Gene Expression Literature Summary

• Symbol: Lifr
• Name: LIF receptor alpha
• ID: MGI:96788

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6	E6.5	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)															1			1	1	3		1		2		1		1		1		5
In situ RNA (section)							1		1	1				1					2	3		2		2		1				4		4
In situ RNA (whole mount)															2		1		2	2				2			2			1
In situ reporter (knock in)															1									2								2
Northern blot											1			1		1				2	2				1	1	1		1	1	1	5
RT-PCR	1	2	1	1	1	2	2	2	2	2		1			1					2			1	1	1	1	2					7
cDNA clones																																4
RNase protection									1	1		1	1	1	1																	2
Primer Extension																																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lifr  LIF receptor alpha   (Synonyms: A230075M04Rik, soluble differentiation-stimulating factor receptor)
Results	Reference
9*	J:130196 Alfonsi F, Filippi P, Salaun D, deLapeyriere O, Durbec P, LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus. Dev Biol. 2008 Jan 1;313(1):267-78
1	J:45763 Arce V, Pollock RA, Philippe JM, Pennica D, Henderson CE, deLapeyriere O, Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1). J Neurosci. 1998 Feb 15;18(4):1440-8
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:272505 Catela C, Correa E, Wen K, Aburas J, Croci L, Consalez GG, Kratsios P, An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2
5*	J:45056 Chambers I, Cozens A, Broadbent J, Robertson M, Lee M, Li M, Smith A, Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region. Biochem J. 1997 Dec 15;328(Pt 3):879-88
1*	J:288446 Christians A, Weiss AC, Martens H, Klopf MG, Hennies I, Haffner D, Kispert A, Weber RG, Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:262472 Edmond M, Hanley O, Philippidou P, Topoisomerase IIbeta Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0404-17.2017
1	J:317814 Fan L, Ou YJ, Zhu YX, Liang YD, Zhou Y, Wang YN, Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts. J Dent Res. 2022 Jan;101(1):63-72
2	J:356300 Finn EH, Smith CL, Rodriguez J, Sidow A, Baker JC, Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta. Dev Biol. 2014 Jun 1;390(1):80-92
4	J:95357 Gregg C, Weiss S, CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development. 2005 Feb;132(3):565-78
1	J:253351 Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS, Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
4*	J:24333 Harvey MB, Leco KJ, Arcellana-Panlilio MY, Zhang X, Edwards DR, Schultz GA, Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor. Development. 1995 APR;121(4):1005-14
1	J:117040 Hatta T, Matsumoto A, Ono A, Udagawa J, Nimura M, Hashimoto R, Otani H, Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos. Neuroreport. 2006 Dec 18;17(18):1863-6
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
6	J:242320 Kosfeld A, Brand F, Weiss AC, Kreuzer M, Goerk M, Martens H, Schubert S, Schafer AK, Riehmer V, Hennies I, Brasen JH, Pape L, Amann K, Krogvold L, Bjerre A, Daniel C, Kispert A, Haffner D, Weber RG, Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations. Hum Mol Genet. 2017 May 01;26(9):1716-1731
3	J:137720 Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T, Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008 Jul;118(7):2393-403
4*	J:82048 Li M, Sendtner M, Smith A, Essential function of LIF receptor in motor neurons. Nature. 1995 Dec 14;378(6558):724-7
1	J:338821 Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ, TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605
2	J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
3	J:120902 Magni P, Dozio E, Ruscica M, Watanobe H, Cariboni A, Zaninetti R, Motta M, Maggi R, Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways. Mol Endocrinol. 2007 May;21(5):1163-74
13*	J:34635 Nichols J, Davidson D, Taga T, Yoshida K, Chambers I, Smith A, Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis. Mech Dev. 1996 Jul;57(2):123-31
6	J:105646 Oberle S, Schober A, Meyer V, Holtmann B, Henderson C, Sendtner M, Unsicker K, Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla. J Neurosci. 2006 Feb 8;26(6):1823-32
1*	J:77294 Oppenheim RW, Wiese S, Prevette D, Armanini M, Wang S, Houenou LJ, Holtmann B, Gotz R, Pennica D, Sendtner M, Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci. 2001 Feb 15;21(4):1283-91
8*	J:31858 Owczarek CM, Layton MJ, Robb LG, Nicola NA, Begley CG, Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice. J Biol Chem. 1996 Mar 8;271(10):5495-504
7	J:46263 Robb L, Li R, Hartley L, Nandurkar HH, Koentgen F, Begley CG, Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med. 1998 Mar;4(3):303-8
3*	J:152946 Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA, Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
2	J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
1	J:84736 Tamura S, Morikawa Y, Senba E, Localization of oncostatin M receptor beta in adult and developing CNS. Neuroscience. 2003;119(4):991-7
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:18353 Tomida M, Yamamoto-Yamaguchi Y, Hozumi M, Three different cDNAs encoding mouse D-factor/LIF receptor. J Biochem. 1994 Mar;115(3):557-62
7*	J:31510 Tomida M, Yamamoto-Yamaguchi Y, Hozumi M, Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver. FEBS Lett. 1993 Nov 15;334(2):193-7
1	J:314320 Wang H, Kane AW, Lee C, Ahn S, Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche. Cell Rep. 2014 Aug 21;8(4):1093-104
4*	J:314223 Wang H, Sakata-Haga H, Masuta H, Tomosugi M, Tsukada T, Shimada H, Sakai D, Shoji H, Hatta T, Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast. Front Cell Dev Biol. 2021;9:618947