Gene Expression Literature Summary
|
Symbol Name ID |
Nppa
natriuretic peptide type A MGI:97367 |
| Age | E5.5 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 2 | 4 | 6 | 3 | 2 | 3 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 8 | |||||||||||||||||
| In situ RNA (section) | 1 | 1 | 1 | 3 | 5 | 20 | 1 | 21 | 2 | 17 | 1 | 11 | 2 | 8 | 14 | 3 | 3 | 5 | 1 | 8 | 4 | 1 | 6 | 13 | |||||||
| In situ RNA (whole mount) | 1 | 4 | 14 | 43 | 4 | 12 | 2 | 4 | 4 | 3 | 1 | 6 | 1 | ||||||||||||||||||
| In situ reporter (knock in) | 1 | 1 | 1 | 1 | 2 | 1 | 1 | ||||||||||||||||||||||||
| Northern blot | 1 | 1 | 1 | 1 | 12 | ||||||||||||||||||||||||||
| Western blot | 1 | 1 | 3 | ||||||||||||||||||||||||||||
| RT-PCR | 1 | 1 | 3 | 3 | 22 | 2 | 13 | 2 | 8 | 1 | 13 | 2 | 8 | 2 | 9 | 2 | 6 | 2 | 3 | 2 | 6 | 1 | 6 | 1 | 1 | 2 | 81 | ||||
| cDNA clones | 1 | 3 | |||||||||||||||||||||||||||||
| RNase protection | 1 | 1 | 1 | 1 | 1 |
| Nppa natriuretic peptide type A (Synonyms: Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd) | |
| Results | Reference |
| 1 | J:345821 Allwood MA, Edgett BA, Platt MJ, Marrow JP, Coyle-Asbil B, Holjak EJB, Nelson VL, Bangali S, Alshamali R, Jacyniak K, Klein JM, Farquharson L, Romanova N, Northrup V, Ogilvie LM, Ayoub A, Ask K, Vickaryous MK, Hare GMT, Brunt KR, Simpson JA, Novel roles of cardiac-derived erythropoietin in cardiac development and function. J Mol Cell Cardiol. 2024 Mar;188:90-104 |
| 1 | J:74656 Andree B, Fleige A, Arnold HH, Brand T, Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Mol Cell Biol. 2002 Mar;22(5):1504-12 |
| 1* | J:38213 Arber S, Hunter JJ, Ross J Jr, Hongo M, Sansig G, Borg J, Perriard JC , Chien KR , Caroni P, MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 7;88(3):393-403 |
| 1 | J:253754 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG, Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016 May 6;6:25541 |
| 1 | J:166932 Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H, Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development. 2010 Nov;137(22):3823-33 |
| 1* | J:252376 Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC, The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017 Dec 1;26(23):4617-4628 |
| 2 | J:149014 Bakker ML, Boukens BJ, Mommersteeg MT, Brons JF, Wakker V, Moorman AF, Christoffels VM, Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res. 2008 Jun 6;102(11):1340-9 |
| 1 | J:185264 Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J, Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3;110(3):456-64 |
| 1 | J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9 |
| 2 | J:213344 Barratt KS, Glanville-Jones HC, Arkell RM, The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis. 2014 Jun;52(6):626-35 |
| 1 | J:304446 Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, de Angelis MH, Handler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D, Creld1 regulates myocardial development and function. J Mol Cell Cardiol. 2021 Mar 24;156:45-56 |
| 1 | J:221142 Beketaev I, Zhang Y, Kim EY, Yu W, Qian L, Wang J, Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015 May;244(5):669-80 |
| 1 | J:153091 Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA, Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14932-6 |
| 2 | J:341993 Bernheim S, Borgel A, Le Garrec JF, Perthame E, Desgrange A, Michel C, Guillemot L, Sart S, Baroud CN, Krezel W, Raimondi F, Bonnet D, Zaffran S, Houyel L, Meilhac SM, Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells. Dev Cell. 2023 Oct 13; |
| 1 | J:180603 Bertrand AT, Renou L, Papadopoulos A, Beuvin M, Lacene E, Massart C, Ottolenghi C, Decostre V, Maron S, Schlossarek S, Cattin ME, Carrier L, Malissen M, Arimura T, Bonne G, DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death. Hum Mol Genet. 2012 Mar 1;21(5):1037-48 |
| 1* | J:276168 Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV, Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition. Sci Rep. 2019 Feb 14;9(1):2106 |
| 1* | J:316441 Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G, Increased susceptibility of HIF-1alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol. 2013 Jul;60:129-41 |
| 1 | J:161903 Boogerd KJ, Wong LY, Christoffels VM, Klarenbeek M, Ruijter JM, Moorman AF, Barnett P, Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res. 2008 Jun 1;78(3):485-93 |
| 1* | J:101738 Briegel KJ, Baldwin HS, Epstein JA, Joyner AL, Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Development. 2005 Jul;132(14):3305-16 |
| 1 | J:334092 Broadway-Stringer S, Jiang H, Wadmore K, Hooper C, Douglas G, Steeples V, Azad AJ, Singer E, Reyat JS, Galatik F, Ehler E, Bennett P, Kalisch-Smith JI, Sparrow DB, Davies B, Djinovic-Carugo K, Gautel M, Watkins H, Gehmlich K, Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2. Cells. 2023 Feb 24;12(5) |
| 3 | J:195548 Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y, Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621 |
| 1 | J:83014 Bruneau BG, The developing heart and congenital heart defects: a make or break situation. Clin Genet. 2003 Apr;63(4):252-61 |
| 4 | J:67359 Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG, Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar;21(5):1730-6 |
| 3 | J:71845 Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG, A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21;106(6):709-21 |
| 1 | J:98516 Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S, T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005 May;132(10):2475-87 |
| 1 | J:178530 Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL, Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2. Dev Biol. 2011 Dec 15;360(2):381-90 |
| 1* | J:152696 Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ, MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009 Sep;119(9):2772-86 |
| 13 | J:31876 Cameron VA, Aitken GD, Ellmers LJ, Kennedy MA, Espiner EA, The sites of gene expression of atrial, brain, and C-type natriuretic peptides in mouse fetal development: temporal changes in embryos and placenta. Endocrinology. 1996 Mar;137(3):817-24 |
| 1 | J:95385 Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN, Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76 |
| 2* | J:79153 Chen F, Kook H, Milewski R, Gitler A, Lu M, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay J, Novotny J, Schwartz R, Harvey R, Mullins M, Epstein J, Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development. Cell. 2002 Sep 20;110(6):713 |
| 1 | J:89476 Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W, BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May;131(9):2219-31 |
| 1 | J:121400 Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM, Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res. 2006 Apr 14;98(7):923-30 |
| 1 | J:171873 Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R, Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J Clin Invest. 2010 Dec 1;120(12):4353-65 |
| 1 | J:300948 Chen X, Liu Y, Xu C, Ba L, Liu Z, Li X, Huang J, Simpson E, Gao H, Cao D, Sheng W, Qi H, Ji H, Sanderson M, Cai CL, Li X, Yang L, Na J, Yamamura K, Liu Y, Huang G, Shou W, Sun N, QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function. Nat Commun. 2021 Jan 4;12(1):89 |
| 1 | J:139946 Chen YH, Ishii M, Sucov HM, Maxson RE Jr, Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75 |
| 7* | J:316204 Chen Z, Xu N, Chong D, Guan S, Jiang C, Yang Z, Li C, Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart. Cardiovasc Res. 2018 Jun 1;114(7):965-978 |
| 1 | J:172665 Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, Delpon E, Tamargo J, Cinca J, Hove-Madsen L, Aranega AE, Franco D, PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. Circ Cardiovasc Genet. 2011 Jun;4(3):269-79 |
| 1 | J:280323 Cho E, Kang H, Kang DK, Lee Y, Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. J Biol Chem. 2019 Mar 29;294(13):4981-4996 |
| 1* | J:133691 Choi M, Stottmann RW, Yang YP, Meyers EN, Klingensmith J, The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007 Feb 2;100(2):220-8 |
| 2 | J:336417 Chong D, Gu Y, Zhang T, Xu Y, Bu D, Chen Z, Xu N, Li L, Zhu X, Wang H, Li Y, Zheng F, Wang D, Li P, Xu L, Hu Z, Li C, Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106 |
| 7* | J:64882 Christoffels VM, Habets PE, Franco D, Campione M, de Jong F, Lamers WH, Bao ZZ, Palmer S, Biben C, Harvey RP, Moorman AF, Chamber formation and morphogenesis in the developing mammalian heart [published erratum appears in Dev Biol 2000 Sep 1;225(1):266]. Dev Biol. 2000 Jul 15;223(2):266-78 |
| 2* | J:89198 Christoffels VM, Hoogaars WM, Tessari A, Clout DE, Moorman AF, Campione M, T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev Dyn. 2004 Apr;229(4):763-70 |
| 3* | J:64020 Christoffels VM, Keijser AG, Houweling AC, Clout DE, Moorman AF, Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Dev Biol. 2000 Aug 15;224(2):263-74 |
| 2 | J:108818 Chuva de Sousa Lopes SM, Hassink RJ, Feijen A, van Rooijen MA, Doevendans PA, Tertoolen L, Brutel de la Riviere A, Mummery CL, Patterning the heart, a template for human cardiomyocyte development. Dev Dyn. 2006 Apr 28;235(7):1994-2002 |
| 1 | J:236425 Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR, Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 Oct 1;418(1):157-65 |
| 1 | J:102537 Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, Carmeliet P, Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res. 2003 Dec 1;60(3):569-79 |
| 1* | J:177922 Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP, Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One. 2011;6(9):e24812 |
| 2 | J:174203 Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M, miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol. 2011 Jun 27;193(7):1197-212 |
| 3 | J:183869 Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q, Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012 Apr 12;484(7393):246-50 |
| 1 | J:271384 D'Amato G, Luxan G, del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL, Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol. 2016 Jan;18(1):7-20 |
| 1 | J:155846 de Lange FJ, Moorman AF, Anderson RH, Manner J, Soufan AT, de Gier-de Vries C, Schneider MD, Webb S, van den Hoff MJ, Christoffels VM, Lineage and morphogenetic analysis of the cardiac valves. Circ Res. 2004 Sep 17;95(6):645-54 |
| 2 | J:176023 del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR, Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9 |
| 9 | J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445 |
| 1 | J:181488 Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG, Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44(3):343-7 |
| 1 | J:91438 DiCicco-Bloom E, Lelievre V, Zhou X, Rodriguez W, Tam J, Waschek JA, Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system. Dev Biol. 2004 Jul 1;271(1):161-75 |
| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 1* | J:88432 Ding JH, Xu X, Yang D, Chu PH, Dalton ND, Ye Z, Yeakley JM, Cheng H, Xiao RP, Ross J, Chen J, Fu XD, Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004 Feb 25;23(4):885-96 |
| 1 | J:208305 Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ, Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013 Nov;15(11):1282-93 |
| 1* | J:251273 Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Volkers M, S100A4 protects the myocardium against ischemic stress. J Mol Cell Cardiol. 2016 Nov;100:54-63 |
| 5 | J:78579 Ellmers LJ, Knowles JW, Kim HS, Smithies O, Maeda N, Cameron VA, Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H707-14 |
| 1 | J:175381 Espinoza-Lewis RA, Liu H, Sun C, Chen C, Jiao K, Chen Y, Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice. Dev Biol. 2011 Aug 15;356(2):359-69 |
| 2* | J:146147 Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y, Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol. 2009 Mar 15;327(2):376-85 |
| 1 | J:271287 Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K, Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease. Cell Rep. 2018 Jan 9;22(2):482-496 |
| 2 | J:307972 Farrell ET, Grimes AC, de Lange WJ, Armstrong AE, Ralphe JC, Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy. Front Physiol. 2017;8:414 |
| 1* | J:37583 Fassler R, Rohwedel J, Maltsev V, Bloch W, Lentini S, Guan K, Gullberg D, Hescheler J, Addicks K, Wobus AM, Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci. 1996 Dec;109(Pt 13):2989-99 |
| 1 | J:97663 Fiore R, Rahim B, Christoffels VM, Moorman AF, Puschel AW, Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system. Mol Cell Biol. 2005 Mar;25(6):2310-9 |
| 1 | J:46384 Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN, Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70 |
| 1* | J:306226 Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W, Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M, Firulli AB, HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. Cardiovasc Res. 2020 Mar 1;116(3):605-618 |
| 1 | J:164028 Firulli BA, McConville DP, Byers JS 3rd, Vincentz JW, Barnes RM, Firulli AB, Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010 Oct;239(10):2748-60 |
| 2 | J:311466 Firulli BA, Toolan KP, Harkin J, Millar H, Pineda S, Firulli AB, The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice. Cardiovasc Res. 2017 Dec 1;113(14):1732-1742 |
| 3 | J:101349 Fischer A, Klattig J, Kneitz B, Diez H, Maier M, Holtmann B, Englert C, Gessler M, Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005 Oct;25(20):8960-70 |
| 3 | J:133699 Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M, Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63 |
| 1 | J:74051 Franco D, Campione M, Kelly R, Zammit PS, Buckingham M, Lamers WH, Moorman AF, Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart. Circ Res. 2000 Nov 24;87(11):984-91 |
| 1* | J:254842 Fujita J, Freire P, Coarfa C, Benham AL, Gunaratne P, Schneider MD, Dejosez M, Zwaka TP, Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs. Cell Rep. 2017 Nov 7;21(6):1562-1573 |
| 1 | J:231297 Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW, A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41 |
| 4* | J:75084 Gaussin V, Van de Putte T, Mishina Y, Hanks MC, Zwijsen A, Huylebroeck D, Behringer RR, Schneider MD, Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2878-83 |
| 1 | J:204450 Gavrilov S, Harvey RP, Papaioannou VE, Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development. PLoS One. 2013;8(7):e70149 |
| 2 | J:79024 Gessler M, Knobeloch K, Helisch A, Amann K, Schumacher N, Rohde E, Fischer A, Leimeister C, Mouse gridlock. No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 -/- Mice. Curr Biol. 2002 Sep 17;12(18):1601 |
| 2 | J:299975 Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M, GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2007322118 |
| 1* | J:71818 Ghosh TK, Packham EA, Bonser AJ, Robinson TE, Cross SJ, Brook JD, Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome. Hum Mol Genet. 2001 Sep 1;10(18):1983-94 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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