Gene Expression Literature Summary

• Symbol: Nos2
• Name: nitric oxide synthase 2, inducible
• ID: MGI:97361

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E4.5	E7	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)						1				2	1	2	1	3	1	2	1		2		1	1	2		1	2	2			1	3			1	1	8
In situ RNA (section)									1			1		1								1			1							1				1
Immunohistochemistry (whole mount)						1		1						1	1		1		1		1								1							2
In situ RNA (whole mount)	1	1	1	1	1	1	1																													1
Northern blot																		1				1				1				1				1		1
Western blot										2		1		2		1				1		1	1	1				1					1			4
RT-PCR		1				1						2		3	1		2	2				2		1	2	2	2		2	2	2			1		13
RNase protection														1	1									1		1		1		1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nos2  nitric oxide synthase 2, inducible   (Synonyms: iNOS, Nos-2, Nos2a, NOS-II)
Results	Reference
1	J:308105 Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco MN, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P, Defining the lineage of thermogenic perivascular adipose tissue. Nat Metab. 2021 Apr;3(4):469-484
6*	J:42234 Arnhold S, Andressen C, Bloch W, Mai JK, Addicks K, NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons. Neurosci Lett. 1997 Jul 4;229(3):165-8
5*	J:96845 Arnhold S, When M, Labbe D, Andressen C, Addicks K, Transient expression of NOS-II during development of the murine enteric nervous system. J Mol Histol. 2004 Nov;35(8-9):741-8
19*	J:53873 Baylis SA, Strijbos PJ, Sandra A, Russell RJ, Rijhsinghani A, Charles IG, Weiner CP, Temporal expression of inducible nitric oxide synthase in mouse and human placenta. Mol Hum Reprod. 1999 Mar;5(3):277-86
10	J:63329 Bloch W, Fleischmann BK, Lorke DE, Andressen C, Hops B, Hescheler J, Addicks K, Nitric oxide synthase expression and role during cardiomyogenesis. Cardiovasc Res. 1999 Aug 15;43(3):675-84
1	J:229471 Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X, Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10
1	J:270087 Brokhman I, Xu J, Coles BLK, Razavi R, Engert S, Lickert H, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D, Dual embryonic origin of the mammalian enteric nervous system. Dev Biol. 2019 Jan 15;445(2):256-270
1	J:341966 Chen X, Song QL, Wang JY, Ji R, Cao ML, Guo DY, Zhang Y, Yang J, FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-kappaB signaling pathways. Free Radic Biol Med. 2023 Oct 10;209(Pt 1):55-69
5*	J:83933 Cheng A, Wang S, Cai J, Rao MS, Mattson MP, Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003 Jun 15;258(2):319-33
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
4	J:59951 Gagioti S, Scavone C, Bevilacqua E, Participation of the mouse implanting trophoblast in nitric oxide production during pregnancy. Biol Reprod. 2000 Feb;62(2):260-8
2	J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
2*	J:142881 Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ, Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol. 2009 Jan 1;182(1):636-46
1*	J:40876 Haddad EK, Duclos AJ, Lapp WS, Baines MG, Early embryo loss is associated with the prior expression of macrophage activation markers in the decidua. J Immunol. 1997 May 15;158(10):4886-92
1	J:83701 Hemberger M, Nozaki T, Masutani M, Cross JC, Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Dev Dyn. 2003 Jun;227(2):185-91
1	J:283846 Hirsch S, El-Achkar T, Robbins L, Basta J, Heitmeier M, Nishinakamura R, Rauchman M, A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury. Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F852-63
1	J:170943 Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A, Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
1*	J:43062 Hunt JS, Miller L, Vassmer D, Croy BA, Expression of the inducible nitric oxide synthase gene in mouse uterine leukocytes and potential relationships with uterine function during pregnancy. Biol Reprod. 1997 Oct;57(4):827-36
2	J:53273 Ji GJ, Fleischmann BK, Bloch W, Feelisch M, Andressen C, Addicks K, Hescheler J, Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. FASEB J. 1999 Feb;13(2):313-24
1	J:326350 Keppner A, Correia M, Santambrogio S, Koay TW, Maric D, Osterhof C, Winter DV, Clerc A, Stumpe M, Chalmel F, Dewilde S, Odermatt A, Kressler D, Hankeln T, Wenger RH, Hoogewijs D, Androglobin, a chimeric mammalian globin, is required for male fertility. Elife. 2022 Jun 14;11:e72374
1	J:152416 Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki-Migishima R, Umeki Y, Hohjoh H, Yanagawa Y, Shinba T, Itoh M, Nakamura K, Goto Y, Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet. 2009 Oct 1;18(19):3708-24
1	J:79871 Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kusaka M, Omichi K, Suzuki R, Kato-Fukui Y, Kamiirisa K, Matsuo M, Kamijo S, Kasahara M, Yoshioka H, Ogata T, Fukuda T, Kondo I, Kato M, Dobyns WB, Yokoyama M, Morohashi K, Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002 Nov;32(3):359-69
3	J:170178 Kobayashi K, Umezawa K, Yasui M, Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biol Reprod. 2011 Feb;84(2):248-54
1*	J:293091 Li Z, Li Y, Jiao J, Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24122-24132
1	J:137621 Lin IC, Smartt JM Jr, Nah HD, Ischiropoulos H, Kirschner RE, Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells. Plast Reconstr Surg. 2008 May;121(5):1554-66; discussion 1567-9
1*	J:204675 Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein JL, Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci. 2013 Oct 23;33(43):16897-914
1	J:355331 Mao Y, Meng Y, Zou K, Qin N, Wang Y, Yan J, Chen P, Cheng Y, Shi W, Zhou C, Chen H, Sheng J, Liu X, Pan J, Huang H, Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
1	J:227683 Marin O, Anderson SA, Rubenstein JL, Origin and molecular specification of striatal interneurons. J Neurosci. 2000 Aug 15;20(16):6063-76
1*	J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
1	J:101254 Miller AA, Hislop AA, Vallance PJ, Haworth SG, Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L299-306
6	J:109243 Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E, Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Development. 2004 May;131(10):2485-96
3	J:354587 Nedomova M, Haberecht-Muller S, Moller S, Venz S, Prochazkova M, Prochazka J, Sedlak F, Chawengsaksophak K, Hammer E, Kasparek P, Adamek M, Sedlacek R, Konvalinka J, Kruger E, Grantz Saskova K, DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
8	J:74206 Nishikimi A, Matsukawa T, Hoshino K, Ikeda S, Kira Y, Sato EF, Inoue M, Yamada M, Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice. Reproduction. 2001 Dec;122(6):957-63
1	J:50463 Pitman JL, Lin TP, Kleeman JE, Erickson GF, MacLeod CL, Normal reproductive and macrophage function in Pem homeobox gene-deficient mice. Dev Biol. 1998 Oct 15;202(2):196-214
1	J:242076 Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Konigshoff M, Hind M, Minelli C, Lloyd CM, Dean CH, Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017 Apr 01;10(4):409-423
4*	J:95790 Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J, Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R652-60
1	J:33809 Sanchez MP, Silos-Santiago I, Frisen J, He B, Lira SA, Barbacid M, Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):70-3
2	J:249590 Sathi GA, Farahat M, Hara ES, Taketa H, Nagatsuka H, Kuboki T, Matsumoto T, MCSF orchestrates branching morphogenesis in developing submandibular gland tissue. J Cell Sci. 2017 May 01;130(9):1559-1569
4	J:64066 Saxena D, Purohit SB, Kumer GP, Laloraya M, Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation. Nitric Oxide. 2000 Aug;4(4):384-91
1*	J:135081 Schmidt H, Stonkute A, Juttner R, Schaffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG, The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007 Oct 22;179(2):331-40
1	J:286073 Shindo R, Ohmuraya M, Komazawa-Sakon S, Miyake S, Deguchi Y, Yamazaki S, Nishina T, Yoshimoto T, Kakuta S, Koike M, Uchiyama Y, Konishi H, Kiyama H, Mikami T, Moriwaki K, Araki K, Nakano H, Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience. 2019 May 31;15:536-551
2	J:148113 Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y, Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia. 2009 May;52(5):962-71
5*	J:40205 Tai XG, Toyo-oka K, Yamamoto N, Yashiro Y, Mu J, Hamaoka T, Fujiwara H, Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes. J Immunol. 1997 May 15;158(10):4696-703
1	J:224366 Uesaka T, Nagashimada M, Enomoto H, Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System. J Neurosci. 2015 Jul 8;35(27):9879-88
1	J:269323 Vazquez P, Hernandez-Sanchez C, Escalona-Garrido C, Pereira L, Contreras C, Lopez M, Balsinde J, de Pablo F, Valverde AM, Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res. 2018 Dec;59(12):2308-2320
6	J:57952 Young HM, Ciampoli D, Hsuan J, Canty AJ, Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn. 1999 Oct;216(2):137-52
1	J:99496 Young HM, Turner KN, Bergner AJ, The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut. Cell Tissue Res. 2005 Apr;320(1):1-9
2	J:300204 Zhao H, Wong RJ, Kalish FS, Nayak NR, Stevenson DK, Effect of heme oxygenase-1 deficiency on placental development. Placenta. 2009 Oct;30(10):861-8
4	J:342401 Zhao H, Wong RJ, Stevenson DK, The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185