About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
MGI:97383

241 matching records from 241 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E P
Immunohistochemistry (section) 1 1 1 12 4 27 6 33 6 39 2 38 5 29 2 14 2 12 1 34 3 74
In situ RNA (section) 1 7 16 2 8 14 1 10 1 8 2 9 4 7 2 33
Immunohistochemistry (whole mount) 1 3 4 1 1 1 1 1
In situ RNA (whole mount) 1 2 1 1 1 1
In situ reporter (knock in) 1 1 2 2 3
Northern blot 1 1 1 2 2 1 1 1 3 1 1 1
Western blot 1 3 2 4 2 1 1 1 1 10
RT-PCR 1 1 1 1 2 3 3 2 6 2 2 3 2 1 2 2 1 1 8
cDNA clones 1 2
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ntrk1  neurotrophic tyrosine kinase, receptor, type 1   (Synonyms: Tkr, TrkA)
Results  Reference
5J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
1J:160730 Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH, Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 2009;4:11
1J:119656 Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F, Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56
5J:267338 Angelim MKSC, Maia LMSS, Mouffle C, Ginhoux F, Low D, Amancio-Dos-Santos A, Makhoul J, Le Corronc H, Mangin JM, Legendre P, Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. 2018 Nov;66(11):2470-2486
3J:78232 Arber S, Ladle DR, Lin JH, Frank E, Jessell TM, ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
1J:192475 Asahina H, Masuba A, Hirano S, Yuri K, Distribution of protocadherin 9 protein in the developing mouse nervous system. Neuroscience. 2012 Dec 6;225:88-104
9J:178481 Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P, The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Dev Biol. 2011 Dec 1;360(1):77-86
1*J:352627 Baltar J, Miranda RM, Cabral M, Rebelo S, Grahammer F, Huber TB, Reguenga C, Monteiro FA, Neph1 is required for neurite branching and is negatively regulated by the PRRXL1 homeodomain factor in the developing spinal cord dorsal horn. Neural Dev. 2024 Jul 24;19(1):13
4*J:201549 Bando T, Morikawa Y, Hisaoka T, Komori T, Miyajima A, Senba E, Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Neurosci Lett. 2013 Aug 26;548:73-8
5J:288459 Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, Akkuratova N, Boucanova F, Medard JJ, Petitpre C, Landy MA, Zhang MD, Harrer P, Stendel C, Stucka R, Dusl M, Kastriti ME, Croci L, Lai HC, Consalez GG, Pattyn A, Ernfors P, Senderek J, Adameyko I, Lallemend F, Hadjab S, Chrast R, PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep. 2019 Mar 26;26(13):3484-3492.e4
1J:81473 Beltran PJ, Bixby JL, Masters BA, Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons. J Comp Neurol. 2003 Feb 17;456(4):384-95
1J:142362 Ben-Zvi A, Manor O, Schachner M, Yaron A, Tessier-Lavigne M, Behar O, The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008 Nov 19;28(47):12427-32
1J:69624 Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY, Proprioceptor pathway development is dependent on math1. Neuron. 2001 May;30(2):411-22
1J:309445 Bernal Sierra YA, Haseleu J, Kozlenkov A, Begay V, Lewin GR, Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Front Mol Neurosci. 2017;10:70
1J:227232 Bin JM, Han D, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE, Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. Cell Rep. 2015 Aug 18;12(7):1099-106
3J:65040 Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R, Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000 Feb;114(2):314-20
1J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
5J:230425 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigere F, Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5:e11627
2J:157721 Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P, Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009 Dec 24;64(6):857-70
1J:149223 Buchmann-Moller S, Miescher I, John N, Krishnan J, Deng CX, Sommer L, Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol. 2009 Jun 15;330(2):329-38
4*J:221644 Calvo L, Anta B, Lopez-Benito S, Martin-Rodriguez C, Lee FS, Perez P, Martin-Zanca D, Arevalo JC, Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015 May 6;35(18):7190-202
1J:312438 Cameron B, Lehrmann E, Chih T, Walters J, Buksch R, Snyder S, Goffena J, Lefcort F, Becker KG, George L, Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway. Biol Open. 2021 Sep 15;10(9):bio058979
1J:326957 Cao Z, Huang C, Lu F, Jiang X, Hu Y, Cao C, Liu Z, Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli. Front Mol Neurosci. 2022;15:901466
1*J:153128 Castets P, Maugenre S, Gartioux C, Rederstorff M, Krol A, Lescure A, Tajbakhsh S, Allamand V, Guicheney P, Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors. BMC Dev Biol. 2009;9:46
1*J:314655 Cesca F, Yabe A, Spencer-Dene B, Arrigoni A, Al-Qatari M, Henderson D, Phillips H, Koltzenburg M, Benfenati F, Schiavo G, Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death Dis. 2011 Nov 3;2:e226
6J:106971 Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q, Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 Feb 2;49(3):365-77
1J:166699 Chen L, Chatterjee M, Li JY, The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci. 2010 Nov 3;30(44):14824-34
1*J:254788 Chen Z, Donnelly CR, Dominguez B, Harada Y, Lin W, Halim AS, Bengoechea TG, Pierchala BA, Lee KF, p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep. 2017 Oct 17;21(3):707-720
3J:70560 Chen Z, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ, The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
5J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
2J:184234 Chirivella L, Cano-Jaimez M, Perez-Sanchez F, Herraez L, Carretero J, Farinas I, Burks DJ, Kirstein M, IRS2 signalling is required for the development of a subset of sensory spinal neurons. Eur J Neurosci. 2012 Feb;35(3):341-52
1J:313341 Comer JD, Pan FC, Willet SG, Haldipur P, Millen KJ, Wright CV, Kaltschmidt JA, Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3. Front Neural Circuits. 2015;9:36
1*J:29763 Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH, Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology. 1995 Nov;136(11):5212-23
3J:338830 Connor B, Moya-Alvarado G, Yamashita N, Kuruvilla R, Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2205426120
2J:93578 Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L, Ablation of TrkA function in the immune system causes B cell abnormalities. Development. 2004 Oct;131(20):5185-95
3J:72304 Coppola V, Kucera J, Palko ME, Martinez-De Velasco J, Lyons WE, Fritzsch B, Tessarollo L, Dissection of NT3 functions in vivo by gene replacement strategy. Development. 2001 Nov;128(21):4315-27
1J:40384 Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH, Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
6J:77445 Cronk KM, Wilkinson GA, Grimes R, Wheeler EF, Jhaveri S, Fundin BT, Silos-Santiago I, Tessarollo L, Reichardt LF, Rice FL, Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC. Development. 2002 Aug;129(15):3739-50
1J:169302 da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F, Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-{beta} signaling. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3395-400
2J:87750 Dai CF, Steyger PS, Wang ZM, Vass Z, Nuttall AL, Expression of Trk A receptors in the mammalian inner ear. Hear Res. 2004 Jan;187(1-2):1-11
3*J:29041 Davies AM, Wyatt S, Nishimura M, Phillips H, NGF receptor expression in sensory neurons develops normally in embryos lacking NGF. Dev Biol. 1995 Oct;171(2):434-8
1J:133953 Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD, A model for neuronal competition during development. Science. 2008 Apr 18;320(5874):369-73
3J:353354 Desiderio S, Schwaller F, Tartour K, Padmanabhan K, Lewin GR, Carroll P, Marmigere F, Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2. Elife. 2024 Feb 22;12
13J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:98501 Ding YQ, Kim JY, Xu YS, Rao Y, Chen ZF, Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. Development. 2005 May;132(9):2047-56
1J:92064 Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF, Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug;131(15):3693-703
2J:95961 Dunston JA, Reimschisel T, Ding YQ, Sweeney E, Johnson RL, Chen ZF, McIntosh I, A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression. Eur J Hum Genet. 2005 Mar;13(3):330-5
1*J:130860 Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E, Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20838-43
6J:160718 Dykes IM, Lanier J, Eng SR, Turner EE, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3
1J:174563 Dykes IM, Tempest L, Lee SI, Turner EE, Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011 Jul 6;31(27):9789-99
1J:133494 Elshatory Y, Gan L, The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008 Mar 26;28(13):3291-7
3J:353479 Erickson AG, Motta A, Kastriti ME, Edwards S, Coulpier F, Theoulle E, Murtazina A, Poverennaya I, Wies D, Ganofsky J, Canu G, Lallemend F, Topilko P, Hadjab S, Fried K, Ruhrberg C, Schwarz Q, Castellani V, Bonanomi D, Adameyko I, Motor innervation directs the correct development of the mouse sympathetic nervous system. Nat Commun. 2024 Aug 16;15(1):7065
5J:35563 Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M, TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J Neurosci. 1996 1;16(19):6208-18
5*J:49434 Farinas I, Wilkinson GA, Backus C, Reichardt LF, Patapoutian A, Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998 Aug;21(2):325-34
1J:299733 Faure L, Wang Y, Kastriti ME, Fontanet P, Cheung KKY, Petitpre C, Wu H, Sun LL, Runge K, Croci L, Landy MA, Lai HC, Consalez GG, de Chevigny A, Lallemend F, Adameyko I, Hadjab S, Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nat Commun. 2020 Aug 21;11(1):4175
3J:245948 Fell SM, Li S, Wallis K, Kock A, Surova O, Rraklli V, Hofig CS, Li W, Mittag J, Henriksson MA, Kenchappa RS, Holmberg J, Kogner P, Schlisio S, Neuroblast differentiation during development and in neuroblastoma requires KIF1Bbeta-mediated transport of TRKA. Genes Dev. 2017 May 15;31(10):1036-1053
2*J:73290 Figueiredo HF, Davis BM, Albers KM, Skin-derived nerve growth factor blocks programmed cell death in the trigeminal ganglia but does not enhance neuron proliferation. Mech Dev. 2001 Dec;109(2):205-14
2*J:198483 Finelli MJ, Murphy KJ, Chen L, Zou H, Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
1J:235934 Fleming MS, Li JJ, Ramos D, Li T, Talmage DA, Abe SI, Arber S, Luo W, A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci. 2016 Oct 5;36(40):10337-10355
4J:202678 Fontanet P, Irala D, Alsina FC, Paratcha G, Ledda F, Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF. J Neurosci. 2013 Oct 2;33(40):15940-51
1J:101205 Fragkouli A, Hearn C, Errington M, Cooke S, Grigoriou M, Bliss T, Stylianopoulou F, Pachnis V, Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci. 2005 Jun;21(11):2923-38
3J:238230 Furlan A, La Manno G, Lubke M, Haring M, Abdo H, Hochgerner H, Kupari J, Usoskin D, Airaksinen MS, Oliver G, Linnarsson S, Ernfors P, Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat Neurosci. 2016 Oct;19(10):1331-40
5J:198834 Furlan A, Lubke M, Adameyko I, Lallemend F, Ernfors P, The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J. 2013 May 29;32(11):1613-25
5J:164668 Gascon E, Gaillard S, Malapert P, Liu Y, Rodat-Despoix L, Samokhvalov IM, Delmas P, Helmbacher F, Maina F, Moqrich A, Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010 Sep 15;30(37):12414-23
3J:196589 Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R, Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
1J:266784 Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L, Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015 Apr 11;13:24
2J:97779 Genc B, Ozdinler PH, Mendoza AE, Erzurumlu RS, A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol. 2004 Dec;2(12):e403
4J:202989 George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F, Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18698-703
8J:210892 Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes JP, Alonso S, Moqrich A, Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet. 2014 Feb;10(2):e1004081
1J:253121 Gresset A, Coulpier F, Gerschenfeld G, Jourdon A, Matesic G, Richard L, Vallat JM, Charnay P, Topilko P, Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin. Stem Cell Reports. 2015 Aug 11;5(2):278-90
1J:76658 Gross MK, Dottori M, Goulding M, Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16;34(4):535-49
1J:153219 Grossmann KS, Wende H, Paul FE, Cheret C, Garratt AN, Zurborg S, Feinberg K, Besser D, Schulz H, Peles E, Selbach M, Birchmeier W, Birchmeier C, The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9
2J:93799 Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD, Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul;5(1):45-57
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2J:170402 Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR, Ginty DD, An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci. 2011 Jan;14(1):31-6
4J:345844 Guo Y, Xiang P, Sun X, Liu W, Zhou J, Yin B, Hou L, Qiang B, Li H, Shu P, Peng X, Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
7J:204192 Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F, A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci. 2013 Nov 6;33(45):17656-66
7J:315755 Hancock ML, Nowakowski DW, Role LW, Talmage DA, Flanagan JG, Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development. 2011 Nov;138(22):4887-98
1J:205590 Hancock ML, Preitner N, Quan J, Flanagan JG, MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci. 2014 Jan 1;34(1):66-78
1J:104804 Harada C, Harada T, Nakamura K, Sakai Y, Tanaka K, Parada LF, Effect of p75(NTR) on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Dev Biol. 2006 Feb 1;290(1):57-65
1J:208752 Hasegawa H, Wang F, Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. J Comp Neurol. 2008 Dec 1;511(4):543-56
1*J:171311 Haupt C, Langhoff J, Huber AB, Adenylate Cyclase 1 modulates peripheral nerve branching patterns. Mol Cell Neurosci. 2010 Dec;45(4):439-48
3*J:278136 Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M, Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019 Aug 7;103(3):412-422.e4
2J:100886 Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S, A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
1J:224836 Hoch RV, Lindtner S, Price JD, Rubenstein JL, OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94
1J:134668 Holstege JC, de Graaff W, Hossaini M, Cano SC, Jaarsma D, van den Akker E, Deschamps J, Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6338-43
2*J:143398 Homma S, Shimada T, Hikake T, Yaginuma H, Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns. 2009 Jan;9(1):1-26
4J:161851 Honma Y, Kawano M, Kohsaka S, Ogawa M, Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development. 2010 Jul;137(14):2319-28
1*J:272611 Howard L, Wosnitzka E, Okakpu D, White MA, Wyatt S, Davies AM, TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation. Development. 2018 Nov 19;145(22):dev165936
1J:339242 Hu B, Lv X, Wei L, Wang Y, Zheng G, Yang C, Zang F, Wang J, Li J, Wu X, Yue Z, Xiao Q, Shao Z, Yuan W, Li J, Cao P, Xu C, Chen H, Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis. Adv Sci (Weinh). 2022 Oct;9(30):e2202620
2J:184447 Hu J, Huang T, Li T, Guo Z, Cheng L, c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci. 2012 Apr 18;32(16):5362-73
1J:243413 Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR, Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017 Aug 01;144(15):2837-2851
3J:173761 Hu ZL, Shi M, Huang Y, Zheng MH, Pei Z, Chen JY, Han H, Ding YQ, The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev. 2011;6:14
2J:95688 Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN, Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 2005 Jan 1;19(1):138-51
6*J:54178 Huang EJ, Wilkinson GA, Farinas I, Backus C, Zang K, Wong SL, Reichardt LF, Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999 May;126(10):2191-203
7J:54859 Huang EJ, Zang K, Schmidt A, Saulys A, Xiang M, Reichardt LF, POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development. 1999 Jul;126(13):2869-82
2J:162791 Huang T, Liu Y, Huang M, Zhao X, Cheng L, Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice. J Mol Cell Biol. 2010 Jun;2(3):152-63
1J:199593 Huber K, Narasimhan P, Shtukmaster S, Pfeifer D, Evans SM, Sun Y, The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. Dev Biol. 2013 Aug 15;380(2):286-98
2J:79268 Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N, Ito Y, Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 2002 Oct;5(10):946-54
2J:184011 John A, Brylka H, Wiegreffe C, Simon R, Liu P, Juttner R, Crenshaw EB 3rd, Luyten FP, Jenkins NA, Copeland NG, Birchmeier C, Britsch S, Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development. Development. 2012 May;139(10):1831-41
1J:233763 Karpinski BA, A Bryan C, Paronett EM, Baker JL, Fernandez A, Horvath A, Maynard TM, Moody SA, LaMantia AS, A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol. 2016 Jul 15;415(2):228-41
2J:306108 Karpinski BA, Maynard TM, Bryan CA, Yitsege G, Horvath A, Lee NH, Moody SA, LaMantia AS, Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022 Feb 1;15(2):dmm047357
1J:213451 Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS, Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
9J:336177 Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L, Calhan OY, Deppmann CD, Zunder ER, A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry. Nat Neurosci. 2022 Nov;25(11):1543-1558
1J:127453 Kettunen P, Spencer-Dene B, Furmanek T, Kvinnsland IH, Dickson C, Thesleff I, Luukko K, Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev. 2007 Nov-Dec;124(11-12):868-83
2*J:209600 Kiris E, Wang T, Yanpallewar S, Dorsey SG, Becker J, Bavari S, Palko ME, Coppola V, Tessarollo L, TrkA in vivo function is negatively regulated by ubiquitination. J Neurosci. 2014 Mar 12;34(11):4090-8
1J:346372 Kolesova H, Hrabalova P, Bohuslavova R, Abaffy P, Fabriciova V, Sedmera D, Pavlinkova G, Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. Front Endocrinol (Lausanne). 2024;15:1344074
1J:140017 Komori T, Gyobu H, Ueno H, Kitamura T, Senba E, Morikawa Y, Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles. J Comp Neurol. 2008 Nov 1;511(1):92-108
1*J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
3J:106980 Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S, A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006 Feb 2;49(3):379-93
4J:100024 Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K, Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005 Jul 27;25(30):7090-9
6J:304297 Landy MA, Goyal M, Casey KM, Liu C, Lai HC, Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. Cell Rep. 2021 Mar 30;34(13):108913
1J:228865 Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A, Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76
4*J:137627 Law CO, Kirby RJ, Aghamohammadzadeh S, Furley AJ, The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals. Development. 2008 Jul;135(14):2361-71
3J:148796 Lechner SG, Frenzel H, Wang R, Lewin GR, Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J. 2009 May 20;28(10):1479-91
1J:164344 Lecoin L, Rocques N, El-Yakoubi W, Ben Achour S, Larcher M, Pouponnot C, Eychene A, MafA transcription factor identifies the early ret-expressing sensory neurons. Dev Neurobiol. 2010 Jun;70(7):485-97
2J:113043 Lee EY, Hu N, Yuan SS, Cox LA, Bradley A, Lee WH, Herrup K, Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 1;8(17):2008-21
1J:146673 Leiper LJ, Ou J, Walczysko P, Kucerova R, Lavery DN, West JD, Collinson JM, Control of patterns of corneal innervation by Pax6. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1122-8
7J:326569 Leonard CE, Quiros J, Lefcort F, Taneyhill LA, Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia. Elife. 2022 Jun 17;11:e71455
3*J:314287 Leslie JR, Imai F, Zhou X, Lang RA, Zheng Y, Yoshida Y, RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Front Mol Neurosci. 2012;5:67
2J:77764 Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, Bernstein Y, Goldenberg D, Xiao C, Fliegauf M, Kremer E, Otto F, Brenner O, Lev-Tov A, Groner Y, The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002 Jul 1;21(13):3454-63
2J:348770 Li W, Lipsius K, Burns NG, Sato R, Rehman A, Xue H, Combs C, Minichiello L, Gangrade H, Tampakakis E, Mukouyama YS, Vascular smooth muscle cell-derived nerve growth factor regulates sympathetic collateral branching to innervate blood vessels in embryonic skin. Biol Open. 2024 May 15;13(5)
1*J:44286 Liebl DJ, Tessarollo L, Palko ME, Parada LF, Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997 Dec 1;17(23):9113-21
1J:201695 Lilley BN, Pan YA, Sanes JR, SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron. 2013 Jul 10;79(1):39-53
3J:166964 Lin L, Lee VM, Wang Y, Lin JS, Sock E, Wegner M, Lei L, Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn. 2011 Jan;240(1):52-64
1J:322701 Liu Y, Chen Q, Jeong HW, Koh BI, Watson EC, Xu C, Stehling M, Zhou B, Adams RH, A specialized bone marrow microenvironment for fetal haematopoiesis. Nat Commun. 2022 Mar 14;13(1):1327
2*J:76363 Lonze BE, Riccio A, Cohen S, Ginty DD, Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002 Apr 25;34(3):371-85
1*J:186470 Lopes C, Liu Z, Xu Y, Ma Q, Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012 Jul 11;32(28):9706-15
1J:182013 Lopes R, Verhey van Wijk N, Neves G, Pachnis V, Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3119-24
1J:354315 Lowenstein ED, Misios A, Buchert S, Ruffault PL, Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice. J Neurosci. 2024 Jul 10;44(28)
1J:184717 Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R, Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol. 2012 Mar;10(3):e1001283
3J:157722 Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD, Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009 Dec 24;64(6):841-56
5*J:126484 Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD, A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
1J:122797 Ma L, Tessier-Lavigne M, Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons. J Neurosci. 2007 Jun 20;27(25):6843-51
1J:56292 Ma Q, Fode C, Guillemot F, Anderson DJ, Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 1999 Jul 1;13(13):1717-28
1J:189960 Madakashira BP, Kobrinski DA, Hancher AD, Arneman EC, Wagner BD, Wang F, Shin H, Lovicu FJ, Reneker LW, Robinson ML, Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 2012 Dec;139(24):4601-12
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:184343 Magno L, Kretz O, Bert B, Ersozlu S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T, The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011 Dec;34(11):1767-82
4J:154926 Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD, LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009 Sep 10;63(5):614-27
2J:92797 Maro GS, Vermeren M, Voiculescu O, Melton L, Cohen J, Charnay P, Topilko P, Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat Neurosci. 2004 Sep;7(9):930-8
14*J:10665 Martin-Zanca D, Barbacid M, Parada LF, Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev. 1990 May;4(5):683-94
1*J:179954 Matsumoto S, Konishi H, Maeda R, Kiryu-Seo S, Kiyama H, Expression analysis of the regenerating gene (Reg) family members Reg-IIIbeta and Reg-IIIgamma in the mouse during development. J Comp Neurol. 2012 Feb 15;520(3):479-94
4J:37118 McEvilly RJ, Erkman L, Luo L, Sawchenko PE, Ryan AF, Rosenfeld MG, Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature. 1996 Dec 12;384(6609):574-7
1J:197761 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL, Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98
1*J:266259 Menard M, Costechareyre C, Coelho-Aguiar JM, Jarrosson-Wuilleme L, Rama N, Blachier J, Kindbeiter K, Bozon M, Cabrera JR, Dupin E, Le Douarin N, Mehlen P, Tauszig-Delamasure S, The dependence receptor TrkC regulates the number of sensory neurons during DRG development. Dev Biol. 2018 Oct 15;442(2):249-261
3J:43790 Molliver DC, Wright DE, Leitner ML, Parsadanian AS, Doster K, Wen D, Yan Q, Snider WD, IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
2J:210605 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH, Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94
1J:97000 Morikawa Y, Tamura S, Minehata K, Donovan PJ, Miyajima A, Senba E, Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J Neurosci. 2004 Feb 25;24(8):1941-7
1J:153555 Mukhopadhyay A, Jarrett J, Chlon T, Kessler JA, HeyL regulates the number of TrkC neurons in dorsal root ganglia. Dev Biol. 2009 Oct 1;334(1):142-51
1J:76659 Muller T, Brohmann H, Pierani A, Heppenstall PA, Lewin GR, Jessell TM, Birchmeier C, The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron. 2002 May 16;34(4):551-62
2J:21291 Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH, Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model. Reprod Toxicol. 1994 Sep-Oct;8(5):383-95
1J:237480 Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G, Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. PLoS Genet. 2016 Dec;12(12):e1006486
2J:309176 Nakajima K, Miranda A, Craig DW, Shekhtman T, Kmoch S, Bleyer A, Szelinger S, Kato T, Kelsoe JR, Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Transl Psychiatry. 2020 Nov 24;10(1):407
1J:134495 Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, Ozaki S, Shiga T, Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008 May;135(9):1703-11
1J:264453 Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD, Specific functions for ERK/MAPK signaling during PNS development. Neuron. 2011 Jan 13;69(1):91-105
1J:163998 Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Giallonardo P, Zhang L, Bibel M, Barde YA, Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature. 2010 Sep 2;467(7311):59-63
2J:295953 Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L, Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo. J Neurosci. 2020 Aug 26;40(35):6691-6708
4J:213126 O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
1J:207212 Oh WJ, Gu C, Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013 Oct 16;80(2):458-69
8J:239276 Ohayon D, Venteo S, Sonrier C, Lafon PA, Garces A, Valmier J, Rivat C, Topilko P, Carroll P, Pattyn A, Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell. 2015 May 04;33(3):343-50
1*J:242220 Ohlen SB, Russell ML, Brownstein MJ, Lefcort F, BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc Natl Acad Sci U S A. 2017 May 09;114(19):5035-5040
2J:149553 Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S, Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature. 2009 Jun 11;459(7248):842-6
1J:316975 Petrie CN, Armitage MN, Kawaja MD, Myenteric expression of nerve growth factor and the p75 neurotrophin receptor regulate axonal remodeling as a consequence of colonic inflammation in mice. Exp Neurol. 2015 Sep;271:228-40
1*J:326026 Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM, Western PS, An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
1J:242690 Qi L, Huang C, Wu X, Tao Y, Yan J, Shi T, Cao C, Han L, Qiu M, Ma Q, Liu Z, Liu Y, Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. J Neurosci. 2017 May 31;37(22):5549-5561
2J:76655 Qian Y, Shirasawa S, Chen CL, Cheng L, Ma Q, Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev. 2002 May 15;16(10):1220-33
1J:184845 Quina LA, Tempest L, Hsu YW, Cox TC, Turner EE, Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion. Dev Biol. 2012 May 1;365(1):152-63
2J:116558 Rebelo S, Chen ZF, Anderson DJ, Lima D, Involvement of DRG11 in the development of the primary afferent nociceptive system. Mol Cell Neurosci. 2006 Nov;33(3):236-46
1J:124186 Rebelo S, Reguenga C, Osorio L, Pereira C, Lopes C, Lima D, DRG11 immunohistochemical expression during embryonic development in the mouse. Dev Dyn. 2007 Sep;236(9):2653-60
1*J:225328 Ren AJ, Wang K, Zhang H, Liu A, Ma X, Liang Q, Cao D, Wood JN, He DZ, Ding YQ, Yuan WJ, Xie Z, Zhang WJ, ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984
5J:217530 Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M, iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910
5J:327897 Rios AS, Paula De Vincenti A, Casadei M, Aquino JB, Brumovsky PR, Paratcha G, Ledda F, Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation. Development. 2022 Aug 15;149(16):dev200583
5J:298882 Roome RB, Bourojeni FB, Mona B, Rastegar-Pouyani S, Blain R, Dumouchel A, Salesse C, Thompson WS, Brookbank M, Gitton Y, Tessarollo L, Goulding M, Johnson JE, Kmita M, Chedotal A, Kania A, Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans. Cell Rep. 2020 Nov 24;33(8):108425
3*J:58028 Russo MA, Giustizieri ML, Favale A, Fantini MC, Campagnolo L, Konda D, Germano F, Farini D, Manna C, Siracusa G, Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis. Biol Reprod. 1999 Oct;61(4):1123-32
1*J:196291 Ryu YK, Collins SE, Ho HY, Zhao H, Kuruvilla R, An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol. 2013 May 1;377(1):79-89
1J:58206 Sacristan MP, de Diego JG, Bonilla M, Martin-Zanca D, Molecular cloning and characterization of the 5' region of the mouse trkA proto-oncogene. Oncogene. 1999 Oct 14;18(42):5836-42
1J:231113 Sajgo S, Ali S, Popescu O, Badea TC, Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol. 2016 Apr 1;524(5):1033-61
1*J:66508 Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T, The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec;28(3):819-33
3J:153212 Schmidt H, Stonkute A, Juttner R, Koesling D, Friebe A, Rathjen FG, C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16847-52
2*J:135081 Schmidt H, Stonkute A, Juttner R, Schaffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG, The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007 Oct 22;179(2):331-40
7J:143238 Schmidt H, Werner M, Heppenstall PA, Henning M, More MI, Kuhbandner S, Lewin GR, Hofmann F, Feil R, Rathjen FG, cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol. 2002 Nov 11;159(3):489-98
2J:171905 Scott A, Hasegawa H, Sakurai K, Yaron A, Cobb J, Wang F, Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci. 2011 May 4;31(18):6741-9
2*J:93853 Sedy J, Szeder V, Walro JM, Ren ZG, Nanka O, Tessarollo L, Sieber-Blum M, Grim M, Kucera J, Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn. 2004 Nov;231(3):551-63
3J:158404 Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T, Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci. 2010 Mar;43(3):296-307
2J:218609 Serinagaoglu Y, Pare J, Giovannini M, Cao X, Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol. 2015 Feb 1;398(1):97-109
1J:187366 Shaker T, Dennis D, Kurrasch DM, Schuurmans C, Neurog1 and Neurog2 coordinately regulate development of the olfactory system. Neural Dev. 2012;7:28
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1J:310449 Shrestha A, Moe K, Luukko K, Taniguchi M, Kettunen P, Sema3A chemorepellant regulates the timing and patterning of dental nerves during development of incisor tooth germ. Cell Tissue Res. 2014 Jul;357(1):15-29
1J:71535 Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS, Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J Neurosci. 2001 Sep 15;21(18):7089-98
1*J:155900 Staaf S, Franck MC, Marmigere F, Mattsson JP, Ernfors P, Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010 Jan;10(1):65-74
4J:221159 Stubbusch J, Narasimhan P, Hennchen M, Huber K, Unsicker K, Ernsberger U, Rohrer H, Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
2J:325356 Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE Jr, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord AS, Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2108760119
1*J:207835 Suo D, Park J, Harrington AW, Zweifel LS, Mihalas S, Deppmann CD, Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014 Jan;17(1):36-45
1J:55842 Sussel L, Marin O, Kimura S, Rubenstein JL, Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug;126(15):3359-70
1J:206855 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T, CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci. 2014 Jan 22;34(4):1370-9
1J:264123 Tanimizu N, Ichinohe N, Mitaka T, Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver. Development. 2018 Apr 25;145(9):dev159095
1J:28346 Taylor LE, Bennett GD, Finnell RH, Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar;15(1):13-25
2J:116956 Teitelman G, Guz Y, Ivkovic S, Ehrlich M, Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells. J Neurobiol. 1998 Mar;34(4):304-18
1*J:12612 Tessarollo L, Tsoulfas P, Martin-Zanca D, Gilbert DJ, Jenkins NA, Copeland NG, Parada LF, trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues [published erratum appears in Development 1993 Aug;118(4):following 1384]. Development. 1993 Jun;118(2):463-75
2*J:67562 Tessarollo L, Vogel KS, Palko ME, Reid SW, Parada LF, Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11844-8
3J:91470 Theriault FM, Roy P, Stifani S, AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10343-8
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4J:237233 Tomlinson RE, Li Z, Zhang Q, Goh BC, Li Z, Thorek DL, Rajbhandari L, Brushart TM, Minichiello L, Zhou F, Venkatesan A, Clemens TL, NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone. Cell Rep. 2016 Sep 06;16(10):2723-35
1J:49575 Tourtellotte WG, Milbrandt J, Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat Genet. 1998 Sep;20(1):87-91
3J:344101 Tsimpos P, Desiderio S, Cabochette P, Poelvoorde P, Kricha S, Vanhamme L, Poulard C, Bellefroid EJ, Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage. Neural Dev. 2024 Jan 2;19(1):1
1J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
3*J:55799 Ulupinar E, Datwani A, Behar O, Fujisawa H, Erzurumlu R, Role of semaphorin III in the developing rodent trigeminal system. Mol Cell Neurosci. 1999 Apr;13(4):281-92
3J:182750 Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H, Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation. Development. 2012 Mar;139(6):1125-32
1J:184316 Venteo S, Bourane S, Mechaly I, Sar C, Abdel Samad O, Puech S, Blostein R, Valmier J, Pattyn A, Carroll P, Regulation of the Na,K-ATPase gamma-subunit FXYD2 by Runx1 and Ret signaling in normal and injured non-peptidergic nociceptive sensory neurons. PLoS One. 2012;7(1):e29852
2J:299610 Venteo S, Desiderio S, Cabochette P, Deslys A, Carroll P, Pattyn A, Neurog2 Deficiency Uncovers a Critical Period of Cell Fate Plasticity and Vulnerability among Neural-Crest-Derived Somatosensory Progenitors. Cell Rep. 2019 Dec 3;29(10):2953-2960.e2
1J:343072 Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San Jose AS, Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B, Brunet JF, Bellefroid EJ, Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
1*J:195264 Vincentz JW, Firulli BA, Lin A, Spicer DB, Howard MJ, Firulli AB, Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
1J:171496 Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD, The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet. 2011 Jun 1;20(11):2182-94
1J:174684 Wang L, Klein R, Zheng B, Marquardt T, Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking. Neuron. 2011 Jul 28;71(2):263-77
1J:270995 Wang L, Tanaka Y, Wang D, Morikawa M, Zhou R, Homma N, Miyamoto Y, Hirokawa N, The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase. Cell Rep. 2018 Sep 11;24(11):2894-2907
3J:186829 Watanabe K, Tamamaki N, Furuta T, Ackerman SL, Ikenaka K, Ono K, Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord. Development. 2006 Apr;133(7):1379-87
1*J:221937 Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips SE, Miller RJ, Wilson SM, Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290
2J:181639 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C, The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6
4*J:65653 Wertz K, Herrmann BG, Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
1*J:64327 White FA, Behar O, The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin3A null mutant mice. Dev Biol. 2000 Sep 1;225(1):79-86
6*J:34321 White FA, Silos-Santiago I, Molliver DC, Nishimura M, Phillips H, Barbacid M, Snider WD, Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. J Neurosci. 1996 Aug 1;16(15):4662-72
3J:145293 Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD, Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron. 2008 May 22;58(4):532-45
6J:93311 Wiggins AK, Wei G, Doxakis E, Wong C, Tang AA, Zang K, Luo EJ, Neve RL, Reichardt LF, Huang EJ, Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 2004 Nov 25;167(2):257-67
3J:196947 Wildner H, Das Gupta R, Brohl D, Heppenstall PA, Zeilhofer HU, Birchmeier C, Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. J Neurosci. 2013 Apr 24;33(17):7299-307
2J:60159 Wolpowitz D, Mason TB, Dietrich P, Mendelsohn M, Talmage DA, Role LW, Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000 Jan;25(1):79-91
1J:272890 Wu Z, Makihara S, Yam PT, Teo S, Renier N, Balekoglu N, Moreno-Bravo JA, Olsen O, Chedotal A, Charron F, Tessier-Lavigne M, Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells. Neuron. 2019 Feb 20;101(4):635-647.e4
8*J:87350 Wyatt S, Davies AM, Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development. J Cell Biol. 1995 Sep;130(6):1435-46
6*J:41123 Wyatt S, Pinon LG, Ernfors P, Davies AM, Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos. EMBO J. 1997 Jun 2;16(11):3115-23
1J:173415 Wyatt SL, Spori B, Vizard TN, Davies AM, Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation. Neural Dev. 2011;6:18
1J:341688 Xie X, Sun L, Duan Y, Lv Z, Yao X, Wang C, Chen X, Tian S, Yan L, Shao Y, Luo H, Liu J, SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
1J:201733 Xu Y, Lopes C, Wende H, Guo Z, Cheng L, Birchmeier C, Ma Q, Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. J Neurosci. 2013 Sep 11;33(37):14738-48
1J:276062 Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C, Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373
1J:131060 Yang X, Zhou Y, Barcarse EA, O'Gorman S, Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol. 2008 Feb 1;314(1):171-88
2J:250141 Yanpallewar S, Wang T, Koh DC, Quarta E, Fulgenzi G, Tessarollo L, Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli. Sci Rep. 2016 Sep 8;6:32957
3J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88
3J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247
2J:207050 Zhao X, Huang H, Chen Y, Liu Y, Zhang Z, Ma Q, Qiu M, Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Sep 17;248:594-601
1J:84641 Zhao Y, Marin O, Hermesz E, Powell A, Flames N, Palkovits M, Rubenstein JL, Westphal H, The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9005-10
5J:121660 Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD, Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007 May;10(5):598-607
6J:183949 Zou M, Li S, Klein WH, Xiang M, Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15;364(2):114-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory