Gene Expression Literature Summary

• Symbol: Myf6
• Name: myogenic factor 6
• ID: MGI:97253

76 matching records from 76 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)				2	2	2		3		1		1		1											1	2
In situ RNA (section)			2	2	2	4	2	4	1	3	1		1	2	1	3	1	4	1	1		3	2		1	3
In situ RNA (whole mount)				1	3	8	7	8	1	2		1		1		1		2		1			1		3	1
In situ reporter (knock in)								3		2		1		1		1		1				1				2
Northern blot											1		1		1				1					1	1	5
RT-PCR	1	1	2	3	1	2	1	8	3	6		3	3	4	1	5	2	1	1	2	4		9		2	17
cDNA clones						1																				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Myf6  myogenic factor 6   (Synonyms: bHLHc4, herculin, MRF4)
Results	Reference
1	J:74656 Andree B, Fleige A, Arnold HH, Brand T, Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Mol Cell Biol. 2002 Mar;22(5):1504-12
1	J:112275 Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME, A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev. 2006 Sep 1;20(17):2450-64
1	J:40477 Baker RK, Haendel MA, Swanson BJ, Shambaugh JC, Micales BK, Lyons GE, In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
1*	J:245730 Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L, Pourquie O, The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818
1	J:42573 Berk M, Desai SY, Heyman HC, Colmenares C, Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes Dev. 1997 Aug 15;11(16):2029-39
8*	J:37014 Block NE, Zhu Z, Kachinsky AM, Dominov JA, Miller JB, Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice. Dev Dyn. 1996 Dec;207(4):382-94
19*	J:40340 Bober E, Lyons GE, Braun T, Cossu G, Buckingham M, Arnold HH, The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development. J Cell Biol. 1991 Jun;113(6):1255-65
1	J:193353 Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombes M, Dandolo L, Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression. FASEB J. 2012 Nov;26(11):4584-91
2*	J:24360 Braun T, Arnold HH, Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. EMBO J. 1995 Mar 15;14(6):1176-86
1*	J:21616 Braun T, Bober E, Rudnicki MA, Jaenisch R, Arnold HH, MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development. 1994 Nov;120(11):3083-92
1	J:116769 Buckingham M, Bajard L, Daubas P, Esner M, Lagha M, Relaix F, Rocancourt D, Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential. Anat Embryol (Berl). 2006 Dec;211 Suppl 7:51-6
1	J:228101 Comai G, Sambasivan R, Gopalakrishnan S, Tajbakhsh S, Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Dev Cell. 2014 Dec 8;31(5):654-67
1	J:206594 Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS, A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
1*	J:127524 Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH, Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol. 2007 Nov 15;311(2):650-64
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:101765 Echizenya M, Kondo S, Takahashi R, Oh J, Kawashima S, Kitayama H, Takahashi C, Noda M, The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Oncogene. 2005 Sep 1;24(38):5850-7
2	J:260112 Filipova D, Henry M, Rotshteyn T, Brunn A, Carstov M, Deckert M, Hescheler J, Sachinidis A, Pfitzer G, Papadopoulos S, Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428
3*	J:134484 Gensch N, Borchardt T, Schneider A, Riethmacher D, Braun T, Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development. 2008 May;135(9):1597-604
2	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
1*	J:235368 Gomez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acin-Perez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jimenez-Alcazar M, Segales J, Lopez-Maderuelo D, Ornes B, Jimenez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Munoz-Canoves P, Redondo JM, The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10;23(5):881-92
2	J:119948 Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX, Maire P, Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16
1	J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:98557 Haines BP, Gupta R, Michael Jones C, Summerbell D, Rigby PW, The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Dev Biol. 2005 May 15;281(2):145-59
6	J:133338 Haldar M, Karan G, Tvrdik P, Capecchi MR, Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell. 2008 Mar;14(3):437-45
9*	J:767 Hannon K, Smith CK 2nd, Bales KR, Santerre RF, Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo. Dev Biol. 1992 May;151(1):137-44
1	J:177323 Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K, G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. J Exp Med. 2011 Apr 11;208(4):715-27
1	J:213153 Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P, Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
1*	J:14208 Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH, Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene [see comments]. Nature. 1993 Aug 5;364(6437):501-6
11	J:35221 Hinterberger TJ, Sassoon DA, Rhodes SJ, Konieczny SF, Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development. Dev Biol. 1991 Sep;147(1):144-56
1	J:191162 Issa ME, Muruganandan S, Ernst MC, Parlee SD, Zabel BA, Butcher EC, Sinal CJ, Goralski KB, Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1621-31
4	J:92799 Kassar-Duchossoy L, Gayraud-Morel B, Gomes D, Rocancourt D, Buckingham M, Shinin V, Tajbakhsh S, Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature. 2004 Sep 23;431(7007):466-71
2*	J:98918 Kassar-Duchossoy L, Giacone E, Gayraud-Morel B, Jory A, Gomes D, Tajbakhsh S, Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev. 2005 Jun 15;19(12):1426-31
1	J:63517 Kaul A, Koster M, Neuhaus H, Braun T, Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell. 2000 Jul 7;102(1):17-9
1*	J:93444 Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR, Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26
1*	J:24348 Kelly R, Alonso S, Tajbakhsh S, Cossu G, Buckingham M, Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice. J Cell Biol. 1995 Apr;129(2):383-96
1	J:245768 Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L, HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561
5*	J:43635 Laurent A, Pinset C, Aurade F, Vidaud M, Montarras D, Expression of myotonic dystrophy protein kinase gene during in vivo and in vitro mouse myogenesis. Cell Mol Biol (Noisy-Le-Grand). 1997 Sep;43(6):881-8
1	J:274465 Lee HJ, Kao CY, Lin SC, Xu M, Xie X, Tsai SY, Tsai MJ, Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. Sci Rep. 2017 Jun 9;7(1):3136
1	J:301249 Lopez-Delgado AC, Delgado I, Cadenas V, Sanchez-Cabo F, Torres M, Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid. Development. 2021 Jan 4;148(1):dev193813
4*	J:39444 Montarras D, Chelly J, Bober E, Arnold H, Ott MO, Gros F, Pinset C, Developmental patterns in the expression of Myf5, MyoD, myogenin, and MRF4 during myogenesis. New Biol. 1991 Jun;3(6):592-600
2	J:229482 Nagandla H, Lopez S, Yu W, Rasmussen TL, Tucker HO, Schwartz RJ, Stewart MD, Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1. Dev Biol. 2016 Feb 1;410(1):86-97
1	J:297035 Nie Y, Cai S, Yuan R, Ding S, Zhang X, Chen L, Chen Y, Mo D, Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis. Cell Death Differ. 2020 May;27(5):1644-1659
2	J:204551 Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB, A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013 Aug 26;26(4):393-404
1	J:92241 Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP, Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Mol Cell Biol. 2004 Aug;24(16):7102-12
2	J:12879 Patapoutian A, Miner JH, Lyons GE, Wold B, Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice. Development. 1993 May;118(1):61-9
5*	J:29279 Patapoutian A, Yoon JK, Miner JH, Wang S, Stark K, Wold B, Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 1995 Oct;121(10):3347-58
1	J:129041 Potthoff MJ, Arnold MA, McAnally J, Richardson JA, Bassel-Duby R, Olson EN, Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007 Dec;27(23):8143-51
2	J:29672 Rawls A, Morris JH, Rudnicki M, Braun T, Arnold HH, Klein WH, Olson EN, Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis. Dev Biol. 1995 Nov;172(1):37-50
1*	J:48809 Rawls A, Valdez MR, Zhang W, Richardson J, Klein WH, Olson EN, Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development. 1998 Jul;125(13):2349-58
3	J:85950 Roth JF, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, Wittwer J, Schorle H, Gassmann M, Eckner R, Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003 Oct 1;22(19):5186-96
6	J:200727 Sambasivan R, Comai G, Le Roux I, Gomes D, Konge J, Dumas G, Cimper C, Tajbakhsh S, Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4. Dev Biol. 2013 Sep 1;381(1):241-55
2	J:150130 Sambasivan R, Gayraud-Morel B, Dumas G, Cimper C, Paisant S, Kelly R, Tajbakhsh S, Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell. 2009 Jun;16(6):810-21
6	J:119082 Schuster-Gossler K, Cordes R, Gossler A, Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):537-42
1	J:138823 Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM, PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
1*	J:104893 Seo KW, Wang Y, Kokubo H, Kettlewell JR, Zarkower DA, Johnson RL, Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Dev Biol. 2006 Feb 1;290(1):200-10
1*	J:168863 Shi X, Bowlin KM, Garry DJ, Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors. Stem Cells. 2010 Mar 31;28(3):462-9
4*	J:20949 Smith TH, Kachinsky AM, Miller JB, Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins. J Cell Biol. 1994 Oct;127(1):95-105
4*	J:79189 Summerbell D, Halai C, Rigby P, Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. Mech Dev. 2002 Sep;117(1-2):331
2	J:272614 Suzuki A, Minamide R, Iwata J, WNT/beta-catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development. Development. 2018 Nov 27;145(23):dev168351
1*	J:30348 Tajbakhsh S, Buckingham ME, Lineage restriction of the myogenic conversion factor myf-5 in the brain. Development. 1995 Dec;121(12):4077-83
3*	J:330271 Tekko T, Lozovska A, Novoa A, Mallo M, Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos. Dev Dyn. 2022 Oct;251(10):1698-1710
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:61155 Valdez MR, Richardson JA, Klein WH, Olson EN, Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol. 2000 Mar 15;219(2):287-98
5	J:160309 Vinagre T, Moncaut N, Carapuco M, Novoa A, Bom J, Mallo M, Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains. Dev Cell. 2010 Apr 20;18(4):655-61
2	J:186268 Vincent SD, Mayeuf A, Niro C, Saitou M, Buckingham M, Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo. Mol Biol Evol. 2012 Oct;29(10):3181-91
1	J:54065 Vivian JL, Gan L, Olson EN, Klein WH, A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 1;208(1):44-55
3*	J:297665 Wood WM, Otis C, Etemad S, Goldhamer DJ, Development and patterning of rib primordia are dependent on associated musculature. Dev Biol. 2020 Dec 1;468(1-2):133-145
5*	J:63331 Yamane A, Mayo M, Shuler C, Crowe D, Ohnuki Y, Dalrymple K, Saeki Y, Expression of myogenic regulatory factors during the development of mouse tongue striated muscle. Arch Oral Biol. 2000 Jan;45(1):71-8
5*	J:74099 Yamane A, Ohnuki Y, Saeki Y, Delayed embryonic development of mouse masseter muscle correlates with delayed MyoD family expression. J Dent Res. 2000 Dec;79(12):1933-6
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:62914 Yoon JK, Moon RT, Wold B, The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91
3*	J:42453 Yoon JK, Olson EN, Arnold HH, Wold BJ, Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus. Dev Biol. 1997 Aug 15;188(2):349-62
2	J:26105 Zhang W, Behringer RR, Olson EN, Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99
11*	J:64537 Zhao W, Dhoot GK, Skeletal muscle precursors in mouse esophagus are determined during early fetal development. Dev Dyn. 2000 Sep;219(1):10-20
1	J:314139 Zhu Q, Liang F, Cai S, Luo X, Duo T, Liang Z, He Z, Chen Y, Mo D, KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors. Cell Death Dis. 2021 May 19;12(6):514