Gene Expression Literature Summary

• Symbol: Lgals3
• Name: lectin, galactose binding, soluble 3
• ID: MGI:96778

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E5.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)	4		1	1	1	1	2	4	2	1	2	3	2	5		3	1		1			12
In situ RNA (section)			1	1				3	1		1	2	1	2	1	1					1	2
In situ RNA (whole mount)			1			1															1
In situ reporter (knock in)																						1
Northern blot		1	1			1		1			1			1			1			1		1
Western blot																		1				2
RT-PCR									1										1			5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lgals3  lectin, galactose binding, soluble 3   (Synonyms: gal3, galectin-3, L-34, Mac-2)
Results	Reference
1	J:235148 Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN, Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503
1	J:267338 Angelim MKSC, Maia LMSS, Mouffle C, Ginhoux F, Low D, Amancio-Dos-Santos A, Makhoul J, Le Corronc H, Mangin JM, Legendre P, Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. 2018 Nov;66(11):2470-2486
1*	J:315095 Bando Y, Yamamoto M, Sakiyama K, Inoue K, Takizawa S, Owada Y, Iseki S, Kondo H, Amano O, Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice. J Mol Histol. 2014 Oct;45(5):507-18
1	J:331471 Brownfield DG, de Arce AD, Ghelfi E, Gillich A, Desai TJ, Krasnow MA, Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. Nat Commun. 2022 Nov 21;13(1):7137
1	J:262187 Cautivo KM, Lizama CO, Tapia PJ, Agarwal AK, Garg A, Horton JD, Cortes VA, AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue. Mol Metab. 2016 Jul;5(7):491-505
1	J:239386 Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim OA, Sotlar K, Schurmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T, Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 Dec 19;5:e20914
2	J:47227 Colnot C, Fowlis D, Ripoche MA, Bouchaert I, Poirier F, Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev Dyn. 1998 Apr;211(4):306-13
1	J:31899 Colnot C, Ripoche MA, Scaerou F, Foulis D, Poirier F, Galectins in mouse embryogenesis. Biochem Soc Trans. 1996 Feb;24(1):141-6
1*	J:66902 Colnot C, Sidhu SS, Balmain N, Poirier F, Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones. Dev Biol. 2001 Jan 1;229(1):203-14
3	J:82892 Dahm R, Bramke S, Dawczynski J, Nagaraj RH, Kasper M, Developmental aspects of galectin-3 expression in the lens. Histochem Cell Biol. 2003 Mar;119(3):219-26
1	J:166533 Daneman R, Zhou L, Kebede AA, Barres BA, Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010 Nov 25;468(7323):562-6
16*	J:26073 Fowlis D, Colnot C, Ripoche MA, Poirier F, Galectin-3 is expressed in the notochord, developing bones, and skin of the postimplantation mouse embryo. Dev Dyn. 1995 Jun;203(2):241-51
2	J:121179 Furuhata S, Ando K, Oki M, Aoki K, Ohnishi S, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T, Ohnami S, Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol Cell Biochem. 2007 Apr;298(1-2):125-38
1	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
1	J:346909 Ha HT, Liu S, Nguyen XT, Vo LK, Leong NC, Nguyen DT, Balamurugan S, Lim PY, Wu Y, Seong E, Nguyen TQ, Oh J, Wenk MR, Cazenave-Gassiot A, Yapici Z, Ong WY, Burmeister M, Nguyen LN, Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. JCI Insight. 2024 Mar 7;:e175462
1*	J:206507 Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL, ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013;9(7):e1003612
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
15	J:47369 Lee VH, Lee AB, Phillips EB, Roberts JK, Weitlauf HM, Spatio-temporal pattern for expression of galectin-3 in the murine utero-placental complex: evidence for differential regulation. Biol Reprod. 1998 May;58(5):1277-82
3	J:275137 Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA, Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development. Elife. 2019 Feb 13;8:e43271
3	J:100747 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z, Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell. 2005 Jun;16(6):3028-39
1	J:295059 Patel MM, Behar AR, Silasi R, Regmi G, Sansam CL, Keshari RS, Lupu F, Lupu C, Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. J Am Heart Assoc. 2018 Nov 20;7(22):e010690
6	J:35047 Phillips B, Knisley K, Weitlauf KD, Dorsett J, Lee V, Weitlauf H, Differential expression of two beta-galactoside-binding lectins in the reproductive tracts of pregnant mice. Biol Reprod. 1996 Sep;55(3):548-58
1	J:16245 Poirier F, Robertson EJ, Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development. 1993 Dec;119(4):1229-36
1	J:187706 Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin JM, Rigo JM, Legendre P, Le Corronc H, Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion. J Neurosci. 2012 Aug 22;32(34):11559-11573
2	J:117794 Sakakura Y, Hosokawa Y, Tsuruga E, Irie K, Nakamura M, Yajima T, Constributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones. Cell Tissue Res. 2006 Apr;328(1):137-51
10	J:240148 Tan SY, Krasnow MA, Developmental origin of lung macrophage diversity. Development. 2016 Apr 15;143(8):1318-27
2	J:74242 Timmons PM, Rigby PW, Poirier F, The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis. Development. 2002 Feb;129(3):635-47
1*	J:64739 Wada R, Tifft CJ, Proia RL, Microglial activation precedes acute neurodegeneration in sandhoff disease and is suppressed by bone marrow transplantation. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10954-9
1	J:183127 Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B, Pancreas-specific deletion of prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology. 2012 Apr;142(4):999-1009.e6
1*	J:127356 Yang E, Shim JS, Woo HJ, Kim KW, Kwon HJ, Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. Biochem Biophys Res Commun. 2007 Nov 16;363(2):336-41
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
2*	J:236180 Zhou H, Black SM, Benson TW, Weintraub NL, Chen W, Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function. Mol Cell Biol. 2016 Aug 1;36(15):2027-38