Gene Expression Literature Summary

• Symbol: Ndst2
• Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
• ID: MGI:97040

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E10	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E17	E17.5	P
In situ RNA (section)						1	1		2			1			2
RT-PCR	1	1	1	1	1	1	1	2		1	1	2	1	1	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ndst2  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2   (Synonyms: glucosaminyl N-deacetylase/N-sulphotransferase-2, [Heparan sulfate]-glucosamine N-sulfotransferase, Mndns)
Results	Reference
5*	J:67535 Aikawa J, Grobe K, Tsujimoto M, Esko JD, Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. J Biol Chem. 2001 Feb 23;276(8):5876-82
1	J:297362 Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A, Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59
1*	J:178840 Dagalv A, Holmborn K, Kjellen L, Abrink M, Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem. 2011 Dec 30;286(52):44433-40
3*	J:81601 Ford-Perriss M, Guimond SE, Greferath U, Kita M, Grobe K, Habuchi H, Kimata K, Esko JD, Murphy M, Turnbull JE, Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology. 2002 Nov;12(11):721-7
1	J:150516 Hu Z, Wang C, Xiao Y, Sheng N, Chen Y, Xu Y, Zhang L, Mo W, Jing N, Hu G, NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. J Cell Sci. 2009 Apr 15;122(Pt 8):1145-54
3	J:316276 Liu C, Gu S, Sun C, Ye W, Song Z, Zhang Y, Chen Y, FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing beta-catenin signaling. Development. 2013 Nov;140(21):4375-85
1	J:138557 Pallerla SR, Lawrence R, Lewejohann L, Pan Y, Fischer T, Schlomann U, Zhang X, Esko JD, Grobe K, Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem. 2008 Jun 13;283(24):16885-94
1	J:119651 Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X, Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec;133(24):4933-44
2	J:353621 Patel VN, Aure MH, Choi SH, Ball JR, Lane ED, Wang Z, Xu Y, Zheng C, Liu X, Martin D, Pailin JY, Prochazkova M, Kulkarni AB, van Kuppevelt TH, Ambudkar IS, Liu J, Hoffman MP, Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
1	J:320380 Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, van Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP, Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Matrix Biol. 2021 Sep;103-104:37-57
3	J:283457 Uijtdewilligen PJE, Versteeg EM, van de Westerlo EMA, van der Vlag J, Daamen WF, van Kuppevelt TH, Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Biomed Res Int. 2018;2018:9873471
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4*	J:103005 Yabe T, Hata T, He J, Maeda N, Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Glycobiology. 2005 Oct;15(10):982-93