Gene Expression Literature Summary

• Symbol: Mrc1
• Name: mannose receptor, C type 1
• ID: MGI:97142

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)	1	2	7	4	9	7	5	6	1	5	4	5		18
Immunohistochemistry (whole mount)					1		1						1	3
In situ RNA (whole mount)		1		1
Western blot														1
RT-PCR						1	1	2						4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mrc1  mannose receptor, C type 1   (Synonyms: CD206, MR)
Results	Reference
1	J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
2	J:312416 Bhattacharjee O, Ayyangar U, Kurbet AS, Lakshmanan V, Palakodeti D, Ginhoux F, Raghavan S, Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Front Immunol. 2021;12:718005
3	J:334326 Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M, A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 Feb 8;
2	J:306023 Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK, A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 May 27;184(11):3056-3074.e21
2	J:211622 DeFalco T, Bhattacharya I, Williams AV, Sams DM, Capel B, Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
1	J:228958 Dieterich LC, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, Shin JW, Hamada M, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M, DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. Cell Rep. 2015 Nov 17;13(7):1493-504
1*	J:260124 Goldmann T, Wieghofer P, Jordao MJ, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FM, Bechmann I, Kerschensteiner M, Linnarsson S, Jung S, Prinz M, Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol. 2016 Jul;17(7):797-805
1	J:302563 Gula G, Ruminski S, Niderla-Bielinska J, Jasinska A, Kiernozek E, Jankowska-Steifer E, Flaht-Zabost A, Ratajska A, Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling. Histochem Cell Biol. 2021 Jan;155(1):117-132
5*	J:333946 Hattori Y, Kato D, Murayama F, Koike S, Asai H, Yamasaki A, Naito Y, Kawaguchi A, Konishi H, Prinz M, Masuda T, Wake H, Miyata T, CD206(+) macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia. Cell Rep. 2023 Feb 7;42(2):112092
2	J:287499 Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A, Miyata T, Transient microglial absence assists postmigratory cortical neurons in proper differentiation. Nat Commun. 2020 Apr 2;11(1):1631
6	J:329324 Hosseini S, Moody SC, Fietz D, Indumathy S, Schuppe HC, Hedger MP, Loveland KL, The changing landscape of immune cells in the fetal mouse testis. Histochem Cell Biol. 2022 Oct;158(4):345-368
3	J:176703 Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD, Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice. Biol Reprod. 2011 Sep;85(3):626-34
1	J:185213 Jaiswal MK, Mallers TM, Larsen B, Kwak-Kim J, Chaouat G, Gilman-Sachs A, Beaman KD, V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012 May;143(5):713-25
1	J:253079 Konishi H, Kobayashi M, Kunisawa T, Imai K, Sayo A, Malissen B, Crocker PR, Sato K, Kiyama H, Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes. Glia. 2017 Dec;65(12):1927-1943
3	J:306875 Lakhia R, Yheskel M, Flaten A, Ramalingam H, Aboudehen K, Ferre S, Biggers L, Mishra A, Chaney C, Wallace DP, Carroll T, Igarashi P, Patel V, Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression. JCI Insight. 2020 Apr 9;5(7)
1	J:310641 Li C, Konishi H, Nishiwaki K, Sato K, Miyata T, Kiyama H, A mouse model of microglia-specific ablation in the embryonic central nervous system. Neurosci Res. 2021 Jun 23;
1	J:317364 Li SY, Gu X, Heinrich A, Hurley EG, Capel B, DeFalco T, Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis. Biol Reprod. 2021 Oct 11;105(4):958-975
2*	J:56240 Lichanska AM, Browne CM, Henkel GW, Murphy KM, Ostrowski MC, McKercher SR, Maki RA, Hume DA, Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. Blood. 1999 Jul 1;94(1):127-38
1	J:333829 Lopez-Tello J, Sferruzzi-Perri AN, Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770
6	J:330324 Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernandez-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lammermann T, Priller J, Kierdorf K, Prinz M, Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748
1	J:354190 Morimoto K, Takahashi R, Takahashi G, Miyajima M, Nakajima K, Maternal immunoglobulins are distributed in the offspring's brain to support the maintenance of cortical interneurons in the postnatal period. Inflamm Regen. 2024 May 15;44(1):24
5	J:301549 Munro DAD, Bradford BM, Mariani SA, Hampton DW, Vink CS, Chandran S, Hume DA, Pridans C, Priller J, CNS macrophages differentially rely on an intronic Csf1r enhancer for their development. Development. 2020 Dec 15;147(23):dev194449
4	J:275137 Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA, Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development. Elife. 2019 Feb 13;8:e43271
2	J:317760 Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M, Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis. 2016 Oct;19(4):513-24
4	J:266578 Plein A, Fantin A, Denti L, Pollard JW, Ruhrberg C, Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018 Oct;562(7726):223-228
1	J:242076 Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Konigshoff M, Hind M, Minelli C, Lloyd CM, Dean CH, Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017 Apr 01;10(4):409-423
5	J:326459 Scott EP, Breyak E, Nishinakamura R, Nakagawa Y, The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos. Glia. 2022 Sep;70(9):1720-1733
4	J:272602 Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A, Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 Mar 11;48(5):617-630.e3
1	J:331695 Siret C, van Lessen M, Bavais J, Jeong HW, Reddy Samawar SK, Kapupara K, Wang S, Simic M, de Fabritus L, Tchoghandjian A, Fallet M, Huang H, Sarrazin S, Sieweke MH, Stumm R, Sorokin L, Adams RH, Schulte-Merker S, Kiefer F, van de Pavert SA, Deciphering the heterogeneity of the Lyve1(+) perivascular macrophages in the mouse brain. Nat Commun. 2022 Nov 30;13(1):7366
1	J:343278 Subileau M, Vittet D, Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):7
10*	J:48210 Takahashi K, Donovan MJ, Rogers RA, Ezekowitz RA, Distribution of murine mannose receptor expression from early embryogenesis through to adulthood. Cell Tissue Res. 1998 May;292(2):311-23
4	J:292317 Utz SG, See P, Mildenberger W, Thion MS, Silvin A, Lutz M, Ingelfinger F, Rayan NA, Lelios I, Buttgereit A, Asano K, Prabhakar S, Garel S, Becher B, Ginhoux F, Greter M, Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development. Cell. 2020 Apr 30;181(3):557-573.e18
1	J:324688 Van Deren DA, De S, Xu B, Eschenbacher KM, Zhang S, Capecchi MR, Defining the Hoxb8 cell lineage during murine definitive hematopoiesis. Development. 2022 Apr 15;149(8):dev200200
2	J:172805 Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S, Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011;12:204
1	J:296348 Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T, Takahashi H, Takano KI, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M, A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Sci Rep. 2017 Jun 20;7(1):3855