Gene Expression Literature Summary

• Symbol: Lmna
• Name: lamin A
• ID: MGI:96794

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)	1	1						1		1	1		1	3	2	1	2	2	4		4				14
In situ RNA (section)																2									1
Immunohistochemistry (whole mount)	1	2	1	2	2	2																			1
In situ reporter (knock in)							1		1			1					1						1		1
Western blot				1		1												1	1	1	3	1		1	14
RT-PCR								1		1			1	1	1	1	1	1	1		3				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lmna  lamin A   (Synonyms: Dhe, lamin A/C)
Results	Reference
1*	J:215974 Adhikari D, Diril MK, Busayavalasa K, Risal S, Nakagawa S, Lindkvist R, Shen Y, Coppola V, Tessarollo L, Kudo NR, Kaldis P, Liu K, Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. J Cell Biol. 2014 Sep 29;206(7):843-53
1	J:347583 Barman B, Thakur MK, Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM. J Cell Sci. 2024 Feb 1;137(3):jcs261422
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5	J:180603 Bertrand AT, Renou L, Papadopoulos A, Beuvin M, Lacene E, Massart C, Ottolenghi C, Decostre V, Maron S, Schlossarek S, Cattin ME, Carrier L, Malissen M, Arimura T, Bonne G, DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death. Hum Mol Genet. 2012 Mar 1;21(5):1037-48
1	J:92551 Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, Wolgemuth DJ, Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004 Aug 20;279(34):35858-66
1	J:306024 Cho Y, Tachibana S, Lam K, Arita Y, Khosrowjerdi S, Zhang O, Liang A, Li R, Andreyev A, Murphy AN, Ross RS, Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice. J Biol Chem. 2021 May 21;:100825
1	J:325357 Chomiak AA, Guo Y, Kopsidas CA, McDaniel DP, Lowe CC, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y, Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 Jun 17;25(6):104354
5	J:264980 Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH 2nd, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec;22(23):4683-93
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:130649 Fossat N, Le Greneur C, Beby F, Vincent S, Godement P, Chatelain G, Lamonerie T, A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. BMC Dev Biol. 2007;7:122
1*	J:245014 Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L, Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Mol Biol Cell. 2016 Jan 01;27(1):35-47
1	J:349860 Hashimoto K, Ohira M, Kodama A, Kimoto M, Inoue M, Tone S, Usui Y, Hanashima A, Goto T, Ogura Y, Ujihara Y, Mohri S, Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
7	J:289360 Houliston E, Guilly MN, Courvalin JC, Maro B, Expression of nuclear lamins during mouse preimplantation development. Development. 1988 Feb;102(2):271-8
1	J:261960 Ito H, Mizuno M, Noguchi K, Morishita R, Iwamoto I, Hara A, Nagata KI, Expression analyses of Phactr1 (phosphatase and actin regulator 1) during mouse brain development. Neurosci Res. 2018 Mar;128:50-57
3	J:357241 Iyyappan R, Aleshkina D, Ming H, Dvoran M, Kakavand K, Jansova D, Del Llano E, Gahurova L, Bruce AW, Masek T, Pospisek M, Horvat F, Kubelka M, Jiang Z, Susor A, The translational oscillation in oocyte and early embryo development. Nucleic Acids Res. 2023 Dec 11;51(22):12076-12091
3	J:197315 Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG, Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
1	J:160544 Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT, A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9861-6
1	J:178993 Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS, Zheng Y, Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011 Dec 23;334(6063):1706-10
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
3*	J:221850 Kubben N, Voncken JW, Konings G, van Weeghel M, van den Hoogenhof MM, Gijbels M, van Erk A, Schoonderwoerd K, van den Bosch B, Dahlmans V, Calis C, Houten SM, Misteli T, Pinto YM, Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins. Nucleus. 2011 May-Jun;2(3):195-207
9	J:311844 Landin MA, Nygard S, Shabestari MG, Babaie E, Reseland JE, Osmundsen H, Mapping the global mRNA transcriptome during development of the murine first molar. Front Genet. 2015;6:47
1	J:351039 Lee IW, Tazehkand AP, Sha ZY, Adhikari D, Carroll J, An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2317316121
2	J:220914 Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG, Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May;25(10):1666-75
2	J:158528 Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG, Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010 Apr 15;19(8):1603-17
1*	J:150047 Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M, SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
1	J:91454 Matsui T, Hayashi-Kisumi F, Kinoshita Y, Katahira S, Morita K, Miyachi Y, Ono Y, Imai T, Tanigawa Y, Komiya T, Tsukita S, Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. Genomics. 2004 Aug;84(2):384-97
1	J:225772 Murray TV, Smyrnias I, Schnelle M, Mistry RK, Zhang M, Beretta M, Martin D, Anilkumar N, de Silva SM, Shah AM, Brewer AC, Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription. J Mol Cell Cardiol. 2015 Feb;79:54-68
2	J:260379 Naeem AS, Zhu Y, Di WL, Marmiroli S, O'Shaughnessy RF, AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation. Cell Death Differ. 2015 Dec;22(12):2123-32
1	J:124128 Rajareddy S, Reddy P, Du C, Liu L, Jagarlamudi K, Tang W, Shen Y, Berthet C, Peng SL, Kaldis P, Liu K, p27kip1 (Cyclin-Dependent Kinase Inhibitor 1B) Controls Ovarian Development by Suppressing Follicle Endowment and Activation and Promoting Follicle Atresia in Mice. Mol Endocrinol. 2007 Sep;21(9):2189-202
1*	J:302139 Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan A, Evers BM, Mammen PPA, Xu L, Bassel-Duby R, Liu N, Olson EN, The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Nat Commun. 2021 Jan 29;12(1):690
1	J:252201 Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA, Mardaryev A, p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct;137(10):2157-2167
1	J:124186 Rebelo S, Reguenga C, Osorio L, Pereira C, Lopes C, Lima D, DRG11 immunohistochemical expression during embryonic development in the mouse. Dev Dyn. 2007 Sep;236(9):2653-60
1	J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
10*	J:289359 Rober RA, Weber K, Osborn M, Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Development. 1989 Feb;105(2):365-78
2	J:339839 Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM, Stroud MJ, Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
1	J:320521 Sharma R, Mei A, Mathew V, Kashpur O, Wallingford MC, Interaction of extraembryonic microglia and neonatal brain development. Exp Neurol. 2022 Jan 19;351:113986
1	J:241448 Shin JY, Mendez-Lopez I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ, Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Hum Mol Genet. 2017 Jan 01;26(1):65-78
1	J:261250 Siddam AD, Gautier-Courteille C, Perez-Campos L, Anand D, Kakrana A, Dang CA, Legagneux V, Mereau A, Viet J, Gross JM, Paillard L, Lachke SA, The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet. 2018 Mar;14(3):e1007278
5	J:336153 Skory RM, Moverley AA, Ardestani G, Alvarez Y, Domingo-Muelas A, Pomp O, Hernandez B, Tetlak P, Bissiere S, Stern CD, Sakkas D, Plachta N, The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization. Nat Commun. 2023 May 29;14(1):3101
1	J:285646 Sola-Carvajal A, Revechon G, Helgadottir HT, Whisenant D, Hagblom R, Dohla J, Katajisto P, Brodin D, Fagerstrom-Billai F, Viceconte N, Eriksson M, Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins. J Invest Dermatol. 2019 Nov;139(11):2272-2280.e12
3	J:246890 Stroud MJ, Feng W, Zhang J, Veevers J, Fang X, Gerace L, Chen J, Nesprin 1alpha2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol. 2017 Jul 03;216(7):1915-1924
1	J:317373 Tran JR, Zheng X, Zheng Y, Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development. Mol Biol Cell. 2016 Dec 15;27(25):3956-3963
2	J:330768 Wang Y, Elsherbiny A, Kessler L, Cordero J, Shi H, Serke H, Lityagina O, Trogisch FA, Mohammadi MM, El-Battrawy I, Backs J, Wieland T, Heineke J, Dobreva G, Lamin A/C-dependent chromatin architecture safeguards naive pluripotency to prevent aberrant cardiovascular cell fate and function. Nat Commun. 2022 Nov 4;13(1):6663
1*	J:270838 Wiederstein JL, Nolte H, Gunther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Holper S, Kruger M, Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356
1*	J:330334 Zhang H, Jiang JC, Wu YW, Yu YS, Wang HN, Ding NZ, Fan HY, The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance. Development. 2022 Oct 1;149(19):dev200497
2	J:228307 Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B, Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71