Gene Expression Literature Summary

• Symbol: Kmt2a
• Name: lysine (K)-specific methyltransferase 2A
• ID: MGI:96995

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E18	E	P
Immunohistochemistry (section)													1		1				1
In situ RNA (section)							1				1			1		1	1		1		2	1		5
In situ RNA (whole mount)												1								2
In situ reporter (knock in)												2			1
Western blot												1	1										2
RT-PCR	2	2	2	2	2	2		1	1	3		1	2		1				1				1	4
cDNA clones														1				1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kmt2a  lysine (K)-specific methyltransferase 2A   (Synonyms: All1, ALL-1, Cxxc7, HTRX1, Mll, Mll1, trithorax Drosophila)
Results	Reference
3	J:71498 Ayton P, Sneddon SF, Palmer DB, Rosewell IR, Owen MJ, Young B, Presley R, Subramanian V, Truncation of the MLL gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. Genesis. 2001 Aug;30(4):201-12
6*	J:238674 Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SE, Huntly BJ, Ottersbach K, Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development. Cell Rep. 2016 Jul 26;16(4):1039-54
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
4	J:278101 Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S, MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep. 2018 Aug 9;8(1):11902
7	J:203762 Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME, Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
1	J:239907 Fulcoli FG, Franzese M, Liu X, Zhang Z, Angelini C, Baldini A, Rebalancing gene haploinsufficiency in vivo by targeting chromatin. Nat Commun. 2016 Jun 03;7:11688
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:338694 Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski J, Jerome-Majewska LA, Sf3b4 regulates chromatin remodeler splicing and Hox expression. Differentiation. 2023 May-Jun;131:59-73
1	J:149811 McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ, Kioussis D, Williams O, Brady HJ, Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal. Cell Stem Cell. 2007 Sep 13;1(3):338-45
7	J:215367 Shao GB, Chen JC, Zhang LP, Huang P, Lu HY, Jin J, Gong AH, Sang JR, Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
1	J:201612 Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ, HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013 Jul 1;123(7):3154-65
5	J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1	J:48502 Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T, Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood. 1998 Jul 1;92(1):108-17
1	J:207555 Yokoyama A, Ficara F, Murphy MJ, Meisel C, Hatanaka C, Kitabayashi I, Cleary ML, MLL becomes functional through intra-molecular interaction not by proteolytic processing. PLoS One. 2013;8(9):e73649
1	J:183048 Yokoyama A, Ficara F, Murphy MJ, Meisel C, Naresh A, Kitabayashi I, Cleary ML, Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci. 2011 Jul 1;124(Pt 13):2208-19
1*	J:49977 Yu BD, Hanson RD, Hess JL, Horning SE, Korsmeyer SJ, MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10632-6
4	J:29958 Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ, Altered Hox expression and segmental identity in Mll-mutant mice. Nature. 1995 Nov 30;378(6556):505-8
3	J:313616 Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen CD, Guo S, Zhang D, Zhao D, Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Front Cell Dev Biol. 2021;9:642931
1	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247