Gene Expression Literature Summary

• Symbol: Nkx2-3
• Name: NK2 homeobox 3
• ID: MGI:97348

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E17	E18	E18.5	E	P
Immunohistochemistry (section)											1		1				1
In situ RNA (section)			1	1	3		1			2				6
In situ RNA (whole mount)	1	1		1	2		1		1							1					1
In situ reporter (knock in)				1	1	2						2			1	2				2		3
RT-PCR								1	1		1	2	1		1	1	1	1	1	1		4
cDNA clones												1
RNase protection																						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-3  NK2 homeobox 3   (Synonyms: Nkx-2.3, Nkx2.3, tinman)
Results	Reference
8*	J:80726 Biben C, Wang CC, Harvey RP, NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. Int J Dev Biol. 2002;46(4):415-22
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:346457 Gao X, Mukaibo T, Wei X, Faustoferri RC, Oei MS, Hwang SK, Yan AJ, Melvin JE, Ovitt CE, Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands. Dev Biol. 2024 May;509:1-10
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:166749 Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM 3rd, Levitt P, Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32
10*	J:270680 Han X, Yoshizaki K, Miyazaki K, Arai C, Funada K, Yuta T, Tian T, Chiba Y, Saito K, Iwamoto T, Yamada A, Takahashi I, Fukumoto S, The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development. J Biol Chem. 2018 Sep 21;293(38):14572-14584
1	J:142415 Hoffman BG, Zavaglia B, Beach M, Helgason CD, Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. 2008;8:81
6*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1	J:59312 Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD, Control of endodermal endocrine development by Hes-1. Nat Genet. 2000 Jan;24(1):36-44
1*	J:181072 Kellermayer Z, Labadi A, Czompoly T, Arnold HH, Balogh P, Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen. J Histochem Cytochem. 2011 Jul;59(7):690-700
1	J:188836 Norden J, Greulich F, Rudat C, Taketo MM, Kispert A, Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50
2*	J:59199 Pabst O, Herbrand H, Takuma N, Arnold HH, NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos. Dev Genes Evol. 2000 Jan;210(1):47-50
11*	J:40049 Pabst O, Schneider A, Brand T, Arnold HH, The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev Dyn. 1997 May;209(1):29-35
1	J:345835 Qiu C, Martin BK, Welsh IC, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O'Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J, A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024 Feb;626(8001):1084-1093
1*	J:61335 Tanaka M, Yamasaki N, Izumo S, Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol Cell Biol. 2000 Apr;20(8):2874-9
8	J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48