Gene Expression Literature Summary

• Symbol: Lyz1
• Name: lysozyme 1
• ID: MGI:96902

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)				1			1		1	25
In situ RNA (section)				1
Western blot										2
RT-PCR	1	1	1		1	1	1	3	5	6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lyz1  lysozyme 1   (Synonyms: Lyz, Lzp-s, renal amyloidosis)
Results	Reference
2	J:151206 Babeu JP, Darsigny M, Lussier CR, Boudreau F, Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G124-34
1*	J:171712 Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, Hooper SB, Cole TJ, cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
1	J:329985 Chae SA, Son JS, de Avila JM, Du M, Zhu MJ, Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 3;
1	J:245870 Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J, YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme. Dev Cell. 2017 Oct 09;43(1):35-47.e4
1	J:284756 Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, Lindahl M, Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Front Endocrinol (Lausanne). 2019;10:765
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:184887 Du A, McCracken KW, Walp ER, Terry NA, Klein TJ, Han A, Wells JM, May CL, Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012 May 1;365(1):175-88
2	J:224084 Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH, Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development. 2015 Jun 15;142(12):2163-72
3	J:242903 Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM, Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 Jul 01;144(13):2517-2528
1	J:312814 Fernandez Vallone V, Leprovots M, Ribatallada-Soriano D, Gerbier R, Lefort A, Libert F, Vassart G, Garcia MI, LGR5 controls extracellular matrix production by stem cells in the developing intestine. EMBO Rep. 2020 Jul 3;21(7):e49224
1	J:285930 Fritsch M, Gunther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Kronke M, Pasparakis M, Kashkar H, Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019 Nov;575(7784):683-687
1*	J:150374 Garcia MI, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G, LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol. 2009 Jul 1;331(1):58-67
1	J:154852 Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H, The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009 Oct;137(4):1333-45.e1-3
2	J:283354 Guiu J, Hannezo E, Yui S, Demharter S, Ulyanchenko S, Maimets M, Jorgensen A, Perlman S, Lundvall L, Mamsen LS, Larsen A, Olesen RH, Andersen CY, Thuesen LL, Hare KJ, Pers TH, Khodosevich K, Simons BD, Jensen KB, Tracing the origin of adult intestinal stem cells. Nature. 2019 Jun;570(7759):107-111
1	J:137419 Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J, Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol. 2008 Jul 15;181(2):1143-52
1	J:239820 Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM, Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017 Feb 01;127(2):593-607
1	J:284576 Kim JE, Fei L, Yin WC, Coquenlorge S, Rao-Bhatia A, Zhang X, Shi SSW, Lee JH, Hahn NA, Rizvi W, Kim KH, Sung HK, Hui CC, Guo G, Kim TH, Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun. 2020 Jan 17;11(1):334
1*	J:212415 Kinzel B, Pikiolek M, Orsini V, Sprunger J, Isken A, Zietzling S, Desplanches M, Dubost V, Breustedt D, Valdez R, Liu D, Theil D, Muller M, Dietrich B, Bouwmeester T, Ruffner H, Tchorz JS, Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
1	J:233975 Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA, Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget. 2015 Nov 10;6(35):37906-18
1	J:321068 Maimets M, Pedersen MT, Guiu J, Dreier J, Thodberg M, Antoku Y, Schweiger PJ, Rib L, Bressan RB, Miao Y, Garcia KC, Sandelin A, Serup P, Jensen KB, Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling. Nat Commun. 2022 Feb 7;13(1):715
1	J:255932 Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J, Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. Nat Commun. 2017 Nov 28;8(1):1819
1*	J:127437 Metzger M, Conrad S, Alvarez-Bolado G, Skutella T, Just L, Gene expression of the repulsive guidance molecules during development of the mouse intestine. Dev Dyn. 2005 Sep;234(1):169-75
1	J:261627 Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, Takumi T, Yokota Y, Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5. Mol Cell Biol. 2018 Feb 20;
1	J:205646 Muncan V, Heijmans J, Krasinski SD, Buller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. Nat Commun. 2011;2:452
2*	J:173765 Mustata RC, Van Loy T, Lefort A, Libert F, Strollo S, Vassart G, Garcia MI, Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep. 2011 Jun;12(6):558-64
1	J:240000 Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S, The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46
1	J:298990 Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N, Bohio AA, Nagi FH, Feng X, Zhang L, Zheng Y, Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
1*	J:252991 Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, Ding H, Loss of HLTF function promotes intestinal carcinogenesis. Mol Cancer. 2012 Mar 27;11:18
2	J:165742 VanDussen KL, Samuelson LC, Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol. 2010 Oct 15;346(2):215-23
1	J:305498 Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W, LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death Dis. 2020 Jul 27;11(7):588
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678
1	J:240239 Weis VG, Knowles BC, Choi E, Goldstein AE, Williams JA, Manning EH, Roland JT, Lapierre LA, Goldenring JR, Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016 Feb 01;2(2):131-157
7	J:344311 Yan W, Chen S, Wang Y, You Y, Lu Y, Wang W, Wu B, Du J, Peng S, Cai W, Xiao Y, Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
2	J:256638 Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, Ueno H, Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity. Sci Rep. 2017 Aug 31;7(1):9891
2	J:215917 Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N, TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014 Sep 1;33(17):1882-95
1	J:336753 Zinina VV, Sauer M, Nigmatullina L, Kreim N, Soshnikova N, TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine. Cells. 2023 May 23;12(11)