Gene Expression Literature Summary

• Symbol: Mt1
• Name: metallothionein 1
• ID: MGI:97171

34 matching records from 34 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1.5	E2.5	E3.5	E5.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)												1		1		1							1	1	4
In situ RNA (section)							1							1				4		1	1		1		4
In situ RNA (whole mount)				1
Northern blot				1	1	1	1		1		1		2	4	1	5		2	3	1	2			1	8
Western blot																								1	2
RT-PCR	1	1	1	2				1		2	1	1	1	2	2	5	1	4	2	2	1	1	3		9
RNase protection																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mt1  metallothionein 1   (Synonyms: Mt-1, MT-I)
Results	Reference
2*	J:290843 Andrews GK, Adamson ED, Gedamu L, The ontogeny of expression of murine metallothionein: comparison with the alpha-fetoprotein gene. Dev Biol. 1984 Jun;103(2):294-303
4*	J:35219 Andrews GK, Huet-Hudson YM, Paria BC, McMaster MT, De SK, Dey SK, Metallothionein gene expression and metal regulation during preimplantation mouse embryo development (MT mRNA during early development). Dev Biol. 1991 May;145(1):13-27
4	J:67892 Andrews GK, Lee DK, Ravindra R, Lichtlen P, Sirito M, Sawadogo M, Schaffner W, The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 2001 Mar 1;20(5):1114-22
1*	J:252376 Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC, The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017 Dec 1;26(23):4617-4628
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:254216 Bin BH, Bhin J, Takaishi M, Toyoshima KE, Kawamata S, Ito K, Hara T, Watanabe T, Irie T, Takagishi T, Lee SH, Jung HS, Rho S, Seo J, Choi DH, Hwang D, Koseki H, Ohara O, Sano S, Tsuji T, Mishima K, Fukada T, Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248
2	J:187177 Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH, Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012 Jun;8(6):e1002770
4*	J:32998 Choudhuri S, Liu WL, Berman NE, Klaassen CD, Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicol Lett. 1996 Mar;84(3):127-33
1	J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
8*	J:287014 De SK, McMaster MT, Dey SK, Andrews GK, Cell-specific metallothionein gene expression in mouse decidua and placentae. Development. 1989 Nov;107(3):611-21
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:108627 Dufner-Beattie J, Huang ZL, Geiser J, Xu W, Andrews GK, Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis. 2006 May;44(5):239-51
11*	J:87178 Dufner-Beattie J, Langmade SJ, Wang F, Eide D, Andrews GK, Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
1*	J:225226 Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ, HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
5	J:126725 Fernandez EL, Dencker L, Tallkvist J, Expression of ZnT-1 (Slc30a1) and MT-1 (Mt1) in the conceptus of cadmium treated mice. Reprod Toxicol. 2007 Nov-Dec;24(3-4):353-8
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:48216 Gunes C, Heuchel R, Georgiev O, Muller KH, Lichtlen P, Bluthmann H, Marino S, Aguzzi A, Schaffner W, Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998 May 15;17(10):2846-54
5*	J:110614 Huang ZL, Dufner-Beattie J, Andrews GK, Expression and regulation of SLC39A family zinc transporters in the developing mouse intestine. Dev Biol. 2006 Jul 15;295(2):571-9
3	J:245044 Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A, ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016 Jan;19(1):53-65
1	J:218509 Kim HJ, Ryu J, Woo HM, Cho SS, Sung MK, Kim SC, Park MH, Park T, Koo SK, Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
3	J:189599 Kumar SD, Vijaya M, Samy RP, Dheen ST, Ren M, Watt F, Kang YJ, Bay BH, Tay SS, Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice. Free Radic Biol Med. 2012 Oct 15;53(8):1595-606
9	J:311844 Landin MA, Nygard S, Shabestari MG, Babaie E, Reseland JE, Osmundsen H, Mapping the global mRNA transcriptome during development of the murine first molar. Front Genet. 2015;6:47
1*	J:65477 Langmade SJ, Ravindra R, Daniels PJ, Andrews GK, The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem. 2000 Nov 3;275(44):34803-9
4	J:53230 Lau JC, Cherian MG, Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. Biochem Cell Biol. 1998;76(4):615-23
3*	J:31252 Lee DK, Fu K, Liang L, Dalton T, Palmiter RD, Andrews GK, Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro. Mol Reprod Dev. 1996 Feb;43(2):158-66
3	J:93106 Lee J, Park J, Jang B, Knudsen TB, Altered expression of genes related to zinc homeostasis in early mouse embryos exposed to di-2-ethylhexyl phthalate. Toxicol Lett. 2004 Aug 30;152(1):1-10
9*	J:30590 Liang L, Fu K, Lee DK, Sobieski RJ, Dalton T, Andrews GK, Activation of the complete mouse metallothionein gene locus in the maternal deciduum. Mol Reprod Dev. 1996 Jan;43(1):25-37
1*	J:119141 Mandel S, Rechavi G, Gozes I, Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol. 2007 Mar 15;303(2):814-24
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
2	J:164957 Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H, Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. Am J Respir Crit Care Med. 2009 Aug 15;180(4):326-38
1	J:164377 Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ, Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62
1	J:118123 Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP, Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. Toxicol Sci. 2007 Feb;95(2):313-20
6*	J:240319 Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A, Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188
1	J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8