Gene Expression Literature Summary

• Symbol: Myhc
• Name: myosin heavy chain, cardiac muscle complex
• ID: MGI:97254

28 matching records from 28 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)	1	2	4	5	8	4	4	4	1	5	9
In situ RNA (section)			1
Immunohistochemistry (whole mount)					1			2		2
In situ RNA (whole mount)				1
Western blot		1		1			2			2	4
RT-PCR		1		1			1	1	1	3	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Myhc  myosin heavy chain, cardiac muscle complex
Results	Reference
3	J:262618 Aldeiri B, Roostalu U, Albertini A, Behnsen J, Wong J, Morabito A, Cossu G, Abrogation of TGF-beta signalling in TAGLN expressing cells recapitulates Pentalogy of Cantrell in the mouse. Sci Rep. 2018 Feb 26;8(1):3658
1	J:251794 Antony N, McDougall AR, Mantamadiotis T, Cole TJ, Bird AD, Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms. Sci Rep. 2016 May 6;6:25569
2	J:253754 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG, Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016 May 6;6:25541
2	J:213517 Azzoni E, Conti V, Campana L, Dellavalle A, Adams RH, Cossu G, Brunelli S, Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo. Development. 2014 May;141(9):1821-34
1	J:195548 Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y, Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621
12	J:196361 Cappellari O, Benedetti S, Innocenzi A, Tedesco FS, Moreno-Fortuny A, Ugarte G, Lampugnani MG, Messina G, Cossu G, Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013 Mar 25;24(6):586-99
5	J:131962 Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6
2	J:309485 Colasanto MP, Eyal S, Mohassel P, Bamshad M, Bonnemann CG, Zelzer E, Moon AM, Kardon G, Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3. Dis Model Mech. 2016 Nov 1;9(11):1257-1269
2	J:197449 Coles GL, Ackerman KG, Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
7	J:228101 Comai G, Sambasivan R, Gopalakrishnan S, Tajbakhsh S, Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Dev Cell. 2014 Dec 8;31(5):654-67
7	J:225351 Gopalakrishnan S, Comai G, Sambasivan R, Francou A, Kelly RG, Tajbakhsh S, A Cranial Mesoderm Origin for Esophagus Striated Muscles. Dev Cell. 2015 Sep 28;34(6):694-704
2	J:217688 Haldar M, Karan G, Watanabe S, Guenther S, Braun T, Capecchi MR, Response: Contributions of the Myf5-independent lineage to myogenesis. Dev Cell. 2014 Dec 8;31(5):539-41
1	J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
2	J:150129 Harel I, Nathan E, Tirosh-Finkel L, Zigdon H, Guimaraes-Camboa N, Evans SM, Tzahor E, Distinct origins and genetic programs of head muscle satellite cells. Dev Cell. 2009 Jun;16(6):822-32
1	J:259618 Hatazawa Y, Ono Y, Hirose Y, Kanai S, Fujii NL, Machida S, Nishino I, Shimizu T, Okano M, Kamei Y, Ogawa Y, Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. FASEB J. 2018 Mar;32(3):1452-1467
4	J:212089 Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V, The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2472-81
1	J:314107 Ito K, Schneeberger M, Gerber A, Jishage M, Marchildon F, Maganti AV, Cohen P, Friedman JM, Roeder RG, Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes Dev. 2021 May 1;35(9-10):729-748
2	J:167712 Mathew SJ, Hansen JM, Merrell AJ, Murphy MM, Lawson JA, Hutcheson DA, Hansen MS, Angus-Hill M, Kardon G, Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development. 2011 Jan;138(2):371-84
1	J:303562 Park YK, Lee JE, Yan Z, McKernan K, O'Haren T, Wang W, Peng W, Ge K, Interplay of BAF and MLL4 promotes cell type-specific enhancer activation. Nat Commun. 2021 Mar 12;12(1):1630
1	J:199127 Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB, Swanson MS, Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Hum Mol Genet. 2013 Sep 1;22(17):3547-58
4	J:342315 Rao J, Djeffal Y, Chal J, Marchiano F, Wang CH, Al Tanoury Z, Gapon S, Mayeuf-Louchart A, Glass I, Sefton EM, Habermann B, Kardon G, Watt FM, Tseng YH, Pourquie O, Reconstructing human brown fat developmental trajectory in vitro. Dev Cell. 2023 Nov 6;58(21):2359-2375.e8
1	J:140299 Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K, Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res. 2007 Aug 3;101(3):277-85
1	J:63121 Svensson EC, Huggins GS, Lin H, Clendenin C, Jiang F, Tufts R, Dardik FB, Leiden JM, A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000 Jul;25(3):353-6
1	J:162596 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J, TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010 Apr 30;285(18):13721-35
1*	J:228946 Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, Chen L, Xie Z, Lu Y, Feng Y, SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57
3	J:204000 Wood WM, Etemad S, Yamamoto M, Goldhamer DJ, MyoD-expressing progenitors are essential for skeletal myogenesis and satellite cell development. Dev Biol. 2013 Dec 1;384(1):114-27
1*	J:299546 Yahya I, Boing M, Pu Q, Puchert M, Oedemis V, Engele J, Brand-Saberi B, Morosan-Puopolo G, Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles. Sci Rep. 2020 Mar 19;10(1):5049
4	J:314139 Zhu Q, Liang F, Cai S, Luo X, Duo T, Liang Z, He Z, Chen Y, Mo D, KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors. Cell Death Dis. 2021 May 19;12(6):514