1		1
RT-PCR	1	1	1	3		2	4	4	3		1	2	6	1	15
cDNA clones	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ldha  lactate dehydrogenase A   (Synonyms: l7R2, lactate dehydrogenase-A, Ldh-1, Ldh1, LDH-A)
Results	Reference
2	J:346910 Ayyangar U, Karkhanis A, Tay H, Afandi AFB, Bhattacharjee O, Ks L, Lee SH, Chan J, Raghavan S, Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:234630 Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA, Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 Jul 20;36(29):7786-801
1	J:240028 Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A, Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4
4	J:347732 Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA, Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance. EMBO Rep. 2024 Apr 10;
2*	J:329220 Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C, Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
2	J:182738 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK, Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13;22(3):651-9
10	J:335574 Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi SH, Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex. Nat Neurosci. 2022 Jul;25(7):865-875
6	J:356661 Esteban-Martinez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Marino G, Seco E, Durand S, Enot D, Grana O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P, Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 2017 Jun 14;36(12):1688-1706
2	J:284149 Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK, A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Development. 2019 Oct 24;146(20):dev182857
1	J:352089 Grammer C, Komorowska JA, Swann JB, Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:310975 He N, Lim SJ, Moreira de Mello JC, Navarro I, Bialecka M, Salvatori DCF, van der Westerlaken LAJ, Pereira LV, Chuva de Sousa Lopes SM, At Term, XmO and XpO Mouse Placentas Show Differences in Glucose Metabolism in the Trophectoderm-Derived Outer Zone. Front Cell Dev Biol. 2017;5:63
1*	J:78912 Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C, Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001 Apr 30;153(3):543-53
1	J:162597 Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J, Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem. 2010 Apr 30;285(18):13646-57
1	J:294228 Kalailingam P, Wang KQ, Toh XR, Nguyen TQ, Chandrakanthan M, Hasan Z, Habib C, Schif A, Radio FC, Dallapiccola B, Weiss K, Nguyen LN, Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3;130(8):4081-4093
2	J:337927 Kawakami H, Chen KQ, Zhang R, Pappas MP, Bailey A, Reisz JA, Corcoran D, Nishinakamura R, D'Alessandro A, Kawakami Y, Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Dev Biol. 2023 Sep;501:28-38
2	J:267504 Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA, Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56
1	J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
1	J:346373 Liu B, Hua D, Shen L, Li T, Tao Z, Fu C, Tang Z, Yang J, Zhang L, Nie A, Jiang Y, Wang J, Li Y, Gu Y, Ning G, NPC1 is required for postnatal islet beta cell differentiation by maintaining mitochondria turnover. Theranostics. 2024;14(5):2058-2074
1	J:355796 Lu X, Zhao ZA, Wang X, Zhang X, Zhai Y, Deng W, Yi Z, Li L, Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent alternative promoter usage during mouse early embryogenesis. Biol Open. 2018 Mar 28;7(3)
1	J:313967 Mass E, Wachten D, Aschenbrenner AC, Voelzmann A, Hoch M, Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Dev Cell. 2014 Mar 31;28(6):711-26
3	J:306925 Menendez-Montes I, Escobar B, Gomez MJ, Albendea-Gomez T, Palacios B, Bonzon-Kulichenko E, Izquierdo-Garcia JL, Alonso AV, Ferrarini A, Jimenez-Borreguero LJ, Ruiz-Cabello J, Vazquez J, Martin-Puig S, Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021 Feb 19;24(2):102124
3	J:237617 Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, Jimenez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S, Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739
1	J:212629 Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K, Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28;111(8):1012-26
3	J:338298 Sakai D, Murakami Y, Shigeta D, Tomosugi M, Sakata-Haga H, Hatta T, Shoji H, Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos. Front Cell Dev Biol. 2023;11:1212375
2	J:323013 Sakai D, Sugawara T, Kurokawa T, Murakami Y, Tomosugi M, Masuta H, Sakata-Haga H, Hatta T, Shoji H, Hif1alpha-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model. Mol Brain. 2022 Mar 31;15(1):28
1	J:270627 Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P, Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet Muscle. 2016;6(1):30
3*	J:345131 Schraps N, Tirre M, Pyschny S, Reis A, Schlierbach H, Seidl M, Kehl HG, Schanzer A, Heger J, Jux C, Drenckhahn JD, Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction. Free Radic Biol Med. 2024 Jan 22;213:248-265
1	J:242899 Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM, Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development. 2017 Jul 01;144(13):2402-2414
1	J:286471 Testini C, Smith RO, Jin Y, Martinsson P, Sun Y, Hedlund M, Sainz-Jaspeado M, Shibuya M, Hellstrom M, Claesson-Welsh L, Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2. EMBO Rep. 2019 Nov 5;20(11):e47845
1	J:348298 Tixi W, Maldonado M, Chang YT, Chiu A, Yeung W, Parveen N, Nelson MS, Hart R, Wang S, Hsu WJ, Fueger P, Kopp JL, Huising MO, Dhawan S, Shih HP, Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation. Elife. 2023 Aug 23;12
1	J:315981 Torregrosa-Carrion R, Pineiro-Sabaris R, Siguero-Alvarez M, Grego-Bessa J, Luna-Zurita L, Fernandes VS, MacGrogan D, Stainier DYR, de la Pompa JL, Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
1	J:299728 Travisano SI, Oliveira VL, Prados B, Grego-Bessa J, Pineiro-Sabaris R, Bou V, Gomez MJ, Sanchez-Cabo F, MacGrogan D, de la Pompa JL, Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade. Elife. 2019 Dec 4;8:e49977
2	J:90859 Verheijen MH, Chrast R, Burrola P, Lemke G, Local regulation of fat metabolism in peripheral nerves. Genes Dev. 2003 Oct 1;17(19):2450-64
1	J:239679 Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, Gonzalez-Billalabeitia E, Hung MC, Song SJ, Song MS, A UBE2O-AMPKalpha2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb 13;31(2):208-224
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:352990 Yang J, Li Y, Tang Y, Yang L, Guo C, Peng C, Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development. BMC Genomics. 2024 Aug 2;25(1):757
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
2	J:227211 Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD, Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186
2*	J:321836 Zhao K, Huang X, Zhao W, Lu B, Yang Z, LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. Development. 2022 Mar 15;149(6):dev200458
2*	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147
1	J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988