Gene Expression Literature Summary

• Symbol: Lrp1
• Name: low density lipoprotein receptor-related protein 1
• ID: MGI:96828

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E17	E18	E18.5	E19	E	P
Immunohistochemistry (section)		1		1		1		1				3		1	1		1		1	1			5
In situ RNA (section)	1	1		1	1	1	1	1		2	1		1	2	2	2	2			1		1	4
In situ RNA (whole mount)						1		1		1		1					1
In situ reporter (knock in)												2											1
Northern blot							2			1	1		2			2		2		1	3		5
Western blot												2	1	1	2					1		2	6
RT-PCR		1	1	1		1			1	1				1		1	1	1					3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lrp1  low density lipoprotein receptor-related protein 1   (Synonyms: A2mr, b2b1554Clo, CD91)
Results	Reference
1	J:273194 Anderson SR, Zhang J, Steele MR, Romero CO, Kautzman AG, Schafer DP, Vetter ML, Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia. J Neurosci. 2019 Mar 13;39(11):2025-2040
6	J:249140 Auderset L, Cullen CL, Young KM, Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System. PLoS One. 2016;11(6):e0155878
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5	J:297574 Bres EE, Safina D, Muller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhauser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A, Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia. 2020 Dec;68(12):2517-2549
1	J:207796 Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kroger S, Johnson EB, Hammer RE, Lin W, Herz J, APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:19195 Gafvels ME, Paavola LG, Boyd CO, Nolan PM, Wittmaack F, Chawla A, Lazar MA, Bucan M, Angelin BO, Strauss JF 3rd, Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19 [published erratum appears in Endocrinology 195 Feb;136(2):795]. Endocrinology. 1994 Jul;135(1):387-94
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:199606 Hennen E, Safina D, Haussmann U, Worsdorfer P, Edenhofer F, Poetsch A, Faissner A, A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice. J Biol Chem. 2013 Jun 7;288(23):16538-45
2*	J:30077 Herz J, Clouthier DE, Hammer RE, LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation [published erratum appears in Cell 1993 May 7;73(3):428]. Cell. 1992 Oct 30;71(3):411-21
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:214694 Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A, LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
1	J:123312 Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato SB, Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1815-23
5*	J:99564 Li Y, Lu W, Bu G, Striking differences of LDL receptor-related protein 1B expression in mouse and human. Biochem Biophys Res Commun. 2005 Aug 5;333(3):868-873
3	J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011 Mar;240(3):577-88
3	J:293699 Lin JI, Feinstein TN, Jha A, McCleary JT, Xu J, Arrigo AB, Rong G, Maclay LM, Ridge T, Xu X, Lo CW, Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening. Commun Biol. 2020 Jun 16;3(1):312
11*	J:17537 Lorent K, Overbergh L, Delabie J, Van Leuven F, Van den Berghe H, Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues. Differentiation. 1994 Feb;55(3):213-23
8	J:25487 Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H, Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase,alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 1995 Apr;65(4):1009-25
1*	J:333788 Mark PR, Murray SA, Yang T, Eby A, Lai A, Lu D, Zieba J, Rajasekaran S, VanSickle EA, Rossetti LZ, Guidugli L, Watkins K, Wright MS, Bupp CP, Prokop JW, Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding. Cold Spring Harb Mol Case Stud. 2022 Oct;8(6)
8	J:217596 Nakajima C, Haffner P, Goerke SM, Zurhove K, Adelmann G, Frotscher M, Herz J, Bock HH, May P, The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. Development. 2014 Dec;141(23):4513-25
3*	J:28325 Overbergh L, Lorent K, Torrekens S, Van Leuven F, Van den Berghe H, Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy. J Lipid Res. 1995 Aug;36(8):1774-86
2*	J:144146 Roebroek AJ, Reekmans S, Lauwers A, Feyaerts N, Smeijers L, Hartmann D, Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol. 2006 Jan;26(2):605-16
1	J:154113 Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E, Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell. 2009 Oct 2;5(4):409-19
2	J:232997 Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A, Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation. Glia. 2016 Aug;64(8):1363-80
3*	J:142399 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Muller U, van Leuven F, Lutjohann D, Walter J, Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci. 2008 Nov 12;28(46):12097-106
6*	J:33753 Teesalu T, Blasi F, Talarico D, Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes. Mech Dev. 1996 May;56(1-2):103-16
5	J:49265 Teesalu T, Blasi F, Talarico D, Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development. Dev Dyn. 1998 Sep;213(1):27-38
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:28328 Umans L, Serneels L, Overbergh L, Lorent K, Van Leuven F, Van den Berghe H, Targeted inactivation of the mouse alpha 2-macroglobulin gene. J Biol Chem. 1995 Aug 25;270(34):19778-85
2	J:310647 Wang F, Wang Q, Liu B, Mei L, Ma S, Wang S, Wang R, Zhang Y, Niu C, Xiong Z, Zheng Y, Zhang Z, Shi J, Song X, The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. Cell Death Differ. 2021 Sep;28(9):2634-2650